Preservation of cellular glutathione status and mitochondrial membrane potential by N-acetylcysteine and insulin sensitizers prevent carbonyl stress-induced human brain endothelial cell apoptosis
Okouchi, Masahiro, Okayama, Naotsuka, Aw, Tak Yee
Published in Current neurovascular research (01.11.2009)
Published in Current neurovascular research (01.11.2009)
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Journal Article
NRF2-dependent glutamate-L-cysteine ligase catalytic subunit expression mediates insulin protection against hyperglycemia- induced brain endothelial cell apoptosis
Okouchi, Masahiro, Okayama, Naotsuka, Alexander, Jonathan Steven, Aw, Tak Yee
Published in Current neurovascular research (01.11.2006)
Published in Current neurovascular research (01.11.2006)
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Journal Article
The mechanisms of inhibitory actions of gliclazide on neutrophils–endothelial cells adhesion and surface expression of endothelial adhesion molecules mediated by a high glucose concentration
Itoh, Makoto, Omi, Hitoshi, Okouchi, Masahiro, Imaeda, Kenro, Shimizu, Manabu, Fukutomi, Tatsuya, Okayama, Naotsuka
Published in Journal of diabetes and its complications (2003)
Published in Journal of diabetes and its complications (2003)
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Journal Article
Neuronal apoptosis in neurodegeneration
Okouchi, Masahiro, Ekshyyan, Oleksandr, Maracine, Magdalena, Aw, Tak Yee
Published in Antioxidants & redox signaling (01.08.2007)
Published in Antioxidants & redox signaling (01.08.2007)
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Journal Article
Participation of high glucose concentrations in neutrophil adhesion and surface expression of adhesion molecules on cultured human endothelial cells
Omi, Hitoshi, Okayama, Naotsuka, Shimizu, Manabu, Okouchi, Masahiro, Ito, Shigenori, Fukutomi, Tatsuya, Itoh, Makoto
Published in Journal of diabetes and its complications (01.05.2002)
Published in Journal of diabetes and its complications (01.05.2002)
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Journal Article
Mechanisms of inhibitory activity of the aldose reductase inhibitor, epalrestat, on high glucose-mediated endothelial injury
Okayama, Naotsuka, Omi, Hitoshi, Okouchi, Masahiro, Imaeda, Kenro, Kato, Takashi, Akao, Masaya, Imai, Seiji, Shimizu, Manabu, Fukutomi, Tatsuya, Itoh, Makoto
Published in Journal of diabetes and its complications (01.09.2002)
Published in Journal of diabetes and its complications (01.09.2002)
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Journal Article
Epidermal Growth Factor Receptor Transactivation Is Necessary for Glucagon-Like Peptide-1 to Protect PC12 Cells from Apoptosis
Kimura, Ryosuke, Okouchi, Masahiro, Kato, Takashi, Imaeda, Kenro, Okayama, Naotsuka, Asai, Kiyofumi, Joh, Takashi
Published in Neuroendocrinology (01.01.2013)
Published in Neuroendocrinology (01.01.2013)
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Journal Article
Cilostazol inhibits high glucose-mediated endothelial-neutrophil adhesion by decreasing adhesion molecule expression via NO production
Omi, Hitoshi, Okayama, Naotsuka, Shimizu, Manabu, Fukutomi, Tatsuya, Nakamura, Atsushi, Imaeda, Kenro, Okouchi, Masahiro, Itoh, Makoto
Published in Microvascular research (01.09.2004)
Published in Microvascular research (01.09.2004)
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Journal Article
Participation of high glucose concentrations in neutrophil adhesion and surface expression of adhesion molecules on cultured human endothelial cells: Effect of antidiabetic medicines
Omi, Hitoshi, Okayama, Naotsuka, Shimizu, Manabu, Okouchi, Masahiro, Ito, Shigenori, Fukutomi, Tatsuya, Itoh, Makoto
Published in Journal of diabetes and its complications (01.05.2002)
Published in Journal of diabetes and its complications (01.05.2002)
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Journal Article
