The immune landscape of common CNS malignancies: implications for immunotherapy
Ott, Martina, Prins, Robert M., Heimberger, Amy B.
Published in Nature reviews. Clinical oncology (01.11.2021)
Published in Nature reviews. Clinical oncology (01.11.2021)
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Journal Article
Osteopontin mediates glioblastoma-associated macrophage infiltration and is a potential therapeutic target
Wei, Jun, Marisetty, Anantha, Schrand, Brett, Gabrusiewicz, Konrad, Hashimoto, Yuuri, Ott, Martina, Grami, Zacharia, Kong, Ling-Yuan, Ling, Xiaoyang, Caruso, Hillary, Zhou, Shouhao, Wang, Y Alan, Fuller, Gregory N, Huse, Jason, Gilboa, Eli, Kang, Nannan, Huang, Xingxu, Verhaak, Roel, Li, Shulin, Heimberger, Amy B
Published in The Journal of clinical investigation (01.01.2019)
Published in The Journal of clinical investigation (01.01.2019)
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Journal Article
Mutational burden, immune checkpoint expression, and mismatch repair in glioma: implications for immune checkpoint immunotherapy
Hodges, Tiffany R, Ott, Martina, Xiu, Joanne, Gatalica, Zoran, Swensen, Jeff, Zhou, Shouhao, Huse, Jason T, de Groot, John, Li, Shulin, Overwijk, Willem W, Spetzler, David, Heimberger, Amy B
Published in Neuro-oncology (Charlottesville, Va.) (01.08.2017)
Published in Neuro-oncology (Charlottesville, Va.) (01.08.2017)
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Journal Article
Immune profiling of human tumors identifies CD73 as a combinatorial target in glioblastoma
Goswami, Sangeeta, Walle, Thomas, Cornish, Andrew E., Basu, Sreyashi, Anandhan, Swetha, Fernandez, Irina, Vence, Luis, Blando, Jorge, Zhao, Hao, Yadav, Shalini Singh, Ott, Martina, Kong, Ling Y., Heimberger, Amy B., de Groot, John, Sepesi, Boris, Overman, Michael, Kopetz, Scott, Allison, James P., Pe’er, Dana, Sharma, Padmanee
Published in Nature medicine (01.01.2020)
Published in Nature medicine (01.01.2020)
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Journal Article
FGL2 promotes tumor progression in the CNS by suppressing CD103+ dendritic cell differentiation
Yan, Jun, Zhao, Qingnan, Gabrusiewicz, Konrad, Kong, Ling-Yuan, Xia, Xueqing, Wang, Jian, Ott, Martina, Xu, Jingda, Davis, R. Eric, Huo, Longfei, Rao, Ganesh, Sun, Shao-Cong, Watowich, Stephanie S., Heimberger, Amy B., Li, Shulin
Published in Nature communications (25.01.2019)
Published in Nature communications (25.01.2019)
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Journal Article
Intratumoral Delivery of STING Agonist Results in Clinical Responses in Canine Glioblastoma
Boudreau, C Elizabeth, Najem, Hinda, Ott, Martina, Horbinski, Craig, Fang, Dexing, DeRay, Chase M, Levine, Jonathan M, Curran, Michael A, Heimberger, Amy B
Published in Clinical cancer research (15.10.2021)
Published in Clinical cancer research (15.10.2021)
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Journal Article
Pan-mutant IDH1 inhibitor BAY 1436032 for effective treatment of IDH1 mutant astrocytoma in vivo
Pusch, Stefan, Krausert, Sonja, Fischer, Viktoria, Balss, Jörg, Ott, Martina, Schrimpf, Daniel, Capper, David, Sahm, Felix, Eisel, Jessica, Beck, Ann-Christin, Jugold, Manfred, Eichwald, Viktoria, Kaulfuss, Stefan, Panknin, Olaf, Rehwinkel, Hartmut, Zimmermann, Katja, Hillig, Roman C., Guenther, Judith, Toschi, Luisella, Neuhaus, Roland, Haegebart, Andrea, Hess-Stumpp, Holger, Bauser, Markus, Wick, Wolfgang, Unterberg, Andreas, Herold-Mende, Christel, Platten, Michael, von Deimling, Andreas
Published in Acta neuropathologica (01.04.2017)
Published in Acta neuropathologica (01.04.2017)
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Journal Article
