Three-Dimensional Cell Culture-Based Screening Identifies the Anthelmintic Drug Nitazoxanide as a Candidate for Treatment of Colorectal Cancer
Senkowski, Wojciech, Zhang, Xiaonan, Olofsson, Maria Hägg, Isacson, Ruben, Höglund, Urban, Gustafsson, Mats, Nygren, Peter, Linder, Stig, Larsson, Rolf, Fryknäs, Mårten
Published in Molecular cancer therapeutics (01.06.2015)
Published in Molecular cancer therapeutics (01.06.2015)
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Journal Article
Inhibition of proteasome deubiquitinating activity as a new cancer therapy
D'Arcy, Pádraig, Brnjic, Slavica, Olofsson, Maria Hägg, Fryknäs, Mårten, Lindsten, Kristina, De Cesare, Michelandrea, Perego, Paola, Sadeghi, Behnam, Hassan, Moustapha, Larsson, Rolf, Linder, Stig
Published in Nature medicine (01.12.2011)
Published in Nature medicine (01.12.2011)
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Journal Article
Targeting Mitochondrial Function to Treat Quiescent Tumor Cells in Solid Tumors
Zhang, Xiaonan, de Milito, Angelo, Olofsson, Maria Hägg, Gullbo, Joachim, D'Arcy, Padraig, Linder, Stig
Published in International journal of molecular sciences (13.11.2015)
Published in International journal of molecular sciences (13.11.2015)
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Journal Article
Book Review
Cytokeratin-18 Is a Useful Serum Biomarker for Early Determination of Response of Breast Carcinomas to Chemotherapy
HÄGG OLOFSSON, Maria, UENO, Takayuki, ANDERSSON, Elina, SHOSHAN, Maria C, MANDIC HAVELKA, Aleksandra, TOI, Masakazu, LINDER, Stig, YANG PAN, REN XU, FENG CAI, VAN DER KUIP, Heiko, MUERDTER, Thomas E, SONNENBERG, Maike, AULITZKY, Walter E, SCHWARZ, Stephan
Published in Clinical cancer research (01.06.2007)
Published in Clinical cancer research (01.06.2007)
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Journal Article
Iron chelators target both proliferating and quiescent cancer cells
Fryknäs, Mårten, Zhang, Xiaonan, Bremberg, Ulf, Senkowski, Wojciech, Olofsson, Maria Hägg, Brandt, Peter, Persson, Ingmar, D’Arcy, Padraig, Gullbo, Joachim, Nygren, Peter, Schughart, Leoni Kunz, Linder, Stig, Larsson, Rolf
Published in Scientific reports (07.12.2016)
Published in Scientific reports (07.12.2016)
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Journal Article
MYC is downregulated by a mitochondrial checkpoint mechanism
Zhang, Xiaonan, Mofers, Arjan, Hydbring, Per, Olofsson, Maria Hägg, Guo, Jing, Linder, Stig, D'Arcy, Padraig
Published in Oncotarget (2017)
Published in Oncotarget (2017)
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Journal Article
Acute lymphoblastic leukemia cells are sensitive to disturbances in protein homeostasis induced by proteasome deubiquitinase inhibition
Mazurkiewicz, Magdalena, Hillert, Ellin-Kristina, Wang, Xin, Pellegrini, Paola, Olofsson, Maria Hägg, Selvaraju, Karthik, D'Arcy, Padraig, Linder, Stig
Published in Oncotarget (28.03.2017)
Published in Oncotarget (28.03.2017)
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Journal Article
Identification of a novel topoisomerase inhibitor effective in cells overexpressing drug efflux transporters
Fayad, Walid, Fryknäs, Mårten, Brnjic, Slavica, Olofsson, Maria Hägg, Larsson, Rolf, Linder, Stig
Published in PloS one (02.10.2009)
Published in PloS one (02.10.2009)
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Journal Article
Restriction of cisplatin induction of acute apoptosis to a subpopulation of cells in a three‐dimensional carcinoma culture model
Fayad, Walid, Brnjic, Slavica, Berglind, Daniel, Blixt, Susanna, Shoshan, Maria C., Berndtsson, Maria, Olofsson, Maria Hägg, Linder, Stig
Published in International journal of cancer (15.11.2009)
Published in International journal of cancer (15.11.2009)
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Journal Article
Identification of Agents that Induce Apoptosis of Multicellular Tumour Spheroids: Enrichment for Mitotic Inhibitors with Hydrophobic Properties
