A therapeutic combination of two small molecule toxin inhibitors provides broad preclinical efficacy against viper snakebite
Albulescu, Laura-Oana, Xie, Chunfang, Ainsworth, Stuart, Alsolaiss, Jaffer, Crittenden, Edouard, Dawson, Charlotte A., Softley, Rowan, Bartlett, Keirah E., Harrison, Robert A., Kool, Jeroen, Casewell, Nicholas R.
Published in Nature communications (15.12.2020)
Published in Nature communications (15.12.2020)
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Senataxin: Genome Guardian at the Interface of Transcription and Neurodegeneration
Groh, Matthias, Albulescu, Laura Oana, Cristini, Agnese, Gromak, Natalia
Published in Journal of molecular biology (27.10.2017)
Published in Journal of molecular biology (27.10.2017)
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Repurposed drugs and their combinations prevent morbidity-inducing dermonecrosis caused by diverse cytotoxic snake venoms
Hall, Steven R., Rasmussen, Sean A., Crittenden, Edouard, Dawson, Charlotte A., Bartlett, Keirah E., Westhorpe, Adam P., Albulescu, Laura-Oana, Kool, Jeroen, Gutiérrez, José María, Casewell, Nicholas R.
Published in Nature communications (14.12.2023)
Published in Nature communications (14.12.2023)
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Dermonecrosis caused by a spitting cobra snakebite results from toxin potentiation and is prevented by the repurposed drug varespladib
Bartlett, Keirah E, Hall, Steven R, Rasmussen, Sean A, Crittenden, Edouard, Dawson, Charlotte A, Albulescu, Laura-Oana, Laprade, William, Harrison, Robert A, Saviola, Anthony J, Modahl, Cassandra M, Jenkins, Timothy P, Wilkinson, Mark C, Gutiérrez, José María, Casewell, Nicholas R
Published in Proceedings of the National Academy of Sciences - PNAS (07.05.2024)
Published in Proceedings of the National Academy of Sciences - PNAS (07.05.2024)
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The Search for Natural and Synthetic Inhibitors That Would Complement Antivenoms as Therapeutics for Snakebite Envenoming
Gutiérrez, José María, Albulescu, Laura-Oana, Clare, Rachel H, Casewell, Nicholas R, Abd El-Aziz, Tarek Mohamed, Escalante, Teresa, Rucavado, Alexandra
Published in Toxins (29.06.2021)
Published in Toxins (29.06.2021)
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RNase H2, mutated in Aicardi‐Goutières syndrome, resolves co-transcriptional R-loops to prevent DNA breaks and inflammation
Cristini, Agnese, Tellier, Michael, Constantinescu, Flavia, Accalai, Clelia, Albulescu, Laura Oana, Heiringhoff, Robin, Bery, Nicolas, Sordet, Olivier, Murphy, Shona, Gromak, Natalia
Published in Nature communications (26.05.2022)
Published in Nature communications (26.05.2022)
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Journal Article
Preclinical validation of a repurposed metal chelator as an early-intervention therapeutic for hemotoxic snakebite
Albulescu, Laura-Oana, Hale, Melissa S, Ainsworth, Stuart, Alsolaiss, Jaffer, Crittenden, Edouard, Calvete, Juan J, Evans, Chloe, Wilkinson, Mark C, Harrison, Robert A, Kool, Jeroen, Casewell, Nicholas R
Published in Science translational medicine (06.05.2020)
Published in Science translational medicine (06.05.2020)
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The medical threat of mamba envenoming in sub-Saharan Africa revealed by genus-wide analysis of venom composition, toxicity and antivenomics profiling of available antivenoms
Ainsworth, Stuart, Petras, Daniel, Engmark, Mikael, Süssmuth, Roderich D., Whiteley, Gareth, Albulescu, Laura-Oana, Kazandjian, Taline D., Wagstaff, Simon C., Rowley, Paul, Wüster, Wolfgang, Dorrestein, Pieter C., Arias, Ana Silvia, Gutiérrez, José M., Harrison, Robert A., Casewell, Nicholas R., Calvete, Juan J.
Published in Journal of proteomics (10.02.2018)
Published in Journal of proteomics (10.02.2018)
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Optimizing drug discovery for snakebite envenoming via a high-throughput phospholipase A2 screening platform
Albulescu, Laura-Oana, Westhorpe, Adam, Clare, Rachel H, Woodley, Christopher M, James, Nivya, Kool, Jeroen, Berry, Neil G, O'Neill, Paul M, Casewell, Nicholas R
Published in Frontiers in pharmacology (11.01.2024)
Published in Frontiers in pharmacology (11.01.2024)
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Author Correction: A therapeutic combination of two small molecule toxin inhibitors provides broad preclinical efficacy against viper snakebite
Albulescu, Laura-Oana, Xie, Chunfang, Ainsworth, Stuart, Alsolaiss, Jaffer, Crittenden, Edouard, Dawson, Charlotte A., Softley, Rowan, Bartlett, Keirah E., Harrison, Robert A., Kool, Jeroen, Casewell, Nicholas R.
