A TMPRSS2 inhibitor acts as a pan-SARS-CoV-2 prophylactic and therapeutic
Shapira, Tirosh, Monreal, I. Abrrey, Dion, Sébastien P., Buchholz, David W., Imbiakha, Brian, Olmstead, Andrea D., Jager, Mason, Désilets, Antoine, Gao, Guang, Martins, Mathias, Vandal, Thierry, Thompson, Connor A. H., Chin, Aaleigha, Rees, William D., Steiner, Theodore, Nabi, Ivan Robert, Marsault, Eric, Sahler, Julie, Diel, Diego G., Van de Walle, Gerlinde R., August, Avery, Whittaker, Gary R., Boudreault, Pierre-Luc, Leduc, Richard, Aguilar, Hector C., Jean, François
Published in Nature (London) (12.05.2022)
Published in Nature (London) (12.05.2022)
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Journal Article
Hijacking of Lipid Droplets by Hepatitis C, Dengue and Zika Viruses-From Viral Protein Moonlighting to Extracellular Release
Cloherty, Alexandra P M, Olmstead, Andrea D, Ribeiro, Carla M S, Jean, François
Published in International journal of molecular sciences (24.10.2020)
Published in International journal of molecular sciences (24.10.2020)
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Journal Article
Human subtilase SKI-1/S1P is a master regulator of the HCV Lifecycle and a potential host cell target for developing indirect-acting antiviral agents
Olmstead, Andrea D, Knecht, Wolfgang, Lazarov, Ina, Dixit, Surjit B, Jean, François
Published in PLoS pathogens (01.01.2012)
Published in PLoS pathogens (01.01.2012)
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Intra-host evolutionary dynamics of the hepatitis C virus among people who inject drugs
Montoya, Vincent, Howe, Anita Y. M., Dong, Weiyan Y., Dong, Winnie, Brumme, Chanson J., Olmstead, Andrea D., Hayashi, Kanna, Richard Harrigan, P., Joy, Jeffrey B.
Published in Scientific reports (11.05.2021)
Published in Scientific reports (11.05.2021)
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Characterizing Longitudinal Antibody Responses in Recovered Individuals Following COVID-19 Infection and Single-Dose Vaccination: A Prospective Cohort Study
Olmstead, Andrea D, Nikiforuk, Aidan M, Schwartz, Sydney, Márquez, Ana Citlali, Valadbeigy, Tahereh, Flores, Eri, Saran, Monika, Goldfarb, David M, Hayden, Althea, Masud, Shazia, Russell, Shannon L, Prystajecky, Natalie, Jassem, Agatha N, Morshed, Muhammad, Sekirov, Inna
Published in Viruses (31.10.2022)
Published in Viruses (31.10.2022)
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Treatment-Induced Viral Cure of Hepatitis C Virus-Infected Patients Involves a Dynamic Interplay among three Important Molecular Players in Lipid Homeostasis: Circulating microRNA (miR)-24, miR-223, and Proprotein Convertase Subtilisin/Kexin Type 9
Hyrina, Anastasia, Olmstead, Andrea D., Steven, Paul, Krajden, Mel, Tam, Edward, Jean, François
Published in EBioMedicine (01.09.2017)
Published in EBioMedicine (01.09.2017)
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Journal Article
A novel class of broad-spectrum active-site-directed 3C-like protease inhibitors with nanomolar antiviral activity against highly immune-evasive SARS-CoV-2 Omicron subvariants
Pérez-Vargas, Jimena, Worrall, Liam J, Olmstead, Andrea D, Ton, Anh-Tien, Lee, Jaeyong, Villanueva, Ivan, Thompson, Connor A H, Dudek, Svenja, Ennis, Siobhan, Smith, Jason R, Shapira, Tirosh, De Guzman, Joshua, Gang, Shutong, Ban, Fuqiang, Vuckovic, Marija, Bielecki, Michael, Kovacic, Suzana, Kenward, Calem, Hong, Christopher Yee, Gordon, Danielle G, Levett, Paul N, Krajden, Mel, Leduc, Richard, Boudreault, Pierre-Luc, Niikura, Masahiro, Paetzel, Mark, Young, Robert N, Cherkasov, Artem, Strynadka, Natalie C J, Jean, François
