Discovery of Novel Steroid-Based Histamine H3 Receptor Antagonists/Inverse Agonists
Ledneczki, István, Tapolcsányi, Pál, Gábor, Eszter, Éles, János, Barabás, Júlia, Béni, Zoltán, Varga, Balázs, Balázs, Ottilia, Román, Viktor, Fodor, László, Szikra, Judit, Vastag, Mónika, Lévay, György, Schmidt, Éva, Lendvai, Balázs, Greiner, István, Kiss, Béla, Némethy, Zsolt, Mahó, Sándor
Published in Journal of medicinal chemistry (14.03.2024)
Published in Journal of medicinal chemistry (14.03.2024)
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Journal Article
Optimization of Novel α7 Nicotinic Acetylcholine Receptor Positive Allosteric Modulators and the Discovery of a Preclinical Development Candidate Molecule (RGH-560)
Ledneczki, István, Némethy, Zsolt, Molnár, Katalin Dudásné, Tapolcsányi, Pál, Ilkei, Viktor, Vágó, István, Kolok, Sándor, Thán, Márta, Laszy, Judit, Balázs, Ottilia, Krámos, Balázs, Szigetvári, Áron, Bata, Imre, Makó, Attila, Visegrády, András, Fodor, László, Vastag, Mónika, Lévay, György, Lendvai, Balázs, Greiner, István, Éles, János
Published in Journal of medicinal chemistry (14.12.2023)
Published in Journal of medicinal chemistry (14.12.2023)
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Journal Article
Cariprazine modulates sleep architecture in rats
Nyitrai, Gabriella, Kiss, Béla, Farkas, Bence, Balázs, Ottilia, Diószegi, Pálma, Lendvai, Balázs, Czurkó, András
Published in Journal of psychopharmacology (Oxford) (01.03.2021)
Published in Journal of psychopharmacology (Oxford) (01.03.2021)
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Journal Article
Discovery and Preclinical Characterization of 3‑((4-(4-Chlorophenyl)-7-fluoroquinoline-3-yl)sulfonyl)benzonitrile, a Novel Non-acetylenic Metabotropic Glutamate Receptor 5 (mGluR5) Negative Allosteric Modulator for Psychiatric Indications
Galambos, János, Bielik, Attila, Krasavin, Mikhail, Orgován, Zoltán, Domány, György, Nógrádi, Katalin, Wágner, Gábor, Balogh, György T, Béni, Zoltán, Kóti, János, Szakács, Zoltán, Bobok, Amrita, Kolok, Sándor, Mikó-Bakk, Mónika L, Vastag, Mónika, Sághy, Katalin, Laszy, Judit, Halász, Attila Sándor, Balázs, Ottilia, Gál, Krisztina, Greiner, István, Szombathelyi, Zsolt, Keserű, György M
Published in Journal of medicinal chemistry (23.03.2017)
Published in Journal of medicinal chemistry (23.03.2017)
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Journal Article
Convergent cross-species pro-cognitive effects of RGH-235, a new potent and selective histamine H 3 receptor antagonist/inverse agonist
Némethy, Zsolt, Kiss, Béla, Lethbridge, Natasha, Chazot, Paul, Hajnik, Tünde, Tóth, Attila, Détári, László, Schmidt, Éva, Czurkó, András, Kostyalik, Diána, Oláh, Vilmos, Hernádi, István, Balázs, Ottilia, Vizi, E Sylvester, Ledneczki, István, Mahó, Sándor, Román, Viktor, Lendvai, Balázs, Lévay, György
Published in European journal of pharmacology (05.02.2022)
Published in European journal of pharmacology (05.02.2022)
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Journal Article
Preclinical pharmacodynamic and pharmacokinetic characterization of the major metabolites of cariprazine
Kiss, Béla, Némethy, Zsolt, Fazekas, Károly, Kurkó, Dalma, Gyertyán, István, Sághy, Katalin, Laszlovszky, István, Farkas, Bence, Kirschner, Norbert, Bolf-Terjéki, Etelka, Balázs, Ottilia, Lendvai, Balázs
