CD19 occupancy with tafasitamab increases therapeutic index of CART19 cell therapy and diminishes severity of CRS
Sakemura, R Leo, Manriquez Roman, Claudia, Horvei, Paulina, Siegler, Elizabeth L, Girsch, James H, Sirpilla, Olivia L, Stewart, Carli M, Yun, Kun, Can, Ismail, Ogbodo, Ekene J, Adada, Mohamad M, Bezerra, Evandro D, Kankeu Fonkoua, Lionel Aurelien, Hefazi, Mehrdad, Ruff, Michael W, Kimball, Brooke L, Mai, Long K, Huynh, Truc N, Nevala, Wendy K, Ilieva, Kristina, Augsberger, Christian, Patra-Kneuer, Maria, Schanzer, Jürgen, Endell, Jan, Heitmüller, Christina, Steidl, Stefan, Parikh, Sameer A, Ding, Wei, Kay, Neil E, Nowakowski, Grzegorz S, Kenderian, Saad S
Published in Blood (18.01.2024)
Published in Blood (18.01.2024)
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Journal Article
Mesenchymal stromal cells with chimaeric antigen receptors for enhanced immunosuppression
Sirpilla, Olivia, Sakemura, R Leo, Hefazi, Mehrdad, Huynh, Truc N, Can, Ismail, Girsch, James H, Tapper, Erin E, Cox, Michelle J, Schick, Kendall J, Manriquez-Roman, Claudia, Yun, Kun, Stewart, Carli M, Ogbodo, Ekene J, Kimball, Brooke L, Mai, Long K, Gutierrez-Ruiz, Omar L, Rodriguez, Makena L, Gluscevic, Martina, Larson, Daniel P, Abel, Alex M, Wierson, Wesley A, Olivier, Gloria, Siegler, Elizabeth L, Kenderian, Saad S
Published in Nature biomedical engineering (01.04.2024)
Published in Nature biomedical engineering (01.04.2024)
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Journal Article
P1359: TUMOR‐SPECIFIC, T‐CELL‐TARGETING MICRORNA IS ASSOCIATED WITH CART CELL FAILURE IN B CELL MALIGNANCIES
Chohan, Karan, Sirpilla, Olivia, Leo Sakemura, R., Cox, Michelle, Hefazi, Mehrdad, Huynh, Truc, Girsch, James, Schick, Kendall, Manriquez Roman, Claudia, Stewart, Carli M., Yun, Kun, Can, Ismail, Ogbodo, Ekene J., Mai, Long, Kimball, Brooke, Ansell, Stephen M., Nora Bennani, N., Johnston, Patrick B., Paludo, Jonas, Villasboas‐Bisneto, Jose C., Khurana, Arushi, Durani, Urshila, Wang, Yucai, Hampel, Paul J., Rosenthal, Allison, Munoz, Javier, Moreno, Eider, Castro, Januario E., Murthy, Hemant S., Kharfan Dabaja, Mohamed, Parikh, Sameer, Kay, Neil, Lin, Yi, Siegler, Elizabeth L., Kenderian, Saad S.
Published in HemaSphere (08.08.2023)
Published in HemaSphere (08.08.2023)
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Identification of IL-4 As a Key Regulator of CAR T-Cell Exhaustion Using Functional Genomics and Correlates of the Zuma-1 Clinical Trial
Stewart, Carli M., Cox, Michelle J., Sakemura, Reona Leo, Ogbodo, Ekene J., Can, Ismail, Manriquez-Roman, Claudia, Yun, Kun, Sirpilla, Olivia, Girsch, James H., Huynh, Truc, Siegler, Elizabeth L., Kim, Jenny J, Mattie, Mike, Scholler, Nathalie, Filosto, Simone, Kenderian, Saad S.
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
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Journal Article
Chimeric Antigen Receptor Engineering of Mesenchymal Stromal Cells (CAR-MSC) Enhance Immunosuppression and Outcomes in Graft Versus Host Disease (GvHD) Preclinical Models
Sirpilla, Olivia, Sakemura, Reona Leo, Hefazi, Mehrdad, Girsch, James H., Huynh, Truc, Cox, Michelle J., Schick, Kendall J., Manriquez-Roman, Claudia, Can, Ismail, Yun, Kun, Stewart, Carli M., Ogbodo, Ekene J., Siegler, Elizabeth L., Kenderian, Saad S.
