Early antiretroviral therapy limits SIV reservoir establishment to delay or prevent post-treatment viral rebound
Okoye, Afam A, Hansen, Scott G, Vaidya, Mukta, Fukazawa, Yoshinori, Park, Haesun, Duell, Derick M, Lum, Richard, Hughes, Colette M, Ventura, Abigail B, Ainslie, Emily, Ford, Julia C, Morrow, David, Gilbride, Roxanne M, Legasse, Alfred W, Hesselgesser, Joseph, Geleziunas, Romas, Li, Yuan, Oswald, Kelli, Shoemaker, Rebecca, Fast, Randy, Bosche, William J, Borate, Bhavesh R, Edlefsen, Paul T, Axthelm, Michael K, Picker, Louis J, Lifson, Jeffrey D
Published in Nature medicine (01.09.2018)
Published in Nature medicine (01.09.2018)
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A live-attenuated RhCMV/SIV vaccine shows long-term efficacy against heterologous SIV challenge
Hansen, Scott G, Marshall, Emily E, Malouli, Daniel, Ventura, Abigail B, Hughes, Colette M, Ainslie, Emily, Ford, Julia C, Morrow, David, Gilbride, Roxanne M, Bae, Jin Y, Legasse, Alfred W, Oswald, Kelli, Shoemaker, Rebecca, Berkemeier, Brian, Bosche, William J, Hull, Michael, Womack, Jennie, Shao, Jason, Edlefsen, Paul T, Reed, Jason S, Burwitz, Ben J, Sacha, Jonah B, Axthelm, Michael K, Früh, Klaus, Lifson, Jeffrey D, Picker, Louis J
Published in Science translational medicine (17.07.2019)
Published in Science translational medicine (17.07.2019)
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Genetically-barcoded SIV facilitates enumeration of rebound variants and estimation of reactivation rates in nonhuman primates following interruption of suppressive antiretroviral therapy
Fennessey, Christine M, Pinkevych, Mykola, Immonen, Taina T, Reynaldi, Arnold, Venturi, Vanessa, Nadella, Priyanka, Reid, Carolyn, Newman, Laura, Lipkey, Leslie, Oswald, Kelli, Bosche, William J, Trivett, Matthew T, Ohlen, Claes, Ott, David E, Estes, Jacob D, Del Prete, Gregory Q, Lifson, Jeffrey D, Davenport, Miles P, Keele, Brandon F
Published in PLoS pathogens (04.05.2017)
Published in PLoS pathogens (04.05.2017)
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Impact of alemtuzumab-mediated lymphocyte depletion on SIV reservoir establishment and persistence
Varco-Merth, Benjamin, Chaunzwa, Morgan, Duell, Derick M, Marenco, Alejandra, Goodwin, William, Dannay, Rachel, Nekorchuk, Michael, Shao, Danica, Busman-Sahay, Kathleen, Fennessey, Christine M, Silipino, Lorna, Hull, Michael, Bosche, William J, Fast, Randy, Oswald, Kelli, Shoemaker, Rebecca, Bochart, Rachele, MacAllister, Rhonda, Labriola, Caralyn S, Smedley, Jeremy V, Axthelm, Michael K, Davenport, Miles P, Edlefsen, Paul T, Estes, Jacob D, Keele, Brandon F, Lifson, Jeffrey D, Lewin, Sharon R, Picker, Louis J, Okoye, Afam A
Published in PLoS pathogens (22.08.2024)
Published in PLoS pathogens (22.08.2024)
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Interleukin-15 response signature predicts RhCMV/SIV vaccine efficacy
Barrenäs, Fredrik, Hansen, Scott G, Law, Lynn, Driscoll, Connor, Green, Richard R, Smith, Elise, Chang, Jean, Golez, Inah, Urion, Taryn, Peng, Xinxia, Whitmore, Leanne, Newhouse, Daniel, Hughes, Colette M, Morrow, David, Randall, Kurt T, Selseth, Andrea N, Ford, Julia C, Gilbride, Roxanne M, Randall, Bryan E, Ainslie, Emily, Oswald, Kelli, Shoemaker, Rebecca, Fast, Randy, Bosche, William J, Axthelm, Michael K, Fukazawa, Yoshinori, Pavlakis, George N, Felber, Barbara K, Fourati, Slim, Sekaly, Rafick-Pierre, Lifson, Jeffrey D, Komorowski, Jan, Kosmider, Ewelina, Shao, Danica, Song, Wenjun, Edlefsen, Paul T, Picker, Louis J, Gale, Michael
