Acceleration of Acetal Hydrolysis by Remote Alkoxy Groups: Evidence for Electrostatic Effects on the Formation of Oxocarbenium Ions
Garcia, Angie, Otte, Douglas A. L., Salamant, Walter A., Sanzone, Jillian R., Woerpel, K. A.
Published in Angewandte Chemie International Edition (02.03.2015)
Published in Angewandte Chemie International Edition (02.03.2015)
Get full text
Journal Article
Influence of Alkoxy Groups on Rates of Acetal Hydrolysis and Tosylate Solvolysis: Electrostatic Stabilization of Developing Oxocarbenium Ion Intermediates and Neighboring-Group Participation To Form Oxonium Ions
Garcia, Angie, Otte, Douglas A. L, Salamant, Walter A, Sanzone, Jillian R, Woerpel, K. A
Published in Journal of organic chemistry (01.05.2015)
Published in Journal of organic chemistry (01.05.2015)
Get full text
Journal Article
Development of a Green and Sustainable Manufacturing Process for Gefapixant Citrate (MK-7264) Part 4: Formylation–Cyclization as a Flow–Batch Process Leads to Significant Improvements in Process Mass Intensity (PMI) and CO Generated versus the Batch–Batch Process
Otte, Douglas A. L, Basu, Kallol, Jellett, Lisa, Whittington, Michael, Spencer, Glenn, Burris, Matthew, Corcoran, Emily B, Stone, Kevin, Nappi, Jarod, Arvary, Rebecca A, Donoghue, David, Ren, Hong, Maloney, Kevin M, Naber, John R
Published in Organic process research & development (20.11.2020)
Published in Organic process research & development (20.11.2020)
Get full text
Journal Article
Development of a Green and Sustainable Manufacturing Process for Gefapixant Citrate (MK-7264) Part 1: Introduction and Process Overview
Ren, Hong, Maloney, Kevin M, Basu, Kallol, Di Maso, Michael J, Humphrey, Guy R, Peng, Feng, Desmond, Richard, Otte, Douglas A. L, Alwedi, Embarek, Liu, Wenjun, Zhang, Si-Wei, Song, Siqing, Arvary, Rebecca A, Zompa, Michael A, Lehnherr, Dan, Martin, Gary E, Chang, Hsieh Yao D, Mohan, Anne E, Guzman, Francisco J, Jellett, Lisa, Lee, Alfred Y, Spencer, Glenn, Fisher, Elizabeth S, Naber, John R, Gao, Hong, Lohani, Sachin, Ruck, Rebecca T, Campeau, Louis-Charles
Published in Organic process research & development (20.11.2020)
Published in Organic process research & development (20.11.2020)
Get full text
Journal Article
Pilot-Scale Operation and Characterization of an Organolithium-Mediated Coupling Reaction in Flow to Form a Ketone Intermediate on the Route to Nemtabrutinib
Franklin, Robert D., Armiger, Travis, Otte, Douglas A. L., Larson, Reed T., Spencer, Glenn, Patel, Pratiq A., Paulines, Mellie June, Hall, Jackson R., Xiao, Kai-Jiong, Fier, Patrick S., Rodrigues, Vailankanni L., Guetschow, Erik D., Kuhl, Nadine, Jellett, Lisa, Corry, James, Chung, Cheol K., Thaisrivongs, David A.
Published in Organic process research & development (17.05.2024)
Published in Organic process research & development (17.05.2024)
Get full text
Journal Article
Development of a Green and Sustainable Manufacturing Process for a Key Intermediate to Nemtabrutinib (MK-1026): Sequential Deprotonation–Lithiation as a Batch–Flow Process
Otte, Douglas A. L., Larson, Reed T., Alwedi, Embarek, Armiger, Travis, Chen, Yonggang, Chung, Cheol K., Corry, James, Desmond, Richard, Fier, Patrick S., Franklin, Robert D., Guetschow, Erik D., Hall, Jackson R., Halsey, Holst M., Hartmanshenn, Clara, Jellett, Lisa, Kuhl, Nadine, Lévesque, François, McMullen, Jonathan P., Patel, Pratiq A., Paulines, Mellie June, Ren, Hong, Rodrigues, Vailankanni L., Ruccolo, Serge, Tan, Lushi, Thaisrivongs, David A., Xiao, Kai-Jiong
Published in Organic process research & development (17.05.2024)
Published in Organic process research & development (17.05.2024)
Get full text
Journal Article
Single-Molecule Imaging of Platinum Ligand Exchange Reaction Reveals Reactivity Distribution
Esfandiari, N. Melody, Wang, Yong, Bass, Jonathan Y, Cornell, Trevor P, Otte, Douglas A. L, Cheng, Ming H, Hemminger, John C, McIntire, Theresa M, Mandelshtam, Vladimir A, Blum, Suzanne A
Published in Journal of the American Chemical Society (03.11.2010)
Published in Journal of the American Chemical Society (03.11.2010)
Get full text
Journal Article
13C NMR Spectroscopy for the Quantitative Determination of Compound Ratios and Polymer End Groups
Otte, Douglas A. L, Borchmann, Dorothee E, Lin, Chin, Weck, Marcus, Woerpel, K. A
Published in Organic letters (21.03.2014)
Published in Organic letters (21.03.2014)
Get full text
Journal Article
A new chemical tool for exploring the physiological function of the PDE2 isozyme
Chambers, Robert J., Abrams, Kristin, Garceau, Norman Y., Kamath, Ajith V., Manley, Christopher M., Lilley, Susan C., Otte, Douglas A., Scott, Dennis O., Sheils, Alissa L., Tess, David A., Vellekoop, A. Samuel, Zhang, Yan, Lam, Kelvin T.
