Human chimeric antigen receptor macrophages for cancer immunotherapy
Klichinsky, Michael, Ruella, Marco, Shestova, Olga, Lu, Xueqing Maggie, Best, Andrew, Zeeman, Martha, Schmierer, Maggie, Gabrusiewicz, Konrad, Anderson, Nicholas R, Petty, Nicholas E, Cummins, Katherine D, Shen, Feng, Shan, Xinhe, Veliz, Kimberly, Blouch, Kristin, Yashiro-Ohtani, Yumi, Kenderian, Saad S, Kim, Miriam Y, O'Connor, Roddy S, Wallace, Stephen R, Kozlowski, Miroslaw S, Marchione, Dylan M, Shestov, Maksim, Garcia, Benjamin A, June, Carl H, Gill, Saar
Published in Nature biotechnology (01.08.2020)
Published in Nature biotechnology (01.08.2020)
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Journal Article
NOTCH1 and NOTCH3 coordinate esophageal squamous differentiation through a CSL-dependent transcriptional network
Ohashi, Shinya, Natsuizaka, Mitsuteru, Yashiro-Ohtani, Yumi, Kalman, Ross A, Nakagawa, Momo, Wu, Lizi, Klein-Szanto, Andres J, Herlyn, Meenhard, Diehl, J Alan, Katz, Jonathan P, Pear, Warren S, Seykora, John T, Nakagawa, Hiroshi
Published in Gastroenterology (New York, N.Y. 1943) (01.12.2010)
Published in Gastroenterology (New York, N.Y. 1943) (01.12.2010)
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389 Engineered microenvironment converters (EM-C): macrophages expressing synthetic cytokine receptors reverse immunosuppressive signals in solid tumors
Sloas, Chris, Huangfu, Yuhao, Beghi, Silvia, Qureshi, Rehman, Ball, Michael, Blumenthal, Daniel, Condamine, Thomas, Klichinsky, Michael, Ohtani, Yumi
Published in Journal for immunotherapy of cancer (01.11.2023)
Published in Journal for immunotherapy of cancer (01.11.2023)
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Journal Article
Protein Tyrosine Phosphatase PRL2 Mediates Notch and Kit Signals in Early T Cell Progenitors
Kobayashi, Michihiro, Nabinger, Sarah C., Bai, Yunpeng, Yoshimoto, Momoko, Gao, Rui, Chen, Sisi, Yao, Chonghua, Dong, Yuanshu, Zhang, Lujuan, Rodriguez, Sonia, Yashiro‐Ohtani, Yumi, Pear, Warren S., Carlesso, Nadia, Yoder, Mervin C., Kapur, Reuben, Kaplan, Mark H., Daniel Lacorazza, Hugo, Zhang, Zhong‐Yin, Liu, Yan
Published in Stem cells (Dayton, Ohio) (01.04.2017)
Published in Stem cells (Dayton, Ohio) (01.04.2017)
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Journal Article
132 CAR macrophages (CAR-M) elicit a systemic anti-tumor immune response and synergize with PD1 blockade in immunocompetent mouse models of HER2+ solid tumors
Pierini, Stefano, Gabbasov, Rashid, Gabitova, Linara, Ohtani, Yumi, Klichinsky, Michael
Published in Journal for immunotherapy of cancer (01.11.2020)
Published in Journal for immunotherapy of cancer (01.11.2020)
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Journal Article
MAFB enhances oncogenic Notch signaling in T cell acute lymphoblastic leukemia
Pajcini, Kostandin V, Xu, Lanwei, Shao, Lijian, Petrovic, Jelena, Palasiewicz, Karol, Ohtani, Yumi, Bailis, Will, Lee, Curtis, Wertheim, Gerald B, Mani, Rajeswaran, Muthusamy, Natarajan, Li, Yunlei, Meijerink, Jules P P, Blacklow, Stephen C, Faryabi, Robert B, Cherry, Sara, Pear, Warren S
Published in Science signaling (14.11.2017)
Published in Science signaling (14.11.2017)
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307 CAR-Macrophages with custom intronic shRNA exhibit enhanced efficacy against solid tumors