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
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Journal Article
Differential Susceptibility to Senescence in CART Cells Based on Co-Stimulatory Signaling
Can, Ismail, Sakemura, Reona Leo, Manriquez-Roman, Claudia, Sirpilla, Olivia, Stewart, Carli M., Yun, Kun, Cox, Michelle J., Huynh, Truc, Girsch, James H., Ogbodo, Ekene J., Kankeu Fonkoua, Lionel A., Hefazi, Mehrdad, Ruff, Michael W., Boysen, Justin C., Siegler, Elizabeth L., Ekiz, Atakan, Kenderian, Saad S., Kay, Neil E.
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
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Journal Article
Immunosuppressive Monocyte Modulation of CAR T Cell Functions and Impact on Response to CART19
Yun, Kun, Sakemura, Reona Leo, Cox, Michelle J., Huynh, Truc, Manriquez-Roman, Claudia, Sirpilla, Olivia, Stewart, Carli M., Girsch, James H., Ogbodo, Ekene J., Can, Ismail, Kimball, Brooke, Kankeu Fonkoua, Lionel A., Hefazi, Mehrdad, Ruff, Michael W., Siegler, Elizabeth L., Mattie, Mike, Nguyen-Mau, Sao-Mai, Filosto, Simone, Kenderian, Saad S.
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
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Journal Article
CD19 Antigen Occupancy on Cancer Cells with the CD19 Monoclonal Antibody Tafasitamab Improves the Activation, Antitumor Efficacy, and Safety Profile of CART19 Cell Therapy
Sakemura, Reona Leo, Manriquez-Roman, Claudia, Horvei, Paulina, Cox, Michelle J., Huynh, Truc, Girsch, James H., Sirpilla, Olivia, Yun, Kun, Stewart, Carli M., Can, Ismail, Ogbodo, Ekene J., Adada, Mohamad M., Kankeu Fonkoua, Lionel A., Hefazi, Mehrdad, Ruff, Michael W., Ilieva-Babinsky, Kristina, Augsberger, Christian, Patra-Kneuer, Maria, Heitmüller, Christina, Steidl, Stefan, Parikh, Sameer A., Ding, Wei, Kay, Neil E., Nowakowski, Grzegorz S., Siegler, Elizabeth L., Kenderian, Saad S.
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
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Journal Article
Optimized Inhibition of GM-CSF in Preclinical Models of Anti-CD19 Chimeric Antigen Receptor T Cell Therapy
Bezerra, Evandro D., Sakemura, Reona, Girsch, James, Stewart, Carli M., Awatramani, Gunjan A, Manriquez-Roman, Claudia, Schick, Kendall J., Can, Ismail, Ogbodo, Ekene J., Tapper, Erin E., Siegler, Elizabeth L., Adada, Mohamad M., Kankeu Fonkoua, Lionel A., Hefazi, Mehrdad, Ruff, Michael W., Slager, Susan L., Parikh, Sameer A., Kay, Neil E., Durrant, Cameron, Ahmed, Omar, Chappell, Dale, Cox, Michelle J., Kenderian, Saad S.
Published in Blood (23.11.2021)
Published in Blood (23.11.2021)
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Journal Article
Favorable Modulation of Chimeric Antigen Receptor T Cells Safety and Efficacy By the Non-Covalent BTK Inhibitor Vecabrutinib
Adada, Mohamad M., Sakemura, Reona, Cox, Michelle J., Manriquez-Roman, Caludia, Siegler, Elizabeth L., Tapper, Erin E., Stewart, Carli M., Schick, Kendall J., Can, Ismail, Ogbodo, Ekene J., Bezerra, Evandro D., Kankeu Fonkoua, Lionel A., Hefazi, Mehrdad, Ruff, Michael W., Taverna, Pietro, Fox, Judith A., Olivier, Gloria, Slager, Susan L., Ding, Wei, Parikh, Sameer A., Kay, Neil E., Kenderian, Saad S.
