Improvement in the variation of inhalation properties of an FK888 dry powder inhaler using an E-haler, by adding coarse lactose in spherical soft agglomerates of fine drug particles, and its absorption in healthy volunteers
Nakate, T., Yoshida, H., Ohike, A., Tokunaga, Y., Ibuki, R., Kawashima, Y.
Published in Journal of drug delivery science and technology (2005)
Published in Journal of drug delivery science and technology (2005)
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Establishment of new preparation method for solid dispersion formulation of tacrolimus
Yamashita, Kazunari, Nakate, Toshiomi, Okimoto, Kazuto, Ohike, Atsuo, Tokunaga, Yuji, Ibuki, Rinta, Higaki, Kazutaka, Kimura, Toshikiro
Published in International journal of pharmaceutics (28.11.2003)
Published in International journal of pharmaceutics (28.11.2003)
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Development of novel sustained-release system, disintegration-controlled matrix tablet (DCMT) with solid dispersion granules of nilvadipine
Tanaka, Nobuyuki, Imai, Keiji, Okimoto, Kazuto, Ueda, Satoshi, Tokunaga, Yuji, Ohike, Atsuo, Ibuki, Rinta, Higaki, Kazutaka, Kimura, Toshikiro
Published in Journal of controlled release (28.11.2005)
Published in Journal of controlled release (28.11.2005)
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Tacrolimus is a class II low-solubility high-permeability drug: The effect of P-glycoprotein efflux on regional permeability of tacrolimus in rats
Tamura, Shigeki, Ohike, Atsuo, Ibuki, Rinta, Amidon, Gordon L., Yamashita, Shinji
Published in Journal of pharmaceutical sciences (01.03.2002)
Published in Journal of pharmaceutical sciences (01.03.2002)
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Formulation development of inhalation powders for FK888 with carrier lactose using Spinhaler® and its absorption in healthy volunteers
Nakate, Toshiomi, Yoshida, Hiromitsu, Ohike, Atsuo, Tokunaga, Yuji, Ibuki, Rinta, Kawashima, Yoshiaki
Published in Journal of controlled release (31.05.2004)
Published in Journal of controlled release (31.05.2004)
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Improvement of pulmonary absorption of cyclopeptide FK224 in rats by co-formulating with β-cyclodextrin
Nakate, Toshiomi, Yoshida, Hiromitsu, Ohike, Atsuo, Tokunaga, Yuji, Ibuki, Rinta, Kawashima, Yoshiaki
Published in European journal of pharmaceutics and biopharmaceutics (01.03.2003)
Published in European journal of pharmaceutics and biopharmaceutics (01.03.2003)
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Journal Article
Formulation development of inhalation powders for FK888 using the E-haler ® to improve the inhalation performance at a high dose, and its absorption in healthy volunteers
Nakate, Toshiomi, Yoshida, Hiromitsu, Ohike, Atsuo, Tokunaga, Yuji, Ibuki, Rinta, Kawashima, Yoshiaki
Published in European journal of pharmaceutics and biopharmaceutics (2005)
Published in European journal of pharmaceutics and biopharmaceutics (2005)
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Comparison of the lung absorption of FK224 inhaled from a pressurized metered dose inhaler and a dry powder inhaler by healthy volunteers
Nakate, Toshiomi, Yoshida, Hiromitsu, Ohike, Atsuo, Tokunaga, Yuji, Ibuki, Rinta, Kawashima, Yoshiaki
Published in European journal of pharmaceutics and biopharmaceutics (01.11.2003)
Published in European journal of pharmaceutics and biopharmaceutics (01.11.2003)
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Journal Article
Factors affecting membrane-controlled drug release for an osmotic pump tablet (OPT) utilizing (SBE)(7m)-beta-CD as both a solubilizer and osmotic agent
Okimoto, K, Ohike, A, Ibuki, R, Aoki, O, Ohnishi, N, Rajewski, R A, Stella, V J, Irie, T, Uekama, K
Published in Journal of controlled release (05.08.1999)
Published in Journal of controlled release (05.08.1999)
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Granulation Monitoring by Fast Fourier Transform Technique
OHIKE, Atsuo, ASHIHARA, Kenichi, IBUKI, Rinta
Published in Chemical & pharmaceutical bulletin (1999)
Published in Chemical & pharmaceutical bulletin (1999)
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Design and evaluation of an osmotic pump tablet (OPT) for chlorpromazine using (SBE)7m-β-CD
OKIMOTO, K, OHIKE, A, IBUKI, R, AOKI, O, OHNISHI, N, IRIE, T, UEKAMA, K, RAJEWSKI, R. A, STELLA, V. J
Published in Pharmaceutical research (01.04.1999)
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Published in Pharmaceutical research (01.04.1999)
Journal Article
Factors affecting membrane-controlled drug release for an osmotic pump tablet (OPT) utilizing (SBE)7m-β-CD as both a solubilizer and osmotic agent
Okimoto, Kazuto, Ohike, Atsuo, Ibuki, Rinta, Aoki, Osamu, Ohnishi, Norio, Rajewski, Roger A., Stella, Valentino J., Irie, Tetsumi, Uekama, Kaneto
Published in Journal of controlled release (05.08.1999)
Published in Journal of controlled release (05.08.1999)
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Journal Article
Analysis of End-Point with Power Consumption in High Speed Mixer
TERASHITA, Keijiro, KATO, Masaya, OHIKE, Atsuo, MIYANAMI, Kei
Published in Chemical & pharmaceutical bulletin (1990)
Published in Chemical & pharmaceutical bulletin (1990)
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Granulation Process and End-Point in High Speed Mixer Granulator
TERASHITA, KEIJIRO, OHIKE, ATSUO, KATO, MASAYA, MIYANAMI, KEI
Published in YAKUGAKU ZASSHI (25.05.1987)
Published in YAKUGAKU ZASSHI (25.05.1987)
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