Pharmacological Inhibition of ULK1 Kinase Blocks Mammalian Target of Rapamycin (mTOR)-dependent Autophagy
Petherick, Katy J., Conway, Owen J.L., Mpamhanga, Chido, Osborne, Simon A., Kamal, Ahmad, Saxty, Barbara, Ganley, Ian G.
Published in The Journal of biological chemistry (01.05.2015)
Published in The Journal of biological chemistry (01.05.2015)
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Transition Periods in the Diurnally-Varying Atmospheric Boundary Layer Over Land
Angevine, Wayne M., Edwards, John M., Lothon, Marie, LeMone, Margaret A., Osborne, Simon R.
Published in Boundary-layer meteorology (01.12.2020)
Published in Boundary-layer meteorology (01.12.2020)
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Targeting the Malaria Parasite cGMP-Dependent Protein Kinase to Develop New Drugs
Baker, David A, Matralis, Alexios N, Osborne, Simon A, Large, Jonathan M, Penzo, Maria
Published in Frontiers in microbiology (17.12.2020)
Published in Frontiers in microbiology (17.12.2020)
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Development of Chemical Entities Endowed with Potent Fast-Killing Properties against Plasmodium falciparum Malaria Parasites
Matralis, Alexios N, Malik, Adnan, Penzo, Maria, Moreno, Inmaculada, Almela, Maria J, Camino, Isabel, Crespo, Benigno, Saadeddin, Anas, Ghidelli-Disse, Sonja, Rueda, Lourdes, Calderon, Felix, Osborne, Simon A, Drewes, Gerard, Böesche, Markus, Fernández-Álvaro, Elena, Martin Hernando, Jose Ignacio, Baker, David A
Published in Journal of medicinal chemistry (24.10.2019)
Published in Journal of medicinal chemistry (24.10.2019)
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Subcellular Discharge of a Serine Protease Mediates Release of Invasive Malaria Parasites from Host Erythrocytes
Yeoh, Sharon, O'Donnell, Rebecca A., Koussis, Konstantinos, Dluzewski, Anton R., Ansell, Keith H., Osborne, Simon A., Hackett, Fiona, Withers-Martinez, Chrislaine, Mitchell, Graham H., Bannister, Lawrence H., Bryans, Justin S., Kettleborough, Catherine A., Blackman, Michael J.
Published in Cell (14.12.2007)
Published in Cell (14.12.2007)
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Imidazopyridazine Inhibitors of Plasmodium falciparum Calcium-Dependent Protein Kinase 1 Also Target Cyclic GMP-Dependent Protein Kinase and Heat Shock Protein 90 To Kill the Parasite at Different Stages of Intracellular Development
Green, Judith L, Moon, Robert W, Whalley, David, Bowyer, Paul W, Wallace, Claire, Rochani, Ankit, Nageshan, Rishi K, Howell, Steven A, Grainger, Munira, Jones, Hayley M, Ansell, Keith H, Chapman, Timothy M, Taylor, Debra L, Osborne, Simon A, Baker, David A, Tatu, Utpal, Holder, Anthony A
Published in Antimicrobial agents and chemotherapy (01.03.2016)
Published in Antimicrobial agents and chemotherapy (01.03.2016)
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Trisubstituted thiazoles as potent and selective inhibitors of Plasmodium falciparum protein kinase G (PfPKG)
Tsagris, Denise J., Birchall, Kristian, Bouloc, Nathalie, Large, Jonathan M., Merritt, Andy, Smiljanic-Hurley, Ela, Wheldon, Mary, Ansell, Keith H., Kettleborough, Catherine, Whalley, David, Stewart, Lindsay B., Bowyer, Paul W., Baker, David A., Osborne, Simon A.
Published in Bioorganic & medicinal chemistry letters (15.10.2018)
Published in Bioorganic & medicinal chemistry letters (15.10.2018)
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Imidazopyridazines as potent inhibitors of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1): Preparation and evaluation of pyrazole linked analogues
Large, Jonathan M., Osborne, Simon A., Smiljanic-Hurley, Ela, Ansell, Keith H., Jones, Hayley M., Taylor, Debra L., Clough, Barbara, Green, Judith L., Holder, Anthony A.
Published in Bioorganic & medicinal chemistry letters (01.11.2013)
Published in Bioorganic & medicinal chemistry letters (01.11.2013)
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Potent bicyclic inhibitors of malarial cGMP-dependent protein kinase: approaches to combining improvements in cell potency, selectivity and structural novelty
Large, Jonathan M., Birchall, Kristian, Bouloc, Nathalie S., Merritt, Andy T., Smiljanic-Hurley, Ela, Tsagris, Denise J., Wheldon, Mary C., Ansell, Keith H., Coombs, Peter J., Kettleborough, Catherine A., Whalley, David, Stewart, Lindsay B., Bowyer, Paul W., Baker, David A., Osborne, Simon A.