Published in Emerging microbes & infections (01.12.2023)
Published in Emerging microbes & infections (01.12.2023)
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Journal Article
DEEMD: Drug Efficacy Estimation Against SARS-CoV-2 Based on Cell Morphology With Deep Multiple Instance Learning
Saberian, M. Sadegh, Moriarty, Kathleen P., Olmstead, Andrea D., Hallgrimson, Christian, Jean, Francois, Nabi, Ivan R., Libbrecht, Maxwell W., Hamarneh, Ghassan
Published in IEEE transactions on medical imaging (01.11.2022)
Published in IEEE transactions on medical imaging (01.11.2022)
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Journal Article
Discovery of lead natural products for developing pan-SARS-CoV-2 therapeutics
Pérez-Vargas, Jimena, Shapira, Tirosh, Olmstead, Andrea D., Villanueva, Ivan, Thompson, Connor A.H., Ennis, Siobhan, Gao, Guang, De Guzman, Joshua, Williams, David E., Wang, Meng, Chin, Aaleigha, Bautista-Sánchez, Diana, Agafitei, Olga, Levett, Paul, Xie, Xuping, Nuzzo, Genoveffa, Freire, Vitor F., Quintana-Bulla, Jairo I., Bernardi, Darlon I., Gubiani, Juliana R., Suthiphasilp, Virayu, Raksat, Achara, Meesakul, Pornphimol, Polbuppha, Isaraporn, Cheenpracha, Sarot, Jaidee, Wuttichai, Kanokmedhakul, Kwanjai, Yenjai, Chavi, Chaiyosang, Boonyanoot, Teles, Helder Lopes, Manzo, Emiliano, Fontana, Angelo, Leduc, Richard, Boudreault, Pierre-Luc, Berlinck, Roberto G.S., Laphookhieo, Surat, Kanokmedhakul, Somdej, Tietjen, Ian, Cherkasov, Artem, Krajden, Mel, Nabi, Ivan Robert, Niikura, Masahiro, Shi, Pei-Yong, Andersen, Raymond J., Jean, François
Published in Antiviral research (01.01.2023)
Published in Antiviral research (01.01.2023)
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Journal Article
Corrigendum to “Discovery of lead natural products for developing pan-SARS-CoV-2 therapeutics” “Antiviral Research 209 (2023)/105484”
Perez-Vargas, Jimena, Shapira, Tirosh, Olmstead, Andrea D., Villanueva, Ivan, Thompson, Connor A.H., Ennis, Siobhan, Gao, Guang, De Guzman, Joshua, Williams, David E., Wang, Meng, Chin, Aaleigha, Bautista-Sanchez, Diana, Agafitei, Olga, Levett, Paul, Xie, Xuping, Nuzzo, Genoveffa, Freire, Vitor F., Quintana-Bulla, Jairo I., Bernardi, Darlon I., Gubiani, Juliana R., Suthiphasilp, Virayu, Raksat, Achara, Meesakul, Pornphimol, Polbuppha, Isaraporn, Cheenpracha, Sarot, Jaidee, Wuttichai, Kanokmedhakul, Kwanjai, Yenjai, Chavi, Chaiyosang, Boonyanoot, Teles, Helder Lopes, Manzo, Emiliano, Fontana, Angelo, Leduc, Richard, Boudreault, Pierre-Luc, Berlinck, Roberto G.S., Laphookhieo, Surat, Kanokmedhakul, Somdej, Tietjen, Ian, Cherkasov, Artem, Krajden, Mel, Nabi, Ivan Robert, Niikura, Masahiro, Shi, Pei-Yong, Andersen, Raymond J., Jean, François
Published in Antiviral research (01.05.2023)
Published in Antiviral research (01.05.2023)
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Journal Article
Differentiation of acute from chronic hepatitis C virus infection by nonstructural 5B deep sequencing: A population‐level tool for incidence estimation
Montoya, Vincent, Olmstead, Andrea D., Janjua, Naveed Z., Tang, Patrick, Grebely, Jason, Cook, Darrel, Richard Harrigan, P., Krajden, Mel
Published in Hepatology (Baltimore, Md.) (01.06.2015)
