CD19 occupancy with tafasitamab increases therapeutic index of CART19 cell therapy and diminishes severity of CRS
Sakemura, R Leo, Manriquez Roman, Claudia, Horvei, Paulina, Siegler, Elizabeth L, Girsch, James H, Sirpilla, Olivia L, Stewart, Carli M, Yun, Kun, Can, Ismail, Ogbodo, Ekene J, Adada, Mohamad M, Bezerra, Evandro D, Kankeu Fonkoua, Lionel Aurelien, Hefazi, Mehrdad, Ruff, Michael W, Kimball, Brooke L, Mai, Long K, Huynh, Truc N, Nevala, Wendy K, Ilieva, Kristina, Augsberger, Christian, Patra-Kneuer, Maria, Schanzer, Jürgen, Endell, Jan, Heitmüller, Christina, Steidl, Stefan, Parikh, Sameer A, Ding, Wei, Kay, Neil E, Nowakowski, Grzegorz S, Kenderian, Saad S
Published in Blood (18.01.2024)
Published in Blood (18.01.2024)
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Journal Article
IL-4 drives exhaustion of CD8+ CART cells
Stewart, Carli M., Siegler, Elizabeth L., Sakemura, R. Leo, Cox, Michelle J., Huynh, Truc, Kimball, Brooke, Mai, Long, Can, Ismail, Manriquez Roman, Claudia, Yun, Kun, Sirpilla, Olivia, Girsch, James H., Ogbodo, Ekene, Mohammed Ismail, Wazim, Gaspar-Maia, Alexandre, Budka, Justin, Kim, Jenny, Scholler, Nathalie, Mattie, Mike, Filosto, Simone, Kenderian, Saad S.
Published in Nature communications (12.09.2024)
Published in Nature communications (12.09.2024)
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Journal Article
Mesenchymal stromal cells with chimaeric antigen receptors for enhanced immunosuppression
Sirpilla, Olivia, Sakemura, R Leo, Hefazi, Mehrdad, Huynh, Truc N, Can, Ismail, Girsch, James H, Tapper, Erin E, Cox, Michelle J, Schick, Kendall J, Manriquez-Roman, Claudia, Yun, Kun, Stewart, Carli M, Ogbodo, Ekene J, Kimball, Brooke L, Mai, Long K, Gutierrez-Ruiz, Omar L, Rodriguez, Makena L, Gluscevic, Martina, Larson, Daniel P, Abel, Alex M, Wierson, Wesley A, Olivier, Gloria, Siegler, Elizabeth L, Kenderian, Saad S
Published in Nature biomedical engineering (01.04.2024)
Published in Nature biomedical engineering (01.04.2024)
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Journal Article
P1359: TUMOR‐SPECIFIC, T‐CELL‐TARGETING MICRORNA IS ASSOCIATED WITH CART CELL FAILURE IN B CELL MALIGNANCIES
Chohan, Karan, Sirpilla, Olivia, Leo Sakemura, R., Cox, Michelle, Hefazi, Mehrdad, Huynh, Truc, Girsch, James, Schick, Kendall, Manriquez Roman, Claudia, Stewart, Carli M., Yun, Kun, Can, Ismail, Ogbodo, Ekene J., Mai, Long, Kimball, Brooke, Ansell, Stephen M., Nora Bennani, N., Johnston, Patrick B., Paludo, Jonas, Villasboas‐Bisneto, Jose C., Khurana, Arushi, Durani, Urshila, Wang, Yucai, Hampel, Paul J., Rosenthal, Allison, Munoz, Javier, Moreno, Eider, Castro, Januario E., Murthy, Hemant S., Kharfan Dabaja, Mohamed, Parikh, Sameer, Kay, Neil, Lin, Yi, Siegler, Elizabeth L., Kenderian, Saad S.
Published in HemaSphere (08.08.2023)
Published in HemaSphere (08.08.2023)
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Journal Article
EXTH-85. EPHA3 CART: DUAL TARGETING OF GLIOBLASTOMA AND TUMOR MICROENVIRONMENT
Ruff, Michael, Ogbodo, Ekene, Siegler, Elizabeth, Sakemura, Leo, Sarkaria, Jann, Kenderian, Saad
Published in Neuro-oncology (Charlottesville, Va.) (10.11.2023)
Published in Neuro-oncology (Charlottesville, Va.) (10.11.2023)
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Journal Article
Chimeric Antigen Receptor Engineering of Mesenchymal Stromal Cells (CAR-MSC) Enhance Immunosuppression and Outcomes in Graft Versus Host Disease (GvHD) Preclinical Models
Sirpilla, Olivia, Sakemura, Reona Leo, Hefazi, Mehrdad, Girsch, James H., Huynh, Truc, Cox, Michelle J., Schick, Kendall J., Manriquez-Roman, Claudia, Can, Ismail, Yun, Kun, Stewart, Carli M., Ogbodo, Ekene J., Siegler, Elizabeth L., Kenderian, Saad S.