Fayad, Walid, Rickardson, Linda, Haglund, Caroline, Olofsson, Maria Hägg, D'Arcy, Padraig, Larsson, Rolf, Linder, Stig, Fryknäs, Mårten
Published in Chemical biology & drug design (01.10.2011)
Published in Chemical biology & drug design (01.10.2011)
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Journal Article
Metabolism of epidermal growth factor receptor targeting probe [11C]PD153035: impact on biodistribution and tumor uptake in rats
Samén, Erik, Arnberg, Fabian, Lu, Li, Olofsson, Maria Hägg, Tegnebratt, Tetyana, Thorell, Jan-Olov, Holmin, Staffan, Stone-Elander, Sharon
Published in Journal of Nuclear Medicine (01.10.2013)
Published in Journal of Nuclear Medicine (01.10.2013)
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Site-specifically 11C-labeled Sel-tagged annexin A5 and a size-matched control for dynamic in vivo PET imaging of protein distribution in tissues prior to and after induced cell death
Cheng, Qing, Lu, Li, Grafström, Jonas, Hägg Olofsson, Maria, Thorell, Jan-Olov, Samén, Erik, Johansson, Katarina, Ahlzén, Hanna-Stina, Linder, Stig, Arnér, Elias S.J., Stone-Elander, Sharon
Published in Biochimica et biophysica acta (01.03.2013)
Published in Biochimica et biophysica acta (01.03.2013)
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Journal Article
The phosphoinositide 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 is effective in inhibiting regrowth of tumour cells after cytotoxic therapy
Hernlund, Emma, Olofsson, Maria Hägg, Fayad, Walid, Fryknäs, Mårten, Lesiak-Mieczkowska, Karolina, Zhang, Xiaonan, Brnjic, Slavica, Schmidt, Vivien, D’Arcy, Padraig, Sjöblom, Tobias, Milito, Angelo De, Larsson, Rolf, Linder, Stig
Published in European journal of cancer (1990) (01.02.2012)
Published in European journal of cancer (1990) (01.02.2012)
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Journal Article
The proteasome deubiquitinase inhibitor VLX1570 shows selectivity for ubiquitin-specific protease-14 and induces apoptosis of multiple myeloma cells
Wang, Xin, Mazurkiewicz, Magdalena, Hillert, Ellin-Kristina, Olofsson, Maria Hägg, Pierrou, Stefan, Hillertz, Per, Gullbo, Joachim, Selvaraju, Karthik, Paulus, Aneel, Akhtar, Sharoon, Bossler, Felicitas, Khan, Asher Chanan, Linder, Stig, D’Arcy, Padraig
Published in Scientific reports (06.06.2016)
Published in Scientific reports (06.06.2016)
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Journal Article
Induction of mitochondrial dysfunction as a strategy for targeting tumour cells in metabolically compromised microenvironments
Zhang, Xiaonan, Fryknäs, Mårten, Hernlund, Emma, Fayad, Walid, De Milito, Angelo, Olofsson, Maria Hägg, Gogvadze, Vladimir, Dang, Long, Påhlman, Sven, Schughart, Leoni A. Kunz, Rickardson, Linda, D′Arcy, Padraig, Gullbo, Joachim, Nygren, Peter, Larsson, Rolf, Linder, Stig
Published in Nature communications (2014)
Published in Nature communications (2014)
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Journal Article
Irreversible inhibition of cytosolic thioredoxin reductase 1 as a mechanistic basis for anticancer therapy
Stafford, William C, Peng, Xiaoxiao, Olofsson, Maria Hägg, Zhang, Xiaonan, Luci, Diane K, Lu, Li, Cheng, Qing, Trésaugues, Lionel, Dexheimer, Thomas S, Coussens, Nathan P, Augsten, Martin, Ahlzén, Hanna-Stina Martinsson, Orwar, Owe, Östman, Arne, Stone-Elander, Sharon, Maloney, David J, Jadhav, Ajit, Simeonov, Anton, Linder, Stig, Arnér, Elias S J
Published in Science translational medicine (14.02.2018)
Published in Science translational medicine (14.02.2018)
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The deubiquitinase inhibitor b-AP15 induces strong proteotoxic stress and mitochondrial damage
Zhang, Xiaonan, Pellegrini, Paola, Saei, Amir Ata, Hillert, Ellin-Kristina, Mazurkiewicz, Magdalena, Olofsson, Maria Hägg, Zubarev, Roman A., D'Arcy, Pádraig, Linder, Stig
Published in Biochemical pharmacology (01.10.2018)
Published in Biochemical pharmacology (01.10.2018)
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