Structurally novel histamine H3 receptor antagonists GSK207040 and GSK334429 improve scopolamine-induced memory impairment and capsaicin-induced secondary allodynia in rats
Medhurst, Andrew D, Briggs, Michael A, Bruton, Gordon, Calver, Andrew R, Chessell, Iain, Crook, Barry, Davis, John B, Davis, Robert P, Foley, Andrew G, Heslop, Teresa, Hirst, Warren D, Medhurst, Stephen J, Ociepka, Sandrine, Ray, Alison, Regan, Ciaran M, Sargent, Becky, Schogger, Joanne, Stean, Tania O, Trail, Brenda K, Upton, Neil, White, Trevor, Orlek, Barry, Wilson, David M
Published in Biochemical pharmacology (15.04.2007)
Published in Biochemical pharmacology (15.04.2007)
Get full text
Journal Article
A Practical Synthesis of Differentially Protected 4,4 '-Dipiperidinyl Ethers: Novel Ligands of Pharmaceutical Interest
Bailey, James M., Bruton, Gordon, Huxley, Anthony, Johnstone, Vicky, Milner, Peter H., Orlek, Barry S., Stemp, Geoffrey
Published in Synlett (23.04.2009)
Published in Synlett (23.04.2009)
Get more information
Journal Article
The discovery and optimisation of benzazepine sulfonamide and sulfones as potent agonists of the motilin receptor
Bailey, James M., Scott, Jackie S., Basilla, Jonathan B., Bolton, Victoria J., Boyfield, Izzy, Evans, David G., Fleury, Etienne, Heightman, Tom D., Jarvie, Emma M., Lawless, Kirk, Matthews, Kim L., McKay, Fiona, Mok, Hindy, Muir, Alison, Orlek, Barry S., Sanger, Gareth J., Stemp, Geoffrey, Stevens, Alexander J., Thompson, Mervyn, Ward, John, Vaidya, Kalindi, Westaway, Susan M.
Published in Bioorganic & medicinal chemistry letters (15.11.2009)
Published in Bioorganic & medicinal chemistry letters (15.11.2009)
Get full text
Journal Article
Comparison of azabicyclic esters and oxadiazoles as ligands for the muscarinic receptor
Orlek, Barry S, Blaney, Frank E, Brown, Frank, Clark, Michael S. G, Hadley, Michael S, Hatcher, John, Riley, Graham J, Rosenberg, Howard E, Wadsworth, Harry J, Wyman, Paul
Published in Journal of medicinal chemistry (01.09.1991)
Published in Journal of medicinal chemistry (01.09.1991)
Get full text
Journal Article
Synthesis and muscarinic activities of quinuclidin-3-yltriazole and -tetrazole derivatives
Wadsworth, Harry J, Jenkins, Sarah M, Orlek, Barry S, Cassidy, Frederick, Clark, Michael S. G, Brown, Frank, Riley, Graham J, Graves, Diane, Hawkins, Julie, Naylor, Christopher B
Published in Journal of medicinal chemistry (01.04.1992)
Published in Journal of medicinal chemistry (01.04.1992)
Get full text
Journal Article
Design of [R-(Z)]-(+)-α-(Methoxyimino)-1-azabicyclo[2.2.2]octane-3-acetonitrile (SB 202026), a Functionally Selective Azabicyclic Muscarinic M1 Agonist Incorporating the N-Methoxy Imidoyl Nitrile Group as a Novel Ester Bioisostere
Bromidge, Steven M, Brown, Frank, Cassidy, Frederick, Clark, Michael S. G, Dabbs, Steven, Hadley, Michael S, Hawkins, Julie, Loudon, Julia M, Naylor, Christopher B, Orlek, Barry S, Riley, Graham J
Published in Journal of medicinal chemistry (19.12.1997)
Published in Journal of medicinal chemistry (19.12.1997)
Get full text
Journal Article
Substituent variation in azabicyclic triazole- and tetrazole-based muscarinic receptor ligands
Jenkins, Sarah M, Wadsworth, Harry J, Bromidge, Steven, Orlek, Barry S, Wyman, Paul A, Riley, Graham J, Hawkins, Julie
Published in Journal of medicinal chemistry (01.06.1992)
Published in Journal of medicinal chemistry (01.06.1992)
Get full text
Journal Article
Structurally novel histamine H 3 receptor antagonists GSK207040 and GSK334429 improve scopolamine-induced memory impairment and capsaicin-induced secondary allodynia in rats
Medhurst, Andrew D., Briggs, Michael A., Bruton, Gordon, Calver, Andrew R., Chessell, Iain, Crook, Barry, Davis, John B., Davis, Robert P., Foley, Andrew G., Heslop, Teresa, Hirst, Warren D., Medhurst, Stephen J., Ociepka, Sandrine, Ray, Alison, Regan, Ciaran M., Sargent, Becky, Schogger, Joanne, Stean, Tania O., Trail, Brenda K., Upton, Neil, White, Trevor, Orlek, Barry, Wilson, David M.