Effects of histamine 2 receptor antagonists on endothelial–neutrophil adhesion and surface expression of endothelial adhesion molecules induced by high glucose levels
Takeuchi, Yoshiyuki, Okayama, Naotsuka, Imaeda, Kenro, Okouchi, Masahiro, Omi, Hitoshi, Imai, Seiji, Akao, Masaya, Takeda, Yutaka, Hukutomi, Tatsuya, Itoh, Makoto
Published in Journal of diabetes and its complications (2007)
Published in Journal of diabetes and its complications (2007)
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Journal Article
Statins inhibit high glucose-mediated neutrophil–endothelial cell adhesion through decreasing surface expression of endothelial adhesion molecules by stimulating production of endothelial nitric oxide
Omi, Hitoshi, Okayama, Naotsuka, Shimizu, Manabu, Fukutomi, Tatsuya, Imaeda, Kenro, Okouchi, Masahiro, Itoh, Makoto
Published in Microvascular research (01.03.2003)
Published in Microvascular research (01.03.2003)
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Journal Article
The antidiabetic agent, gliclazide, reduces high insulin-enhanced neutrophil-transendothelial migration through direct effects on the endothelium
Okouchi, Masahiro, Okayama, Naotsuka, Omi, Hitoshi, Imaeda, Kenro, Fukutomi, Tatsuya, Nakamura, Atsushi, Itoh, Makoto
Published in Diabetes/metabolism research and reviews (01.05.2004)
Published in Diabetes/metabolism research and reviews (01.05.2004)
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Journal Article
Insulin enhances leukocyte–endothelial cell adhesion in the retinal microcirculation through surface expression of intercellular adhesion molecule-1
Hirata, Fumisato, Yoshida, Munenori, Niwa, Yuji, Okouchi, Masahiro, Okayama, Naotsuka, Takeuchi, Yoshiyuki, Itoh, Makoto, Ogura, Yuichiro
Published in Microvascular research (01.05.2005)
Published in Microvascular research (01.05.2005)
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Journal Article
Cerivastatin ameliorates high insulin-enhanced neutrophil–endothelial cell adhesion and endothelial intercellular adhesion molecule-1 expression by inhibiting mitogen-activated protein kinase activation
Okouchi, Masahiro, Okayama, Naotsuka, Omi, Hitoshi, Imaeda, Kenro, Shimizu, Manabu, Fukutomi, Tatsuya, Itoh, Makoto
Published in Journal of diabetes and its complications (01.11.2003)
Published in Journal of diabetes and its complications (01.11.2003)
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Journal Article
Mechanisms of inhibitory activity of the aldose reductase inhibitor, epalrestat, on high glucose-mediated endothelial injury: Neutrophil–endothelial cell adhesion and surface expression of endothelial adhesion molecules
Okayama, Naotsuka, Omi, Hitoshi, Okouchi, Masahiro, Imaeda, Kenro, Kato, Takashi, Akao, Masaya, Imai, Seiji, Shimizu, Manabu, Fukutomi, Tatsuya, Itoh, Makoto
Published in Journal of diabetes and its complications (01.09.2002)
Published in Journal of diabetes and its complications (01.09.2002)
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Journal Article
Protective actions of gliclazide on high insulin-enhanced neutrophil–endothelial cell interactions through inhibition of mitogen activated protein kinase and protein kinase C pathways
Okouchi, Masahiro, Okayama, Naotsuka, Omi, Hitoshi, Imaeda, Kenro, Fukutomi, Tatsuya, Nakamura, Atsushi, Itoh, Makoto
Published in Microvascular Research (2004)
Published in Microvascular Research (2004)
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Book Review
Journal Article
Effects of Diabetic Medicines on High Glucose-Mediated Neutrophil Adherence and Expression of Adhesion Molecules in Human Cultured Endothelial Cells
OMI, HITOSHI, OKAYAMA, NAOTSUKA, SHIMIZU, MANABU, OKOUCHI, MASAHIRO, MIYACHI, NOBORU, AKAO, MASAYA, ITOH, MAKOTO
Published in Diabetes (New York, N.Y.) (01.05.2000)
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Published in Diabetes (New York, N.Y.) (01.05.2000)
Journal Article