Dosing-Time Makes the Poison: Circadian Regulation and Pharmacotherapy
Dallmann, Robert, Okyar, Alper, Lévi, Francis
Published in Trends in molecular medicine (01.05.2016)
Published in Trends in molecular medicine (01.05.2016)
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Journal Article
Molecular Aspects of Circadian Pharmacology and Relevance for Cancer Chronotherapy
Ozturk, Narin, Ozturk, Dilek, Kavakli, Ibrahim Halil, Okyar, Alper
Published in International journal of molecular sciences (17.10.2017)
Published in International journal of molecular sciences (17.10.2017)
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Journal Article
Reproductive effects of subchronic exposure to acetamiprid in male rats
Arıcan, Emre Yağmur, Gökçeoğlu Kayalı, Damla, Ulus Karaca, Bahar, Boran, Tuğçe, Öztürk, Narin, Okyar, Alper, Ercan, Feriha, Özhan, Gül
Published in Scientific reports (02.06.2020)
Published in Scientific reports (02.06.2020)
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Journal Article
Circadian timing in cancer treatments
Lévi, Francis, Okyar, Alper, Dulong, Sandrine, Innominato, Pasquale F, Clairambault, Jean
Published in Annual review of pharmacology and toxicology (01.02.2010)
Published in Annual review of pharmacology and toxicology (01.02.2010)
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Journal Article
A CLOCK-binding small molecule disrupts the interaction between CLOCK and BMAL1 and enhances circadian rhythm amplitude
Doruk, Yagmur Umay, Yarparvar, Darya, Akyel, Yasemin Kubra, Gul, Seref, Taskin, Ali Cihan, Yilmaz, Fatma, Baris, Ibrahim, Ozturk, Nuri, Türkay, Metin, Ozturk, Narin, Okyar, Alper, Kavakli, Ibrahim Halil
Published in The Journal of biological chemistry (13.03.2020)
Published in The Journal of biological chemistry (13.03.2020)
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Journal Article
Sex-, feeding-, and circadian time-dependency of P-glycoprotein expression and activity - implications for mechanistic pharmacokinetics modeling
Okyar, Alper, Kumar, Swati A., Filipski, Elisabeth, Piccolo, Enza, Ozturk, Narin, Xandri-Monje, Helena, Pala, Zeliha, Abraham, Kristin, Gomes, Ana Rita Gato de Jesus, Orman, Mehmet N., Li, Xiao-Mei, Dallmann, Robert, Lévi, Francis, Ballesta, Annabelle
Published in Scientific reports (19.07.2019)
Published in Scientific reports (19.07.2019)
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Journal Article
Discovery of a small molecule that selectively destabilizes Cryptochrome 1 and enhances life span in p53 knockout mice
Gul, Seref, Akyel, Yasemin Kubra, Gul, Zeynep Melis, Isin, Safak, Ozcan, Onur, Korkmaz, Tuba, Selvi, Saba, Danis, Ibrahim, Ipek, Ozgecan Savlug, Aygenli, Fatih, Taskin, Ali Cihan, Akarlar, Büşra Aytül, Ozlu, Nurhan, Ozturk, Nuri, Ozturk, Narin, Ünal, Durişehvar Özer, Guzel, Mustafa, Turkay, Metin, Okyar, Alper, Kavakli, Ibrahim Halil
Published in Nature communications (08.11.2022)
Published in Nature communications (08.11.2022)
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Journal Article
Diurnal Changes in Capecitabine Clock-Controlled Metabolism Enzymes Are Responsible for Its Pharmacokinetics in Male Mice
Akyel, Yasemin Kubra, Ozturk Civelek, Dilek, Ozturk Seyhan, Narin, Gul, Seref, Gazioglu, Isil, Pala Kara, Zeliha, Lévi, Francis, Kavakli, Ibrahim Halil, Okyar, Alper
Published in Journal of biological rhythms (01.04.2023)
Published in Journal of biological rhythms (01.04.2023)
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Journal Article
Therapeutic Effect of C-Vx Substance in K18-hACE2 Transgenic Mice Infected with SARS-CoV-2
