Reengineering an Antiarrhythmic Drug Using Patient hiPSC Cardiomyocytes to Improve Therapeutic Potential and Reduce Toxicity
McKeithan, Wesley L., Feyen, Dries A.M., Bruyneel, Arne A.N., Okolotowicz, Karl J., Ryan, Daniel A., Sampson, Kevin J., Potet, Franck, Savchenko, Alex, Gómez-Galeno, Jorge, Vu, Michelle, Serrano, Ricardo, George, Alfred L., Kass, Robert S., Cashman, John R., Mercola, Mark
Published in Cell stem cell (05.11.2020)
Published in Cell stem cell (05.11.2020)
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Journal Article
A Novel Inhibitor Targets Both Wnt Signaling and ATM/p53 in Colorectal Cancer
Cheng, Jiongjia, Dwyer, Mary, Okolotowicz, Karl J, Mercola, Mark, Cashman, John R
Published in Cancer research (Chicago, Ill.) (01.09.2018)
Published in Cancer research (Chicago, Ill.) (01.09.2018)
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Journal Article
A Novel Small Molecule Inhibits Tumor Growth and Synergizes Effects of Enzalutamide on Prostate Cancer
Cheng, Jiongjia, Moore, Stephanie, Gomez-Galeno, Jorge, Lee, Dong-Hoon, Okolotowicz, Karl J, Cashman, John R
Published in The Journal of pharmacology and experimental therapeutics (01.12.2019)
Published in The Journal of pharmacology and experimental therapeutics (01.12.2019)
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Journal Article
Preclinical Studies of Noncharged Oxime Reactivators for Organophosphate Exposure
Okolotowicz, Karl J., Dwyer, Mary, Smith, Emily, Cashman, John R.
Published in Journal of biochemical and molecular toxicology (01.01.2014)
Published in Journal of biochemical and molecular toxicology (01.01.2014)
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Journal Article
Inhibition of Bfl-1 with N-aryl maleimides
Cashman, John R., MacDonald, Mary, Ghirmai, Senait, Okolotowicz, Karl J., Sergienko, Eduard, Brown, Brock, Garcia, Xochella, Zhai, Dayong, Dahl, Russell, Reed, John C.
Published in Bioorganic & medicinal chemistry letters (15.11.2010)
Published in Bioorganic & medicinal chemistry letters (15.11.2010)
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Journal Article
Inhibition of Protein Kinase C-Driven Nuclear Factor-κB Activation: Synthesis, Structure−Activity Relationship, and Pharmacological Profiling of Pathway Specific Benzimidazole Probe Molecules
Peddibhotla, Satyamaheshwar, Shi, Ranxin, Khan, Pasha, Smith, Layton H, Mangravita-Novo, Arianna, Vicchiarelli, Michael, Su, Ying, Okolotowicz, Karl J, Cashman, John R, Reed, John C, Roth, Gregory P
Published in Journal of medicinal chemistry (24.06.2010)
Published in Journal of medicinal chemistry (24.06.2010)
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Journal Article
Chemical Biology Strategy Reveals Pathway-Selective Inhibitor of NF-κB Activation Induced by Protein Kinase C
Shi, Ranxin, Re, Daniel, Dudl, Eric, Cuddy, Michael, Okolotowicz, Karl J, Dahl, Russell, Su, Ying, Hurder, Andrew, Kitada, Shinichi, Peddibhotla, Satyamaheshwar, Roth, Gregory P, Smith, Layton H, Kipps, Thomas J, Cosford, Nicholas, Cashman, John, Reed, John C
Published in ACS chemical biology (19.03.2010)
Published in ACS chemical biology (19.03.2010)
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Journal Article
Stereoselective synthesis of mexiletine and structural analogs with chiral tert-butanesulfinamide
Ryan, Daniel A., Okolotowicz, Karl J., Mercola, Mark, Cashman, John R.
Published in Tetrahedron letters (08.07.2015)
Published in Tetrahedron letters (08.07.2015)
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Journal Article
Inactivation of Protein Farnesyltransferase by Active-Site-Targeted Dicarbonyl Compounds
Okolotowicz, Karl J., Lee, Wei-Jen, Hartman, Rosemarie F., Kim, Ann Y., Ottersberg, Steven R., Robinson, Jr, Dale E., Lefler, Scott R., Rose, Seth D.
Published in Archiv der Pharmazie (Weinheim) (01.06.2001)
Published in Archiv der Pharmazie (Weinheim) (01.06.2001)
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Journal Article
Corrigendum to “Selective benzimidazole inhibitors of the antigen receptor-mediated NF-κB activation pathway” [Bioorg. Med. Chem. 18 (2010) 1918–1924]
Okolotowicz, Karl J., Shi, Ranxin, Zheng, Xueying, MacDonald, Mary, Reed, John C., Cashman, John R.
Published in Bioorganic & medicinal chemistry (01.02.2011)
Published in Bioorganic & medicinal chemistry (01.02.2011)
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Journal Article
Inhibition of protein kinase C-driven nuclear factor-kappaB activation: synthesis, structure-activity relationship, and pharmacological profiling of pathway specific benzimidazole probe molecules
Peddibhotla, Satyamaheshwar, Shi, Ranxin, Khan, Pasha, Smith, Layton H, Mangravita-Novo, Arianna, Vicchiarelli, Michael, Su, Ying, Okolotowicz, Karl J, Cashman, John R, Reed, John C, Roth, Gregory P
Published in Journal of medicinal chemistry (24.06.2010)
Published in Journal of medicinal chemistry (24.06.2010)
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Journal Article
Chemical biology strategy reveals pathway-selective inhibitor of NF-kappaB activation induced by protein kinase C
Shi, Ranxin, Re, Daniel, Dudl, Eric, Cuddy, Michael, Okolotowicz, Karl J, Dahl, Russell, Su, Ying, Hurder, Andrew, Kitada, Shinichi, Peddibhotla, Satyamaheshwar, Roth, Gregory P, Smith, Layton H, Kipps, Thomas J, Cosford, Nicholas, Cashman, John, Reed, John C
Published in ACS chemical biology (19.03.2010)
Published in ACS chemical biology (19.03.2010)
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Journal Article
ANTICANCER AGENTS BASED ON PREVENTION OF PROTEIN PRENYLATION
ROBINSON, DALE E, OTTERSBERG, STEVEN R, LEFLER, SCOTT R, OKOLOTOWICZ, KARL J, ROSE, SETH D, HARTMAN, ROSEMARIE F
Year of Publication 08.10.2013
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Year of Publication 08.10.2013
Patent
INHIBITORS OF ANTIGEN RECEPTOR-INDUCED NF- KAPPA B ACTIVATION
REED, JOHN, C, OKOLOTOWICZ, KARL, J, RE, DANIEL, SHI, RANXIN, CASHMAN, JOHN, R
Year of Publication 10.08.2011
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Year of Publication 10.08.2011
Patent
Conjugated nitro alkene anticancer agents based on isoprenoid metabolism
OKOLOTOWICZ KARL J, HOUTCHENS JASON, ROSE SETH D, HARTMAN ROSEMARIE F
Year of Publication 12.07.2011
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Year of Publication 12.07.2011
Patent