Imprime PGG-Mediated Anti-Cancer Immune Activation Requires Immune Complex Formation
Chan, Anissa S H, Jonas, Adria Bykowski, Qiu, Xiaohong, Ottoson, Nadine R, Walsh, Richard M, Gorden, Keith B, Harrison, Ben, Maimonis, Peter J, Leonardo, Steven M, Ertelt, Kathleen E, Danielson, Michael E, Michel, Kyle S, Nelson, Mariana, Graff, Jeremy R, Patchen, Myra L, Bose, Nandita
Published in PloS one (03.11.2016)
Published in PloS one (03.11.2016)
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Journal Article
Imprime PGG Enhances Anti-Tumor Effects of Tumor-Targeting, Anti-Angiogenic, and Immune Checkpoint Inhibitor Antibodies
Chan, Anissa S H, Kangas, Takashi O, Qiu, Xiaohong, Uhlik, Mark T, Fulton, Ross B, Ottoson, Nadine R, Gorden, Keith B, Yokoyama, Yumi, Danielson, Michael E, Jevne, Trinda M, Michel, Kyle S, Graff, Jeremy R, Bose, Nandita
Published in Frontiers in oncology (26.05.2022)
Published in Frontiers in oncology (26.05.2022)
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Journal Article
Immune Pharmacodynamic Responses of the Novel Cancer Immunotherapeutic Imprime PGG in Healthy Volunteers
Bose, Nandita, Ottoson, Nadine R, Qiu, Xiaohong, Harrison, Ben, Lowe, Jamie R, Uhlik, Mark T, Rathmann, Blaine T, Kangas, Takashi O, Jordan, Lindsay R, Ertelt, Kathleen E, Jonas, Adria Bykowski, Walsh, Richard M, Chan, Anissa S H, Fulton, Ross B, Leonardo, Steven M, Fraser, Kathryn A, Gorden, Keith B, Matson, Mark A, Graff, Jeremy R, Huhn, Richard D
Published in The Journal of immunology (1950) (15.05.2019)
Published in The Journal of immunology (1950) (15.05.2019)
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Journal Article
Whole glucan particles as a vaccine against murine aspergillosis
CLEMONS, Karl V, DANIELSON, Michael E, MICHEL, Kyle S, MIN LIU, OTTOSON, Nadine C, LEONARDO, Steven M, MARTINEZ, Marife, CHEN, Vicky, ANTONYSAMY, Mary A, STEVENS, David A
Published in Journal of medical microbiology (01.12.2014)
Published in Journal of medical microbiology (01.12.2014)
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Abstract LB-087: Imprime PGG drives adaptive immune resistance within the tumor microenvironment by modulating the myeloid compartment and enhances the efficacy of anti-PD1 antibody in vivo
Bykowski Jonas, Adria L., Chan, Anissa SH, Ottoson, Nadine R., Qiu, Xiaohong, Fraser, Kathryn, Kangas, Takashi O., Fulton, Ross, Rathmann, Blaine, Graff, Jeremy R., Bose, Nandita
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Abstract 4708: Imprime (beta-1,3/1,6 glucan) synergizes with a CD40 agonist to stimulate T cell-dependent antitumor activity in a poorly immunogenic model of pancreatic carcinoma
Liu, Mingen, Graham, Kathleen, Chan, Anissa S., Ottoson, Nadine R., Bose, Nandita, Beatty, Gregory L.
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Immunoglobulin Restores Immune Responses to BTH1677 in Patients With Low Levels of Antibodies to Beta-glucan
Hurley, Peter J, Bose, Nandita, Jha, Gautam, Gargano, Michele, Ottoson, Nadine, Gorden, Keith, Rathmann, Blaine, Harrison, Ben, Qiu, Xiaohong, Dudek, Arkadiusz Z
Published in Anticancer research (01.03.2020)
Published in Anticancer research (01.03.2020)
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Abstract 3280: Imprime PGG synergizes with anti-angiogenic antibodies to repolarize the immune microenvironment, suppressing xenograft tumor growth in vivo
Fraser, Kathryn, Ottoson, Nadine, Qiu, Xiahong, Chan, Anissa, Jonas, Adria, Kangas, Takashi, Graff, Jeremy, Bose, Nandita
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Abstract LB-225: Imprime PGG modulates the function of monocyte-derived M2 macrophages and dendritic cells to drive T-cell expansion
Chan, Anissa SH, Qiu, Xiaohong, Jonas, Adria, Kangas, Takashi, Ottoson, Nadine R., Bose, Nandita
Published in Cancer research (Chicago, Ill.) (01.08.2015)
Published in Cancer research (Chicago, Ill.) (01.08.2015)
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Journal Article
Imprime PGG, a yeast β-glucan PAMP elicits a coordinated immune response in combination with anti-PD1 antibody
Qiu, Xiaohong, Chan, Anissa S.H., Jonas, Adria Bykowski, Kangas, Takashi, Ottoson, Nadine R., Graff, Jeremy R., Bose, Nandita
Published in The Journal of immunology (1950) (01.05.2016)
Published in The Journal of immunology (1950) (01.05.2016)
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Journal Article
Abstract A02: Imprime PGG modulates the myeloid component of the tumor microenvironment to coordinate an antitumor immune response
Fraser, Kathryn, Ottoson, Nadine, Qiu, Xiaohong, Chan, Anissa SH, Jonas, Adria, Kangas, Takashi, Graff, Jeremy, Bose, Nandita
Published in Cancer research (Chicago, Ill.) (01.02.2016)
Published in Cancer research (Chicago, Ill.) (01.02.2016)
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Abstract LB-228: Imprime PGG treatment elicits a coordinated antitumor immune response that triggers enhanced expression of PD-L1 on tumor cells as well as monocyte-derived macrophages and dendritic cells
Bose, Nandita, Chan, Anissa SH, Jonas, Adria, Qiu, Xiaohong, Ottoson, Nadine R., Kangas, Takashi, Graff, Jeremy R.
