Specific Inhibition of the Bifunctional Farnesyl/Geranylgeranyl Diphosphate Synthase in Malaria Parasites via a New Small-Molecule Binding Site
Gisselberg, Jolyn E., Herrera, Zachary, Orchard, Lindsey M., Llinás, Manuel, Yeh, Ellen
Published in Cell chemical biology (15.02.2018)
Published in Cell chemical biology (15.02.2018)
Get full text
Journal Article
Dissecting the role of PfAP2-G in malaria gametocytogenesis
Josling, Gabrielle A., Russell, Timothy J., Venezia, Jarrett, Orchard, Lindsey, van Biljon, Riëtte, Painter, Heather J., Llinás, Manuel
Published in Nature communications (20.03.2020)
Published in Nature communications (20.03.2020)
Get full text
Journal Article
Multistage and transmission-blocking targeted antimalarials discovered from the open-source MMV Pandemic Response Box
Reader, Janette, van der Watt, Mariëtte E., Taylor, Dale, Le Manach, Claire, Mittal, Nimisha, Ottilie, Sabine, Theron, Anjo, Moyo, Phanankosi, Erlank, Erica, Nardini, Luisa, Venter, Nelius, Lauterbach, Sonja, Bezuidenhout, Belinda, Horatscheck, Andre, van Heerden, Ashleigh, Spillman, Natalie J., Cowell, Anne N., Connacher, Jessica, Opperman, Daniel, Orchard, Lindsey M., Llinás, Manuel, Istvan, Eva S., Goldberg, Daniel E., Boyle, Grant A., Calvo, David, Mancama, Dalu, Coetzer, Theresa L., Winzeler, Elizabeth A., Duffy, James, Koekemoer, Lizette L., Basarab, Gregory, Chibale, Kelly, Birkholtz, Lyn-Marié
Published in Nature communications (11.01.2021)
Published in Nature communications (11.01.2021)
Get full text
Journal Article
Refining the transcriptome of the human malaria parasite Plasmodium falciparum using amplification-free RNA-seq
Chappell, Lia, Ross, Philipp, Orchard, Lindsey, Russell, Timothy J, Otto, Thomas D, Berriman, Matthew, Rayner, Julian C, Llinás, Manuel
Published in BMC genomics (08.06.2020)
Published in BMC genomics (08.06.2020)
Get full text
Journal Article
Hierarchical transcriptional control regulates Plasmodium falciparum sexual differentiation
van Biljon, Riëtte, van Wyk, Roelof, Painter, Heather J, Orchard, Lindsey, Reader, Janette, Niemand, Jandeli, Llinás, Manuel, Birkholtz, Lyn-Marie
Published in BMC genomics (03.12.2019)
Published in BMC genomics (03.12.2019)
Get full text
Journal Article
Red Blood Cell Invasion by the Malaria Parasite Is Coordinated by the PfAP2-I Transcription Factor
Santos, Joana Mendonca, Josling, Gabrielle, Ross, Philipp, Joshi, Preeti, Orchard, Lindsey, Campbell, Tracey, Schieler, Ariel, Cristea, Ileana M., Llinás, Manuel
Published in Cell host & microbe (14.06.2017)
Published in Cell host & microbe (14.06.2017)
Get full text
Journal Article
Piperaquine-resistant PfCRT mutations differentially impact drug transport, hemoglobin catabolism and parasite physiology in Plasmodium falciparum asexual blood stages
Okombo, John, Mok, Sachel, Qahash, Tarrick, Yeo, Tomas, Bath, Jade, Orchard, Lindsey M, Owens, Edward, Koo, Imhoi, Albert, Istvan, Llinás, Manuel, Fidock, David A
Published in PLoS pathogens (01.10.2022)
Published in PLoS pathogens (01.10.2022)
Get full text
Journal Article
A seven-helix protein constitutes stress granules crucial for regulating translation during human-to-mosquito transmission of Plasmodium falciparum
Bennink, Sandra, von Bohl, Andreas, Ngwa, Che J, Henschel, Leonie, Kuehn, Andrea, Pilch, Nicole, Weißbach, Tim, Rosinski, Alina N, Scheuermayer, Matthias, Repnik, Urska, Przyborski, Jude M, Minns, Allen M, Orchard, Lindsey M, Griffiths, Gareth, Lindner, Scott E, Llinás, Manuel, Pradel, Gabriele
Published in PLoS pathogens (01.08.2018)
Published in PLoS pathogens (01.08.2018)
Get full text
Journal Article
Lipopeptisomes: Anticancer peptide-assembled particles for fusolytic oncotherapy
Aronson, Matthew R., Simonson, Andrew W., Orchard, Lindsey M., Llinás, Manuel, Medina, Scott H.
