The Myeloma Drug Lenalidomide Promotes the Cereblon-Dependent Destruction of Ikaros Proteins
Lu, Gang, Middleton, Richard E., Sun, Huahang, Naniong, MarkVic, Ott, Christopher J., Mitsiades, Constantine S., Wong, Kwok-Kin, Bradner, James E., Kaelin, William G.
Published in Science (American Association for the Advancement of Science) (17.01.2014)
Published in Science (American Association for the Advancement of Science) (17.01.2014)
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Journal Article
Targeted degradation of the enhancer lysine acetyltransferases CBP and p300
Vannam, Raghu, Sayilgan, Jan, Ojeda, Samuel, Karakyriakou, Barbara, Hu, Eileen, Kreuzer, Johannes, Morris, Robert, Herrera Lopez, Xcanda Ixchel, Rai, Sumit, Haas, Wilhelm, Lawrence, Michael, Ott, Christopher J.
Published in Cell chemical biology (15.04.2021)
Published in Cell chemical biology (15.04.2021)
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Journal Article
BET Bromodomain Proteins Function as Master Transcription Elongation Factors Independent of CDK9 Recruitment
Winter, Georg E., Mayer, Andreas, Buckley, Dennis L., Erb, Michael A., Roderick, Justine E., Vittori, Sarah, Reyes, Jaime M., di Iulio, Julia, Souza, Amanda, Ott, Christopher J., Roberts, Justin M., Zeid, Rhamy, Scott, Thomas G., Paulk, Joshiawa, Lachance, Kate, Olson, Calla M., Dastjerdi, Shiva, Bauer, Sophie, Lin, Charles Y., Gray, Nathanael S., Kelliher, Michelle A., Churchman, L. Stirling, Bradner, James E.
Published in Molecular cell (06.07.2017)
Published in Molecular cell (06.07.2017)
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A chemical probe toolbox for dissecting the cancer epigenome
Shortt, Jake, Ott, Christopher J., Johnstone, Ricky W., Bradner, James E.
Published in Nature reviews. Cancer (01.03.2017)
Published in Nature reviews. Cancer (01.03.2017)
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Journal Article
BET bromodomain inhibition targets both c-Myc and IL7R in high-risk acute lymphoblastic leukemia
Ott, Christopher J., Kopp, Nadja, Bird, Liat, Paranal, Ronald M., Qi, Jun, Bowman, Teresa, Rodig, Scott J., Kung, Andrew L., Bradner, James E., Weinstock, David M.
Published in Blood (04.10.2012)
Published in Blood (04.10.2012)
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Enhancer Architecture and Essential Core Regulatory Circuitry of Chronic Lymphocytic Leukemia
Ott, Christopher J., Federation, Alexander J., Schwartz, Logan S., Kasar, Siddha, Klitgaard, Josephine L., Lenci, Romina, Li, Qiyuan, Lawlor, Matthew, Fernandes, Stacey M., Souza, Amanda, Polaski, Donald, Gadi, Deepti, Freedman, Matthew L., Brown, Jennifer R., Bradner, James E.
Published in Cancer cell (10.12.2018)
Published in Cancer cell (10.12.2018)
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BET-Bromodomain Inhibitors Engage the Host Immune System and Regulate Expression of the Immune Checkpoint Ligand PD-L1
Hogg, Simon J., Vervoort, Stephin J., Deswal, Sumit, Ott, Christopher J., Li, Jason, Cluse, Leonie A., Beavis, Paul A., Darcy, Phillip K., Martin, Benjamin P., Spencer, Andrew, Traunbauer, Anna K., Sadovnik, Irina, Bauer, Karin, Valent, Peter, Bradner, James E., Zuber, Johannes, Shortt, Jake, Johnstone, Ricky W.