Ulbegi Polat, Hivda, Abaci, Irem, Tas Ekiz, Arzu, Aksoy, Ozge, Oktelik, Fatma Betul, Yilmaz, Vuslat, Tekin, Saban, Okyar, Alper, Oncul, Oral, Deniz, Gunnur
Published in International journal of molecular sciences (26.07.2023)
Published in International journal of molecular sciences (26.07.2023)
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Journal Article
Circadian Dysfunction in Adipose Tissue: Chronotherapy in Metabolic Diseases
Civelek, Erkan, Ozturk Civelek, Dilek, Akyel, Yasemin Kubra, Kaleli Durman, Deniz, Okyar, Alper
Published in Biology (Basel, Switzerland) (01.08.2023)
Published in Biology (Basel, Switzerland) (01.08.2023)
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Journal Article
A combined experimental and mathematical approach for molecular-based optimization of irinotecan circadian delivery
Ballesta, Annabelle, Dulong, Sandrine, Abbara, Chadi, Cohen, Boris, Okyar, Alper, Clairambault, Jean, Levi, Francis
Published in PLoS computational biology (01.09.2011)
Published in PLoS computational biology (01.09.2011)
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Journal Article
Toxic effects of subchronic oral acetamiprid exposure in rats
Karaca, Bahar Ulus, Arican, Yağmur Emre, Boran, Tugce, Binay, Sevgi, Okyar, Alper, Kaptan, Engin, Özhan, Gül
Published in Toxicology and industrial health (01.11.2019)
Published in Toxicology and industrial health (01.11.2019)
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Journal Article
Gliclazide alone or in combination with atorvastatin ameliorated reproductive damage in streptozotocin-induced type 2 diabetic male rats
Öztaş, Ezgi, Yılmaz, Tugba Ekiz, Güzel, Elif, Sezer, Zehra, Okyar, Alper, Özhan, Gül
Published in Saudi pharmaceutical journal (01.03.2019)
Published in Saudi pharmaceutical journal (01.03.2019)
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Journal Article
Chronomodulated oxaliplatin plus Capecitabine (XELOX) as a first line chemotherapy in metastatic colorectal cancer: A Phase II Brunch regimen study
Pilancı, Kezban Nur, Saglam, Sezer, Okyar, Alper, Yucel, Serap, Pala-Kara, Zeliha, Ordu, Cetin, Namal, Esat, Ciftci, Rumeysa, Iner-Koksal, Ulkuhan, Kaytan-Saglam, Esra
Published in Cancer chemotherapy and pharmacology (01.07.2016)
Published in Cancer chemotherapy and pharmacology (01.07.2016)
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Journal Article
Strain- and sex-dependent circadian changes in abcc2 transporter expression: implications for irinotecan chronotolerance in mouse ileum
Okyar, Alper, Piccolo, Enza, Ahowesso, Constance, Filipski, Elisabeth, Hossard, Virginie, Guettier, Catherine, La Sorda, Rosanna, Tinari, Nicola, Iacobelli, Stefano, Lévi, Francis
Published in PloS one (03.06.2011)
Published in PloS one (03.06.2011)
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Journal Article
The association of ABCC5 and ABCC11 polymorphisms with the pharmacokinetics of 5-FU in advanced gastric cancer patients
PALA KARA, Zeliha, OZTAS, Ezgi, OZTURK, Dilek, AKYEL, Yasemin, TURNA, Zeynep, OKYAR, Alper, ÖZHAN, Gül
Published in Clinical and experimental health sciences (Online) (01.09.2020)
Published in Clinical and experimental health sciences (Online) (01.09.2020)
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Journal Article
Effect of Aloe vera leaves on blood glucose level in type I and type II diabetic rat models
Okyar, Alper, Can, Ayşe, Akev, Nuriye, Baktir, Gül, Sütlüpinar, Nurhayat
Published in Phytotherapy research (01.03.2001)
Published in Phytotherapy research (01.03.2001)
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