A Novel Inhibitor Targets Both Wnt Signaling and ATM/p53 in Colorectal Cancer
Cheng, Jiongjia, Dwyer, Mary, Okolotowicz, Karl J, Mercola, Mark, Cashman, John R
Published in Cancer research (Chicago, Ill.) (01.09.2018)
Published in Cancer research (Chicago, Ill.) (01.09.2018)
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Journal Article
Reengineering an Antiarrhythmic Drug Using Patient hiPSC Cardiomyocytes to Improve Therapeutic Potential and Reduce Toxicity
McKeithan, Wesley L., Feyen, Dries A.M., Bruyneel, Arne A.N., Okolotowicz, Karl J., Ryan, Daniel A., Sampson, Kevin J., Potet, Franck, Savchenko, Alex, Gómez-Galeno, Jorge, Vu, Michelle, Serrano, Ricardo, George, Alfred L., Kass, Robert S., Cashman, John R., Mercola, Mark
Published in Cell stem cell (05.11.2020)
Published in Cell stem cell (05.11.2020)
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Journal Article
A Novel Small Molecule Inhibits Tumor Growth and Synergizes Effects of Enzalutamide on Prostate Cancer
Cheng, Jiongjia, Moore, Stephanie, Gomez-Galeno, Jorge, Lee, Dong-Hoon, Okolotowicz, Karl J, Cashman, John R
Published in The Journal of pharmacology and experimental therapeutics (01.12.2019)
Published in The Journal of pharmacology and experimental therapeutics (01.12.2019)
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Journal Article
Preclinical Studies of Noncharged Oxime Reactivators for Organophosphate Exposure
Okolotowicz, Karl J., Dwyer, Mary, Smith, Emily, Cashman, John R.
Published in Journal of biochemical and molecular toxicology (01.01.2014)
Published in Journal of biochemical and molecular toxicology (01.01.2014)
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Journal Article
Human‐induced pluripotent stem cell‐derived cardiomyocytes: Cardiovascular properties and metabolism and pharmacokinetics of deuterated mexiletine analogs
Gomez‐Galeno, Jorge, Okolotowicz, Karl, Johnson, Mark, McKeithan, Wesley L., Mercola, Mark, Cashman, John R.
Published in Pharmacology research & perspectives (01.08.2021)
Published in Pharmacology research & perspectives (01.08.2021)
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Journal Article
Inhibition of Bfl-1 with N-aryl maleimides
Cashman, John R., MacDonald, Mary, Ghirmai, Senait, Okolotowicz, Karl J., Sergienko, Eduard, Brown, Brock, Garcia, Xochella, Zhai, Dayong, Dahl, Russell, Reed, John C.
Published in Bioorganic & medicinal chemistry letters (15.11.2010)
Published in Bioorganic & medicinal chemistry letters (15.11.2010)
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Journal Article
Inhibition of Protein Kinase C-Driven Nuclear Factor-κB Activation: Synthesis, Structure−Activity Relationship, and Pharmacological Profiling of Pathway Specific Benzimidazole Probe Molecules
Peddibhotla, Satyamaheshwar, Shi, Ranxin, Khan, Pasha, Smith, Layton H, Mangravita-Novo, Arianna, Vicchiarelli, Michael, Su, Ying, Okolotowicz, Karl J, Cashman, John R, Reed, John C, Roth, Gregory P
Published in Journal of medicinal chemistry (24.06.2010)
Published in Journal of medicinal chemistry (24.06.2010)
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Journal Article
Chemical Biology Strategy Reveals Pathway-Selective Inhibitor of NF-κB Activation Induced by Protein Kinase C
Shi, Ranxin, Re, Daniel, Dudl, Eric, Cuddy, Michael, Okolotowicz, Karl J, Dahl, Russell, Su, Ying, Hurder, Andrew, Kitada, Shinichi, Peddibhotla, Satyamaheshwar, Roth, Gregory P, Smith, Layton H, Kipps, Thomas J, Cosford, Nicholas, Cashman, John, Reed, John C
Published in ACS chemical biology (19.03.2010)
Published in ACS chemical biology (19.03.2010)
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Journal Article
Synthesis and SAR of b‑Annulated 1,4-Dihydropyridines Define Cardiomyogenic Compounds as Novel Inhibitors of TGFβ Signaling
Schade, Dennis, Lanier, Marion, Willems, Erik, Okolotowicz, Karl, Bushway, Paul, Wahlquist, Christine, Gilley, Cynthia, Mercola, Mark, Cashman, John R
Published in Journal of medicinal chemistry (26.11.2012)
Published in Journal of medicinal chemistry (26.11.2012)
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Journal Article
Human iPSC-derived cardiomyocytes and pyridyl-phenyl mexiletine analogs
Johnson, Mark, Gomez-Galeno, Jorge, Ryan, Daniel, Okolotowicz, Karl, McKeithan, Wesley L., Sampson, Kevin J., Kass, Robert S., Mercola, Mark, Cashman, John R.
