Preclinical Efficacy and Anti-Inflammatory Mechanisms of Action of the Bruton Tyrosine Kinase Inhibitor Rilzabrutinib for Immune-Mediated Disease
Langrish, Claire L, Bradshaw, J Michael, Francesco, Michelle R, Owens, Timothy D, Xing, Yan, Shu, Jin, LaStant, Jacob, Bisconte, Angelina, Outerbridge, Catherine, White, Stephen D, Hill, Ronald J, Brameld, Ken A, Goldstein, David M, Nunn, Philip A
Published in The Journal of immunology (1950) (01.04.2021)
Published in The Journal of immunology (1950) (01.04.2021)
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Prolonged and tunable residence time using reversible covalent kinase inhibitors
Bradshaw, J Michael, McFarland, Jesse M, Paavilainen, Ville O, Bisconte, Angelina, Tam, Danny, Phan, Vernon T, Romanov, Sergei, Finkle, David, Shu, Jin, Patel, Vaishali, Ton, Tony, Li, Xiaoyan, Loughhead, David G, Nunn, Philip A, Karr, Dane E, Gerritsen, Mary E, Funk, Jens Oliver, Owens, Timothy D, Verner, Erik, Brameld, Ken A, Hill, Ronald J, Goldstein, David M, Taunton, Jack
Published in Nature chemical biology (01.07.2015)
Published in Nature chemical biology (01.07.2015)
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Co‐inhibition of immunoproteasome subunits LMP2 and LMP7 is required to block autoimmunity
Basler, Michael, Lindstrom, Michelle M, LaStant, Jacob J, Bradshaw, J Michael, Owens, Timothy D, Schmidt, Christian, Maurits, Elmer, Tsu, Christopher, Overkleeft, Herman S, Kirk, Christopher J, Langrish, Claire L, Groettrup, Marcus
Published in EMBO reports (01.12.2018)
Published in EMBO reports (01.12.2018)
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2012 Young Investigator Award winner: The distribution of body mass as a significant risk factor for lumbar spinal fusion postoperative infections
Mehta, Ankit I, Babu, Ranjith, Karikari, Isaac O, Grunch, Betsy, Agarwal, Vijay J, Owens, Timothy R, Friedman, Allan H, Bagley, Carlos A, Gottfried, Oren N
Published in Spine (Philadelphia, Pa. 1976) (01.09.2012)
Published in Spine (Philadelphia, Pa. 1976) (01.09.2012)
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Discovery of the Irreversible Covalent FGFR Inhibitor 8‑(3-(4-Acryloylpiperazin-1-yl)propyl)-6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-(methylamino)pyrido[2,3‑d]pyrimidin-7(8H)‑one (PRN1371) for the Treatment of Solid Tumors
Brameld, Ken A, Owens, Timothy D, Verner, Erik, Venetsanakos, Eleni, Bradshaw, J. Michael, Phan, Vernon T, Tam, Danny, Leung, Kwan, Shu, Jin, LaStant, Jacob, Loughhead, David G, Ton, Tony, Karr, Dane E, Gerritsen, Mary E, Goldstein, David M, Funk, Jens Oliver
Published in Journal of medicinal chemistry (10.08.2017)
Published in Journal of medicinal chemistry (10.08.2017)
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Structure-Based Drug Design of RN486, a Potent and Selective Bruton’s Tyrosine Kinase (BTK) Inhibitor, for the Treatment of Rheumatoid Arthritis
Lou, Yan, Han, Xiaochun, Kuglstatter, Andreas, Kondru, Rama K., Sweeney, Zachary K., Soth, Michael, McIntosh, Joel, Litman, Renee, Suh, Judy, Kocer, Buelent, Davis, Dana, Park, Jaehyeon, Frauchiger, Sandra, Dewdney, Nolan, Zecic, Hasim, Taygerly, Joshua P., Sarma, Keshab, Hong, Junbae, Hill, Ronald J., Gabriel, Tobias, Goldstein, David M., Owens, Timothy D.
Published in Journal of medicinal chemistry (08.01.2015)
Published in Journal of medicinal chemistry (08.01.2015)
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Spinal cord astrocytomas: a modern 20-year experience at a single institution
Babu, Ranjith, Karikari, Isaac O, Owens, Timothy R, Bagley, Carlos A
Published in Spine (Philadelphia, Pa. 1976) (01.04.2014)
Published in Spine (Philadelphia, Pa. 1976) (01.04.2014)
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Discovery of Reversible Covalent Bruton’s Tyrosine Kinase Inhibitors PRN473 and PRN1008 (Rilzabrutinib)
Owens, Timothy D, Brameld, Ken A, Verner, Erik J, Ton, Tony, Li, Xiaoyan, Zhu, Jiang, Masjedizadeh, Mohammad R, Bradshaw, J. Michael, Hill, Ronald J, Tam, Danny, Bisconte, Angelina, Kim, Eun Ok, Francesco, Michelle, Xing, Yan, Shu, Jin, Karr, Dane, LaStant, Jacob, Finkle, David, Loewenstein, Natalie, Haberstock-Debic, Helena, Taylor, Michael J, Nunn, Philip, Langrish, Claire L, Goldstein, David M
Published in Journal of medicinal chemistry (14.04.2022)
Published in Journal of medicinal chemistry (14.04.2022)
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Journal Article
Bruton’s Tyrosine Kinase Inhibitors: Approaches to Potent and Selective Inhibition, Preclinical and Clinical Evaluation for Inflammatory Diseases and B Cell Malignancies
Lou, Yan, Owens, Timothy D, Kuglstatter, Andreas, Kondru, Rama K, Goldstein, David M
Published in Journal of medicinal chemistry (24.05.2012)
Published in Journal of medicinal chemistry (24.05.2012)
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RN486, a selective Bruton's tyrosine kinase inhibitor, abrogates immune hypersensitivity responses and arthritis in rodents
Xu, Daigen, Kim, Yong, Postelnek, Jennifer, Vu, Minh Diem, Hu, Dong-Qing, Liao, Cheng, Bradshaw, Mike, Hsu, Jonathan, Zhang, Jun, Pashine, Achal, Srinivasan, Dinesh, Woods, John, Levin, Anita, O'Mahony, Alison, Owens, Timothy D, Lou, Yan, Hill, Ronald J, Narula, Satwant, DeMartino, Julie, Fine, Jay S
Published in The Journal of pharmacology and experimental therapeutics (01.04.2012)
Published in The Journal of pharmacology and experimental therapeutics (01.04.2012)
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Phase 1 clinical trial evaluating safety, exposure and pharmacodynamics of BTK inhibitor tolebrutinib (PRN2246, SAR442168)
Owens, Timothy D., Smith, Patrick F., Redfern, Andrew, Xing, Yan, Shu, Jin, Karr, Dane E., Hartmann, Sonja, Francesco, Michelle R., Langrish, Claire L., Nunn, Philip A., Gourlay, Steven G.
