Molecular mechanism of antifolate transport-deficiency in a methotrexate-resistant MOLT-3 human leukemia cell line
GONG, M, YESS, J, CONNOLLY, T, IVY, S. P, OHNUMA, T, COWAN, K. H, MOSCOW, J. A
Published in Blood (01.04.1997)
Published in Blood (01.04.1997)
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Abstract 4595: RPL18A as putative target of rigosertib
Oussenko, Irina, Divakar, Saikrishna, Reddy, M. V. Ramana, Holland, James F., Reddy, E. Premkumar, Ohnuma, Takao
Published in Cancer research (Chicago, Ill.) (01.10.2014)
Published in Cancer research (Chicago, Ill.) (01.10.2014)
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Abstract 3797: Hyperphosphorylation and desumoylation of RanGAP1·SUMO1
Oussenko, Irina, Holland, James F., Reddy, E. Premkumar, Ohnuma, Takao
Published in Cancer research (Chicago, Ill.) (15.04.2012)
Published in Cancer research (Chicago, Ill.) (15.04.2012)
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Abstract 694: Structure-function analysis of RPL18A, a putative binding target of rigosertib
Oussenko, Irina A., Gupta, Yogesh K., Vasquez-Del Carpio, Rodrigo, Ramana-Reddy, M.V., Aggarwal, Aneel K., Reddy, E. Premkumar, Holland, James F., Ohnuma, Takao
Published in Cancer research (Chicago, Ill.) (01.08.2015)
Published in Cancer research (Chicago, Ill.) (01.08.2015)
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Abstract 2500: ON 01910. Na, a clinical stage anticancer mitotic inhibitor, produces prolonged hyperphosphorylation of RanGAP1•SUMO1 as a potential mechanism of G2/M arrest and apoptosis
Oussenko, Irina, Holland, James F., Reddy, E. Premkumar, Ohnuma, Takao
Published in Cancer research (Chicago, Ill.) (15.04.2010)
Published in Cancer research (Chicago, Ill.) (15.04.2010)
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In vitro confirmation of newly established lung cancer cell lines using flow cytometry and multicellular tumor spheroids
Inoue, Shoichi, Takaoka, Kazuo, Endo, Takashi, Mizuno, Shigetaka, Ogawa, Yoshihiko, Yoshida, Michihiro, Ohnuma, Takao
Published in Lung cancer (Amsterdam, Netherlands) (01.05.1997)
Published in Lung cancer (Amsterdam, Netherlands) (01.05.1997)
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Discontinuous drug binding to proteins: binding of an antineoplastic benzyl styryl sulfone to albumin and enzymes in vitro and in phase I clinical trials
Cho, Sool Yeon, Ohnuma, Takao, Silverman, Lewis R, Holland, James F, Roboz, John
Published in Drug metabolism and disposition (01.09.2010)
Published in Drug metabolism and disposition (01.09.2010)
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Evaluation of ON01910.Na In Patients with a Myelodysplastic Syndrome (MDS) or Acute Myeloid Leukemia (AML) Relapsed or Refractory to Hypomethylating Agents: A Phase I Study
Silverman, Lewis R, Navada, Shyamala C., Odchimar-Reissig, Rosalie, Najfeld, Vesna, Ohnuma, Takao, Wilhelm, Francois, Reddy, E. Premkumar, Holland, James F.
Published in Blood (19.11.2010)
Published in Blood (19.11.2010)
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Abstract 2766: Multicenter pharmacokinetic evaluation of ON 01910. Na, a novel broad-spectrum anticancer agent, in Phase I single agent clinical trials in patients with solid tumors
Maniar, Manoj, Mani, Sridhar, Ghalib, Mohammed H., Roboz, John, Ohnuma, Takao, Advani, Suresh, Rao, Raghunadh, Doval, D, Acharya, Manmohan, O'Rourke, Edward, Wilhelm, Francois, Holland, James F., Taft, David
Published in Cancer research (Chicago, Ill.) (15.04.2010)
Published in Cancer research (Chicago, Ill.) (15.04.2010)
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Effects of a Novel Benzyl Styryl Sulfone Derivative ON 01910.Na On the Myelodysplastic Syndrome (MDS) Derived Clone in Patients Relapsing Following Response to Azacitidine (AzaC) Therapy
Silverman, Lewis R., Odchimar-Reissig, Rosalie, Navada, Shyamala C., Ohnuma, Takao, Najfeld, Vesna, Wilhelm, Francois, Reddy, E. Premkumar, Holland, James F
Published in Blood (20.11.2009)
Published in Blood (20.11.2009)
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Phase 1 study of intravenous rigosertib (ON 01910.Na), a novel benzyl styryl sulfone structure producing G2/M arrest and apoptosis, in adult patients with advanced cancer
Ohnuma, Takao, Lehrer, Deborah, Ren, Chen, Cho, Sool Yeon, Maniar, Manoj, Silverman, Lewis, Sung, Max, Gretz, 3rd, Herbert F, Benisovich, Vladimir, Navada, Shyamala, Akahoho, Eugene, Wilck, Eric, Taft, David R, Roboz, John, Wilhelm, Francois, Holland, James F
Published in American journal of cancer research (01.01.2013)
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Published in American journal of cancer research (01.01.2013)
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Biologic and pharmacologic effects of harringtonine on human leukemia-lymphoma cells
Takemura, Y, Ohnuma, T, Chou, T C, Okano, T, Holland, J F
Published in Cancer chemotherapy and pharmacology (01.04.1985)
Published in Cancer chemotherapy and pharmacology (01.04.1985)
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Microbiological assay of bleomycin: Inactivation, tissue distribution, and clearance
Ohnuma, Takao, Holland, James F., Masuda, Hisayuki, Waligunda, Judith A., Goldberg, Gregg A.
Published in Cancer (01.05.1974)
Published in Cancer (01.05.1974)
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Marked inhibition of glioblastoma target cell tumorigenicity in vitro by retrovirus-mediated transfer of a hairpin ribozyme against deletion-mutant epidermal growth factor receptor messenger RNA
Halatsch, M E, Schmidt, U, Bötefür, I C, Holland, J F, Ohnuma, T
Published in Journal of neurosurgery (01.02.2000)
Published in Journal of neurosurgery (01.02.2000)
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