Published in Cell reports (Cambridge) (28.02.2017)
Published in Cell reports (Cambridge) (28.02.2017)
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Cohesin Members Stag1 and Stag2 Display Distinct Roles in Chromatin Accessibility and Topological Control of HSC Self-Renewal and Differentiation
Viny, Aaron D., Bowman, Robert L., Liu, Yu, Lavallée, Vincent-Philippe, Eisman, Shira E., Xiao, Wenbin, Durham, Benjamin H., Navitski, Anastasia, Park, Jane, Braunstein, Stephanie, Alija, Besmira, Karzai, Abdul, Csete, Isabelle S., Witkin, Matthew, Azizi, Elham, Baslan, Timour, Ott, Christopher J., Pe’er, Dana, Dekker, Job, Koche, Richard, Levine, Ross L.
Published in Cell stem cell (07.11.2019)
Published in Cell stem cell (07.11.2019)
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Spiclypeus shipporum gen. et sp. nov., a Boldly Audacious New Chasmosaurine Ceratopsid (Dinosauria: Ornithischia) from the Judith River Formation (Upper Cretaceous: Campanian) of Montana, USA
Mallon, Jordan C, Ott, Christopher J, Larson, Peter L, Iuliano, Edward M, Evans, David C
Published in PloS one (18.05.2016)
Published in PloS one (18.05.2016)
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Journal Article
Dose-dependent role of the cohesin complex in normal and malignant hematopoiesis
Viny, Aaron D, Ott, Christopher J, Spitzer, Barbara, Rivas, Martin, Meydan, Cem, Papalexi, Efthymia, Yelin, Dana, Shank, Kaitlyn, Reyes, Jaime, Chiu, April, Romin, Yevgeniy, Boyko, Vitaly, Thota, Swapna, Maciejewski, Jaroslaw P, Melnick, Ari, Bradner, James E, Levine, Ross L
Published in The Journal of experimental medicine (19.10.2015)
Published in The Journal of experimental medicine (19.10.2015)
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Journal Article
Functional TRIM24 degrader via conjugation of ineffectual bromodomain and VHL ligands
Gechijian, Lara N., Buckley, Dennis L., Lawlor, Matthew A., Reyes, Jaime M., Paulk, Joshiawa, Ott, Christopher J., Winter, Georg E., Erb, Michael A., Scott, Thomas G., Xu, Mousheng, Seo, Hyuk-Soo, Dhe-Paganon, Sirano, Kwiatkowski, Nicholas P., Perry, Jennifer A., Qi, Jun, Gray, Nathanael S., Bradner, James E.
Published in Nature chemical biology (01.04.2018)
Published in Nature chemical biology (01.04.2018)
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A hotspot mutation in transcription factor IKZF3 drives B cell neoplasia via transcriptional dysregulation
Lazarian, Gregory, Yin, Shanye, ten Hacken, Elisa, Sewastianik, Tomasz, Uduman, Mohamed, Font-Tello, Alba, Gohil, Satyen H., Li, Shuqiang, Kim, Ekaterina, Joyal, Heather, Billington, Leah, Witten, Elizabeth, Zheng, Mei, Huang, Teddy, Severgnini, Mariano, Lefebvre, Valerie, Rassenti, Laura Z., Gutierrez, Catherine, Georgopoulos, Katia, Ott, Christopher J., Wang, Lili, Kipps, Thomas J., Burger, Jan A., Livak, Kenneth J., Neuberg, Donna S., Baran-Marszak, Fanny, Cymbalista, Florence, Carrasco, Ruben D., Wu, Catherine J.