Constitutive IDO expression in human cancer is sustained by an autocrine signaling loop involving IL-6, STAT3 and the AHR
Litzenburger, Ulrike M, Opitz, Christiane A, Sahm, Felix, Rauschenbach, Katharina J, Trump, Saskia, Winter, Marcus, Ott, Martina, Ochs, Katharina, Lutz, Christian, Liu, Xiangdong, Anastasov, Natasa, Lehmann, Irina, Höfer, Thomas, von Deimling, Andreas, Wick, Wolfgang, Platten, Michael
Published in Oncotarget (28.02.2014)
Published in Oncotarget (28.02.2014)
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Journal Article
Author Correction: Hypomorphic Brca2 and Rad51c double mutant mice display Fanconi anemia, cancer and polygenic replication stress
Tomaszowski, Karl-Heinz, Roy, Sunetra, Guerrero, Carolina, Shukla, Poojan, Keshvani, Caezaan, Chen, Yue, Ott, Martina, Wu, Xiaogang, Zhang, Jianhua, DiNardo, Courtney D., Schindler, Detlev, Schlacher, Katharina
Published in Nature communications (12.03.2024)
Published in Nature communications (12.03.2024)
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Journal Article
Hypomorphic Brca2 and Rad51c double mutant mice display Fanconi anemia, cancer and polygenic replication stress
Tomaszowski, Karl-Heinz, Roy, Sunetra, Guerrero, Carolina, Shukla, Poojan, Keshvani, Caezaan, Chen, Yue, Ott, Martina, Wu, Xiaogang, Zhang, Jianhua, DiNardo, Courtney D., Schindler, Detlev, Schlacher, Katharina
Published in Nature communications (11.03.2023)
Published in Nature communications (11.03.2023)
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Journal Article
K27M-mutant histone-3 as a novel target for glioma immunotherapy
Ochs, Katharina, Ott, Martina, Bunse, Theresa, Sahm, Felix, Bunse, Lukas, Deumelandt, Katrin, Sonner, Jana K., Keil, Melanie, von Deimling, Andreas, Wick, Wolfgang, Platten, Michael
Published in Oncoimmunology (12.05.2017)
Published in Oncoimmunology (12.05.2017)
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Journal Article
Pre-treatment with the viral Toll-like receptor 3 agonist poly(I:C) modulates innate immunity and protects neutropenic mice infected intracerebrally with Escherichia coli
Ribes, Sandra, Arcilla, Christa, Ott, Martina, Schütze, Sandra, Hanisch, Uwe-Karsten, Nessler, Stefan, Nau, Roland
Published in Journal of neuroinflammation (17.01.2020)
Published in Journal of neuroinflammation (17.01.2020)
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Journal Article
Tryptophan‐2,3‐dioxygenase is regulated by prostaglandin E2 in malignant glioma via a positive signaling loop involving prostaglandin E receptor‐4
Ochs, Katharina, Ott, Martina, Rauschenbach, Katharina J., Deumelandt, Katrin, Sahm, Felix, Opitz, Christiane A., Deimling, Andreas, Wick, Wolfgang, Platten, Michael
Published in Journal of neurochemistry (01.03.2016)
Published in Journal of neurochemistry (01.03.2016)
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Journal Article
Fourier Transform Infrared Microscopy Enables Guidance of Automated Mass Spectrometry Imaging to Predefined Tissue Morphologies
Rabe, Jan-Hinrich, A. Sammour, Denis, Schulz, Sandra, Munteanu, Bogdan, Ott, Martina, Ochs, Katharina, Hohenberger, Peter, Marx, Alexander, Platten, Michael, Opitz, Christiane A., Ory, Daniel S., Hopf, Carsten
Published in Scientific reports (10.01.2018)
Published in Scientific reports (10.01.2018)
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Journal Article
Cell-directed aptamer therapeutic targeting for cancers including those within the central nervous system
Wei, Jun, Song, Renduo, Sabbagh, Aria, Marisetty, Anantha, Shukla, Neal, Fang, Dexing, Najem, Hinda, Ott, Martina, Long, James, Zhai, Lijie, Lesniak, Maciej S., James, Charles David, Platanias, Leonidas, Curran, Michael, Heimberger, Amy B.
