Transcriptome-wide association study of schizophrenia and chromatin activity yields mechanistic disease insights
Gusev, Alexander, Mancuso, Nicholas, Won, Hyejung, Kousi, Maria, Finucane, Hilary K., Reshef, Yakir, Song, Lingyun, Safi, Alexias, McCarroll, Steven, Neale, Benjamin M., Ophoff, Roel A., O’Donovan, Michael C., Crawford, Gregory E., Geschwind, Daniel H., Katsanis, Nicholas, Sullivan, Patrick F., Pasaniuc, Bogdan, Price, Alkes L.
Published in Nature genetics (01.04.2018)
Published in Nature genetics (01.04.2018)
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An integrative multi-scale analysis of the dynamic DNA methylation landscape in aging
Yuan, Tian, Jiao, Yinming, de Jong, Simone, Ophoff, Roel A, Beck, Stephan, Teschendorff, Andrew E
Published in PLoS genetics (01.02.2015)
Published in PLoS genetics (01.02.2015)
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Accelerated aging in the brain, epigenetic aging in blood, and polygenic risk for schizophrenia
Teeuw, Jalmar, Ori, Anil P.S., Brouwer, Rachel M., de Zwarte, Sonja M.C., Schnack, Hugo G., Hulshoff Pol, Hilleke E., Ophoff, Roel A.
Published in Schizophrenia research (01.05.2021)
Published in Schizophrenia research (01.05.2021)
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Genetic analysis of DNA methylation and gene expression levels in whole blood of healthy human subjects
van Eijk, Kristel R, de Jong, Simone, Boks, Marco P M, Langeveld, Terry, Colas, Fabrice, Veldink, Jan H, de Kovel, Carolien G F, Janson, Esther, Strengman, Eric, Langfelder, Peter, Kahn, René S, van den Berg, Leonard H, Horvath, Steve, Ophoff, Roel A
Published in BMC genomics (17.11.2012)
Published in BMC genomics (17.11.2012)
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The relationship of DNA methylation with age, gender and genotype in twins and healthy controls
Boks, Marco P, Derks, Eske M, Weisenberger, Daniel J, Strengman, Erik, Janson, Esther, Sommer, Iris E, Kahn, René S, Ophoff, Roel A
Published in PloS one (26.08.2009)
Published in PloS one (26.08.2009)
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Aging effects on DNA methylation modules in human brain and blood tissue
Horvath, Steve, Zhang, Yafeng, Langfelder, Peter, Kahn, René S, Boks, Marco PM, van Eijk, Kristel, van den Berg, Leonard H, Ophoff, Roel A
Published in Genome biology (03.10.2012)
Published in Genome biology (03.10.2012)
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Brain network analysis reveals affected connectome structure in bipolar I disorder
Collin, Guusje, van den Heuvel, Martijn P., Abramovic, Lucija, Vreeker, Annabel, de Reus, Marcel A., van Haren, Neeltje E.M., Boks, Marco P.M., Ophoff, Roel A., Kahn, René S.
Published in Human brain mapping (01.01.2016)
Published in Human brain mapping (01.01.2016)
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A gene co-expression network in whole blood of schizophrenia patients is independent of antipsychotic-use and enriched for brain-expressed genes
de Jong, Simone, Boks, Marco P M, Fuller, Tova F, Strengman, Eric, Janson, Esther, de Kovel, Carolien G F, Ori, Anil P S, Vi, Nancy, Mulder, Flip, Blom, Jan Dirk, Glenthøj, Birte, Schubart, Chris D, Cahn, Wiepke, Kahn, René S, Horvath, Steve, Ophoff, Roel A
Published in PloS one (27.06.2012)
Published in PloS one (27.06.2012)
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Common variants on 8p12 and 1q24.2 confer risk of schizophrenia
Shi, Yongyong, Li, Zhiqiang, Xu, Qi, Wang, Ti, Li, Tao, Shen, Jiawei, Zhang, Fengyu, Chen, Jianhua, Zhou, Guoquan, Ji, Weidong, Li, Baojie, Xu, Yifeng, Liu, Dengtang, Wang, Peng, Yang, Ping, Liu, Benxiu, Sun, Wensheng, Wan, Chunling, Qin, Shengying, He, Guang, Steinberg, Stacy, Cichon, Sven, Werge, Thomas, Sigurdsson, Engilbert, Tosato, Sarah, Palotie, Aarno, Nöthen, Markus M, Rietschel, Marcella, Ophoff, Roel A, Collier, David A, Rujescu, Dan, Clair, David St, Stefansson, Hreinn, Stefansson, Kari, Ji, Jue, Wang, Qingzhong, Li, Wenjin, Zheng, Linqing, Zhang, Hairong, Feng, Guoyin, He, Lin
Published in Nature genetics (01.12.2011)
Published in Nature genetics (01.12.2011)
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Recurrent CNVs Disrupt Three Candidate Genes in Schizophrenia Patients
Vrijenhoek, Terry, Buizer-Voskamp, Jacobine E., van der Stelt, Inge, Strengman, Eric, Sabatti, Chiara, Geurts van Kessel, Ad, Brunner, Han G., Ophoff, Roel A., Veltman, Joris A.