Published in PLoS pathogens (06.07.2021)
Published in PLoS pathogens (06.07.2021)
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Comparative Characterization of Transfection- and Infection-Derived Simian Immunodeficiency Virus Challenge Stocks for In Vivo Nonhuman Primate Studies
Del Prete, Gregory Q, Scarlotta, Matthew, Newman, Laura, Reid, Carolyn, Parodi, Laura M, Roser, James D, Oswald, Kelli, Marx, Preston A, Miller, Christopher J, Desrosiers, Ronald C, Barouch, Dan H, Pal, Ranajit, Piatak, Jr, Michael, Chertova, Elena, Giavedoni, Luis D, O'Connor, David H, Lifson, Jeffrey D, Keele, Brandon F
Published in Journal of Virology (01.04.2013)
Published in Journal of Virology (01.04.2013)
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Gleevec-mediated inhibition of Rad51 expression and enhancement of tumor cell radiosensitivity
RUSSELL, Jeffery S, BRADY, Kristin, BURGAN, William E, CERRA, Michael A, OSWALD, Kelli A, CAMPHAUSEN, Kevin, TOFILON, Philip J
Published in Cancer research (Chicago, Ill.) (01.11.2003)
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Published in Cancer research (Chicago, Ill.) (01.11.2003)
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Enhanced cell killing induced by the combination of radiation and the heat shock protein 90 inhibitor 17-allylamino-17-demethoxygeldanamycin: A multitarget approach to radiosensitization
RUSSELL, Jeffery S, BURGAN, William, OSWALD, Kelli A, CAMPHAUSEN, Kevin, TOFILON, Philip J
Published in Clinical cancer research (01.09.2003)
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Published in Clinical cancer research (01.09.2003)
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Enhanced Tumor Cell Radiosensitivity and Abrogation of G2 and S Phase Arrest by the Hsp90 Inhibitor 17-(Dimethylaminoethylamino)-17-demethoxygeldanamycin
BULL, Elizabeth E. A, DOTE, Hideaki, BRADY, Kristin J, BURGAN, William E, CARTER, Donna J, CERRA, Michael A, OSWALD, Kelli A, HOLLINGSHEAD, Melinda G, CAMPHAUSEN, Kevin, TOFILON, Philip J
Published in Clinical cancer research (01.12.2004)
Published in Clinical cancer research (01.12.2004)
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Suppression of Viremia and Evolution of Human Immunodeficiency Virus Type 1 Drug Resistance in a Macaque Model for Antiretroviral Therapy
AMBROSE, Zandrea, PALMER, Sarah, WEI SHAO, BISCHOFBERGER, Norbert, MALDARELLI, Frank, KIMATA, Jason T, MELLORS, John W, HU, Shiu-Lok, COFFIN, John M, LIFSON, Jeffrey D, KEWALRAMANI, Vineet N, BOLTZ, Valerie F, KEARNEY, Mary, LARSEN, Kay, POLACINO, Patricia, FLANARY, Leon, OSWALD, Kelli, PIATAK, Michael, SMEDLEY, Jeremy
Published in Journal of Virology (01.11.2007)
Published in Journal of Virology (01.11.2007)
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Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine
Hansen, Scott G, Ford, Julia C, Lewis, Matthew S, Ventura, Abigail B, Hughes, Colette M, Coyne-Johnson, Lia, Whizin, Nathan, Oswald, Kelli, Shoemaker, Rebecca, Swanson, Tonya, Legasse, Alfred W, Chiuchiolo, Maria J, Parks, Christopher L, Axthelm, Michael K, Nelson, Jay A, Jarvis, Michael A, Piatak, Jr, Michael, Lifson, Jeffrey D, Picker, Louis J
