Excellence in Medicinal Chemistry: Celebrating ACS Medicinal Chemistry Division (MEDI) Awards. A Call for Nominations
Blanco, Maria-Jesus, Bryant-Friedrich, Amanda, Georg, Gunda, Ali, Amjad, Ornstein, Paul L., Ferrins, Lori
Published in Journal of medicinal chemistry (08.06.2023)
Published in Journal of medicinal chemistry (08.06.2023)
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In vitro pharmacological and rat pharmacokinetic characterization of LY3020371, a potent and selective mGlu 2/3 receptor antagonist
Witkin, Jeffrey M, Ornstein, Paul L, Mitch, Charles H, Li, Renhua, Smith, Stephon C, Heinz, Beverly A, Wang, Xu-Shan, Xiang, Chuanxi, Carter, Joan H, Anderson, Wesley H, Li, Xia, Broad, Lisa M, Pasqui, Francesca, Fitzjohn, Stephen M, Sanger, Helen E, Smith, Jodi L, Catlow, John, Swanson, Steven, Monn, James A
Published in Neuropharmacology (01.03.2017)
Published in Neuropharmacology (01.03.2017)
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Transmembrane AMPA Receptor Regulatory Proteins and Cornichon-2 Allosterically Regulate AMPA Receptor Antagonists and Potentiators
Schober, Douglas A., Gill, Martin B., Yu, Hong, Gernert, Douglas L., Jeffries, Matthew W., Ornstein, Paul L., Kato, Akihiko S., Felder, Christian C., Bredt, David S.
Published in The Journal of biological chemistry (15.04.2011)
Published in The Journal of biological chemistry (15.04.2011)
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Kainate receptors are involved in synaptic plasticity
Collingridge, Graham L, Bortolotto, Zuner A, Clarke, Vernon R. J, Delany, Caroline M, Parry, Michael C, Smolders, Ilse, Vignes, Michel, Ho, Ken H, Miu, Peter, Brinton, Bradford T, Fantaske, Robert, Ogden, Ann, Gates, Mary, Ornstein, Paul L, Lodge, David, Bleakman, David
Published in Nature (London) (18.11.1999)
Published in Nature (London) (18.11.1999)
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Journal Article
A hippocampal GluR5 kainate receptor regulating inhibitory synaptic transmission
Bleakman, David, Clarke, Vernon R. J, Ballyk, Barbara A, Hoo, Ken H, Mandelzys, Allan, Pellizzari, Andrew, Bath, Catherine P, Thomas, Justyn, Sharpe, Erica F, Davies, Ceri H, Ornstein, Paul L, Schoepp, Darryle D, Kamboj, Rajender K, Collingridge, Graham L, Lodge, David
Published in Nature (London) (09.10.1997)
Published in Nature (London) (09.10.1997)
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Pharmacological Characterization of the Competitive GLUK5 Receptor Antagonist Decahydroisoquinoline LY466195 in Vitro and in Vivo
Weiss, Brianne, Alt, Andrew, Ogden, Ann Marie, Gates, Mary, Dieckman, Donna K, Clemens-Smith, Amy, Ho, Ken H, Jarvie, Keith, Rizkalla, Geihan, Wright, Rebecca A, Calligaro, David O, Schoepp, Darryle, Mattiuz, Edward L, Stratford, Robert E, Johnson, Bryan, Salhoff, Craig, Katofiasc, Mary, Phebus, Lee A, Schenck, Kathryn, Cohen, Marlene, Filla, Sandra A, Ornstein, Paul L, Johnson, Kirk W, Bleakman, David
Published in The Journal of pharmacology and experimental therapeutics (01.08.2006)
Published in The Journal of pharmacology and experimental therapeutics (01.08.2006)
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Journal Article
Antiallodynic and Antihyperalgesic Effects of Selective Competitive GLUK5 (GluR5) Ionotropic Glutamate Receptor Antagonists in the Capsaicin and Carrageenan Models in Rats
Jones, Carrie K, Alt, Andrew, Ogden, Ann Marie, Bleakman, David, Simmons, Rosa M A, Iyengar, Smriti, Dominguez, Esteban, Ornstein, Paul L, Shannon, Harlan E
Published in The Journal of pharmacology and experimental therapeutics (01.10.2006)
