Safety, pharmacokinetics, and antimalarial activity of the novel plasmodium eukaryotic translation elongation factor 2 inhibitor M5717: a first-in-human, randomised, placebo-controlled, double-blind, single ascending dose study and volunteer infection study
McCarthy, James S, Yalkinoglu, Özkan, Odedra, Anand, Webster, Rebecca, Oeuvray, Claude, Tappert, Aliona, Bezuidenhout, Deon, Giddins, Marla J, Dhingra, Satish K, Fidock, David A, Marquart, Louise, Webb, Lachlan, Yin, Xiaoyan, Khandelwal, Akash, Bagchus, Wilhelmina M
Published in The Lancet infectious diseases (01.12.2021)
Published in The Lancet infectious diseases (01.12.2021)
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Journal Article
Reproducibility of malaria sporozoite challenge model in humans for evaluating efficacy of vaccines and drugs: a systematic review
Shibeshi, Workineh, Bagchus, Wilhelmina, Yalkinoglu, Özkan, Tappert, Aliona, Engidawork, Ephrem, Oeuvray, Claude
Published in BMC infectious diseases (20.12.2021)
Published in BMC infectious diseases (20.12.2021)
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Causal chemoprophylactic activity of cabamiquine against Plasmodium falciparum in a controlled human malaria infection: a randomised, double-blind, placebo-controlled study in the Netherlands
van der Plas, Johan L, Kuiper, Vincent P, Bagchus, Wilhelmina M, Bödding, Matthias, Yalkinoglu, Özkan, Tappert, Aliona, Seitzinger, Andrea, Spangenberg, Thomas, Bezuidenhout, Deon, Wilkins, Justin, Oeuvray, Claude, Dhingra, Satish K, Thathy, Vandana, Fidock, David A, Smidt, Lisanne C A, Roozen, Geert V T, Koopman, Jan Pieter R, Lamers, Olivia A C, Sijtsma, Jeroen, van Schuijlenburg, Roos, Wessels, Els, Meij, Pauline, Kamerling, Ingrid M C, Roestenberg, Meta, Khandelwal, Akash
Published in The Lancet infectious diseases (01.10.2023)
Published in The Lancet infectious diseases (01.10.2023)
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Journal Article
Kinetics of free and ligand-bound atacicept in human serum
Eslami, Mahya, Willen, Daniela, Papasouliotis, Orestis, Schuepbach-Mallpell, Sonia, Willen, Laure, Donzé, Olivier, Yalkinoglu, Özkan, Schneider, Pascal
Published in Frontiers in immunology (02.12.2022)
Published in Frontiers in immunology (02.12.2022)
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Journal Article
BAFF 60-mer, and Differential BAFF 60-mer Dissociating Activities in Human Serum, Cord Blood and Cerebrospinal Fluid
Eslami, Mahya, Meinl, Edgar, Eibel, Hermann, Willen, Laure, Donzé, Olivier, Distl, Ottmar, Schneider, Holm, Speiser, Daniel E., Tsiantoulas, Dimitrios, Yalkinoglu, Özkan, Samy, Eileen, Schneider, Pascal
Published in Frontiers in cell and developmental biology (06.11.2020)
Published in Frontiers in cell and developmental biology (06.11.2020)
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Journal Article
Evaluation of a multiphasic parasite clearance profile after treatment of experimental human infection with the investigational anti-malarial M5717 using segmented mixed effect models
Yin, Xiaoyan, Li, Ying, Bagchus, Wilhelmina, Yalkinoglu, Özkan, Bezuidenhout, Deon, Tappert, Aliona, McCarthy, James, Marquart, Louise, Oeuvray, Claude
Published in Malaria journal (28.06.2023)
Published in Malaria journal (28.06.2023)
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Journal Article
Comparison of the Effects of the Thrombin Inhibitor r-Hirudin in Four Animal Models of Neointima Formation After Arterial Injury
Gerdes, Christoph, Faber-Steinfeld, Verona, Yalkinoglu, Ozkan, Wohlfeil, Stefan
Published in Arteriosclerosis, thrombosis, and vascular biology (01.10.1996)
