Combination treatment with a PI3K/Akt/mTOR pathway inhibitor overcomes resistance to anti-HER2 therapy in PIK3CA-mutant HER2-positive breast cancer cells
Fujimoto, Yumi, Morita, Tomoko Yamamori, Ohashi, Akihiro, Haeno, Hiroshi, Hakozaki, Yumi, Fujii, Masanori, Kashima, Yukie, Kobayashi, Susumu S., Mukohara, Toru
Published in Scientific reports (10.12.2020)
Published in Scientific reports (10.12.2020)
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Report of the use of patient‐derived xenograft models in the development of anticancer drugs in Japan
Tsumura, Ryo, Koga, Yoshikatsu, Hamada, Akinobu, Kuwata, Takeshi, Sasaki, Hiroki, Doi, Toshihiko, Aikawa, Katsuji, Ohashi, Akihiro, Katano, Ikumi, Ikarashi, Yoshinori, Ito, Mamoru, Ochiai, Atsushi
Published in Cancer science (01.09.2020)
Published in Cancer science (01.09.2020)
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Potentiality of multiple modalities for single-cell analyses to evaluate the tumor microenvironment in clinical specimens
Kashima, Yukie, Togashi, Yosuke, Fukuoka, Shota, Kamada, Takahiro, Irie, Takuma, Suzuki, Ayako, Nakamura, Yoshiaki, Shitara, Kohei, Minamide, Tatsunori, Yoshida, Taku, Taoka, Naofumi, Kawase, Tatsuya, Wada, Teiji, Inaki, Koichiro, Chihara, Masataka, Ebisuno, Yukihiko, Tsukamoto, Sakiyo, Fujii, Ryo, Ohashi, Akihiro, Suzuki, Yutaka, Tsuchihara, Katsuya, Nishikawa, Hiroyoshi, Doi, Toshihiko
Published in Scientific reports (11.01.2021)
Published in Scientific reports (11.01.2021)
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Impacts of the STING‐IFNAR1‐STAT1‐IRF1 pathway on the cellular immune reaction induced by fractionated irradiation
Du, Junyan, Kageyama, Shun‐Ichiro, Yamashita, Riu, Hirata, Hidenari, Hakozaki, Yumi, Okumura, Masayuki, Motegi, Atsushi, Hojo, Hidehiro, Nakamura, Masaki, Hirano, Yasuhiro, Sunakawa, Hironori, Minamide, Tatsunori, Kotani, Daisuke, Tanaka, Kosuke, Yano, Tomonori, Kojima, Takashi, Ohashi, Akihiro, Tsuchihara, Katsuya, Akimoto, Tetsuo
Published in Cancer science (01.04.2022)
Published in Cancer science (01.04.2022)
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Journal Article
Control of BRCA2 Cellular and Clinical Functions by a Nuclear Partner, PALB2
Xia, Bing, Sheng, Qing, Nakanishi, Koji, Ohashi, Akihiro, Wu, Jianmin, Christ, Nicole, Liu, Xinggang, Jasin, Maria, Couch, Fergus J., Livingston, David M.
Published in Molecular cell (23.06.2006)
Published in Molecular cell (23.06.2006)
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Long-read sequencing for non-small-cell lung cancer genomes
Sakamoto, Yoshitaka, Xu, Liu, Seki, Masahide, Yokoyama, Toshiyuki T, Kasahara, Masahiro, Kashima, Yukie, Ohashi, Akihiro, Shimada, Yoko, Motoi, Noriko, Tsuchihara, Katsuya, Kobayashi, Susumu S, Kohno, Takashi, Shiraishi, Yuichi, Suzuki, Ayako, Suzuki, Yutaka
Published in Genome research (01.09.2020)
Published in Genome research (01.09.2020)
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CDC7 inhibition induces replication stress-mediated aneuploid cells with an inflammatory phenotype sensitizing tumors to immune checkpoint blockade
Morita, Tomoko Yamamori, Yu, Jie, Kashima, Yukie, Kamata, Ryo, Yamamoto, Gaku, Minamide, Tatsunori, Mashima, Chiaki, Yoshiya, Miyuki, Sakae, Yuta, Yamauchi, Toyohiro, Hakozaki, Yumi, Kageyama, Shun-ichiro, Nakamura, Akito, Lightcap, Eric, Tanaka, Kosuke, Niu, Huifeng, Kannan, Karuppiah, Ohashi, Akihiro
Published in Nature communications (18.11.2023)
Published in Nature communications (18.11.2023)
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Journal Article
A Novel Time-Dependent CENP-E Inhibitor with Potent Antitumor Activity
Ohashi, Akihiro, Ohori, Momoko, Iwai, Kenichi, Nambu, Tadahiro, Miyamoto, Maki, Kawamoto, Tomohiro, Okaniwa, Masanori
Published in PloS one (09.12.2015)
Published in PloS one (09.12.2015)
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TP-064, a potent and selective small molecule inhibitor of PRMT4 for multiple myeloma
Nakayama, Kazuhide, Szewczyk, Magdalena M, Dela Sena, Carlo, Wu, Hong, Dong, Aiping, Zeng, Hong, Li, Fengling, de Freitas, Renato Ferreira, Eram, Mohammad S, Schapira, Matthieu, Baba, Yuji, Kunitomo, Mihoko, Cary, Douglas R, Tawada, Michiko, Ohashi, Akihiro, Imaeda, Yasuhiro, Saikatendu, Kumar Singh, Grimshaw, Charles E, Vedadi, Masoud, Arrowsmith, Cheryl H, Barsyte-Lovejoy, Dalia, Kiba, Atsushi, Tomita, Daisuke, Brown, Peter J
Published in Oncotarget (06.04.2018)
Published in Oncotarget (06.04.2018)