Published in Blood (23.11.2021)
Published in Blood (23.11.2021)
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Journal Article
TNFR2 As a Target to Improve CD19-Directed CART Cell Fitness and Antitumor Activity in Large B Cell Lymphoma
Manriquez Roman, Claudia, Cox, Michelle J., Sakemura, Reona, Yun, Kun, Adada, Mohamad M., Siegler, Elizabeth L., Sirpilla, Olivia, Tapper, Erin E., Stewart, Carli M., Ogbodo, Ekene J., Can, Ismail, Schick, Kendall J., Bezerra, Evandro D., Kankeu Fonkoua, Lionel A., Hefazi, Mehrdad, Ruff, Michael W., Ding, Wei, Parikh, Sameer A., Slager, Susan L., Kay, Neil E., Olivier, Gloria, Scholler, Nathalie, Bot, Adrian, Mattie, Mike, Kim, Jenny J., Filosto, Simone, Kenderian, Saad S.
Published in Blood (23.11.2021)
Published in Blood (23.11.2021)
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Journal Article
The Impact of Prior Treatment with a CD19 Targeting Monoclonal Antibody on Subsequent Treatment with CD19 Targeting CART Cell Therapy in Preclinical Models
Sakemura, Reona, Horvei, Paulina, Manriquez-Roman, Claudia, Ogbodo, Ekene J., Tapper, Erin E., Siegler, Elizabeth L., Stewart, Carli M., Schick, Kendall J., Can, Ismail, Adada, Mohamad M., Bezerra, Evandro D., Kankeu Fonkoua, Lionel A., Hefazi, Mehrdad, Ruff, Michael W., Augsberger, Christian, Schanzer, Juergen, Patra-Kneuer, Maria, Heitmüller, Christina, Steidl, Stefan, Endell, Jan, Ding, Wei, Parikh, Sameer A., Slager, Susan L., Kay, Neil E., Nowakowski, Grzegorz S., Cox, Michelle J., Kenderian, Saad S.
Published in Blood (23.11.2021)
Published in Blood (23.11.2021)
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Journal Article
Abstract 1153: IL-4 depletion leads to the improvement of CART cell therapy
Stewart, Carli, Cox, Michelle J., Sakemura, Reona, Ogbodo, Ekene J., Can, Ismail, Roman, Claudia Manriquez, Yun, Kun, Sirpilla, Olivia, Girsch, James H., Huynh, Truc, Siegler, Elizabeth L., Kim, Jenny J., Mattie, Mike, Scholler, Nathalie, Filosto, Simone, Kenderian, Saad S.
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Published in Cancer research (Chicago, Ill.) (04.04.2023)
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Journal Article
Abstract 5017: Simultaneous targeting of EphA3 on glioblastoma and tumor microenvironment to overcome resistance to CART cell therapy in brain cancer
Ogbodo, Ekene J., Ruff, Michael W., Sakemura, Reona L., ManriquezRoman, Claudia, Huynh, Truc, Girsch, James H., Sirpilla, Olivia L., Yun, Kun, Stewart, Carli M., Can, Ismail, Fonkoua, Lionel K., Hefazi, Mehrdad, Siegler, Elizabeth L., Kenderian, Saad S.
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Published in Cancer research (Chicago, Ill.) (04.04.2023)
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Journal Article
68 - Bioengineering Mesenchymal Stromal Cells with Chimeric Antigen Receptors Induces Superior Immunosuppressive Efficacy in Preclinical Graft Versus Host Disease Models
Sirpilla, Olivia, Sakemura, R. Leo, Hefazi, Mehrdad, Huynh, Truc N, Girsch, James H., Can, Ismail, Yun, Kun, Roman, Claudia Manriquez, Stewart, Carli M., Ogbodo, Ekene J., Siegler, Elizabeth L., Kenderian, Saad S.
Published in Transplantation and cellular therapy (01.02.2023)
Published in Transplantation and cellular therapy (01.02.2023)
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Journal Article
Bioengineering Mesenchymal Stromal Cells with Chimeric Antigen Receptors Induces Superior Immunosuppressive Efficacy in Preclinical Graft Versus Host Disease Models
Sirpilla, Olivia, Sakemura, R. Leo, Hefazi, Mehrdad, Huynh, Truc N, Girsch, James H., Can, Ismail, Yun, Kun, Roman, Claudia Manriquez, Stewart, Carli M., Ogbodo, Ekene J., Siegler, Elizabeth L., Kenderian, Saad S.