Published in Nature (London) (26.05.2011)
Published in Nature (London) (26.05.2011)
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Immune clearance of highly pathogenic SIV infection
Hansen, Scott G, Piatak, Jr, Michael, Ventura, Abigail B, Hughes, Colette M, Gilbride, Roxanne M, Ford, Julia C, Oswald, Kelli, Shoemaker, Rebecca, Li, Yuan, Lewis, Matthew S, Gilliam, Awbrey N, Xu, Guangwu, Whizin, Nathan, Burwitz, Benjamin J, Planer, Shannon L, Turner, John M, Legasse, Alfred W, Axthelm, Michael K, Nelson, Jay A, Früh, Klaus, Sacha, Jonah B, Estes, Jacob D, Keele, Brandon F, Edlefsen, Paul T, Lifson, Jeffrey D, Picker, Louis J
Published in Nature (London) (01.10.2013)
Published in Nature (London) (01.10.2013)
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Antibody-mediated protection against SHIV challenge includes systemic clearance of distal virus
Liu, Jinyan, Ghneim, Khader, Sok, Devin, Bosche, William J., Li, Yuan, Chipriano, Elizabeth, Berkemeier, Brian, Oswald, Kelli, Borducchi, Erica, Cabral, Crystal, Peter, Lauren, Brinkman, Amanda, Shetty, Mayuri, Jimenez, Jessica, Mondesir, Jade, Lee, Benjamin, Giglio, Patricia, Chandrashekar, Abishek, Abbink, Peter, Colantonio, Arnaud, Gittens, Courtney, Baker, Chantelle, Wagner, Wendeline, Lewis, Mark G., Li, Wenjun, Sekaly, Rafick-Pierre, Lifson, Jeffrey D., Burton, Dennis R., Barouch, Dan H.
Published in Science (American Association for the Advancement of Science) (02.09.2016)
Published in Science (American Association for the Advancement of Science) (02.09.2016)
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Effector memory T cell responses are associated with protection of rhesus monkeys from mucosal simian immunodeficiency virus challenge
Oswald, Kelli, Trubey, Charles M, Axthelm, Michael K, Jarvis, Michael A, Hansen, Scott G, Legasse, Alfred W, Nelson, Jay A, Siess, Don C, Whizin, Nathan, Coyne-Johnson, Lia, Lifson, Jeffrey D, Piatak, Michael, Picker, Louis J, Vieville, Cassandra, Drummond, Derek D
Published in Nature medicine (01.03.2009)
Published in Nature medicine (01.03.2009)
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Modulation of MHC-E transport by viral decoy ligands is required for RhCMV/SIV vaccine efficacy
Verweij, Marieke C, Hansen, Scott G, Iyer, Ravi, John, Nessy, Malouli, Daniel, Morrow, David, Scholz, Isabel, Womack, Jennie, Abdulhaqq, Shaheed, Gilbride, Roxanne M, Hughes, Colette M, Ventura, Abigail B, Ford, Julia C, Selseth, Andrea N, Oswald, Kelli, Shoemaker, Rebecca, Berkemeier, Brian, Bosche, William J, Hull, Michael, Shao, Jason, Sacha, Jonah B, Axthelm, Michael K, Edlefsen, Paul T, Lifson, Jeffrey D, Picker, Louis J, Früh, Klaus
Published in Science (American Association for the Advancement of Science) (30.04.2021)
Published in Science (American Association for the Advancement of Science) (30.04.2021)
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Early antiretroviral therapy in SIV-infected rhesus macaques reveals a multiphasic, saturable dynamic accumulation of the rebound competent viral reservoir
Brandon F. Keele, Afam A. Okoye, Christine M. Fennessey, Benjamin Varco-Merth, Taina T. Immonen, Emek Kose, Andrew Conchas, Mykola Pinkevych, Leslie Lipkey, Laura Newman, Agatha Macairan, Marjorie Bosche, William J. Bosche, Brian Berkemeier, Randy Fast, Mike Hull, Kelli Oswald, Rebecca Shoemaker, Lorna Silipino, Robert J. Gorelick, Derick Duell, Alejandra Marenco, William Brantley, Jeremy Smedley, Michael Axthelm, Miles P. Davenport, Jeffrey D. Lifson, Louis J. Picker
