Search Results - "Ontoria, Jesus M." :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

SAR evolution towards potent C-terminal carboxamide peptide inhibitors of Zika virus NS2B-NS3 protease

SAR evolution towards potent C-terminal carboxamide peptide inhibitors of Zika virus NS2B-NS3 protease

by Colarusso, Stefania, Ferrigno, Federica, Ponzi, Simona, Pavone, Francesca, Conte, Immacolata, Abate, Luigi, Beghetto, Elisa, Missineo, Antonino, Amaudrut, Jerome, Bresciani, Alberto, Paonessa, Giacomo, Tomei, Licia, Montalbetti, Christian, Bianchi, Elisabetta, Toniatti, Carlo, Ontoria, Jesus M.
Published in Bioorganic & medicinal chemistry (01.03.2022)

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Discovery of 2-{4-[(3S)-Piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide (MK-4827): A Novel Oral Poly(ADP-ribose)polymerase (PARP) Inhibitor Efficacious in BRCA-1 and -2 Mutant Tumors

Discovery of 2-{4-[(3S)-Piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide (MK-4827): A Novel Oral Poly(ADP-ribose)polymerase (PARP) Inhibitor Efficacious in BRCA-1 and -2 Mutant Tumors

by Jones, Philip, Altamura, Sergio, Boueres, Julia, Ferrigno, Federica, Fonsi, Massimiliano, Giomini, Claudia, Lamartina, Stefania, Monteagudo, Edith, Ontoria, Jesus M, Orsale, Maria Vittoria, Palumbi, Maria Cecilia, Pesci, Silvia, Roscilli, Giuseppe, Scarpelli, Rita, Schultz-Fademrecht, Carsten, Toniatti, Carlo, Rowley, Michael
Published in Journal of medicinal chemistry (26.11.2009)

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Discovery of 2-(1H-imidazo-2-yl)piperazines as a new class of potent and non-cytotoxic inhibitors of Trypanosoma brucei growth in vitro

Discovery of 2-(1H-imidazo-2-yl)piperazines as a new class of potent and non-cytotoxic inhibitors of Trypanosoma brucei growth in vitro

by Ferrigno, Federica, Biancofiore, Ilaria, Malancona, Savina, Ponzi, Simona, Paonessa, Giacomo, Graziani, Rita, Bresciani, Alberto, Gennari, Nadia, Di Marco, Annalise, Kaiser, Marcel, Summa, Vincenzo, Harper, Steven, Ontoria, Jesus M.
Published in Bioorganic & medicinal chemistry letters (15.12.2018)

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Direct-to-biology platform: From synthesis to biological evaluation of SHP2 allosteric inhibitors

Direct-to-biology platform: From synthesis to biological evaluation of SHP2 allosteric inhibitors

by Ponzi, Simona, Ferrigno, Federica, Bisbocci, Monica, Alli, Cristina, Ontoria, Jesus M., Petrocchi, Alessia, Toniatti, Carlo, Torrente, Esther
Published in Bioorganic & medicinal chemistry letters (01.03.2024)

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Identification of thieno[3,2- b]pyrroles as allosteric inhibitors of hepatitis C virus NS5B polymerase

Identification of thieno[3,2- b]pyrroles as allosteric inhibitors of hepatitis C virus NS5B polymerase

by Ontoria, Jesus M., Martìn Hernando, Jose I., Malancona, Savina, Attenni, Barbara, Stansfield, Ian, Conte, Immacolata, Ercolani, Caterina, Habermann, Jörg, Ponzi, Simona, Di Filippo, Marcello, Koch, Uwe, Rowley, Michael, Narjes, Frank
Published in Bioorganic & medicinal chemistry letters (01.08.2006)

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Discovery of 4-((1-(1H-imidazol-2-yl)alkoxy)methyl)pyridines as a new class of Trypanosoma cruzi growth inhibitors

Discovery of 4-((1-(1H-imidazol-2-yl)alkoxy)methyl)pyridines as a new class of Trypanosoma cruzi growth inhibitors

by Ponzi, Simona, Bresciani, Alberto, Kaiser, Marcel, Nardi, Valentina, Nizi, Emanuela, Ontoria, Jesus M., Pace, Paola, Paonessa, Giacomo, Summa, Vincenzo, Harper, Steven
Published in Bioorganic & medicinal chemistry letters (15.04.2020)

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Discovery of a Novel Series of Imidazopyrazine Derivatives as Potent SHP2 Allosteric Inhibitors

Discovery of a Novel Series of Imidazopyrazine Derivatives as Potent SHP2 Allosteric Inhibitors

by Torrente, Esther, Fodale, Valentina, Ciammaichella, Alina, Ferrigno, Federica, Ontoria, Jesus M., Ponzi, Simona, Rossetti, Ilaria, Sferrazza, Alessio, Amaudrut, Jérôme, Missineo, Antonino, Esposito, Simone, Palombo, Simone, Nibbio, Martina, Cerretani, Mauro, Bisbocci, Monica, Cellucci, Antonella, di Marco, Annalise, Alli, Cristina, Pucci, Vincenzo, Toniatti, Carlo, Petrocchi, Alessia
Published in ACS medicinal chemistry letters (09.02.2023)