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
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Journal Article
Identification of IL-4 As a Key Regulator of CAR T-Cell Exhaustion Using Functional Genomics and Correlates of the Zuma-1 Clinical Trial
Stewart, Carli M., Cox, Michelle J., Sakemura, Reona Leo, Ogbodo, Ekene J., Can, Ismail, Manriquez-Roman, Claudia, Yun, Kun, Sirpilla, Olivia, Girsch, James H., Huynh, Truc, Siegler, Elizabeth L., Kim, Jenny J, Mattie, Mike, Scholler, Nathalie, Filosto, Simone, Kenderian, Saad S.
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
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Journal Article
Affinity of Anti-CD19 Antibodies Determines Subsequent CART19 Activation, Apoptosis and CRS in Preclinical Models
Sakemura, R. Leo, Manriquez Roman, Claudia, Mai, Long K., Kimball, Brooke L., Huynh, Truc, Feigin, Jennifer M., Girsch, James H., Sirpilla, Olivia L., Yun, Kun, Stewart, Carli M., Gutierrez Ruiz, Omar, Can, Ismail, Ogbodo, Ekene, Kankeu Fonkoua, Lionel Aurelien, Hefazi, Mehrdad, Ruff, Michael W., Jaehrling, Jan, Ilieva, Kristina, Patra-Kneuer, Maria, Heitmüller, Christina, Steidl, Stefan, Siegler, Elizabeth L., Kenderian, Saad S.
Published in Blood (02.11.2023)
Published in Blood (02.11.2023)
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Journal Article
Differential Susceptibility to Senescence in CART Cells Based on Co-Stimulatory Signaling
Can, Ismail, Sakemura, Reona Leo, Manriquez-Roman, Claudia, Sirpilla, Olivia, Stewart, Carli M., Yun, Kun, Cox, Michelle J., Huynh, Truc, Girsch, James H., Ogbodo, Ekene J., Kankeu Fonkoua, Lionel A., Hefazi, Mehrdad, Ruff, Michael W., Boysen, Justin C., Siegler, Elizabeth L., Ekiz, Atakan, Kenderian, Saad S., Kay, Neil E.
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
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Journal Article
Immunosuppressive Monocyte Modulation of CAR T Cell Functions and Impact on Response to CART19
Yun, Kun, Sakemura, Reona Leo, Cox, Michelle J., Huynh, Truc, Manriquez-Roman, Claudia, Sirpilla, Olivia, Stewart, Carli M., Girsch, James H., Ogbodo, Ekene J., Can, Ismail, Kimball, Brooke, Kankeu Fonkoua, Lionel A., Hefazi, Mehrdad, Ruff, Michael W., Siegler, Elizabeth L., Mattie, Mike, Nguyen-Mau, Sao-Mai, Filosto, Simone, Kenderian, Saad S.
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
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Journal Article
CD19 Antigen Occupancy on Cancer Cells with the CD19 Monoclonal Antibody Tafasitamab Improves the Activation, Antitumor Efficacy, and Safety Profile of CART19 Cell Therapy
Sakemura, Reona Leo, Manriquez-Roman, Claudia, Horvei, Paulina, Cox, Michelle J., Huynh, Truc, Girsch, James H., Sirpilla, Olivia, Yun, Kun, Stewart, Carli M., Can, Ismail, Ogbodo, Ekene J., Adada, Mohamad M., Kankeu Fonkoua, Lionel A., Hefazi, Mehrdad, Ruff, Michael W., Ilieva-Babinsky, Kristina, Augsberger, Christian, Patra-Kneuer, Maria, Heitmüller, Christina, Steidl, Stefan, Parikh, Sameer A., Ding, Wei, Kay, Neil E., Nowakowski, Grzegorz S., Siegler, Elizabeth L., Kenderian, Saad S.
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
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Journal Article
Optimized Inhibition of GM-CSF in Preclinical Models of Anti-CD19 Chimeric Antigen Receptor T Cell Therapy
Bezerra, Evandro D., Sakemura, Reona, Girsch, James, Stewart, Carli M., Awatramani, Gunjan A, Manriquez-Roman, Claudia, Schick, Kendall J., Can, Ismail, Ogbodo, Ekene J., Tapper, Erin E., Siegler, Elizabeth L., Adada, Mohamad M., Kankeu Fonkoua, Lionel A., Hefazi, Mehrdad, Ruff, Michael W., Slager, Susan L., Parikh, Sameer A., Kay, Neil E., Durrant, Cameron, Ahmed, Omar, Chappell, Dale, Cox, Michelle J., Kenderian, Saad S.
Published in Blood (23.11.2021)
Published in Blood (23.11.2021)
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Journal Article
Favorable Modulation of Chimeric Antigen Receptor T Cells Safety and Efficacy By the Non-Covalent BTK Inhibitor Vecabrutinib
Adada, Mohamad M., Sakemura, Reona, Cox, Michelle J., Manriquez-Roman, Caludia, Siegler, Elizabeth L., Tapper, Erin E., Stewart, Carli M., Schick, Kendall J., Can, Ismail, Ogbodo, Ekene J., Bezerra, Evandro D., Kankeu Fonkoua, Lionel A., Hefazi, Mehrdad, Ruff, Michael W., Taverna, Pietro, Fox, Judith A., Olivier, Gloria, Slager, Susan L., Ding, Wei, Parikh, Sameer A., Kay, Neil E., Kenderian, Saad S.