Published in PLoS pathogens (01.04.2024)
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Published in PLoS pathogens (01.04.2024)
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RhCMV/SIV tropism modulation programs unconventional CD8+ T cell priming and vaccine efficacy
Hancock, Meaghan, Hansen, Scott, Malouli, Daniel, Marshall, Emily, Hughes, Collette, Randall, Kurt T., Morrow, David, Ford, Julia, Gilbride, Roxanne, Selseth, Andrea, Trethewy, Renee Espinosa, Bishop, Lindsey, Oswald, Kelli, Shoemaker, Rebecca, Berkemeier, Brian, Bosche, William, Hull, Michael, Nekorchuk, Michael, Busman-Sahay, Kathleen, Estes, Jacob, Axthelm, Michael, Smedley, Jeremy, Shao, Danica, Edlefsen, Paul, Lifson, Jeffrey, Fruh, Klaus, Nelson, Jay, Picker, Louis J
Published in The Journal of immunology (1950) (01.05.2022)
Published in The Journal of immunology (1950) (01.05.2022)
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Antibody-mediated depletion of viral reservoirs is limited in SIV-infected macaques treated early with antiretroviral therapy
Swanstrom, Adrienne E, Immonen, Taina T, Oswald, Kelli, Pyle, Cathi, Thomas, James A, Bosche, William J, Silipino, Lorna, Hull, Michael, Newman, Laura, Coalter, Vicky, Wiles, Adam, Wiles, Rodney, Kiser, Jacob, Morcock, David R, Shoemaker, Rebecca, Fast, Randy, Breed, Matthew W, Kramer, Joshua, Donohue, Duncan, Malys, Tyler, Fennessey, Christine M, Trubey, Charles M, Deleage, Claire, Estes, Jacob D, Lifson, Jeffrey D, Keele, Brandon F, Del Prete, Gregory Q
Published in The Journal of clinical investigation (15.03.2021)
Published in The Journal of clinical investigation (15.03.2021)
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Lymph node T cell responses predict the efficacy of live attenuated SIV vaccines
Fukazawa, Yoshinori, Park, Haesun, Cameron, Mark J, Lefebvre, Francois, Lum, Richard, Coombes, Noel, Mahyari, Eisa, Hagen, Shoko I, Bae, Jin Young, Reyes, 3rd, Marcelo Delos, Swanson, Tonya, Legasse, Alfred W, Sylwester, Andrew, Hansen, Scott G, Smith, Andrew T, Stafova, Petra, Shoemaker, Rebecca, Li, Yuan, Oswald, Kelli, Axthelm, Michael K, McDermott, Adrian, Ferrari, Guido, Montefiori, David C, Edlefsen, Paul T, Piatak, Jr, Michael, Lifson, Jeffrey D, Sékaly, Rafick P, Picker, Louis J
Published in Nature medicine (01.11.2012)
Published in Nature medicine (01.11.2012)
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Balancing Trained Immunity with Persistent Immune Activation and the Risk of Simian Immunodeficiency Virus Infection in Infant Macaques Vaccinated with Attenuated Mycobacterium tuberculosis or Mycobacterium bovis BCG Vaccine
Jensen, Kara, Dela Pena-Ponce, Myra Grace, Piatak, Jr, Michael, Shoemaker, Rebecca, Oswald, Kelli, Jacobs, Jr, William R, Fennelly, Glenn, Lucero, Carissa, Mollan, Katie R, Hudgens, Michael G, Amedee, Angela, Kozlowski, Pamela A, Estes, Jacob D, Lifson, Jeffrey D, Van Rompay, Koen K A, Larsen, Michelle, De Paris, Kristina
Published in Clinical and vaccine immunology (01.01.2017)
Published in Clinical and vaccine immunology (01.01.2017)
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