Published in American journal of human genetics (01.10.2008)
Published in American journal of human genetics (01.10.2008)
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Transcriptome analysis in whole blood reveals increased microbial diversity in schizophrenia
Olde Loohuis, Loes M., Mangul, Serghei, Ori, Anil P. S., Jospin, Guillaume, Koslicki, David, Yang, Harry Taegyun, Wu, Timothy, Boks, Marco P., Lomen-Hoerth, Catherine, Wiedau-Pazos, Martina, Cantor, Rita M., de Vos, Willem M., Kahn, René S., Eskin, Eleazar, Ophoff, Roel A.
Published in Translational psychiatry (10.05.2018)
Published in Translational psychiatry (10.05.2018)
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ROP: dumpster diving in RNA-sequencing to find the source of 1 trillion reads across diverse adult human tissues
Mangul, Serghei, Yang, Harry Taegyun, Strauli, Nicolas, Gruhl, Franziska, Porath, Hagit T, Hsieh, Kevin, Chen, Linus, Daley, Timothy, Christenson, Stephanie, Wesolowska-Andersen, Agata, Spreafico, Roberto, Rios, Cydney, Eng, Celeste, Smith, Andrew D, Hernandez, Ryan D, Ophoff, Roel A, Santana, Jose Rodriguez, Levanon, Erez Y, Woodruff, Prescott G, Burchard, Esteban, Seibold, Max A, Shifman, Sagiv, Eskin, Eleazar, Zaitlen, Noah
Published in Genome Biology (15.02.2018)
Published in Genome Biology (15.02.2018)
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Is human blood a good surrogate for brain tissue in transcriptional studies?
Cai, Chaochao, Langfelder, Peter, Fuller, Tova F, Oldham, Michael C, Luo, Rui, van den Berg, Leonard H, Ophoff, Roel A, Horvath, Steve
Published in BMC genomics (20.10.2010)
Published in BMC genomics (20.10.2010)
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Weighted gene co-expression network analysis of the peripheral blood from Amyotrophic Lateral Sclerosis patients
Saris, Christiaan G J, Horvath, Steve, van Vught, Paul W J, van Es, Michael A, Blauw, Hylke M, Fuller, Tova F, Langfelder, Peter, DeYoung, Joseph, Wokke, John H J, Veldink, Jan H, van den Berg, Leonard H, Ophoff, Roel A
Published in BMC genomics (27.08.2009)
Published in BMC genomics (27.08.2009)
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ITPR2 as a susceptibility gene in sporadic amyotrophic lateral sclerosis: a genome-wide association study
van Es, Michael A, MD, Van Vught, Paul W, MSc, Blauw, Hylke M, MD, Franke, Lude, MSc, Saris, Christiaan G, MD, Andersen, Peter M, MD, Van Den Bosch, Ludo, PhD, de Jong, Sonja W, MD, van 't Slot, Ruben, BSc, Birve, Anna, PhD, Lemmens, Robin, MD, de Jong, Vianney, MD, Baas, Frank, PhD, Schelhaas, Helenius J, MD, Sleegers, Kristel, MD, Van Broeckhoven, Christine, PhD, Wokke, John HJ, MD, Wijmenga, Cisca, PhD, Robberecht, Wim, MD, Veldink, Jan H, MD, Ophoff, Roel A, PhD, van den Berg, Leonard H, MD
Published in Lancet neurology (01.10.2007)
Published in Lancet neurology (01.10.2007)
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Genome-Wide Analysis Shows Increased Frequency of Copy Number Variation Deletions in Dutch Schizophrenia Patients
Buizer-Voskamp, Jacobine E, Muntjewerff, Jan-Willem, Strengman, Eric, Sabatti, Chiara, Stefansson, Hreinn, Vorstman, Jacob A.S, Ophoff, Roel A
Published in Biological psychiatry (1969) (01.10.2011)
Published in Biological psychiatry (1969) (01.10.2011)
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Genetic liability for schizophrenia predicts risk of immune disorders
Stringer, Sven, Kahn, René S, de Witte, Lot D, Ophoff, Roel A, Derks, Eske M
Published in Schizophrenia research (01.11.2014)
Published in Schizophrenia research (01.11.2014)
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Migraine: a complex genetic disorder
Wessman, Maija, PhD, Terwindt, Gisela M, MD, Kaunisto, Mari A, PhD, Palotie, Aarno, MD, Ophoff, Roel A, PhD
Published in Lancet neurology (01.06.2007)
Published in Lancet neurology (01.06.2007)
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Accurate and Fast Multiple-Testing Correction in eQTL Studies
Sul, Jae Hoon, Raj, Towfique, de Jong, Simone, de Bakker, Paul I.W., Raychaudhuri, Soumya, Ophoff, Roel A., Stranger, Barbara E., Eskin, Eleazar, Han, Buhm
Published in American journal of human genetics (04.06.2015)
Published in American journal of human genetics (04.06.2015)
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