Published in Bioorganic & medicinal chemistry letters (01.10.2019)
Published in Bioorganic & medicinal chemistry letters (01.10.2019)
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Optimization of an Imidazopyridazine Series of Inhibitors of Plasmodium falciparum Calcium-Dependent Protein Kinase 1 (PfCDPK1)
Chapman, Timothy M, Osborne, Simon A, Wallace, Claire, Birchall, Kristian, Bouloc, Nathalie, Jones, Hayley M, Ansell, Keith H, Taylor, Debra L, Clough, Barbara, Green, Judith L, Holder, Anthony A
Published in Journal of medicinal chemistry (24.04.2014)
Published in Journal of medicinal chemistry (24.04.2014)
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Potent inhibitors of malarial P. Falciparum protein kinase G: Improving the cell activity of a series of imidazopyridines
Large, Jonathan M., Birchall, Kristian, Bouloc, Nathalie S., Merritt, Andy T., Smiljanic-Hurley, Ela, Tsagris, Denise J., Wheldon, Mary C., Ansell, Keith H., Coombs, Peter J., Kettleborough, Catherine A., Whalley, David, Stewart, Lindsay B., Bowyer, Paul W., Baker, David A., Osborne, Simon A.
Published in Bioorganic & medicinal chemistry letters (01.02.2019)
Published in Bioorganic & medicinal chemistry letters (01.02.2019)
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Substituted imidazopyridazines are potent and selective inhibitors of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1)
Chapman, Timothy M., Osborne, Simon A., Bouloc, Nathalie, Large, Jonathan M., Wallace, Claire, Birchall, Kristian, Ansell, Keith H., Jones, Hayley M., Taylor, Debra, Clough, Barbara, Green, Judith L., Holder, Anthony A.
Published in Bioorganic & medicinal chemistry letters (15.05.2013)
Published in Bioorganic & medicinal chemistry letters (15.05.2013)
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Biochemical and antiparasitic properties of inhibitors of the Plasmodium falciparum calcium-dependent protein kinase PfCDPK1
Ansell, Keith H, Jones, Hayley M, Whalley, David, Hearn, Alisdair, Taylor, Debra L, Patin, Emmanuel C, Chapman, Timothy M, Osborne, Simon A, Wallace, Claire, Birchall, Kristian, Large, Jonathan, Bouloc, Nathalie, Smiljanic-Hurley, Ela, Clough, Barbara, Moon, Robert W, Green, Judith L, Holder, Anthony A
Published in Antimicrobial agents and chemotherapy (01.10.2014)
Published in Antimicrobial agents and chemotherapy (01.10.2014)
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Substituted aminopyrimidine protein kinase B (PknB) inhibitors show activity against Mycobacterium tuberculosis
Chapman, Timothy M., Bouloc, Nathalie, Buxton, Roger S., Chugh, Jasveen, Lougheed, Kathryn E.A., Osborne, Simon A., Saxty, Barbara, Smerdon, Stephen J., Taylor, Debra L., Whalley, David
Published in Bioorganic & medicinal chemistry letters (01.05.2012)
Published in Bioorganic & medicinal chemistry letters (01.05.2012)
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A potent series targeting the malarial cGMP-dependent protein kinase clears infection and blocks transmission
Baker, David A, Stewart, Lindsay B, Large, Jonathan M, Bowyer, Paul W, Ansell, Keith H, Jiménez-Díaz, María B, El Bakkouri, Majida, Birchall, Kristian, Dechering, Koen J, Bouloc, Nathalie S, Coombs, Peter J, Whalley, David, Harding, Denise J, Smiljanic-Hurley, Ela, Wheldon, Mary C, Walker, Eloise M, Dessens, Johannes T, Lafuente, María José, Sanz, Laura M, Gamo, Francisco-Javier, Ferrer, Santiago B, Hui, Raymond, Bousema, Teun, Angulo-Barturén, Iñigo, Merritt, Andy T, Croft, Simon L, Gutteridge, Winston E, Kettleborough, Catherine A, Osborne, Simon A
Published in Nature communications (05.09.2017)
Published in Nature communications (05.09.2017)
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Vision System Experimentation in Furniture Industrial Environment
Bhullar, Gurbaksh, Osborne, Simon, Núñez Ariño, María José, Del Agua Navarro, Juan, Gigante Valencia, Fernando
Published in Future internet (01.08.2021)
Published in Future internet (01.08.2021)
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New anti-tuberculosis agents amongst known drugs
Lougheed, Kathryn E.A, Taylor, Debra L, Osborne, Simon A, Bryans, Justin S, Buxton, Roger S
Published in Tuberculosis (Edinburgh, Scotland) (01.09.2009)
Published in Tuberculosis (Edinburgh, Scotland) (01.09.2009)
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