Published in Nature communications (24.06.2021)
Published in Nature communications (24.06.2021)
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Journal Article
A Decoy-Receptor Approach Using Nicotinic Acetylcholine Receptor Mimics Reveals Their Potential as Novel Therapeutics Against Neurotoxic Snakebite
Albulescu, Laura-Oana, Kazandjian, Taline, Slagboom, Julien, Bruyneel, Ben, Ainsworth, Stuart, Alsolaiss, Jaffer, Wagstaff, Simon C, Whiteley, Gareth, Harrison, Robert A, Ulens, Chris, Kool, Jeroen, Casewell, Nicholas R
Published in Frontiers in pharmacology (30.07.2019)
Published in Frontiers in pharmacology (30.07.2019)
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Journal Article
Snakebite drug discovery: high-throughput screening to identify novel snake venom metalloproteinase toxin inhibitors
Clare, Rachel H, Dawson, Charlotte A, Westhorpe, Adam, Albulescu, Laura-Oana, Woodley, Christopher M, Mosallam, Nada, Chong, Daniel J W, Kool, Jeroen, Berry, Neil G, O'Neill, Paul M, Casewell, Nicholas R
Published in Frontiers in pharmacology (11.01.2024)
Published in Frontiers in pharmacology (11.01.2024)
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Journal Article
Antivenom Neutralization of Coagulopathic Snake Venom Toxins Assessed by Bioactivity Profiling Using Nanofractionation Analytics
Xie, Chunfang, Slagboom, Julien, Albulescu, Laura-Oana, Bruyneel, Ben, Still, Kristina B M, Vonk, Freek J, Somsen, Govert W, Casewell, Nicholas R, Kool, Jeroen
Published in Toxins (16.01.2020)
Published in Toxins (16.01.2020)
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Journal Article
In Vitro Immunological Cross-Reactivity of Thai Polyvalent and Monovalent Antivenoms with Asian Viper Venoms
Chaisakul, Janeyuth, Rusmili, Muhamad Rusdi Ahmad, Alsolaiss, Jaffer, Albulescu, Laura-Oana, Harrison, Robert A, Othman, Iekhsan, Casewell, Nicholas R
Published in Toxins (03.12.2020)
Published in Toxins (03.12.2020)
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Journal Article
Neutralizing Effects of Small Molecule Inhibitors and Metal Chelators on Coagulopathic Viperinae Snake Venom Toxins
Xie, Chunfang, Albulescu, Laura-Oana, Bittenbinder, Mátyás A, Somsen, Govert W, Vonk, Freek J, Casewell, Nicholas R, Kool, Jeroen
Published in Biomedicines (20.08.2020)
Published in Biomedicines (20.08.2020)
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Journal Article
Correction: Pathology-specific experimental antivenoms for haemotoxic snakebite: The impact of immunogen diversity on the in vitro cross-reactivity and in vivo neutralisation of geographically diverse snake venoms
Alomran, Nessrin, Alsolaiss, Jaffer, Albulescu, Laura-Oana, Crittenden, Edouard, Harrison, Robert A, Ainsworth, Stuart, Casewell, Nicholas R
Published in PLoS neglected tropical diseases (02.06.2022)
Published in PLoS neglected tropical diseases (02.06.2022)
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Journal Article
Solenodon genome reveals convergent evolution of venom in eulipotyphlan mammals
Casewell, Nicholas R., Petras, Daniel, Card, Daren C., Suranse, Vivek, Mychajliw, Alexis M., Richards, David, Koludarov, Ivan, Albulescu, Laura-Oana, Slagboom, Julien, Hempel, Benjamin-Florian, Ngum, Neville M., Kennerley, Rosalind J., Brocca, Jorge L., Whiteley, Gareth, Harrison, Robert A., Bolton, Fiona M. S., Debono, Jordan, Vonk, Freek J., Alföldi, Jessica, Johnson, Jeremy, Karlsson, Elinor K., Lindblad-Toh, Kerstin, Mellor, Ian R., Süssmuth, Roderich D., Fry, Bryan G., Kuruppu, Sanjaya, Hodgson, Wayne C., Kool, Jeroen, Castoe, Todd A., Barnes, Ian, Sunagar, Kartik, Undheim, Eivind A. B., Turveyb, Samuel T.
Published in Proceedings of the National Academy of Sciences - PNAS (17.12.2019)
Published in Proceedings of the National Academy of Sciences - PNAS (17.12.2019)
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Journal Article
Pathology-specific experimental antivenoms for haemotoxic snakebite: The impact of immunogen diversity on the in vitro cross-reactivity and in vivo neutralisation of geographically diverse snake venoms
Alomran, Nessrin, Alsolaiss, Jaffer, Albulescu, Laura-Oana, Crittenden, Edouard, Harrison, Robert A, Ainsworth, Stuart, Casewell, Nicholas R
Published in PLoS neglected tropical diseases (01.08.2021)
Published in PLoS neglected tropical diseases (01.08.2021)
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Journal Article
Repurposing DMPS, a metal chelator, as a rapid field intervention for treating hemotoxic snakebite
Albulescu, Laura-Oana, Xie, Chunfang, Hale, Melissa, Calvete, Juan Jose, Harrison, Robert Antonius, Kool, Jeroen, Casewell, Nicholas Robert
Published in Toxicon (Oxford) (20.04.2020)
Published in Toxicon (Oxford) (20.04.2020)
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Journal Article
Neutralising effects of small molecule toxin inhibitors on nanofractionated coagulopathic Crotalinae snake venoms
Xie, Chunfang, Slagboom, Julien, Albulescu, Laura-Oana, Somsen, Govert W., Vonk, Freek J., Casewell, Nicholas R., Kool, Jeroen
Published in Acta pharmaceutica Sinica. B (01.10.2020)
Published in Acta pharmaceutica Sinica. B (01.10.2020)
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