CH5424802, a Selective ALK Inhibitor Capable of Blocking the Resistant Gatekeeper Mutant
Sakamoto, Hiroshi, Tsukaguchi, Toshiyuki, Hiroshima, Sayuri, Kodama, Tatsushi, Kobayashi, Takamitsu, Fukami, Takaaki A., Oikawa, Nobuhiro, Tsukuda, Takuo, Ishii, Nobuya, Aoki, Yuko
Published in Cancer cell (17.05.2011)
Published in Cancer cell (17.05.2011)
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Design and synthesis of a highly selective, orally active and potent anaplastic lymphoma kinase inhibitor (CH5424802)
Kinoshita, Kazutomo, Asoh, Kohsuke, Furuichi, Noriyuki, Ito, Toshiya, Kawada, Hatsuo, Hara, Sousuke, Ohwada, Jun, Miyagi, Takuho, Kobayashi, Takamitsu, Takanashi, Kenji, Tsukaguchi, Toshiyuki, Sakamoto, Hiroshi, Tsukuda, Takuo, Oikawa, Nobuhiro
Published in Bioorganic & medicinal chemistry (01.02.2012)
Published in Bioorganic & medicinal chemistry (01.02.2012)
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Selective TRK Inhibitor CH7057288 against TRK Fusion-Driven Cancer
Tanaka, Hiroshi, Sase, Hitoshi, Tsukaguchi, Toshiyuki, Hasegawa, Masami, Tanimura, Hiromi, Yoshida, Miyuki, Sakata, Kiyoaki, Fujii, Toshihiko, Tachibana, Yukako, Takanashi, Kenji, Higashida, Atsuko, Hasegawa, Kiyoshi, Ono, Yoshiyuki, Oikawa, Nobuhiro, Mio, Toshiyuki
Published in Molecular cancer therapeutics (01.12.2018)
Published in Molecular cancer therapeutics (01.12.2018)
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High-throughput screening of ecdysone agonists using a reporter gene assay followed by 3-D QSAR analysis of the molting hormonal activity
Wheelock, Craig E., Nakagawa, Yoshiaki, Harada, Toshiyuki, Oikawa, Nobuhiro, Akamatsu, Miki, Smagghe, Guy, Stefanou, Dimitra, Iatrou, Kostas, Swevers, Luc
Published in Bioorganic & medicinal chemistry (15.02.2006)
Published in Bioorganic & medicinal chemistry (15.02.2006)
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Design, synthesis and antifungal activity of a novel water soluble prodrug of antifungal triazole
Ohwada, Jun, Tsukazaki, Masao, Hayase, Tadakatsu, Oikawa, Nobuhiro, Isshiki, Yoshiaki, Fukuda, Hiroshi, Mizuguchi, Eisaku, Sakaitani, Masahiro, Shiratori, Yasuhiko, Yamazaki, Toshikazu, Ichihara, Shigeyasu, Umeda, Isao, Shimma, Nobuo
Published in Bioorganic & medicinal chemistry letters (01.01.2003)
Published in Bioorganic & medicinal chemistry letters (01.01.2003)
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MITF suppression improves the sensitivity of melanoma cells to a BRAF inhibitor
Aida, Satoshi, Sonobe, Yukiko, Tanimura, Hiromi, Oikawa, Nobuhiro, Yuhki, Munehiro, Sakamoto, Hiroshi, Mizuno, Takakazu
Published in Cancer letters (28.11.2017)
Published in Cancer letters (28.11.2017)
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Discovery of CH7057288 as an Orally Bioavailable, Selective, and Potent pan-TRK Inhibitor
Ito, Toshiya, Kinoshita, Kazutomo, Tomizawa, Masaki, Shinohara, Shojiro, Nishii, Hiroki, Matsushita, Masayuki, Hattori, Kazuo, Kohchi, Yasunori, Kohchi, Masami, Hayase, Tadakatsu, Watanabe, Fumio, Hasegawa, Kiyoshi, Tanaka, Hiroshi, Kuramoto, Shino, Takanashi, Kenji, Oikawa, Nobuhiro
Published in Journal of medicinal chemistry (22.09.2022)
Published in Journal of medicinal chemistry (22.09.2022)
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Abstract 4179: Potent and selective TRK inhibitor CH7057288
Tanaka, Hiroshi, Sase, Hitoshi, Tsukaguchi, Toshiyuki, Tanimura, Hiromi, Hasegawa, Masami, Hasegawa, Kiyoshi, Ono, Yoshiyuki, Oikawa, Nobuhiro, Sakamoto, Hiroshi, Mio, Toshiyuki
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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9-Substituted 6,6-Dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazoles as Highly Selective and Potent Anaplastic Lymphoma Kinase Inhibitors
Kinoshita, Kazutomo, Kobayashi, Takamitsu, Asoh, Kohsuke, Furuichi, Noriyuki, Ito, Toshiya, Kawada, Hatsuo, Hara, Sousuke, Ohwada, Jun, Hattori, Kazuo, Miyagi, Takuho, Hong, Woo-Sang, Park, Min-Jeong, Takanashi, Kenji, Tsukaguchi, Toshiyuki, Sakamoto, Hiroshi, Tsukuda, Takuo, Oikawa, Nobuhiro
Published in Journal of medicinal chemistry (22.09.2011)
Published in Journal of medicinal chemistry (22.09.2011)
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Hydrophilically functionalized pyrazoles from sugars11Enantiopure Building Blocks from Sugars. Part 22. For Part 21, see Ref.[1].—Presented, in part, at the 9th European Carbohydrate Symposium, Utrecht, The Netherlands, July 1997; Abstract E1
