Optimization of a Novel Quinazolinone-Based Series of Transient Receptor Potential A1 (TRPA1) Antagonists Demonstrating Potent in Vivo Activity
Schenkel, Laurie B, Olivieri, Philip R, Boezio, Alessandro A, Deak, Holly L, Emkey, Renee, Graceffa, Russell F, Gunaydin, Hakan, Guzman-Perez, Angel, Lee, Josie H, Teffera, Yohannes, Wang, Weiya, Youngblood, Beth D, Yu, Violeta L, Zhang, Maosheng, Gavva, Narender R, Lehto, Sonya G, Geuns-Meyer, Stephanie
Published in Journal of medicinal chemistry (24.03.2016)
Published in Journal of medicinal chemistry (24.03.2016)
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Synthesis of 4-Substituted Chlorophthalazines, Dihydrobenzoazepinediones, 2-Pyrazolylbenzoic Acid, and 2-Pyrazolylbenzohydrazide via 3-Substituted 3-Hydroxyisoindolin-1-ones
Nguyen, Hanh Nho, Cee, Victor J, Deak, Holly L, Du, Bingfan, Faber, Kathleen Panter, Gunaydin, Hakan, Hodous, Brian L, Hollis, Steven L, Krolikowski, Paul H, Olivieri, Philip R, Patel, Vinod F, Romero, Karina, Schenkel, Laurie B, Geuns-Meyer, Stephanie D
Published in Journal of organic chemistry (20.04.2012)
Published in Journal of organic chemistry (20.04.2012)
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Evolution of a Highly Selective and Potent 2-(Pyridin-2-yl)-1,3,5-triazine Tie-2 Kinase Inhibitor
Hodous, Brian L, Geuns-Meyer, Stephanie D, Hughes, Paul E, Albrecht, Brian K, Bellon, Steve, Bready, James, Caenepeel, Sean, Cee, Victor J, Chaffee, Stuart C, Coxon, Angela, Emery, Maurice, Fretland, Jenne, Gallant, Paul, Gu, Yan, Hoffman, Doug, Johnson, Rebecca E, Kendall, Richard, Kim, Joseph L, Long, Alexander M, Morrison, Michael, Olivieri, Philip R, Patel, Vinod F, Polverino, Anthony, Rose, Paul, Tempest, Paul, Wang, Ling, Whittington, Douglas A, Zhao, Huilin
Published in Journal of medicinal chemistry (22.02.2007)
Published in Journal of medicinal chemistry (22.02.2007)
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Synthesis, structural analysis, and SAR studies of triazine derivatives as potent, selective Tie-2 inhibitors
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Published in Bioorganic & medicinal chemistry letters (15.05.2007)
Published in Bioorganic & medicinal chemistry letters (15.05.2007)
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Preclinical Evaluation of AMG 900, a Novel Potent and Highly Selective Pan-Aurora Kinase Inhibitor with Activity in Taxane-Resistant Tumor Cell Lines
PAYTON, Marc, BUSH, Tammy L, NHO NGUYEN, Hanh, OLIVIERI, Philip R, ROMERO, Karina, SCHENKEL, Laurie B, BAK, Annette, STANTON, Mary, DUSSAULT, Isabelle, PATEL, Vinod F, GEUNS-MEYER, Stephanie, RADINSKY, Robert, CHUNG, Grace, KENDALL, Richard L, ZIEGLER, Beth, EDEN, Patrick, MCELROY, Patricia, ROSS, Sandra, CEE, Victor J, DEAK, Holly L, HODOUS, Brian L
Published in Cancer research (Chicago, Ill.) (01.12.2010)
Published in Cancer research (Chicago, Ill.) (01.12.2010)
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Discovery of N‑(4-(3-(2-Aminopyrimidin-4-yl)pyridin-2-yloxy)phenyl)-4-(4-methylthiophen-2-yl)phthalazin-1-amine (AMG 900), A Highly Selective, Orally Bioavailable Inhibitor of Aurora Kinases with Activity against Multidrug-Resistant Cancer Cell Lines
Geuns-Meyer, Stephanie, Cee, Victor J, Deak, Holly L, Du, Bingfan, Hodous, Brian L, Nguyen, Hanh Nho, Olivieri, Philip R, Schenkel, Laurie B, Vaida, Karina R, Andrews, Paul, Bak, Annette, Be, Xuhai, Beltran, Pedro J, Bush, Tammy L, Chaves, Mary K, Chung, Grace, Dai, Yang, Eden, Patrick, Hanestad, Kelly, Huang, Liyue, Lin, Min-Hwa Jasmine, Tang, Jin, Ziegler, Beth, Radinsky, Robert, Kendall, Richard, Patel, Vinod F, Payton, Marc
Published in Journal of medicinal chemistry (09.07.2015)
Published in Journal of medicinal chemistry (09.07.2015)
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Pyridyl-pyrimidine benzimidazole derivatives as potent, selective, and orally bioavailable inhibitors of Tie-2 kinase
Cee, Victor J., Cheng, Alan C., Romero, Karina, Bellon, Steve, Mohr, Christopher, Whittington, Douglas A., Bak, Annette, Bready, James, Caenepeel, Sean, Coxon, Angela, Deak, Holly L., Fretland, Jenne, Gu, Yan, Hodous, Brian L., Huang, Xin, Kim, Joseph L., Lin, Jasmine, Long, Alexander M., Nguyen, Hanh, Olivieri, Philip R., Patel, Vinod F., Wang, Ling, Zhou, Yihong, Hughes, Paul, Geuns-Meyer, Stephanie