Sloas, Chris, Gabbasov, Rashid, Anderson, Nicholas, Huangfu, Yuhao, Nagar, Karan, Ciccaglione, Kerri, Tobin, Tierra, Minutolo, Nicholas, Condamine, Thomas, Klichinsky, Michael, Ohtani, Yumi
Published in Journal for immunotherapy of cancer (01.11.2023)
Published in Journal for immunotherapy of cancer (01.11.2023)
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Journal Article
The expression of Sox17 identifies and regulates haemogenic endothelium
Clarke, Raedun L, Yzaguirre, Amanda D, Yashiro-Ohtani, Yumi, Bondue, Antoine, Blanpain, Cedric, Pear, Warren S, Speck, Nancy A, Keller, Gordon
Published in Nature cell biology (01.05.2013)
Published in Nature cell biology (01.05.2013)
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Journal Article
Long-range enhancer activity determines Myc sensitivity to Notch inhibitors in T cell leukemia
Yashiro-Ohtani, Yumi, Wang, Hongfang, Zang, Chongzhi, Arnett, Kelly L, Bailis, Will, Ho, Yugong, Knoechel, Birgit, Lanauze, Claudia, Louis, Lumena, Forsyth, Katherine S, Chen, Sujun, Chung, Yoonjie, Schug, Jonathan, Blobel, Gerd A, Liebhaber, Stephen A, Bernstein, Bradley E, Blacklow, Stephen C, Liu, Xiaole Shirley, Aster, Jon C, Pear, Warren S
Published in Proceedings of the National Academy of Sciences - PNAS (18.11.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (18.11.2014)
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Journal Article
1514 In vivo CAR-M: redirecting endogenous myeloid cells with mRNA for cancer immunotherapy
Varghese, Bindu, Mori, Simone, Pierini, Stefano, Bagashev, Asen, Ohtani, Yumi, Gabbasov, Rashid, Ross, Kayleigh, Huang, Shuo, Bona, Amanda, Merdiana, Sherly, Slovik, Kate, Worth, Alison, Nagar, Karan, Saporito, Robert, Shaw, Lauren, Ball, Michael, Qureshi, Rehman, Minutolo, Nicholas, Tosh, Kevin, Lee, Claudia, Lukacs, Christine, Guey, Lin, Klichinsky, Michael, Condamine, Thomas
Published in Journal for immunotherapy of cancer (01.11.2023)
Published in Journal for immunotherapy of cancer (01.11.2023)
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Journal Article
Modulating the strength and threshold of NOTCH oncogenic signals by mir-181a-1/b-1
Fragoso, Rita, Mao, Tin, Wang, Song, Schaffert, Steven, Gong, Xue, Yue, Sibiao, Luong, Richard, Min, Hyeyoung, Yashiro-Ohtani, Yumi, Davis, Mark, Pear, Warren, Chen, Chang-Zheng
Published in PLoS genetics (01.08.2012)
Published in PLoS genetics (01.08.2012)
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Journal Article
139 Chimeric antigen receptor macrophages (CAR-M) elicit a systemic anti-tumor immune response and synergize with PD1 blockade in immunocompetent mouse models of HER2+ solid tumors
Pierini, Stefano, Klichinsky, Michael, Gabbasov, Rashid, Worth, Alison, Ramos, Ilyssa, Blumenthal, Daniel, Gabitova, Linara, Abramson, Sascha, Condamine, Thomas, Ball, Michael, Ohtani, Yumi
Published in Journal for immunotherapy of cancer (01.11.2021)
Published in Journal for immunotherapy of cancer (01.11.2021)
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Journal Article
Pre-TCR signaling inactivates Notch1 transcription by antagonizing E2A
Yashiro-Ohtani, Yumi, He, Yiping, Ohtani, Takuya, Jones, Mary E, Shestova, Olga, Xu, Lanwei, Fang, Terry C, Chiang, Mark Y, Intlekofer, Andrew M, Blacklow, Stephen C, Zhuang, Yuan, Pear, Warren S