Published in Oncoimmunology (31.12.2022)
Published in Oncoimmunology (31.12.2022)
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Journal Article
Laquinimod, a prototypic quinoline-3-carboxamide and aryl hydrocarbon receptor agonist, utilizes a CD155-mediated natural killer/dendritic cell interaction to suppress CNS autoimmunity
Ott, Martina, Avendaño-Guzmán, Erika, Ullrich, Evelyn, Dreyer, Carolin, Strauss, Judith, Harden, Markus, Schön, Margarete, Schön, Michael P, Bernhardt, Günter, Stadelmann, Christine, Wegner, Christiane, Brück, Wolfgang, Nessler, Stefan
Published in Journal of neuroinflammation (26.02.2019)
Published in Journal of neuroinflammation (26.02.2019)
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Journal Article
Profiling of patients with glioma reveals the dominant immunosuppressive axis is refractory to immune function restoration
Ott, Martina, Tomaszowski, Karl-Heinz, Marisetty, Anantha, Kong, Ling-Yuan, Wei, Jun, Duna, Maya, Blumberg, Katia, Ji, Xiaorong, Jacobs, Carmen, Fuller, Gregory N, Langford, Lauren A, Huse, Jason T, Long, James P, Hu, Jian, Li, Shulin, Weinberg, Jeffrey S, Prabhu, Sujit S, Sawaya, Raymond, Ferguson, Sherise, Rao, Ganesh, Lang, Frederick F, Curran, Michael A, Heimberger, Amy B
Published in JCI insight (03.09.2020)
Published in JCI insight (03.09.2020)
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Journal Article
A first-in-human Phase I trial of the oral p-STAT3 inhibitor WP1066 in patients with recurrent malignant glioma
Groot, John de, Ott, Martina, Wei, Jun, Kassab, Cynthia, Fang, Dexing, Najem, Hinda, O'Brien, Barbara, Weathers, Shiao-Pei, Matsouka, Carlos Kamiya, Majd, Nazanin K, Harrison, Rebecca A, Fuller, Gregory N, Huse, Jason T, Long, James P, Sawaya, Raymond, Rao, Ganesh, MacDonald, Tobey J, Priebe, Waldemar, DeCuypere, Michael, Heimberger, Amy B
Published in CNS oncology (01.06.2022)
Published in CNS oncology (01.06.2022)
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Journal Article
Promotion of glioblastoma cell motility by enhancer of zeste homolog 2 (EZH2) is mediated by AXL receptor kinase
Ott, Martina, Litzenburger, Ulrike M, Sahm, Felix, Rauschenbach, Katharina J, Tudoran, Ruxandra, Hartmann, Christian, Marquez, Victor E, von Deimling, Andreas, Wick, Wolfgang, Platten, Michael
Published in PloS one (15.10.2012)
Published in PloS one (15.10.2012)
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Protein kinase Cβ as a therapeutic target stabilizing blood–brain barrier disruption in experimental autoimmune encephalomyelitis
Lanz, Tobias V., Becker, Simon, Osswald, Matthias, Bittner, Stefan, Schuhmann, Michael K., Opitz, Christiane A., Gaikwad, Sadanand, Wiestler, Benedikt, Litzenburger, Ulrike M., Sahm, Felix, Ott, Martina, Iwantscheff, Simeon, Grabitz, Carl, Mittelbronn, Michel, von Deimling, Andreas, Winkler, Frank, Meuth, Sven G., Wick, Wolfgang, Platten, Michael
Published in Proceedings of the National Academy of Sciences - PNAS (03.09.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (03.09.2013)
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