Published in Arteriosclerosis, thrombosis, and vascular biology (01.10.1996)
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Journal Article
Translation of liver stage activity of M5717, a Plasmodium elongation factor 2 inhibitor: from bench to bedside
Khandelwal, Akash, Arez, Francisca, Alves, Paula M, Badolo, Lassina, Brito, Catarina, Fischli, Christoph, Fontinha, Diana, Oeuvray, Claude, Prudêncio, Miguel, Rottmann, Matthias, Wilkins, Justin, Yalkinoglu, Özkan, Bagchus, Wilhelmina M, Spangenberg, Thomas
Published in Malaria journal (15.05.2022)
Published in Malaria journal (15.05.2022)
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Journal Article
No interactions between heparin and atacicept, an antagonist of B cell survival cytokines
Kowalczyk‐Quintas, Christine, Willen, Daniela, Willen, Laure, Golob, Michaela, Schuepbach‐Mallepell, Sonia, Peter, Benjamin, Eslami, Mahya, Vigolo, Michele, Broly, Hervé, Samy, Eileen, Yalkinoglu, Özkan, Schneider, Pascal
Published in British journal of pharmacology (01.10.2019)
Published in British journal of pharmacology (01.10.2019)
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Journal Article
Population pharmacokinetics of atacicept in systemic lupus erythematosus: An analysis of three clinical trials
Pitsiu, Maria, Yalkinoglu, Özkan, Farrell, Colm, Girard, Pascal, Vazquez‐Mateo, Cristina, Papasouliotis, Orestis
Published in CPT: pharmacometrics and systems pharmacology (01.08.2023)
Published in CPT: pharmacometrics and systems pharmacology (01.08.2023)
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Open-Label, Randomized, Two-Way, Crossover Study Assessing the Bioequivalence of the Liquid Formulation versus the Freeze-Dried Formulation of Recombinant Human FSH and Recombinant Human LH in a Fixed 2:1 Combination (Pergoveris ® ) in Pituitary-Suppressed Healthy Women
Bagchus, Wilhelmina, Yalkinoglu, Özkan, Wolna, Peter
Published in Frontiers in endocrinology (Lausanne) (11.01.2018)
Published in Frontiers in endocrinology (Lausanne) (11.01.2018)
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Journal Article
DNA amplification of adeno-associated virus as a response to cellular genotoxic stress
YALKINOGLU, A. O, HEILBRONN, R, BÜRKLE, A, SCHLEHOFER, J. R, ZUR HAUSEN, H
Published in Cancer research (Chicago, Ill.) (01.06.1988)
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Published in Cancer research (Chicago, Ill.) (01.06.1988)
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Unique and redundant roles of mouse BCMA, TACI, BAFF, APRIL, and IL-6 in supporting antibody-producing cells in different tissues
Eslami, Mahya, Schuepbach-Mallepell, Sonia, Diana, Daniela, Willen, Laure, Kowalczyk-Quintas, Christine, Desponds, Chantal, Peter, Benjamin, Vigolo, Michele, Renevey, François, Donzé, Olivier, Luther, Sanjiv A., Yalkinoglu, Özkan, Alouche, Nagham, Schneider, Pascal
Published in Proceedings of the National Academy of Sciences - PNAS (16.07.2024)
Published in Proceedings of the National Academy of Sciences - PNAS (16.07.2024)
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Journal Article
Asia‐Inclusive Global Development of Enpatoran: Results of an Ethno‐Bridging Study, Intrinsic/Extrinsic Factor Assessments and Disease Trajectory Modeling to Inform Design of a Phase II Multiregional Clinical Trial
Klopp‐Schulze, Lena, Gopalakrishnan, Sathej, Yalkinoglu, Özkan, Kuroki, Yoshihiro, Lu, Hong, Goteti, Kosalaram, Krebs‐Brown, Axel, Nogueira Filho, Marco, Gradhand, Ulrike, Fluck, Markus, Shaw, Jamie, Dong, Jennifer, Venkatakrishnan, Karthik
Published in Clinical pharmacology and therapeutics (01.06.2024)
Published in Clinical pharmacology and therapeutics (01.06.2024)