Published in Genes & development (15.07.2009)
Published in Genes & development (15.07.2009)
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Journal Article
The unique target specificity of a nonpeptide chemokine receptor antagonist: selective blockade of two Th1 chemokine receptors CCR5 and CXCR3
Gao, Ping, Zhou, Xu‐Yu, Yashiro‐Ohtani, Yumi, Yang, Yi‐Fu, Sugimoto, Naotoshi, Ono, Shiro, Nakanishi, Tsuyoshi, Obika, Satoshi, Imanishi, Takeshi, Egawa, Takeshi, Nagasawa, Takashi, Fujiwara, Hiromi, Hamaoka, Toshiyuki
Published in Journal of leukocyte biology (01.02.2003)
Published in Journal of leukocyte biology (01.02.2003)
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Journal Article
Notch regulation of early thymocyte development
Yashiro-Ohtani, Yumi, Ohtani, Takuya, Pear, Warren S
Published in Seminars in immunology (01.10.2010)
Published in Seminars in immunology (01.10.2010)
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Journal Article
Active Notch1 Confers a Transformed Phenotype to Primary Human Melanocytes
PINNIX, Chelsea C, LEE, John T, YASHIRO-OHTANI, Yumi, NATHANSON, Katherine L, BENGSTON, Ana, POLLOCK, Pamela M, WEERARATNA, Ashani T, NICKOLOFF, Brian J, PEAR, Warren S, CAPOBIANCO, Anthony J, HERLYN, Meenhard, LIU, Zhao-Jun, MCDAID, Ronan, BALINT, Klara, BEVERLY, Levi J, BRAFFORD, Patricia A, MIN XIAO, HIMES, Benjamin, ZABIEROWSKI, Susan E
Published in Cancer research (Chicago, Ill.) (01.07.2009)
Published in Cancer research (Chicago, Ill.) (01.07.2009)
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Journal Article
Induction of surface CCR4 and its functionality in mouse Th2 cells is regulated differently during Th2 development
Morimoto, Yasunari, Bian, Yang, Gao, Ping, Yashiro‐Ohtani, Yumi, Zhou, Xu‐Yu, Ono, Shiro, Nakahara, Hirokazu, Kogo, Mikihiko, Hamaoka, Toshiyuki, Fujiwara, Hiromi
Published in Journal of leukocyte biology (01.09.2005)
Published in Journal of leukocyte biology (01.09.2005)
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Journal Article
Fusogenic liposomes efficiently deliver exogenous antigen through the cytoplasm into the MHC class I processing pathway
Nakanishi, Tsuyoshi, Hayashi, Akira, Kunisawa, Jun, Tsutsumi, Yasuo, Tanaka, Keiichi, Yashiro‐Ohtani, Yumi, Nakanishi, Mahito, Fujiwara, Hiromi, Hamaoka, Toshiyuki, Mayumi, Tadanori
Published in European journal of immunology (01.06.2000)
Published in European journal of immunology (01.06.2000)
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Journal Article
A mechanism underlying STAT4‐mediated up‐regulation of IFN‐γ induction inTCR‐triggered T cells
Park, Woong‐Ryeon, Nakahira, Masakiyo, Sugimoto, Naotoshi, Bian, Yang, Yashiro‐Ohtani, Yumi, Zhou, Xu‐Yu, Yang, Yi‐Fu, Hamaoka, Toshiyuki, Fujiwara, Hiromi
Published in International immunology (01.02.2004)
Published in International immunology (01.02.2004)
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Journal Article
A critical role for TCF―1 in T―lineage specification and differentiation
WEBER, Brittany Nicole, WEI-SHINE CHI, Anthony, CHAVEZ, Alejandro, YASHIRO-OHTANI, Yumi, QI YANG, SHESTOVA, Olga, BHANDOOLA, Avinash
Published in Nature (London) (04.08.2011)
Published in Nature (London) (04.08.2011)
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