PLCγ2 regulates TREM2 signalling and integrin-mediated adhesion and migration of human iPSC-derived macrophages
Obst, Juliane, Hall-Roberts, Hazel L, Smith, Thomas B, Kreuzer, Mira, Magno, Lorenza, Di Daniel, Elena, Davis, John B, Mead, Emma
Published in Scientific reports (06.10.2021)
Published in Scientific reports (06.10.2021)
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Journal Article
Inhibition of IL-12/IL-23 signaling reduces Alzheimer's disease-like pathology and cognitive decline
Vom Berg, Johannes, Prokop, Stefan, Miller, Kelly R, Obst, Juliane, Kälin, Roland E, Lopategui-Cabezas, Ileana, Wegner, Anja, Mair, Florian, Schipke, Carola G, Peters, Oliver, Winter, York, Becher, Burkhard, Heppner, Frank L
Published in Nature medicine (01.12.2012)
Published in Nature medicine (01.12.2012)
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Journal Article
The Role of Microglia in Prion Diseases: A Paradigm of Functional Diversity
Obst, Juliane, Simon, Emilie, Mancuso, Renzo, Gomez-Nicola, Diego
Published in Frontiers in aging neuroscience (23.06.2017)
Published in Frontiers in aging neuroscience (23.06.2017)
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Journal Article
TREM2 Alzheimer's variant R47H causes similar transcriptional dysregulation to knockout, yet only subtle functional phenotypes in human iPSC-derived macrophages
Hall-Roberts, Hazel, Agarwal, Devika, Obst, Juliane, Smith, Thomas B, Monzón-Sandoval, Jimena, Di Daniel, Elena, Webber, Caleb, James, William S, Mead, Emma, Davis, John B, Cowley, Sally A
Published in Alzheimer's research & therapy (16.11.2020)
Published in Alzheimer's research & therapy (16.11.2020)
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Journal Article
Inhibition of IL-34 Unveils Tissue-Selectivity and Is Sufficient to Reduce Microglial Proliferation in a Model of Chronic Neurodegeneration
Obst, Juliane, Simon, Emilie, Martin-Estebane, Maria, Pipi, Elena, Barkwill, Liana M, Gonzalez-Rivera, Ivette, Buchanan, Fergus, Prescott, Alan R, Faust, Dorte, Fox, Simon, Brownlees, Janet, Taylor, Debra, Perry, V Hugh, Nuthall, Hugh, Atkinson, Peter J, Karran, Eric, Routledge, Carol, Gomez-Nicola, Diego
Published in Frontiers in immunology (08.10.2020)
Published in Frontiers in immunology (08.10.2020)
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Journal Article
Replicative senescence dictates the emergence of disease-associated microglia and contributes to Aβ pathology
Hu, Yanling, Fryatt, Gemma L., Ghorbani, Mohammadmersad, Obst, Juliane, Menassa, David A., Martin-Estebane, Maria, Muntslag, Tim A.O., Olmos-Alonso, Adrian, Guerrero-Carrasco, Monica, Thomas, Daniel, Cragg, Mark S., Gomez-Nicola, Diego
Published in Cell reports (Cambridge) (08.06.2021)
Published in Cell reports (Cambridge) (08.06.2021)
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Journal Article
Interleukin‐12/23 deficiency differentially affects pathology in male and female Alzheimer's disease‐like mice
Eede, Pascale, Obst, Juliane, Benke, Eileen, Yvon‐Durocher, Genevieve, Richard, Bernhard C, Gimber, Niclas, Schmoranzer, Jan, Böddrich, Annett, Wanker, Erich E, Prokop, Stefan, Heppner, Frank L
Published in EMBO reports (04.03.2020)
Published in EMBO reports (04.03.2020)
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Journal Article
Targeting SHIP1 for therapeutic intervention in Alzheimer’s disease
Obst, Juliane, Bradshaw, William, Roberts, Hazel Hall, Priestley, Richard, Jimenez‐Antunez, Carmen, Cowley, Sally A., Gileadi, Opher, Mead, Emma, Daniel, Elena Di, Davis, John B.
Published in Alzheimer's & dementia (01.12.2020)
Published in Alzheimer's & dementia (01.12.2020)
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Journal Article
Targeting SHIP1 for therapeutic intervention in Alzheimer’s disease: Nonhuman/Target identification and validation studies: Inflammation and innate immunity
Obst, Juliane, Bradshaw, William, Roberts, Hazel Hall, Priestley, Richard, Jimenez‐Antunez, Carmen, Cowley, Sally A., Gileadi, Opher, Mead, Emma, Daniel, Elena Di, Davis, John B.
Published in Alzheimer's & dementia (01.12.2020)
Published in Alzheimer's & dementia (01.12.2020)
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Journal Article
Reducing Alzheimer's disease beta-amyloid and cognitive deficits by manipulating il-12/il-23 signaling
Obst, Juliane, Prokop, Stefan, vom Berg, Johannes, Miller, Kelly, Kälin, Roland, Lopategui-Cabezas, Ileana, Wegner, Anja, Mair, Florian, Winter, York, Becher, Burkhard, Heppner, Frank L
Published in Alzheimer's & dementia (2013)
Published in Alzheimer's & dementia (2013)
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Journal Article
P4‐337: Reducing Alzheimer's disease beta‐amyloid and cognitive deficits by manipulating il‐12/il‐23 signaling
Obst, Juliane, Prokop, Stefan, Berg, Johannes, Miller, Kelly, Kälin, Roland, Lopategui‐Cabezas, Ileana, Wegner, Anja, Mair, Florian, Winter, York, Becher, Burkhard, Heppner, Frank L.
Published in Alzheimer's & dementia (01.07.2012)
Published in Alzheimer's & dementia (01.07.2012)
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Journal Article
Replicative senescence dictates the emergence of disease-associated microglia and contributes to Aβ pathology
Hu, Yanling, Fryatt, Gemma L, Ghorbani, Mohammadmersad, Obst, Juliane, Menassa, David A, Martin-Estebane, Maria, Muntslag, Tim A O, Olmos-Alonso, Adrian, Guerrero-Carrasco, Monica, Thomas, Daniel, Cragg, Mark S, Gomez-Nicola, Diego
Published in bioRxiv (22.03.2021)
Published in bioRxiv (22.03.2021)
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Paper
TREM2 knockout, but not the R47H Alzheimer’s variant, reduces neural phagocytosis and survival of human iPSC-derived macrophages
Hall-Roberts, Hazel, Obst, Juliane, Smith, Thomas B, Elena Di Daniel, Mead, Emma, James, William S, Davis, John B, Cowley, Sally A
Published in Research Square (05.03.2020)
Published in Research Square (05.03.2020)
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Web Resource
Inhibition of IL34 unveils tissue-selectivity and is sufficient to reduce microglial proliferation in chronic neurodegeneration
Obst, Juliane, Simon, Emilie, Martin-Estebane, Maria, Pipi, Elena, Barkwill, Liana, Gonzalez-Rivera, Ivette, Buchanan, Fergus, Prescott, Alan R, Faust, Dorte, Fox, Simon, Brownlees, Janet, Taylor, Debra, Perry, V Hugh, Nuthall, Hugh, Atkinson, Peter J, Karran, Eric, Routledge, Carol, Gomez-Nicola, Diego
Published in bioRxiv (13.03.2020)
Published in bioRxiv (13.03.2020)
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