Published in Bioorganic & medicinal chemistry letters (15.08.2021)
Published in Bioorganic & medicinal chemistry letters (15.08.2021)
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Journal Article
Antiarrhythmic Hit to Lead Refinement in a Dish Using Patient-Derived iPSC Cardiomyocytes
Cashman, John R, Ryan, Daniel, McKeithan, Wesley L, Okolotowicz, Karl, Gomez-Galeno, Jorge, Johnson, Mark, Sampson, Kevin J, Kass, Robert S, Pezhouman, Arash, Karagueuzian, Hrayr S, Mercola, Mark
Published in Journal of medicinal chemistry (13.05.2021)
Published in Journal of medicinal chemistry (13.05.2021)
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Journal Article
Stereoselective synthesis of mexiletine and structural analogs with chiral tert-butanesulfinamide
Ryan, Daniel A., Okolotowicz, Karl J., Mercola, Mark, Cashman, John R.
Published in Tetrahedron letters (08.07.2015)
Published in Tetrahedron letters (08.07.2015)
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Journal Article
Small-molecule probe reveals a kinase cascade that links stress signaling to TCF/LEF and Wnt responsiveness
Cheng, Jiongjia, Tsuda, Masanao, Okolotowicz, Karl, Dwyer, Mary, Bushway, Paul J., Colas, Alexandre R., Lancman, Joseph J., Schade, Dennis, Perea-Gil, Isaac, Bruyneel, Arne A.N., Lee, Jaechol, Vadgama, Nirmal, Quach, Justine, McKeithan, Wesley L., Biechele, Travis L., Wu, Joseph C., Moon, Randall T., Si Dong, P. Duc, Karakikes, Ioannis, Cashman, John R., Mercola, Mark
Published in Cell chemical biology (20.05.2021)
Published in Cell chemical biology (20.05.2021)
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Journal Article
Chemical Synthesis of Two Series of Nerve Agent Model Compounds and Their Stereoselective Interaction with Human Acetylcholinesterase and Human Butyrylcholinesterase
Barakat, Nora H, Zheng, Xueying, Gilley, Cynthia B, MacDonald, Mary, Okolotowicz, Karl, Cashman, John R, Vyas, Shubham, Beck, Jeremy M, Hadad, Christopher M, Zhang, Jun
Published in Chemical research in toxicology (01.10.2009)
Published in Chemical research in toxicology (01.10.2009)
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Journal Article
Inactivation of Protein Farnesyltransferase by Active-Site-Targeted Dicarbonyl Compounds
Okolotowicz, Karl J., Lee, Wei-Jen, Hartman, Rosemarie F., Kim, Ann Y., Ottersberg, Steven R., Robinson, Jr, Dale E., Lefler, Scott R., Rose, Seth D.
Published in Archiv der Pharmazie (Weinheim) (01.06.2001)
Published in Archiv der Pharmazie (Weinheim) (01.06.2001)
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