Disposition of Nirmatrelvir, an Orally Bioavailable Inhibitor of SARS-CoV-2 3C-Like Protease, across Animals and Humans
Eng, Heather, Dantonio, Alyssa L, Kadar, Eugene P, Obach, R Scott, Di, Li, Lin, Jian, Patel, Nandini C, Boras, Britton, Walker, Gregory S, Novak, Jonathan J, Kimoto, Emi, Singh, Ravi Shankar P, Kalgutkar, Amit S
Published in Drug metabolism and disposition (01.05.2022)
Published in Drug metabolism and disposition (01.05.2022)
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Cytochrome P450 3A Time-Dependent Inhibition Assays Are Too Sensitive for Identification of Drugs Causing Clinically Significant Drug-Drug Interactions: A Comparison of Human Liver Microsomes and Hepatocytes and Definition of Boundaries for Inactivation Rate Constants
Eng, Heather, Tseng, Elaine, Cerny, Matthew A, Goosen, Theunis C, Obach, R Scott
Published in Drug metabolism and disposition (01.06.2021)
Published in Drug metabolism and disposition (01.06.2021)
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An oral SARS-CoV-2 Mpro inhibitor clinical candidate for the treatment of COVID-19
Owen, Dafydd R, Allerton, Charlotte M N, Anderson, Annaliesa S, Aschenbrenner, Lisa, Avery, Melissa, Berritt, Simon, Boras, Britton, Cardin, Rhonda D, Carlo, Anthony, Coffman, Karen J, Dantonio, Alyssa, Li, Di, Eng, Heather, Ferre, RoseAnn, Gajiwala, Ketan S, Gibson, Scott A, Greasley, Samantha E, Hurst, Brett L, Kadar, Eugene P, Kalgutkar, Amit S, Lee, Jack C, Lee, Jisun, Liu, Wei, Mason, Stephen W, Noell, Stephen, Novak, Jonathan J, Obach, R Scott, Ogilvie, Kevin, Patel, Nandini C, Pettersson, Martin, Rai, Devendra K, Reese, Matthew R, Sammons, Matthew F, Sathish, Jean G, Singh, Ravi Shankar P, Steppan, Claire M, Stewart, Al E, Tuttle, Jamison B, Updyke, Lawrence, Verhoest, Patrick R, Wei, Liuqing, Yang, Qingyi, Zhu, Yuao
Published in Science (American Association for the Advancement of Science) (24.12.2021)
Published in Science (American Association for the Advancement of Science) (24.12.2021)
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Cytochrome P450 3A4 mRNA is a more reliable marker than CYP3A4 activity for detecting pregnane X receptor-activated induction of drug-metabolizing enzymes
Fahmi, Odette A, Kish, Mary, Boldt, Sherri, Obach, R Scott
Published in Drug metabolism and disposition (01.09.2010)
Published in Drug metabolism and disposition (01.09.2010)
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Preclinical characterization of an intravenous coronavirus 3CL protease inhibitor for the potential treatment of COVID19
Boras, Britton, Jones, Rhys M., Anson, Brandon J., Arenson, Dan, Aschenbrenner, Lisa, Bakowski, Malina A., Beutler, Nathan, Binder, Joseph, Chen, Emily, Eng, Heather, Hammond, Holly, Hammond, Jennifer, Haupt, Robert E., Hoffman, Robert, Kadar, Eugene P., Kania, Rob, Kimoto, Emi, Kirkpatrick, Melanie G., Lanyon, Lorraine, Lendy, Emma K., Lillis, Jonathan R., Logue, James, Luthra, Suman A., Ma, Chunlong, Mason, Stephen W., McGrath, Marisa E., Noell, Stephen, Obach, R. Scott, O’ Brien, Matthew N., O’Connor, Rebecca, Ogilvie, Kevin, Owen, Dafydd, Pettersson, Martin, Reese, Matthew R., Rogers, Thomas F., Rosales, Romel, Rossulek, Michelle I., Sathish, Jean G., Shirai, Norimitsu, Steppan, Claire, Ticehurst, Martyn, Updyke, Lawrence W., Weston, Stuart, Zhu, Yuao, White, Kris M., García-Sastre, Adolfo, Wang, Jun, Chatterjee, Arnab K., Mesecar, Andrew D., Frieman, Matthew B., Anderson, Annaliesa S., Allerton, Charlotte
Published in Nature communications (18.10.2021)
Published in Nature communications (18.10.2021)
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A comprehensive listing of bioactivation pathways of organic functional groups
Kalgutkar, Amit S, Gardner, Iain, Obach, R Scott, Shaffer, Christopher L, Callegari, Ernesto, Henne, Kirk R, Mutlib, Abdul E, Dalvie, Deepak K, Lee, Jae S, Nakai, Yasuhiro, O'Donnell, John P, Boer, Jason, Harriman, Shawn P
Published in Current drug metabolism (01.06.2005)
Published in Current drug metabolism (01.06.2005)
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Nonclassical Phenyl Bioisosteres as Effective Replacements in a Series of Novel Open-Source Antimalarials
Tse, Edwin G, Houston, Sevan D, Williams, Craig M, Savage, G. Paul, Rendina, Louis M, Hallyburton, Irene, Anderson, Mark, Sharma, Raman, Walker, Gregory S, Obach, R. Scott, Todd, Matthew H
Published in Journal of medicinal chemistry (22.10.2020)
Published in Journal of medicinal chemistry (22.10.2020)
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Development of Robust Quantitative Structure-Activity Relationship Models for CYP2C9, CYP2D6, and CYP3A4 Catalysis and Inhibition
Gonzalez, Eric, Jain, Sankalp, Shah, Pranav, Torimoto-Katori, Nao, Zakharov, Alexey, Nguyễn, Ðắc-Trung, Sakamuru, Srilatha, Huang, Ruili, Xia, Menghang, Obach, R Scott, Hop, Cornelis E C A, Simeonov, Anton, Xu, Xin
Published in Drug metabolism and disposition (01.09.2021)
Published in Drug metabolism and disposition (01.09.2021)
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