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Journal Article
Assessment of the potential of the MET inhibitor tepotinib to affect the pharmacokinetics of CYP3A4 and P-gp substrates
Yalkinoglu, Özkan, Becker, Andreas, Krebs-Brown, Axel, Vetter, Claudia, Lüpfert, Christian, Perrin, Dominique, Heuer, Jürgen, Biedert, Herlind, Hirt, Stefan, Bytyqi, Afrim, Bachmann, Angelika, Strotmann, Rainer
Published in Investigational new drugs (01.08.2023)
Published in Investigational new drugs (01.08.2023)
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Journal Article
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Atacicept in a Randomized Trial in Healthy Caucasian and Japanese Subjects
Willen, Daniela, Uhl, Wolfgang, Wolna, Peter, Papasouliotis, Orestis, Yalkinoglu, Özkan
Published in European journal of drug metabolism and pharmacokinetics (01.02.2020)
Published in European journal of drug metabolism and pharmacokinetics (01.02.2020)
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Journal Article
Efficacy and Safety of New Orodispersible Tablet Formulations of Praziquantel (Racemate and L-Praziquantel) in Schistosoma mansoni-Infected Preschool-Age Children and Infants: A Randomized Dose-Finding Phase 2 Study
N’Goran, Eliézer K., Yalkinoglu, Özkan, Kourany-Lefoll, Elly, Tappert, Aliona, Hayward, Brooke, Yin, Xiaoyan, Bezuidenhout, Deon, Huber, Eric, Aka, N. A. David, Ouattara, Mamadou, Bagchus, Wilhelmina
Published in Frontiers in tropical diseases (12.10.2021)
Published in Frontiers in tropical diseases (12.10.2021)
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Journal Article
Enpatoran in COVID‐19 pneumonia: Safety and efficacy results from a phase II randomized trial
McKinnon, John E., Santiaguel, Joel, Murta de Oliveira, Claudia, Yu, Dongzi, Khursheed, Mukhy, Moreau, Flavie, Klopp‐Schulze, Lena, Shaw, Jamie, Roy, Sanjeev, Kao, Amy H., Barbers, Richard, El Ghazal, Roland, Ramachandruni, Srikanth, Zervos, Marcus, De La Rosa, Benjamin, Lima, Marina Andrade, Aguiar, Valeria Cristina, Candida, Caroline, Dal Pizzol, Felipe, Faria Freire, Antonio, Marinho, Ivan Silva, Sato, Victor Augusto Hamamoto, Souza, Tamara Newman Lobato, Germar, Arnold, Raymond, Lawrence O., Santiaguel, Joel M., Bhagat, Pavankumar, Docampo, Zaida Rodriguez, Dörr, Katrin Zaragoza, Englund, Janice, Filho, Marco Antonio Ferraz Nogueira, Garrot, Marcela, Kao, Amy, Labaune, Jean‐Pierre, Knuth, Melanie, Martinez‐Lopez, Noelia, Mondrup, Thomas, Murgasova, Zuzana, Rojik, Christopher, Ruoff, Joerg, Schicker, Simone, Schneider‐Olt, Beate, Thomas, Angela, Thomas, Erik, Yalkinoglu, Özkan, Yeager, Marie
Published in Clinical and translational science (01.12.2023)
Published in Clinical and translational science (01.12.2023)
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Journal Article
Comparison of POC-CCA with Kato-Katz in Diagnosing Schistosoma mansoni Infection in a Pediatric L-Praziquantel Clinical Trial
Yin, Xiaoyan, N’Goran, Eliézer K., Ouattara, Mamadou, Aka, NAD, Diakité, Nana R., Bassa, Fidèle K., Kourany-Lefoll, Elly, Tappert, Aliona, Yalkinoglu, Özkan, Huber, Eric, Bezuidenhout, Deon, Bagchus, Wilhelmina M., Hayward, Brooke
Published in Frontiers in tropical diseases (17.06.2021)
Published in Frontiers in tropical diseases (17.06.2021)
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Journal Article
Prolonged inhibition of interleukin-6 mediated signaling
Holz, Josefin-Beate, Sargentini-Maier, Maria Laura, Yalkinoglu, Ozkan, De Bruyn, Steven, Rossenu, Stefaan
Year of Publication 01.12.2016
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Year of Publication 01.12.2016
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