Published in Drug design, development and therapy (01.09.2019)
Published in Drug design, development and therapy (01.09.2019)
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Journal Article
Discovery of novel steroidal histamine H-3 receptor antagonists/inverse agonists. Part 2. Versatile steroidal carboxamide derivatives
Ledneczki, Istvan, Nemethy, Zsolt, Tapolcsanyi, Pal, Eles, Janos, Greiner, Istvan, Gabor, Eszter, Varga, Balazs, Balazs, Ottilia, Roman, Viktor, Levay, Gyorgy, Maho, Sandor
Published in Bioorganic & medicinal chemistry letters (15.10.2019)
Published in Bioorganic & medicinal chemistry letters (15.10.2019)
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Journal Article
Discovery of Novel Steroid-Based Histamine H 3 Receptor Antagonists/Inverse Agonists
Ledneczki, István, Tapolcsányi, Pál, Gábor, Eszter, Éles, János, Barabás, Júlia, Béni, Zoltán, Varga, Balázs, Balázs, Ottilia, Román, Viktor, Fodor, László, Szikra, Judit, Vastag, Mónika, Lévay, György, Schmidt, Éva, Lendvai, Balázs, Greiner, István, Kiss, Béla, Némethy, Zsolt, Mahó, Sándor
Published in Journal of medicinal chemistry (14.03.2024)
Published in Journal of medicinal chemistry (14.03.2024)
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Journal Article
Preclinical Formulation in Early Drug Research
Balazs, Ottilia
Published in Solubility, Delivery and ADME Problems of Drugs and Drug Candidates (01.09.2011)
Published in Solubility, Delivery and ADME Problems of Drugs and Drug Candidates (01.09.2011)
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Book Chapter
Discovery of novel steroidal histamine H3 receptor antagonists/inverse agonists. Part 2. Versatile steroidal carboxamide derivatives
Ledneczki, István, Némethy, Zsolt, Tapolcsányi, Pál, Éles, János, Greiner, István, Gábor, Eszter, Varga, Balázs, Balázs, Ottilia, Román, Viktor, Lévay, György, Mahó, Sándor
Published in Bioorganic & medicinal chemistry letters (15.10.2019)
Published in Bioorganic & medicinal chemistry letters (15.10.2019)
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Journal Article
Convergent cross-species pro-cognitive effects of RGH-235, a new potent and selective histamine H3 receptor antagonist/inverse agonist
Némethy, Zsolt, Kiss, Béla, Lethbridge, Natasha, Chazot, Paul, Hajnik, Tünde, Tóth, Attila, Détári, László, Schmidt, Éva, Czurkó, András, Kostyalik, Diána, Oláh, Vilmos, Hernádi, István, Balázs, Ottilia, Vizi, E. Sylvester, Ledneczki, István, Mahó, Sándor, Román, Viktor, Lendvai, Balázs, Lévay, György
Published in European journal of pharmacology (05.02.2022)
Published in European journal of pharmacology (05.02.2022)
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Journal Article
Comparison of dog and guinea pig cardiovascular telemetry
Cseko, Csongor, Komlódi, Zsolt, Makó, Éva, Balázs, Ottilia
Published in Journal of pharmacological and toxicological methods (01.09.2016)
Published in Journal of pharmacological and toxicological methods (01.09.2016)
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Journal Article
HTS-based discovery and optimization of novel positive allosteric modulators of the α7 nicotinic acetylcholine receptor