Published in Hepatology (Baltimore, Md.) (01.06.2015)
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Methamphetamine injecting is associated with phylogenetic clustering of hepatitis C virus infection among street-involved youth in Vancouver, Canada
Cunningham, Evan B, Jacka, Brendan, DeBeck, Kora, Applegate, Tanya L, Harrigan, P. Richard, Krajden, Mel, Marshall, Brandon D.L, Montaner, Julio, Lima, Viviane Dias, Olmstead, Andrea D, Milloy, M.-J, Wood, Evan, Grebely, Jason
Published in Drug and alcohol dependence (01.07.2015)
Published in Drug and alcohol dependence (01.07.2015)
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Journal Article
Development and validation of a real-time, reverse transcription PCR assay for rapid and low-cost genotyping of hepatitis C virus genotypes 1a, 1b, 2, and 3a
Olmstead, Andrea D., Lee, Tracy D., Chow, Ron, Gunadasa, Kingsley, Auk, Brian, Krajden, Mel, Jassem, Agatha N.
Published in Journal of virological methods (01.06.2017)
Published in Journal of virological methods (01.06.2017)
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Journal Article
A systematic, deep sequencing-based methodology for identification of mixed-genotype hepatitis C virus infections
Olmstead, Andrea D., Montoya, Vincent, Chui, Celia K., Dong, Winnie, Joy, Jeffrey B., Tai, Vera, Poon, Art F.Y., Nguyen, Thuy, Brumme, Chanson J., Martinello, Marianne, Matthews, Gail V., Richard Harrigan, P., Dore, Gregory J., Applegate, Tanya L., Grebely, Jason, Howe, Anita Y.M.
Published in Infection, genetics and evolution (01.04.2019)
Published in Infection, genetics and evolution (01.04.2019)
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Journal Article
A molecular phylogenetics-based approach for identifying recent hepatitis C virus transmission events
Olmstead, Andrea D., Joy, Jeffrey B., Montoya, Vincent, Luo, Iris, Poon, Art F.Y., Jacka, Brendan, Lamoury, François, Applegate, Tanya, Montaner, Julio, Khudyakov, Yury, Grebely, Jason, Cook, Darrel, Harrigan, P. Richard, Krajden, Mel
Published in Infection, genetics and evolution (01.07.2015)
Published in Infection, genetics and evolution (01.07.2015)
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Journal Article
In-cell selectivity profiling of membrane-anchored and replicase-associated hepatitis C virus NS3-4A protease reveals a common, stringent substrate recognition profile
Martin, Morgan M., Condotta, Stephanie A., Fenn, Jeremy, Olmstead, Andrea D., Jean, François
Published in Biological chemistry (01.10.2011)
Published in Biological chemistry (01.10.2011)
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Journal Article
A novel highly potent inhibitor of TMPRSS2-like proteases blocks SARS-CoV-2 variants of concern and is broadly protective against infection and mortality in mice
Shapira, Tirosh, Monreal, I Abrrey, Dion, Sébastien P, Jager, Mason, Désilets, Antoine, Olmstead, Andrea D, Vandal, Thierry, Buchholz, David W, Imbiakha, Brian, Gao, Guang, Chin, Aaleigha, Rees, William D, Steiner, Theodore, Nabi, Ivan Robert, Marsault, Eric, Sahler, Julie, August, Avery, Van de Walle, Gerlinde, Whittaker, Gary R, Boudreault, Pierre-Luc, Aguilar, Hector C, Leduc, Richard, Jean, François
Published in bioRxiv : the preprint server for biology (04.05.2021)
Published in bioRxiv : the preprint server for biology (04.05.2021)
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