Published in Blood (23.11.2021)
Published in Blood (23.11.2021)
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Journal Article
TNFR2 As a Target to Improve CD19-Directed CART Cell Fitness and Antitumor Activity in Large B Cell Lymphoma
Manriquez Roman, Claudia, Cox, Michelle J., Sakemura, Reona, Yun, Kun, Adada, Mohamad M., Siegler, Elizabeth L., Sirpilla, Olivia, Tapper, Erin E., Stewart, Carli M., Ogbodo, Ekene J., Can, Ismail, Schick, Kendall J., Bezerra, Evandro D., Kankeu Fonkoua, Lionel A., Hefazi, Mehrdad, Ruff, Michael W., Ding, Wei, Parikh, Sameer A., Slager, Susan L., Kay, Neil E., Olivier, Gloria, Scholler, Nathalie, Bot, Adrian, Mattie, Mike, Kim, Jenny J., Filosto, Simone, Kenderian, Saad S.
Published in Blood (23.11.2021)
Published in Blood (23.11.2021)
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Journal Article
The Impact of Prior Treatment with a CD19 Targeting Monoclonal Antibody on Subsequent Treatment with CD19 Targeting CART Cell Therapy in Preclinical Models
Sakemura, Reona, Horvei, Paulina, Manriquez-Roman, Claudia, Ogbodo, Ekene J., Tapper, Erin E., Siegler, Elizabeth L., Stewart, Carli M., Schick, Kendall J., Can, Ismail, Adada, Mohamad M., Bezerra, Evandro D., Kankeu Fonkoua, Lionel A., Hefazi, Mehrdad, Ruff, Michael W., Augsberger, Christian, Schanzer, Juergen, Patra-Kneuer, Maria, Heitmüller, Christina, Steidl, Stefan, Endell, Jan, Ding, Wei, Parikh, Sameer A., Slager, Susan L., Kay, Neil E., Nowakowski, Grzegorz S., Cox, Michelle J., Kenderian, Saad S.
Published in Blood (23.11.2021)
Published in Blood (23.11.2021)
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Journal Article
Abstract 6813: Immunosuppressive monocytes suppress CART19 functions through modulation of the IL-1 pathway
Yun, Kun, Sakemura, Reona, Huynh, Truc, Roman, Claudia Manriquez, Sirpilla, Olivia, Stewart, Carli, Girsch, James, Ogbodo, Ekene, Can, Ismail, Feigin, Jennifer, Mai, Long, Xia, Hong, Kimball, Brooke, Rodriguez, Makena, Fonkoua, Lionel Kankeu, Hefazi, Mehrdad, Ruff, Michael, Siegler, Elizabeth, Kenderian, Saad
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Published in Cancer research (Chicago, Ill.) (22.03.2024)
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Abstract 1153: IL-4 depletion leads to the improvement of CART cell therapy
Stewart, Carli, Cox, Michelle J., Sakemura, Reona, Ogbodo, Ekene J., Can, Ismail, Roman, Claudia Manriquez, Yun, Kun, Sirpilla, Olivia, Girsch, James H., Huynh, Truc, Siegler, Elizabeth L., Kim, Jenny J., Mattie, Mike, Scholler, Nathalie, Filosto, Simone, Kenderian, Saad S.
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Published in Cancer research (Chicago, Ill.) (04.04.2023)
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Abstract 5017: Simultaneous targeting of EphA3 on glioblastoma and tumor microenvironment to overcome resistance to CART cell therapy in brain cancer
Ogbodo, Ekene J., Ruff, Michael W., Sakemura, Reona L., ManriquezRoman, Claudia, Huynh, Truc, Girsch, James H., Sirpilla, Olivia L., Yun, Kun, Stewart, Carli M., Can, Ismail, Fonkoua, Lionel K., Hefazi, Mehrdad, Siegler, Elizabeth L., Kenderian, Saad S.
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Published in Cancer research (Chicago, Ill.) (04.04.2023)
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Journal Article
68 - Bioengineering Mesenchymal Stromal Cells with Chimeric Antigen Receptors Induces Superior Immunosuppressive Efficacy in Preclinical Graft Versus Host Disease Models
Sirpilla, Olivia, Sakemura, R. Leo, Hefazi, Mehrdad, Huynh, Truc N, Girsch, James H., Can, Ismail, Yun, Kun, Roman, Claudia Manriquez, Stewart, Carli M., Ogbodo, Ekene J., Siegler, Elizabeth L., Kenderian, Saad S.
Published in Transplantation and cellular therapy (01.02.2023)
Published in Transplantation and cellular therapy (01.02.2023)
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