Ledneczki, István, Horváth, Anita, Tapolcsányi, Pál, Éles, János, Molnár, Katalin Dudás, Vágó, István, Visegrády, András, Kiss, László, Szigetvári, Áron, Kóti, János, Krámos, Balázs, Mahó, Sándor, Holm, Patrik, Kolok, Sándor, Fodor, László, Thán, Márta, Kostyalik, Diána, Balázs, Ottilia, Vastag, Mónika, Greiner, István, Lévay, György, Lendvai, Balázs, Némethy, Zsolt
Published in European journal of medicinal chemistry (15.10.2021)
Published in European journal of medicinal chemistry (15.10.2021)
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Journal Article
Discovery of novel positive allosteric modulators of the α7 nicotinic acetylcholine receptor: Scaffold hopping approach
Ledneczki, István, Tapolcsányi, Pál, Gábor, Eszter, Visegrády, András, Vass, Márton, Éles, János, Holm, Patrik, Horváth, Anita, Pocsai, Anikó, Mahó, Sándor, Greiner, István, Krámos, Balázs, Béni, Zoltán, Kóti, János, Káncz, Anna E., Thán, Márta, Kolok, Sándor, Laszy, Judit, Balázs, Ottilia, Bugovits, Gyula, Nagy, József, Vastag, Mónika, Szájli, Ágota, Bozó, Éva, Lévay, György, Lendvai, Balázs, Némethy, Zsolt
Published in European journal of medicinal chemistry (15.03.2021)
Published in European journal of medicinal chemistry (15.03.2021)
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Journal Article
Discovery of novel steroidal histamine H3 receptor antagonists/inverse agonists
Ledneczki, Istvan, Tapolcsányi, Pál, Gábor, Eszter, Éles, János, Greiner, István, Schmidt, Éva, Némethy, Zsolt, Kedves, Rita Soukupné, Balázs, Ottilia, Román, Viktor, Lévay, György, Mahó, Sándor
Published in Bioorganic & medicinal chemistry letters (01.10.2017)
Published in Bioorganic & medicinal chemistry letters (01.10.2017)
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Journal Article
Discovery of novel steroidal histamine H-3 receptor antagonists inverse agonists
Ledneczki, Istvan, Tapolcsanyi, Pal, Gabor, Eszter, Eles, Janos, Greiner, Istvan, Schmidt, Eva, Nemethy, Zsolt, Kedves, Rita Soukupne, Balaks, Ottilia, Roman, Viktor, Levay, Gyorgy, Maho, Sandor
Published in Bioorganic & medicinal chemistry letters (01.10.2017)
Published in Bioorganic & medicinal chemistry letters (01.10.2017)
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Journal Article
H3 ANTAGONISTS CONTAINING PHENOXYPIPERIDINE CORE STRUCTURE
BARTÁNÉ SZALAI, GIZELLA, SCHMIDT, ÉVA, KISS, BÉLA, WÁGNER, GÁBOR ANDRÁS, NAGY, NOÉMI, BALÁZS, OTTÍLIA
Year of Publication 31.12.2018
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Year of Publication 31.12.2018
Patent
H3 ANTAGONISTS CONTAINING PHENOXYPIPERIDINE CORE STRUCTURE
Schmidt, Éva, Wágner, Gábor András, Balázs, Ottília, Bartáné Szalai, Gizella, Nagy, Noémi, Kiss, Béla
Year of Publication 28.12.2018
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Year of Publication 28.12.2018
Patent
H3 ANTAGONISTS CONTAINING PHENOXYPIPERIDINE CORE STRUCTURE
WÁGNER, GÁBOR, ANDRÁS, SCHMIDT, ÉVA, KISS, BÉLA, BARTÁNÉ, SZALAI, GIZELLA, NAGY, NOÉMI, BALÁZS, OTTÍLIA
Year of Publication 30.11.2018
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Year of Publication 30.11.2018
Patent
H3-ANTAGONISTER INDEHOLDENDE PHENOXYPIPERIDIN KERNESTRUKTUR
SCHMIDT, Éva, KISS, Béla, BALÁZS, Ottília, BARTÁNÉ SZALAI, Gizella, WÁGNER, Gábor András, NAGY, Noémi
Year of Publication 12.11.2018
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Year of Publication 12.11.2018
Patent