Published in Bioorganic & medicinal chemistry letters (15.01.2006)
Published in Bioorganic & medicinal chemistry letters (15.01.2006)
Get full text
Journal Article
Influence of Alkoxy Groups on Rates of Acetal Hydrolysis and Tosylate Solvolysis: Electrostatic Stabilization of Developing Oxocarbenium Ion Intermediates and Neighboring-Group Participation To Form Oxoniunn Ions
Garcia, Angie, Otte, Douglas A. L., Salamant, Walter A., Sanzone, Jillian R., Woerpel, K. A.
Published in Journal of organic chemistry (01.05.2015)
Published in Journal of organic chemistry (01.05.2015)
Get full text
Journal Article
13 C NMR Spectroscopy for the Quantitative Determination of Compound Ratios and Polymer End Groups
Otte, Douglas A. L., Borchmann, Dorothee E., Lin, Chin, Weck, Marcus, Woerpel, K. A.
Published in Organic letters (21.03.2014)
Published in Organic letters (21.03.2014)
Get full text
Journal Article
BTK 억제제 및 그의 중간체의 합성
CHEN YONGGANG, TAN LUSHI, KUETHE JEFFREY T, CORRY JAMES, XIAO KAIJIONG, KUHL NADINE, DI MASO MICHAEL J, LEVESQUE FRANCOIS, OTTE DOUGLAS, SIROTA ERIC, FORSTATER JACOB H, PRIER CHRISTOPHER K, SHEVLIN MICHAEL, WANG ZHIXUN, NARSIMHAN KARTHIK, LARSON REED, THAISRIVONGS DAVID A, TURNBULL BEN W. H, DESMOND RICHARD
Year of Publication 30.01.2024
Get full text
Year of Publication 30.01.2024
Patent
SYNTHESIS OF BTK INHIBITOR AND INTERMEDIATES THEREOF
KUHL, Nadine, TURNBULL, Ben, DI MASO, Michael, NARSIMHAN, Karthik, FORSTATER, Jacob, LARSON, Reed, SHEVLIN, Michael, XIAO, Kaijiong, CORRY, James, TAN, Lushi, WANG, Zhixun, LEVESQUE, Francois, OTTE, Douglas, CHEN, Yonggang, KUETHE, Jeffrey, SIROTA, Eric, THAISRIVONGS, David, PRIER, Christopher, DESMOND, Richard
Year of Publication 16.11.2023
Get full text
Year of Publication 16.11.2023
Patent
SYNTHESIS OF BTK INHIBITOR AND INTERMEDIATES THEREOF
KUHL, Nadine, TURNBULL, Ben, NARSIMHAN, Karthik, DI MASO, Michael, LARSON, Reed, FORSTATER, Jacob, SHEVLIN, Michael, XIAO, Kaijiong, CORRY, James, TAN, Lushi, WANG, Zhixun, LEVESQUE, Francois, OTTE, Douglas, CHEN, Yonggang, KUETHE, Jeffrey, SIROTA, Eric, THAISRIVONGS, David, PRIER, Christopher, DESMOND, Richard
Year of Publication 09.11.2023
Get full text
Year of Publication 09.11.2023
Patent
SYNTHESIS OF BTK INHIBITOR AND INTERMEDIATES THEREOF
Tan, Lushi, Narsimhan, Karthik, Sirota, Eric, Corry, James, Otte, Douglas, Xiao, Kaijiong, Kuhl, Nadine, Thaisrivongs, David A, Chen, Yonggang, Larson, Reed, Kuethe, Jeffrey T, Shevlin, Michael, Forstater, Jacob H, Levesque, Francois, Prier, Christopher K, Desmond, Richard, Di Maso, Michael J, Wang, Zhixun, Turnbull, Ben W. H
Year of Publication 08.08.2024
Get full text
Year of Publication 08.08.2024
Patent
SYNTHESIS OF BTK INHIBITOR AND INTERMEDIATES THEREOF
KUHL, Nadine, NARSIMHAN, Karthik, LARSON, Reed, TURNBULL, Ben, W. H, FORSTATER, Jacob, H, KUETHE, Jeffrey, T, SHEVLIN, Michael, XIAO, Kaijiong, DI MASO, Michael, J, CORRY, James, PRIER, Christopher, K, TAN, Lushi, WANG, Zhixun, LEVESQUE, Francois, OTTE, Douglas, CHEN, Yonggang, SIROTA, Eric, DESMOND, Richard, THAISRIVONGS, David, A
Year of Publication 10.04.2024
Get full text
Year of Publication 10.04.2024
Patent