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Optimization of 2-(1H-imidazo-2-yl)piperazines series of Trypanosoma brucei growth inhibitors as potential treatment for the second stage of HAT

Optimization of 2-(1H-imidazo-2-yl)piperazines series of Trypanosoma brucei growth inhibitors as potential treatment for the second stage of HAT

by Ciammaichella, Alina, Ferrigno, Federica, Basta, Andreina, D'Amico, Melania, Biancofiore, Ilaria, Nardi, Valentina, Ponzi, Simona, Graziani, Rita, Gennari, Nadia, Vittoria Orsale, Maria, Fini, Ivan, Paonessa, Giacomo, Summa, Vincenzo, Harper, Steven, Ontoria, Jesus M.
Published in Bioorganic & medicinal chemistry letters (15.06.2020)

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The Design and Enzyme-Bound Crystal Structure of Indoline Based Peptidomimetic Inhibitors of Hepatitis C Virus NS3 Protease

The Design and Enzyme-Bound Crystal Structure of Indoline Based Peptidomimetic Inhibitors of Hepatitis C Virus NS3 Protease

by Ontoria, Jesus M, Di Marco, Stefania, Conte, Immacolata, Di Francesco, M. Emilia, Gardelli, Cristina, Koch, Uwe, Matassa, Victor G, Poma, Marco, Steinkühler, Christian, Volpari, Cinzia, Harper, Steven
Published in Journal of medicinal chemistry (16.12.2004)

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Improved Selective Class I HDAC and Novel Selective HDAC3 Inhibitors: Beyond Hydroxamic Acids and Benzamides

Improved Selective Class I HDAC and Novel Selective HDAC3 Inhibitors: Beyond Hydroxamic Acids and Benzamides

by Bresciani, Alberto, Ontoria, Jesus M, Biancofiore, Ilaria, Cellucci, Antonella, Ciammaichella, Alina, Di Marco, Annalise, Ferrigno, Federica, Francone, Alessandra, Malancona, Savina, Monteagudo, Edith, Nizi, Emanuela, Pace, Paola, Ponzi, Simona, Rossetti, Ilaria, Veneziano, Maria, Summa, Vincenzo, Harper, Steven
Published in ACS medicinal chemistry letters (11.04.2019)

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Combined Peptide and Small-Molecule Approach toward Nonacidic THIQ Inhibitors of the KEAP1/NRF2 Interaction

Combined Peptide and Small-Molecule Approach toward Nonacidic THIQ Inhibitors of the KEAP1/NRF2 Interaction

by Ontoria, Jesus M, Biancofiore, Ilaria, Fezzardi, Paola, Ferrigno, Federica, Torrente, Esther, Colarusso, Stefania, Bianchi, Elisabetta, Andreini, Matteo, Patsilinakos, Alexandros, Kempf, Georg, Augustin, Martin, Steinbacher, Stefan, Summa, Vincenzo, Pacifici, Robert, Muñoz-Sanjuan, Ignacio, Park, Larry, Bresciani, Alberto, Dominguez, Celia, Sherman, Leticia Toledo, Harper, Steven
Published in ACS medicinal chemistry letters (14.05.2020)

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Identification of Novel, Selective, and Stable Inhibitors of Class II Histone Deacetylases. Validation Studies of the Inhibition of the Enzymatic Activity of HDAC4 by Small Molecules as a Novel Approach for Cancer Therapy

Identification of Novel, Selective, and Stable Inhibitors of Class II Histone Deacetylases. Validation Studies of the Inhibition of the Enzymatic Activity of HDAC4 by Small Molecules as a Novel Approach for Cancer Therapy

by Ontoria, Jesus M, Altamura, Sergio, Di Marco, Annalise, Ferrigno, Federica, Laufer, Ralph, Muraglia, Ester, Palumbi, Maria Cecilia, Rowley, Michael, Scarpelli, Rita, Schultz-Fademrecht, Carsten, Serafini, Sergio, Steinkühler, Christian, Jones, Philip
Published in Journal of medicinal chemistry (12.11.2009)

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Discovery of a Selective Series of Inhibitors of Plasmodium falciparum HDACs

Discovery of a Selective Series of Inhibitors of Plasmodium falciparum HDACs

by Ontoria, Jesus M, Paonessa, Giacomo, Ponzi, Simona, Ferrigno, Federica, Nizi, Emanuela, Biancofiore, Ilaria, Malancona, Savina, Graziani, Rita, Roberts, David, Willis, Paul, Bresciani, Alberto, Gennari, Nadia, Cecchetti, Ottavia, Monteagudo, Edith, Orsale, Maria V, Veneziano, Maria, Di Marco, Annalise, Cellucci, Antonella, Laufer, Ralph, Altamura, Sergio, Summa, Vincenzo, Harper, Steven
Published in ACS medicinal chemistry letters (12.05.2016)