Published in Transplantation and cellular therapy (01.02.2023)
Published in Transplantation and cellular therapy (01.02.2023)
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Journal Article
Abstract 3841: Tumor-derived microRNA125a induces CART cell apoptosis and failure in B cell malignancies
Sirpilla, Olivia, Sakemura, R. Leo, Can, Ismail, Huynh, Truc N., GIrsch, James H., Roman, Claudia Manriquez, Stewart, Carli M., Yun, Kun, Ogbodo, Ekene J., Mai, Long, Ruiz, Omar Gutierrez, Rodriguez, Makena, Kimball, Brooke, Xia, Hong, Villasboas, Jose C., Ansell, Stephen, Bennani, Nora, Johnston, Patrick B., Paludo, Jonas, Castro, Januario, Kharfandabaja, Mohamed, Parikh, Sameer, Kay, Neil, Lin, Yi, Siegler, Elizabeth, Kenderian, Saad
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Published in Cancer research (Chicago, Ill.) (22.03.2024)
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Abstract 3849: Frontline ibrutinib-based therapy enhances CART cell functions in patients with CLL: Analysis of the phase 3 randomized clinical trial ECOG-ACRIN E1912
Huynh, Truc Ngoc, Wang, Victoria, Shanafelt, Tait, Siegler, Elizabeth L., Stewart, Carli M., Yun, Kun, Mai, Long K., Sirpilla, Olivia, Girsch, James H., Manriquez-Roman, Claudia, Feigin, Jennifer M., Rodriguez, Makena, Kimball, Brooke L., Xia, Hong, Sakemura, Reona L., Can, Ismail, Gutierrez-Ruiz, Omar L., Ogbodo, Ekene J., Tapper, Erin E., Fonkoua, Lionel A., Hefazi, Mehrdad T., Ruff, Michael W., Parikh, Sameer, Kay, Neil E., Kenderian, Saad J.
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Published in Cancer research (Chicago, Ill.) (22.03.2024)
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Journal Article
Abstract 4082: Impact of immunosuppressive monocytes on CART19 cell effector functions and outcomes
Yun, Kun, Sakemura, Reona Leo, Cox, Michelle J., Huynh, Truc, Manriquez-Roman, Claudia, Sirpilla, Olivia, Stewart, Carli M., Girsch, James H., Ogbodo, Ekene J., Can, Ismail, Kimball, Brooke, Fonkoua, Lionel A. Kankeu, Hefazi, Mehrdad, Ruff, Michael W., Siegler, Elizabeth L., Mattie, Mike, Nguyen-Mau, Sao-Mai, Filosto, Simone, Kenderian, Saad S.
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Published in Cancer research (Chicago, Ill.) (04.04.2023)
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Journal Article
Transient CD19 Occupancy with Tafasitamab at the Time of Anti-CD19 Chimeric Antigen Receptor T (CART19) Cell Infusion Diminishes Severity and Incidence of CRS and Improves the Therapeutic Index of CART19 Cell Therapy in Preclinical Models
Sakemura, R. Leo, Roman, Claudia Manriquez, Horvei, Paulina, Huynh, Truc N, Girsch, James H., Sirpilla, Olivia, Yun, Kun, Stewart, Carli M., Can, Ismail, Ogbodo, Ekene J., Adada, Mohamad M., Kankeu Fonkoua, Lionel Aurelien, Hefazi, Mehrdad, Ruff, Michael W., Ilieva-Babinsky, Kristina, Augsberger, Christian, Patra-Kneuer, Maria, Heitmüller, Christina, Steidl, Stefan, Parikh, Sameer A., Ding, Wei, Kay, Neil E., Nowakowski, Grzegorz S, Siegler, Elizabeth L., Kenderian, Saad S.
Published in Transplantation and cellular therapy (01.02.2023)
Published in Transplantation and cellular therapy (01.02.2023)
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