Published in Bioorganic & medicinal chemistry letters (15.01.2009)
Published in Bioorganic & medicinal chemistry letters (15.01.2009)
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Discovery of a Potent, Selective, and Orally Bioavailable Pyridinyl-Pyrimidine Phthalazine Aurora Kinase Inhibitor
Cee, Victor J, Schenkel, Laurie B, Hodous, Brian L, Deak, Holly L, Nguyen, Hanh N, Olivieri, Philip R, Romero, Karina, Bak, Annette, Be, Xuhai, Bellon, Steve, Bush, Tammy L, Cheng, Alan C, Chung, Grace, Coats, Steve, Eden, Patrick M, Hanestad, Kelly, Gallant, Paul L, Gu, Yan, Huang, Xin, Kendall, Richard L, Lin, Min-Hwa Jasmine, Morrison, Michael J, Patel, Vinod F, Radinsky, Robert, Rose, Paul E, Ross, Sandra, Sun, Ji-Rong, Tang, Jin, Zhao, Huilin, Payton, Marc, Geuns-Meyer, Stephanie D
Published in Journal of medicinal chemistry (09.09.2010)
Published in Journal of medicinal chemistry (09.09.2010)
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Alkynylpyrimidine Amide Derivatives as Potent, Selective, and Orally Active Inhibitors of Tie-2 Kinase
Cee, Victor J, Albrecht, Brian K, Geuns-Meyer, Stephanie, Hughes, Paul, Bellon, Steve, Bready, James, Caenepeel, Sean, Chaffee, Stuart C, Coxon, Angela, Emery, Maurice, Fretland, Jenne, Gallant, Paul, Gu, Yan, Hodous, Brian L, Hoffman, Doug, Johnson, Rebecca E, Kendall, Richard, Kim, Joseph L, Long, Alexander M, McGowan, David, Morrison, Michael, Olivieri, Philip R, Patel, Vinod F, Polverino, Anthony, Powers, David, Rose, Paul, Wang, Ling, Zhao, Huilin
Published in Journal of medicinal chemistry (22.02.2007)
Published in Journal of medicinal chemistry (22.02.2007)
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AURORA KINASE MODULATORS AND METHOD OF USE
PATEL VINOD F, ROMERO KARINA, CEE VICTOR J, DU BINGFAN, NGUYEN HANH NHO, DEAK HOLLY L, HODOUS BRIAN L, OLIVIERI PHILIP R, SCHENKEL LAURIE, GEUNS MEYER STEPHANIE D
Year of Publication 09.12.2011
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Year of Publication 09.12.2011
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Abstract 5776: Discovery of AMG 900, a highly selective, orally bioavailable inhibitor of aurora kinases with efficacy in preclinical antitumor models and activity against multidrug-resistant cells
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Published in Cancer research (Chicago, Ill.) (15.04.2010)
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Biaryl acyl-sulfonamide compounds as sodium channel inhibitors
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Year of Publication 30.05.2017
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Year of Publication 30.05.2017
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Biaryl Acyl-Sulfonamide Compounds as Sodium Channel Inhibitors
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Multi-cyclic compounds and methods of use
PATEL VINOD F, TEMPEST PAUL A, HODOUS BRIAN L, OLIVIERI PHILIP R, GEUNS-MEYER STEPHANIE D
Year of Publication 02.09.2014
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Year of Publication 02.09.2014
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ARYL NITROGEN-CONTAINING BICYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS
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Year of Publication 02.10.2019
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Year of Publication 02.10.2019
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AURORA KINASE MODULATORS AND METHOD OF USE
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AURORA KINASE MODULATORS AND METHOD OF USE
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BRIDGED BICYCLIC AMINO THIAZINE DIOXIDE COMPOUNDS AS INHIBITORS OF BETA-SECRETASE AND METHODS OF USE THEREOF
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Bridged bicyclic amino thiazine dioxide compounds as inhibitors of beta-secretase and methods of use thereof
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Year of Publication 04.08.2015
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