Published in Clinical and translational science (01.02.2022)
Published in Clinical and translational science (01.02.2022)
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Thickness of subcutaneous fat as a risk factor for infection in cervical spine fusion surgery
Mehta, Ankit I, Babu, Ranjith, Sharma, Richa, Karikari, Isaac O, Grunch, Betsy H, Owens, Timothy R, Agarwal, Vijay J, Sampson, John H, Lad, Shivanand P, Friedman, Allan H, Kuchibhatla, Maragatha, Bagley, Carlos A, Gottfried, Oren N
Published in Journal of bone and joint surgery. American volume (20.02.2013)
Published in Journal of bone and joint surgery. American volume (20.02.2013)
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Outcome and prognostic factors in adult cerebellar glioblastoma
Babu, Ranjith, Sharma, Richa, Karikari, Isaac O, Owens, Timothy R, Friedman, Allan H, Adamson, Cory
Published in Journal of clinical neuroscience (01.08.2013)
Published in Journal of clinical neuroscience (01.08.2013)
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Targeting Interleukin-2-inducible T-cell Kinase (ITK) and Resting Lymphocyte Kinase (RLK) Using a Novel Covalent Inhibitor PRN694
Zhong, Yiming, Dong, Shuai, Strattan, Ethan, Ren, Li, Butchar, Jonathan P., Thornton, Kelsey, Mishra, Anjali, Porcu, Pierluigi, Bradshaw, J. Michael, Bisconte, Angelina, Owens, Timothy D., Verner, Erik, Brameld, Ken A., Funk, Jens Oliver, Hill, Ronald J., Johnson, Amy J., Dubovsky, Jason A.
Published in The Journal of biological chemistry (06.03.2015)
Published in The Journal of biological chemistry (06.03.2015)
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The Irreversible Covalent Fibroblast Growth Factor Receptor Inhibitor PRN1371 Exhibits Sustained Inhibition of FGFR after Drug Clearance
Venetsanakos, Eleni, Brameld, Ken A, Phan, Vernon T, Verner, Erik, Owens, Timothy D, Xing, Yan, Tam, Danny, LaStant, Jacob, Leung, Kwan, Karr, Dane E, Hill, Ronald J, Gerritsen, Mary E, Goldstein, David M, Funk, Jens Oliver, Bradshaw, J Michael
Published in Molecular cancer therapeutics (01.12.2017)
Published in Molecular cancer therapeutics (01.12.2017)
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A Small Molecule Inhibitor of ITK and RLK Impairs Th1 Differentiation and Prevents Colitis Disease Progression
Cho, Hyoung-Soo, Shin, Hyun Mu, Haberstock-Debic, Helena, Xing, Yan, Owens, Timothy D, Funk, Jens Oliver, Hill, Ronald J, Bradshaw, J Michael, Berg, Leslie J
Published in The Journal of immunology (1950) (15.11.2015)
Published in The Journal of immunology (1950) (15.11.2015)
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Journal Article
Spinal cavernous and capillary hemangiomas in adults
Babu, Ranjith, Owens, Timothy R, Karikari, Isaac O, Moreno, Jessica, Cummings, Thomas J, Gottfried, Oren N, Bagley, Carlos A
Published in Spine (Philadelphia, Pa. 1976) (01.04.2013)
Published in Spine (Philadelphia, Pa. 1976) (01.04.2013)
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Finding the perfect spot for fluorine: Improving potency up to 40-fold during a rational fluorine scan of a Bruton's Tyrosine Kinase (BTK) inhibitor scaffold
Lou, Yan, Sweeney, Zachary K., Kuglstatter, Andreas, Davis, Dana, Goldstein, David M., Han, Xiaochun, Hong, Junbae, Kocer, Buelent, Kondru, Rama K., Litman, Renee, McIntosh, Joel, Sarma, Keshab, Suh, Judy, Taygerly, Joshua, Owens, Timothy D.
Published in Bioorganic & medicinal chemistry letters (15.01.2015)
Published in Bioorganic & medicinal chemistry letters (15.01.2015)
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Journal Article
Timing of tracheostomy after anterior cervical spine fixation
Babu, Ranjith, Owens, Timothy R, Thomas, Steven, Karikari, Isaac O, Grunch, Betsy H, Moreno, Jessica R, Lad, Shivanand P, Bagley, Carlos A
Published in The journal of trauma and acute care surgery (01.04.2013)
Published in The journal of trauma and acute care surgery (01.04.2013)
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