Published in Cancer research (Chicago, Ill.) (01.08.2015)
Published in Cancer research (Chicago, Ill.) (01.08.2015)
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Abstract LB-080: Imprime PGG, a -glucan PAMP (pathogen-associated molecular pattern) activates the direct killing functions of innate immune cells in concert with tumor targeting antibodies
Leonardo, Steven M, Fulton, Ross B, Gorden, Keith B, Fraser, Katy, Harrison, Ben, Kangas, Takashi, Jonas, Adria, Yokoyama, Yumi, Ottoson, Nadine, Bose, Nandita, Graff, Jeremy R
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Abstract 2335: Imprime PGG triggers PD-L1 expression on tumor and myeloid cells and prevents tumor establishment in combination with PD-L1 treatment in vivo
Fraser, Kathryn, Chan, Anissa, Fulton, Ross, Leonardo, Steven, Jonas, Adria, Qiu, Xiaohong, Ottoson, Nadine, Kangas, Takashi, Gordon, Keith, Graff, Jeremy, Bose, Nandita
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Journal Article
Abstract 2335: Imprime PGG triggers PD-L1 expression on tumor and myeloid cells and prevents tumor establishment in combination with αPD-L1 treatment in vivo
Fraser, Kathryn, Chan, Anissa, Fulton, Ross, Leonardo, Steven, Jonas, Adria, Qiu, Xiaohong, Ottoson, Nadine, Kangas, Takashi, Gordon, Keith, Graff, Jeremy, Bose, Nandita
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Abstract LB-089: Imprime PGG, a β-glucan PAMP (pathogen-associated molecular pattern), effectively elicits in vivo maturation of antigen presenting cells in mice and humans, suggesting potential synergy with checkpoint inhibitor therapy
Fulton, Ross B., Leonardo, Steven M., Jonas, Adria B., Fraser, Kathryn A., Chan, Anissa S.H., Ottoson, Nadine R., Danielson, Michael E., Bose, Nandita, Graff, Jeremy R., Gorden, Keith
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Journal Article
Abstract LB-080: Imprime PGG, a β-glucan PAMP (pathogen-associated molecular pattern) activates the direct killing functions of innate immune cells in concert with tumor targeting antibodies
Leonardo, Steven M., Fulton, Ross B., Gorden, Keith B., Fraser, Katy, Harrison, Ben, Kangas, Takashi, Jonas, Adria, Yokoyama, Yumi, Ottoson, Nadine, Bose, Nandita, Graff, Jeremy R.
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Journal Article
Abstract A98: Imprime PGG, a soluble yeast β glucan, primes innate immune effector cells to recognize and eradicate tumor cells
Leonardo, Steven M., Jonas, Adria, Ottoson, Nadine, Qiu, Xiaohong, Chan, Anissa, Graff, Jeremy, Bose, Nandita, Gorden, Keith
Published in Molecular cancer therapeutics (01.12.2015)
Published in Molecular cancer therapeutics (01.12.2015)
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Abstract A3: Imprime PGG triggers a coordinated anti-cancer immune response in concert with anti-angiogenic antibodies, re-polarizing the immune microenvironment to suppress tumor growth
Fraser, Kathryn, Ottoson, Nadine, Qiu, Xiahong, Chan, Anissa SH, Jonas, Adria, Kangas, Takashi, Graff, Jeremy, Bose, Nandita
Published in Molecular cancer therapeutics (01.12.2015)
Published in Molecular cancer therapeutics (01.12.2015)
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