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Identification of substituted pyrazolo[1,5-a]quinazolin-5(4H)-one as potent poly(ADP-ribose)polymerase-1 (PARP-1) inhibitors

Identification of substituted pyrazolo[1,5-a]quinazolin-5(4H)-one as potent poly(ADP-ribose)polymerase-1 (PARP-1) inhibitors

by Orvieto, Federica, Branca, Danila, Giomini, Claudia, Jones, Philip, Koch, Uwe, Ontoria, Jesus M., Palumbi, Maria Cecilia, Rowley, Michael, Toniatti, Carlo, Muraglia, Ester
Published in Bioorganic & medicinal chemistry letters (01.08.2009)

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Identification of a series of 4-[3-(quinolin-2-yl)-1,2,4-oxadiazol-5-yl]piperazinyl ureas as potent smoothened antagonist hedgehog pathway inhibitors

Identification of a series of 4-[3-(quinolin-2-yl)-1,2,4-oxadiazol-5-yl]piperazinyl ureas as potent smoothened antagonist hedgehog pathway inhibitors

by Ontoria, Jesus M., Bufi, Laura Llauger, Torrisi, Caterina, Bresciani, Alberto, Giomini, Claudia, Rowley, Michael, Serafini, Sergio, Bin, Hu, Hao, Wu, Steinkühler, Christian, Jones, Philip
Published in Bioorganic & medicinal chemistry letters (15.09.2011)

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Allosteric inhibitors of hepatitis C virus NS5B polymerase thumb domain site II: Structure-based design and synthesis of new templates

Allosteric inhibitors of hepatitis C virus NS5B polymerase thumb domain site II: Structure-based design and synthesis of new templates

by Malancona, Savina, Donghi, Monica, Ferrara, Marco, Martin Hernando, Josè I., Pompei, Marco, Pesci, Silvia, Ontoria, Jesus M., Koch, Uwe, Rowley, Michael, Summa, Vincenzo
Published in Bioorganic & medicinal chemistry (15.04.2010)

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Identification and Biological Evaluation of a Series of 1H-Benzo[de]isoquinoline-1,3(2H)-diones as Hepatitis C Virus NS5B Polymerase Inhibitors

Identification and Biological Evaluation of a Series of 1H-Benzo[de]isoquinoline-1,3(2H)-diones as Hepatitis C Virus NS5B Polymerase Inhibitors

by Ontoria, Jesus M, Rydberg, Edwin H, Di Marco, Stefania, Tomei, Licia, Attenni, Barbara, Malancona, Savina, Martin Hernando, José I, Gennari, Nadia, Koch, Uwe, Narjes, Frank, Rowley, Michael, Summa, Vincenzo, Carroll, Steve S, Olsen, David B, De Francesco, Raffaele, Altamura, Sergio, Migliaccio, Giovanni, Carfì, Andrea
Published in Journal of medicinal chemistry (27.08.2009)

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Synthesis and biological evaluation of substituted 2-phenyl-2H-indazole-7-carboxamides as potent poly(ADP-ribose) polymerase (PARP) inhibitors

Synthesis and biological evaluation of substituted 2-phenyl-2H-indazole-7-carboxamides as potent poly(ADP-ribose) polymerase (PARP) inhibitors

by SCARPELLI, Rita, BOUERES, Julia K, CERRETANI, Mauro, FERRIGNO, Federica, ONTORIA, Jesus M, ROWLEY, Michael, SCHULTZ-FADEMRECHT, Carsten, TONIATTI, Carlo, JONES, Philip
Published in Bioorganic & medicinal chemistry letters (15.01.2010)

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N-(2-alkylaminoethyl)-4-(1,2,4-oxadiazol-5-yl)piperazine-1-carboxamides as highly potent smoothened antagonists

N-(2-alkylaminoethyl)-4-(1,2,4-oxadiazol-5-yl)piperazine-1-carboxamides as highly potent smoothened antagonists

by Muraglia, Ester, Ontoria, Jesus M., Branca, Danila, Dessole, Gabriella, Bresciani, Alberto, Fonsi, Massimiliano, Giuliano, Claudio, Llauger Bufi, Laura, Monteagudo, Edith, Palumbi, Maria Cecilia, Torrisi, Caterina, Rowley, Michael, Steinkühler, Christian, Jones, Philip
Published in Bioorganic & medicinal chemistry letters (15.09.2011)

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Discovery and SAR of novel, potent and selective hexahydrobenzonaphthyridinone inhibitors of poly(ADP-ribose)polymerase-1 (PARP-1)

Discovery and SAR of novel, potent and selective hexahydrobenzonaphthyridinone inhibitors of poly(ADP-ribose)polymerase-1 (PARP-1)

by Torrisi, Caterina, Bisbocci, Monica, Ingenito, Raffaele, Ontoria, Jesus M., Rowley, Michael, Schultz-Fademrecht, Carsten, Toniatti, Carlo, Jones, Philip
Published in Bioorganic & medicinal chemistry letters (15.01.2010)

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