Published in Biochemical pharmacology (15.04.2007)
Published in Biochemical pharmacology (15.04.2007)
Get full text
Journal Article
Lipopeptide substrates for SpsB, the Staphylococcus aureus type I signal peptidase: design, conformation and conversion to α-ketoamide inhibitors
Bruton, Gordon, Huxley, Anthony, O'Hanlon, Peter, Orlek, Barry, Eggleston, Drake, Humphries, John, Readshaw, Simon, West, Andrew, Ashman, Stephen, Brown, Murray, Moore, Keith, Pope, Andrew, O'Dwyer, Karen, Wang, Lei
Published in European journal of medicinal chemistry (01.04.2003)
Published in European journal of medicinal chemistry (01.04.2003)
Get full text
Journal Article
Conference Proceeding
PIPERAZINE DERIVATIVE HAVING AFFINITY FOR THE HISTAMINE H3 RECEPTOR
THEOBALD PAMELA JOAN, RASSIAS GERACIMOS, ORLEK BARRY SIDNEY, BEST DESMOND JOHN, MAK SING YEUNG
Year of Publication 04.06.2010
Get full text
Year of Publication 04.06.2010
Patent
Structurally novel histamine H3 receptor antagonists GSK207040 and GSK334429 improve scopolamine-induced memory impairment and capsaicin-induced secondary allodynia in rats: Art Hancock memorial special issue: Adrenergic and histaminergic pharmacology
MEDHURST, Andrew D, BRINGS, Michael A, HIRST, Warren D, MEDHURST, Stephen J, OCIEPKA, Sandrine, RAY, Alison, REGAN, Ciaran M, SARGENT, Becky, SCHOGGER, Joanne, STEAN, Tania O, TRAIL, Brenda K, UPTON, Neil, BRUTON, Gordon, WHITE, Treuor, ORLEK, Barry, WILSON, David M, CALUER, Andrew R, CHESSELL, Iain, CROOK, Barry, DAVIS, John B, DAVIS, Robert P, FOLEY, Andrew G, HESLOP, Teresa
Published in Biochemical pharmacology (2007)
Get full text
Published in Biochemical pharmacology (2007)
Journal Article
USE OF STERIC BUTTRESSES TO ENHANCE INTRAMOLECULAR CYCLOADDITIONS
ORLEK, BS, SAMMES, PG, WELLER, DJ
Published in Journal of the Chemical Society. Chemical communications (1993)
Published in Journal of the Chemical Society. Chemical communications (1993)
Get full text
Journal Article
STERIC ACCELERATION OF INTRAMOLECULAR AZIDE CYCLOADDITIONS
ORLEK, BS, SAMMES, PG, WELLER, DJ
Published in Journal of the Chemical Society. Chemical communications (1993)
Published in Journal of the Chemical Society. Chemical communications (1993)
Get full text
Journal Article