Published in Acta biomaterialia (15.10.2018)
Published in Acta biomaterialia (15.10.2018)
Get full text
Journal Article
Atypical Molecular Basis for Drug Resistance to Mitochondrial Function Inhibitors in Plasmodium falciparum
Painter, Heather J, Morrisey, Joanne M, Mather, Michael W, Orchard, Lindsey M, Luck, Cuyler, Smilkstein, Martin J, Riscoe, Michael K, Vaidya, Akhil B, Llinás, Manuel
Published in Antimicrobial agents and chemotherapy (17.02.2021)
Published in Antimicrobial agents and chemotherapy (17.02.2021)
Get full text
Journal Article
H3K36 methylation reprograms gene expression to drive early gametocyte development in Plasmodium falciparum
Connacher, Jessica, Josling, Gabrielle A, Orchard, Lindsey M, Reader, Janette, Llinás, Manuel, Birkholtz, Lyn-Marié
Published in Epigenetics & chromatin (01.04.2021)
Published in Epigenetics & chromatin (01.04.2021)
Get full text
Journal Article
Transcriptional Profiling Defines Histone Acetylation as a Regulator of Gene Expression during Human-to-Mosquito Transmission of the Malaria Parasite Plasmodium falciparum
Ngwa, Che J, Kiesow, Meike J, Papst, Olga, Orchard, Lindsey M, Filarsky, Michael, Rosinski, Alina N, Voss, Till S, Llinás, Manuel, Pradel, Gabriele
Published in Frontiers in cellular and infection microbiology (24.07.2017)
Published in Frontiers in cellular and infection microbiology (24.07.2017)
Get full text
Journal Article
Characterization of the Plasmodium falciparum and P. berghei glycerol 3‐phosphate acyltransferase involved in FASII fatty acid utilization in the malaria parasite apicoplast
Shears, Melanie J., MacRae, James I., Mollard, Vanessa, Goodman, Christopher D., Sturm, Angelika, Orchard, Lindsey M., Llinás, Manuel, McConville, Malcolm J., Botté, Cyrille Y., McFadden, Geoffrey I.
Published in Cellular microbiology (01.01.2017)
Published in Cellular microbiology (01.01.2017)
Get full text
Journal Article
The transcriptional regulator HDP1 controls expansion of the inner membrane complex during early sexual differentiation of malaria parasites
Campelo Morillo, Riward A., Tong, Xinran, Xie, Wei, Abel, Steven, Orchard, Lindsey M., Daher, Wassim, Patel, Dinshaw J., Llinás, Manuel, Le Roch, Karine G., Kafsack, Björn F. C.
Published in Nature microbiology (01.02.2022)
Published in Nature microbiology (01.02.2022)
Get full text
Journal Article
The G9a Histone Methyltransferase Inhibitor BIX-01294 Modulates Gene Expression during Plasmodium falciparum Gametocyte Development and Transmission
Ngwa, Che Julius, Kiesow, Meike Jutta, Orchard, Lindsey Marie, Farrukh, Afia, Llinás, Manuel, Pradel, Gabriele
Published in International journal of molecular sciences (14.10.2019)
Published in International journal of molecular sciences (14.10.2019)
Get full text
Journal Article
Publisher Correction: The transcriptional regulator HDP1 controls expansion of the inner membrane complex during early sexual differentiation of malaria parasites
Campelo Morillo, Riward A., Tong, Xinran, Xie, Wei, Abel, Steven, Orchard, Lindsey M., Daher, Wassim, Patel, Dinshaw J., Llinás, Manuel, Le Roch, Karine G., Kafsack, Björn F. C.
Published in Nature microbiology (01.03.2022)
Published in Nature microbiology (01.03.2022)
Get full text
Journal Article
A single-nucleotide polymorphism in a Plasmodium berghei ApiAP2 transcription factor alters the development of host immunity
Akkaya, Munir, Bansal, Abhisheka, Sheehan, Patrick W, Pena, Mirna, Molina-Cruz, Alvaro, Orchard, Lindsey M, Cimperman, Clare K, Qi, Chen-Feng, Ross, Philipp, Yazew, Takele, Sturdevant, Daniel, Anzick, Sarah L, Thiruvengadam, Girija, Otto, Thomas Dan, Billker, Oliver, Llinás, Manuel, Miller, Louis H, Pierce, Susan K
Published in Science advances (01.02.2020)
Published in Science advances (01.02.2020)
Get full text
Journal Article
Chemogenomic Fingerprints Associated with Stage-Specific Gametocytocidal Compound Action against Human Malaria Parasites
Niemand, Jandeli, van Biljon, Riëtte, van der Watt, Mariëtte, van Heerden, Ashleigh, Reader, Janette, van Wyk, Roelof, Orchard, Lindsey, Chibale, Kelly, Llinás, Manuel, Birkholtz, Lyn-Marié
Published in ACS infectious diseases (08.10.2021)
Published in ACS infectious diseases (08.10.2021)
Get full text
Journal Article