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Wnt activation disturbs cell competition and causes diffuse invasion of transformed cells through NF-κB-MMP21 pathway
Nakai, Kazuki, Lin, Hancheng, Yamano, Shotaro, Tanaka, Shinya, Kitamoto, Sho, Saitoh, Hitoshi, Sakuma, Kenta, Kurauchi, Junpei, Akter, Eilma, Konno, Masamitsu, Ishibashi, Kojiro, Kamata, Ryo, Ohashi, Akihiro, Koseki, Jun, Takahashi, Hirotaka, Yokoyama, Hideshi, Shiraki, Yukihiro, Enomoto, Atsushi, Abe, Sohei, Hayakawa, Yoku, Ushiku, Tetsuo, Mutoh, Michihiro, Fujita, Yasuyuki, Kon, Shunsuke
Published in Nature communications (03.11.2023)
Published in Nature communications (03.11.2023)
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Journal Article
Inactivation of Brca2 Promotes Trp53-Associated but Inhibits KrasG12D-Dependent Pancreatic Cancer Development in Mice
Rowley, Matthew, Ohashi, Akihiro, Mondal, Gourish, Mills, Lisa, Yang, Lin, Zhang, Lizhi, Sundsbak, Rhianna, Shapiro, Virginia, Muders, Michael H, Smyrk, Thomas, Couch, Fergus J
Published in Gastroenterology (New York, N.Y. 1943) (01.04.2011)
Published in Gastroenterology (New York, N.Y. 1943) (01.04.2011)
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Identification of a new class of potent Cdc7 inhibitors designed by putative pharmacophore model: Synthesis and biological evaluation of 2,3-dihydrothieno[3,2-d]pyrimidin-4(1H)-ones
Kurasawa, Osamu, Oguro, Yuya, Miyazaki, Tohru, Homma, Misaki, Mori, Kouji, Iwai, Kenichi, Hara, Hideto, Skene, Robert, Hoffman, Isaac, Ohashi, Akihiro, Yoshida, Sei, Ishikawa, Tomoyasu, Cho, Nobuo
Published in Bioorganic & medicinal chemistry (01.04.2017)
Published in Bioorganic & medicinal chemistry (01.04.2017)
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Journal Article
Molecular mechanism and potential target indication of TAK-931, a novel CDC7-selective inhibitor
Iwai, Kenichi, Nambu, Tadahiro, Dairiki, Ryo, Ohori, Momoko, Yu, Jie, Burke, Kristine, Gotou, Masamitsu, Yamamoto, Yukiko, Ebara, Shunsuke, Shibata, Sachio, Hibino, Ryosuke, Nishizawa, Satoru, Miyazaki, Tohru, Homma, Misaki, Oguro, Yuya, Imada, Takashi, Cho, Nobuo, Uchiyama, Noriko, Kogame, Akifumi, Takeuchi, Toshiyuki, Kurasawa, Osamu, Yamanaka, Kazunori, Niu, Huifeng, Ohashi, Akihiro
Published in Science advances (01.05.2019)
Published in Science advances (01.05.2019)
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Journal Article
Cleavage of Hsp70.1 causes lysosomal cell death under stress conditions
Yamashima, Tetsumori, Mochly-Rosen, Daria, Wakatsuki, Soichi, Mizukoshi, Eishiro, Seike, Takuya, Larus, Isabel Maria, Chen, Che-Hong, Takemura, Miho, Saito, Hisashi, Ohashi, Akihiro
Published in Frontiers in molecular biosciences (27.05.2024)
Published in Frontiers in molecular biosciences (27.05.2024)
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Journal Article
A CDC7 inhibitor sensitizes DNA-damaging chemotherapies by suppressing homologous recombination repair to delay DNA damage recovery
Iwai, Kenichi, Nambu, Tadahiro, Kashima, Yukie, Yu, Jie, Eng, Kurt, Miyamoto, Kazumasa, Kakoi, Kazuyo, Gotou, Masamitsu, Takeuchi, Toshiyuki, Kogame, Akifumi, Sappal, Jessica, Murai, Saomi, Haeno, Hiroshi, Kageyama, Shun-Ichiro, Kurasawa, Osamu, Niu, Huifeng, Kannan, Karuppiah, Ohashi, Akihiro
Published in Science advances (01.05.2021)
Published in Science advances (01.05.2021)
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Journal Article
Functional evaluation and cancer risk assessment of BRCA2 unclassified variants
KANGJIAN WU, HINSON, Shannon R, OHASHI, Akihiro, FARRUGIA, Daniel, WENDT, Patricia, TAVTIGIAN, Sean V, DEFFENBAUGH, Amie, GOLDGAR, David, COUCH, Fergus J
Published in Cancer research (Chicago, Ill.) (15.01.2005)
Published in Cancer research (Chicago, Ill.) (15.01.2005)
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Journal Article
Fanconi Anemia Complementation Group D2 (FANCD2) Functions Independently of BRCA2- and RAD51-associated Homologous Recombination in Response to DNA Damage
Ohashi, Akihiro, Zdzienicka, Malgorzata Z., Chen, Junjie, Couch, Fergus J.
Published in The Journal of biological chemistry (15.04.2005)
Published in The Journal of biological chemistry (15.04.2005)
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Journal Article
Mating Disruption of a Flighted Spongy Moth, Lymantria Dispar Japonica (Motchulsky) in Japan
Minegishi, Hiroyuki, Ohashi, Akihiro, Nakamuta, Kiyoshi
Published in Journal of chemical ecology (29.06.2024)
Published in Journal of chemical ecology (29.06.2024)
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