Potent, Orally Bioavailable, and Efficacious Macrocyclic Inhibitors of Factor XIa. Discovery of Pyridine-Based Macrocycles Possessing Phenylazole Carboxamide P1 Groups
Corte, James R, Pinto, Donald J. P, Fang, Tianan, Osuna, Honey, Yang, Wu, Wang, Yufeng, Lai, Amy, Clark, Charles G, Sun, Jung-Hui, Rampulla, Richard, Mathur, Arvind, Kaspady, Mahammed, Neithnadka, Premsai Rai, Li, Yi-Xin Cindy, Rossi, Karen A, Myers, Joseph E, Sheriff, Steven, Lou, Zhen, Harper, Timothy W, Huang, Christine, Zheng, Joanna J, Bozarth, Jeffrey M, Wu, Yiming, Wong, Pancras C, Crain, Earl J, Seiffert, Dietmar A, Luettgen, Joseph M, Lam, Patrick Y. S, Wexler, Ruth R, Ewing, William R
Published in Journal of medicinal chemistry (23.01.2020)
Published in Journal of medicinal chemistry (23.01.2020)
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Journal Article
Structure-Based Design of Macrocyclic Factor XIa Inhibitors: Discovery of the Macrocyclic Amide Linker
Corte, James R, Fang, Tianan, Osuna, Honey, Pinto, Donald J. P, Rossi, Karen A, Myers, Joseph E, Sheriff, Steven, Lou, Zhen, Zheng, Joanna J, Harper, Timothy W, Bozarth, Jeffrey M, Wu, Yiming, Luettgen, Joseph M, Seiffert, Dietmar A, Decicco, Carl P, Wexler, Ruth R, Quan, Mimi L
Published in Journal of medicinal chemistry (09.02.2017)
Published in Journal of medicinal chemistry (09.02.2017)
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Journal Article
Orally bioavailable amine-linked macrocyclic inhibitors of factor XIa
Fang, Tianan, Corte, James R., Gilligan, Paul J., Jeon, Yoon, Osuna, Honey, Rossi, Karen A., Myers, Joseph E., Sheriff, Steven, Lou, Zhen, Zheng, Joanna J., Harper, Timothy W., Bozarth, Jeffrey M., Wu, Yiming, Luettgen, Joseph M., Seiffert, Dietmar A., Wexler, Ruth R., Lam, Patrick Y.S.
Published in Bioorganic & medicinal chemistry letters (15.02.2020)
Published in Bioorganic & medicinal chemistry letters (15.02.2020)
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Journal Article
Macrocyclic inhibitors of Factor XIa: Discovery of alkyl-substituted macrocyclic amide linkers with improved potency
Corte, James R., Yang, Wu, Fang, Tianan, Wang, Yufeng, Osuna, Honey, Lai, Amy, Ewing, William R., Rossi, Karen A., Myers, Joseph E., Sheriff, Steven, Lou, Zhen, Zheng, Joanna J., Harper, Timothy W., Bozarth, Jeffrey M., Wu, Yiming, Luettgen, Joseph M., Seiffert, Dietmar A., Quan, Mimi L., Wexler, Ruth R., Lam, Patrick Y.S.
Published in Bioorganic & medicinal chemistry letters (15.08.2017)
Published in Bioorganic & medicinal chemistry letters (15.08.2017)
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Journal Article
Novel phenylalanine derived diamides as Factor XIa inhibitors
Smith, Leon M., Orwat, Michael J., Hu, Zilun, Han, Wei, Wang, Cailan, Rossi, Karen A., Gilligan, Paul J., Pabbisetty, Kumar B., Osuna, Honey, Corte, James R., Rendina, Alan R., Luettgen, Joseph M., Wong, Pancras C., Narayanan, Ranga, Harper, Timothy W., Bozarth, Jeffrey M., Crain, Earl J., Wei, Anzhi, Ramamurthy, Vidhyashankar, Morin, Paul E., Xin, Baomin, Zheng, Joanna, Seiffert, Dietmar A., Quan, Mimi L., Lam, Patrick Y.S., Wexler, Ruth R., Pinto, Donald J.P.
Published in Bioorganic & medicinal chemistry letters (15.01.2016)
Published in Bioorganic & medicinal chemistry letters (15.01.2016)
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Journal Article
Labeled nucleotide analogs, reaction mixtures, and methods and systems for sequencing
Brogley, Louis, Yue, Stephen, Shen, Gene, Lapin, Yuri, Fedorov, Andrei, Sebo, Lubomir, Osuna, Honey
Year of Publication 04.06.2024
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Year of Publication 04.06.2024
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LABELED NUCLEOTIDE ANALOGS, REACTION MIXTURES, AND METHODS AND SYSTEMS FOR SEQUENCING
OSUNA, Honey, BROGLEY, Louis, LAPIN, Yuri, YUE, Stephen, FEDOROV, Andrei, SEBO, Lubomir, SHEN, Gene
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Year of Publication 16.11.2023
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Protected fluorescent reagent compounds
Brogley, Louis, Yue, Stephen, Shen, Gene, Lapin, Yuri, Fedorov, Andrei, Lyle, John, Sebo, Lubomir, Hanes, Jeremiah, Zheng, Frank, Osuna, Honey
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Year of Publication 13.08.2024
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Labeled nucleotide analogs, reaction mixtures, and methods and systems for sequencing
Brogley, Louis, Yue, Stephen, Shen, Gene, Lapin, Yuri, Fedorov, Andrei, Sebo, Lubomir, Osuna, Honey
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Year of Publication 11.10.2022
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PROTECTED FLUORESCENT REAGENT COMPOUNDS
OSUNA, Honey, BROGLEY, Louis, LYLE, John, LAPIN, Yuri, ZHENG, Frank, YUE, Stephen, FEDOROV, Andrei, SEBO, Lubomir, HANES, Jeremiah, SHEN, Gene
Year of Publication 22.06.2023
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Year of Publication 22.06.2023
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Protected fluorescent reagent compounds
Brogley, Louis, Yue, Stephen, Shen, Gene, Lapin, Yuri, Fedorov, Andrei, Lyle, John, Sebo, Lubomir, Hanes, Jeremiah, Zheng, Frank, Osuna, Honey
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Year of Publication 14.02.2023
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LABELED NUCLEOTIDE ANALOGS, REACTION MIXTURES, AND METHODS AND SYSTEMS FOR SEQUENCING
OSUNA, Honey, BROGLEY, Louis, LAPIN, Yuri, YUE, Stephen, FEDOROV, Andrei, SEBO, Lubomir, SHEN, Gene
Year of Publication 20.05.2021
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Year of Publication 20.05.2021
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