Oikawa, Nobuhiro, Müller, Christoph, Kunz, Markwart, Lichtenthaler, Frieder W
Published in Carbohydrate research (01.07.1998)
Published in Carbohydrate research (01.07.1998)
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Discovery of novel tetracyclic compounds as anaplastic lymphoma kinase inhibitors
Kinoshita, Kazutomo, Ono, Yoshiyuki, Emura, Takashi, Asoh, Kohsuke, Furuichi, Noriyuki, Ito, Toshiya, Kawada, Hatsuo, Tanaka, Shota, Morikami, Kenji, Tsukaguchi, Toshiyuki, Sakamoto, Hiroshi, Tsukuda, Takuo, Oikawa, Nobuhiro
Published in Bioorganic & medicinal chemistry letters (15.06.2011)
Published in Bioorganic & medicinal chemistry letters (15.06.2011)
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Analysis and prediction of hydrophobicity parameters of substituted acetanilides, benzamides and related aromatic compounds
Nakagawa, Y. (Kyoto University, Kyoto, Japan), Izumi, K, Oikawa, N, Sotomatsu, T, Shigemura, M, Fujita, T
Published in Environmental toxicology and chemistry (01.07.1992)
Published in Environmental toxicology and chemistry (01.07.1992)
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Abstract DDT01-02: CH5424802: A selective ALK inhibitor
Sakamoto, Hiroshi, Oikawa, Nobuhiro, Tsukuda, Takuo, Shimma, Nobuo, Ishii, Nobuya, Aoki, Yuko
Published in Cancer research (Chicago, Ill.) (15.04.2011)
Published in Cancer research (Chicago, Ill.) (15.04.2011)
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Abstract 3559: A new selective ALK inhibitor CH5424802 shows potent efficacy against ALK-positive cancers including the gatekeeper mutant-driven tumors
Sakamoto, Hiroshi, Tsukaguchi, Toshiyuki, Hiroshima, Sayuri, Kodama, Tatsushi, Kobayashi, Takamitsu, Fukami, Takaaki A., Oikawa, Nobuhiro, Tsukuda, Takuo, Ishii, Nobuya, Aoki, Yuko
Published in Cancer research (Chicago, Ill.) (15.04.2011)
Published in Cancer research (Chicago, Ill.) (15.04.2011)
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Journal Article
9-Substituted 6,6-Dimethyl-11-oxo-6,11-dihydro-5 H -benzo[ b ]carbazoles as Highly Selective and Potent Anaplastic Lymphoma Kinase Inhibitors
Kinoshita, Kazutomo, Kobayashi, Takamitsu, Asoh, Kohsuke, Furuichi, Noriyuki, Ito, Toshiya, Kawada, Hatsuo, Hara, Sousuke, Ohwada, Jun, Hattori, Kazuo, Miyagi, Takuho, Hong, Woo-Sang, Park, Min-Jeong, Takanashi, Kenji, Tsukaguchi, Toshiyuki, Sakamoto, Hiroshi, Tsukuda, Takuo, Oikawa, Nobuhiro
Published in Journal of medicinal chemistry (22.09.2011)
Published in Journal of medicinal chemistry (22.09.2011)
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Abstract 3593: Generation of a potent and selective inhibitor of ALK, CH5424802, showing superior oral bioavailability, PK profile and in vivo efficacy
Oikawa, Nobuhiro, Kinoshita, Kazutomo, Asoh, Kohsuke, Furuichi, Noriyuki, Itoh, Toshiya, Kawada, Hatsuo, Hara, Sosuke, Miyagi, Takuho, Ohwada, Jun, Taniguchi, Saori, Hattori, Kazuo, Tsukuda, Takuo, Takanashi, Kenji, Sakamoto, Hiroshi, Tsukaguchi, Toshiyuki, Ishii, Nobuya, Aoki, Yuko, Shimma, Nobuo
Published in Cancer research (Chicago, Ill.) (15.04.2011)
Published in Cancer research (Chicago, Ill.) (15.04.2011)
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Identification of a Novel Vascular Endothelial Growth Factor Receptor 2 Inhibitor and Its Effect for Choroidal Neovascularization In Vivo
Takahashi, Hidenori, Tamaki, Yasuhiro, Ishii, Nobuya, Oikawa, Nobuhiro, Mizuguchi, Eisaku, Francis, Jasmine H., Inoue, Yuji, Iriyama, Aya, Obata, Ryo, Yanagi, Yasuo
Published in Current eye research (01.01.2008)
Published in Current eye research (01.01.2008)
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Design and synthesis of novel prodrugs of 2′-deoxy-2′-methylidenecytidine activated by membrane dipeptidase overexpressed in tumor tissues
Kohchi, Yasunori, Hattori, Kazuo, Oikawa, Nobuhiro, Mizuguchi, Eisaku, Isshiki, Yoshiaki, Aso, Kohsuke, Yoshinari, Kiyoshi, Shirai, Haruyoshi, Miwa, Masanori, Inagaki, Yukiko, Ura, Masako, Ogawa, Kotaroh, Okabe, Hisafumi, Ishitsuka, Hideo, Shimma, Nobuo
Published in Bioorganic & medicinal chemistry letters (15.04.2007)
Published in Bioorganic & medicinal chemistry letters (15.04.2007)
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