Synthesis and Biological Evaluation of 8-Oxoadenine Derivatives as Toll-like Receptor 7 Agonists Introducing the Antedrug Concept
Kurimoto, Ayumu, Hashimoto, Kazuki, Nakamura, Tomoaki, Norimura, Kei, Ogita, Haruhisa, Takaku, Haruo, Bonnert, Roger, McInally, Tom, Wada, Hiroki, Isobe, Yoshiaki
Published in Journal of medicinal chemistry (08.04.2010)
Published in Journal of medicinal chemistry (08.04.2010)
Get full text
Journal Article
Prodrugs of 9-Benzyl-8-hydroxy-2-(2-hydroxyethylthio)adenine: Potent Interferon Inducing Agents in Monkeys
Kurimoto, Ayumu, Tobe, Masanori, Ogita, Haruhisa, Ogino, Tetsuhiro, Takaku, Haruo, Ichii, Shinji, Kawakami, Hajime, Isobe, Yoshiaki
Published in Chemical & pharmaceutical bulletin (01.04.2004)
Published in Chemical & pharmaceutical bulletin (01.04.2004)
Get full text
Journal Article
Synthesis of Potent and Selective Inhibitors against the Proliferation of Human Coronary Artery Smooth Muscle Cells
Ogita, Haruhisa, Isobe, Yoshiaki, Takaku, Haruo, Sekine, Rena, Goto, Yuso, Misawa, Satoru, Hayashi, Hideya
Published in Chemical & Pharmaceutical Bulletin (01.02.2003)
Published in Chemical & Pharmaceutical Bulletin (01.02.2003)
Get full text
Journal Article
Prodrugs of 9-Benzyl-8-hydroxy-2-(2-hydroxyethylthio)adenine：Potent Interferon Inducing Agents in Monkeys
Ayumu KURIMOTO, Masanori TOBE, Haruhisa OGITA, Tetsuhiro OGINO, Haruo TAKAKU, Shinji ICHII, Hajime KAWAKAMI, Yoshiaki ISOBE
Published in Chemical & Pharmaceutical Bulletin (2004)
Get full text
Published in Chemical & Pharmaceutical Bulletin (2004)
Journal Article
Synthesis and structure–activity relationship of diarylamide derivatives as selective inhibitors of the proliferation of human coronary artery smooth muscle cells
Ogita, Haruhisa, Isobe, Yoshiaki, Takaku, Haruo, Sekine, Rena, Goto, Yuso, Misawa, Satoru, Hayashi, Hideya
Published in Bioorganic & medicinal chemistry letters (26.02.2001)
Published in Bioorganic & medicinal chemistry letters (26.02.2001)
Get full text
Journal Article
Synthesis and evaluation of 2-substituted 8-hydroxyadenines as potent interferon inducers with improved oral bioavailabilities
KURIMOTO, Ayumu, OGINO, Tetsuhiro, ICHII, Shinji, ISOBE, Yoshiaki, TOBE, Masanori, OGITA, Haruhisa, TAKAKU, Haruo, SAJIKI, Hironao, HIROTA, Kosaku, KAWAKAMI, Hajime
Published in Bioorganic & medicinal chemistry (01.03.2004)
Published in Bioorganic & medicinal chemistry (01.03.2004)
Get full text
Journal Article
Synthesis and Biological Evaluation of Novel 9-Substituted-8-Hydroxyadenine Derivatives as Potent Interferon Inducers
Isobe, Yoshiaki, Kurimoto, Ayumu, Tobe, Masanori, Hashimoto, Kazuki, Nakamura, Tomoaki, Norimura, Kei, Ogita, Haruhisa, Takaku, Haruo
Published in Journal of medicinal chemistry (23.03.2006)
Published in Journal of medicinal chemistry (23.03.2006)
Get full text
Journal Article
Discovery of 8-Hydroxyadenines as a Novel Type of Interferon Inducer
Hirota, Kosaku, Kazaoka, Kazunori, Niimoto, Itaru, Kumihara, Hiroshi, Sajiki, Hironao, Isobe, Yoshiaki, Takaku, Haruo, Tobe, Masanori, Ogita, Haruhisa, Ogino, Tetsuhiro, Ichii, Shinji, Kurimoto, Ayumu, Kawakami, Hajime