Published in Cancer cell (08.03.2021)
Published in Cancer cell (08.03.2021)
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An epigenetic mechanism of resistance to targeted therapy in T cell acute lymphoblastic leukemia
Knoechel, Birgit, Roderick, Justine E, Williamson, Kaylyn E, Zhu, Jiang, Lohr, Jens G, Cotton, Matthew J, Gillespie, Shawn M, Fernandez, Daniel, Ku, Manching, Wang, Hongfang, Piccioni, Federica, Silver, Serena J, Jain, Mohit, Pearson, Daniel, Kluk, Michael J, Ott, Christopher J, Shultz, Leonard D, Brehm, Michael A, Greiner, Dale L, Gutierrez, Alejandro, Stegmaier, Kimberly, Kung, Andrew L, Root, David E, Bradner, James E, Aster, Jon C, Kelliher, Michelle A, Bernstein, Bradley E
Published in Nature genetics (01.04.2014)
Published in Nature genetics (01.04.2014)
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Journal Article
Therapy-induced APOBEC3A drives evolution of persistent cancer cells
Isozaki, Hideko, Sakhtemani, Ramin, Abbasi, Ammal, Nikpour, Naveed, Stanzione, Marcello, Oh, Sunwoo, Langenbucher, Adam, Monroe, Susanna, Su, Wenjia, Cabanos, Heidie Frisco, Siddiqui, Faria M., Phan, Nicole, Jalili, Pégah, Timonina, Daria, Bilton, Samantha, Gomez-Caraballo, Maria, Archibald, Hannah L., Nangia, Varuna, Dionne, Kristin, Riley, Amanda, Lawlor, Matthew, Banwait, Mandeep Kaur, Cobb, Rosemary G., Zou, Lee, Dyson, Nicholas J., Ott, Christopher J., Benes, Cyril, Getz, Gad, Chan, Chang S., Shaw, Alice T., Gainor, Justin F., Lin, Jessica J., Sequist, Lecia V., Piotrowska, Zofia, Yeap, Beow Y., Engelman, Jeffrey A., Lee, Jake June-Koo, Maruvka, Yosef E., Buisson, Rémi, Lawrence, Michael S., Hata, Aaron N.
Published in Nature (London) (10.08.2023)
Published in Nature (London) (10.08.2023)
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Journal Article
BET bromodomain protein inhibition reverses chimeric antigen receptor extinction and reinvigorates exhausted T cells in chronic lymphocytic leukemia
Kong, Weimin, Dimitri, Alexander, Wang, Wenliang, Jung, In-Young, Ott, Christopher J, Fasolino, Maria, Wang, Yan, Kulikovskaya, Irina, Gupta, Minnal, Yoder, Todd, DeNizio, Jamie E, Everett, John K, Williams, Erik F, Xu, Jun, Scholler, John, Reich, Tyler J, Bhoj, Vijay G, Haines, Kathleen M, Maus, Marcela V, Melenhorst, J. Joseph, Young, Regina M, Jadlowsky, Julie K, Marcucci, Katherine T, Bradner, James E, Levine, Bruce L, Porter, David L, Bushman, Frederic D, Kohli, Rahul M, June, Carl H, Davis, Megan M, Lacey, Simon F, Vahedi, Golnaz, Fraietta, Joseph A
Published in The Journal of clinical investigation (15.08.2021)
Published in The Journal of clinical investigation (15.08.2021)
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Journal Article
Acetyl-CoA biosynthesis drives resistance to histone acetyltransferase inhibition
Bishop, Timothy R., Subramanian, Chitra, Bilotta, Eric M., Garnar-Wortzel, Leopold, Ramos, Anissa R., Zhang, Yuxiang, Asiaban, Joshua N., Ott, Christopher J., Rock, Charles O., Erb, Michael A.
Published in Nature chemical biology (01.10.2023)
Published in Nature chemical biology (01.10.2023)
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Journal Article
Collateral lethality between HDAC1 and HDAC2 exploits cancer-specific NuRD complex vulnerabilities
Zhang, Yuxiang, Remillard, David, Onubogu, Ugoma, Karakyriakou, Barbara, Asiaban, Joshua N., Ramos, Anissa R., Bowland, Kirsten, Bishop, Timothy R., Barta, Paige A., Nance, Stephanie, Durbin, Adam D., Ott, Christopher J., Janiszewska, Michalina, Cravatt, Benjamin F., Erb, Michael A.
Published in Nature structural & molecular biology (01.08.2023)
Published in Nature structural & molecular biology (01.08.2023)
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Journal Article
Epigenetic regulation of NFE2 overexpression in myeloproliferative neoplasms
Peeken, Jan C., Jutzi, Jonas S., Wehrle, Julius, Koellerer, Christoph, Staehle, Hans F., Becker, Heiko, Schoenwandt, Elias, Seeger, Thalia S., Schanne, Daniel H., Gothwal, Monika, Ott, Christopher J., Gründer, Albert, Pahl, Heike L.
Published in Blood (03.05.2018)
Published in Blood (03.05.2018)
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