Published in Journal of medicinal chemistry (05.12.2002)
Published in Journal of medicinal chemistry (05.12.2002)
Get full text
Journal Article
MACROLIDE DERIVATIVE
ASANO, YASUO, TANIKAWA, TETSUYA, KASHIMURA, MASATO, OGITA, HARUHISA, KUBO, TAKEKAZU, KAWAMURA, MADOKA
Year of Publication 17.01.2013
Get full text
Year of Publication 17.01.2013
Patent
Synthesis and structure–Activity relationships of 2-Amino-8-hydroxyadenines as orally active interferon inducing agents
Kurimoto, Ayumu, Ogino, Tetsuhiro, Ichii, Shinji, Isobe, Yoshiaki, Tobe, Masanori, Ogita, Haruhisa, Takaku, Haruo, Sajiki, Hironao, Hirota, Kosaku, Kawakami, Hajime
Published in Bioorganic & medicinal chemistry (01.12.2003)
Published in Bioorganic & medicinal chemistry (01.12.2003)
Get full text
Journal Article
C-4 POSITION SUBSTITUTED MACROLIDE DERIVATIVE
SASAMOTO NAOKI, HAYASHI MASATO, KASHIMURA MASATO, KANEMOTO KENICHI, YAMAMOTO KANAKO, SUGIMOTO TOMOHIRO, YOSHIDA SATOSHI, OGITA HARUHISA, TAMURA KEIJI, KUMURA KOU, KUROSAKA JUN, USHIKI YASUNOBU, MIURA TOMOAKI, SHITARA EIKI
Year of Publication 21.01.2014
Get full text
Year of Publication 21.01.2014
Patent
MACROLIDE DERIVATIVE
KASHIMURA, MASATO, TAKAYAMA, KIYOSHI, OGITA, HARUHISA, ASAKA, TOSHIFUMI, KAWAMURA, MADOKA
Year of Publication 15.11.2007
Get full text
Year of Publication 15.11.2007
Patent
Synthesis and structure–activity relationships of 2-substituted-8-hydroxyadenine derivatives as orally available interferon inducers without emetic side effects
Isobe, Yoshiaki, Tobe, Masanori, Ogita, Haruhisa, Kurimoto, Ayumu, Ogino, Tetsuhiro, Kawakami, Hajime, Takaku, Haruo, Sajiki, Hironao, Hirota, Kosaku, Hayashi, Hideya
Published in Bioorganic & medicinal chemistry (15.08.2003)
Published in Bioorganic & medicinal chemistry (15.08.2003)
Get full text
Journal Article
Synthesis and Structure–Activity Relationship of Diarylamide Derivatives as Selective Inhibitors of the Proliferation of Human Endothelial Cells
Ogita, Haruhisa, Isobe, Yoshiaki, Takaku, Haruo, Sekine, Rena, Goto, Yuso, Misawa, Satoru, Hayashi, Hideya
Published in Bioorganic & medicinal chemistry (01.11.2002)
Published in Bioorganic & medicinal chemistry (01.11.2002)
Get full text
Journal Article
8-OXOADENINE COMPOUND
NAKAMURA, TOMOAKI, HASHIMOTO, KAZUKI, KURIMOTO, AYUMU, OGITA, HARUHISA, ISOBE, YOSHIAKI
Year of Publication 06.10.2005
Get full text
Year of Publication 06.10.2005
Patent
Prodrugs of 9-Benzyl-8-hydroxy-2-(2-hydroxyethylthio)adenine
Kurimoto, Ayumu, Tobe, Masanori, Ogita, Haruhisa, Ogino, Tetsuhiro, Takaku, Haruo, Ichii, Shinji, Kawakami, Hajime, Isobe, Yoshiaki
Published in Chemical & pharmaceutical bulletin (01.04.2004)
Get full text
Published in Chemical & pharmaceutical bulletin (01.04.2004)
Journal Article
NOVEL ADENINE COMPOUND
NAKAMURA, KEI, NAKAMURA, TOMOAKI, MCINALLY, THOMAS, HASHIMOTO, KAZUKI, KURIMOTO, AYUMU, OGITA, HARUHISA, MILLICHIP, IAN, BONNERT, ROGER, ISOBE, YOSHIAKI
Year of Publication 29.03.2007
Get full text
Year of Publication 29.03.2007
Patent