Published in The Journal of pharmacology and experimental therapeutics (01.10.2006)
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Journal Article
Excellence in Medicinal Chemistry: Celebrating ACS Medicinal Chemistry Division (MEDI) Awards. A Call for Nominations
Blanco, Maria-Jesus, Bryant-Friedrich, Amanda, Georg, Gunda, Ali, Amjad, Ornstein, Paul L, Ferrins, Lori, Trippier, Paul C
Published in ACS medicinal chemistry letters (08.06.2023)
Published in ACS medicinal chemistry letters (08.06.2023)
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Journal Article
The synthesis and evaluation of triazolopyrimidines as anti-tubercular agents
Zuniga, Edison S., Korkegian, Aaron, Mullen, Steven, Hembre, Erik J., Ornstein, Paul L., Cortez, Guillermo, Biswas, Kallolmay, Kumar, Naresh, Cramer, Jeffrey, Masquelin, Thierry, Hipskind, Philip A., Odingo, Joshua, Parish, Tanya
Published in Bioorganic & medicinal chemistry (01.08.2017)
Published in Bioorganic & medicinal chemistry (01.08.2017)
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Forebrain-selective AMPA-receptor antagonism guided by TARP γ-8 as an antiepileptic mechanism
Kato, Akihiko S, Burris, Kevin D, Gardinier, Kevin M, Gernert, Douglas L, Porter, Warren J, Reel, Jon, Ding, Chunjin, Tu, Yuan, Schober, Douglas A, Lee, Matthew R, Heinz, Beverly A, Fitch, Thomas E, Gleason, Scott D, Catlow, John T, Yu, Hong, Fitzjohn, Stephen M, Pasqui, Francesca, Wang, He, Qian, Yuewei, Sher, Emanuele, Zwart, Ruud, Wafford, Keith A, Rasmussen, Kurt, Ornstein, Paul L, Isaac, John T R, Nisenbaum, Eric S, Bredt, David S, Witkin, Jeffrey M
Published in Nature medicine (01.12.2016)
Published in Nature medicine (01.12.2016)
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Journal Article
Discovery of the First α‑Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Antagonist Dependent upon Transmembrane AMPA Receptor Regulatory Protein (TARP) γ‑8
Gardinier, Kevin M, Gernert, Douglas L, Porter, Warren J, Reel, Jon K, Ornstein, Paul L, Spinazze, Patrick, Stevens, F. Craig, Hahn, Patric, Hollinshead, Sean P, Mayhugh, Daniel, Schkeryantz, Jeff, Khilevich, Albert, De Frutos, Oscar, Gleason, Scott D, Kato, Akihiko S, Luffer-Atlas, Debra, Desai, Prashant V, Swanson, Steven, Burris, Kevin D, Ding, Chunjin, Heinz, Beverly A, Need, Anne B, Barth, Vanessa N, Stephenson, Gregory A, Diseroad, Benjamin A, Woods, Tim A, Yu, Hong, Bredt, David, Witkin, Jeffrey M
Published in Journal of medicinal chemistry (26.05.2016)
Published in Journal of medicinal chemistry (26.05.2016)
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Journal Article
Modulation of TARP γ8-Containing AMPA Receptors as a Novel Therapeutic Approach for Chronic Pain
Knopp, Kelly L, Simmons, Rosa Maria A, Guo, Wenhong, Adams, Benjamin L, Gardinier, Kevin M, Gernert, Douglas L, Ornstein, Paul L, Porter, Warren, Reel, Jon, Ding, Chunjin, Wang, He, Qian, Yuewei, Burris, Kevin D, Need, Anne, Barth, Vanessa, Swanson, Steven, Catlow, John, Witkin, Jeffrey M, Zwart, Ruud, Sher, Emanuele, Choong, Kar-Chan, Wall, Theron M, Schober, Douglas, Felder, Christian C, Kato, Akihiko S, Bredt, David S, Nisenbaum, Eric S
Published in The Journal of pharmacology and experimental therapeutics (01.06.2019)
Published in The Journal of pharmacology and experimental therapeutics (01.06.2019)
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[ 3H]-LY341495 as a novel antagonist radioligand for group II metabotropic glutamate (mGlu) receptors: characterization of binding to membranes of mGlu receptor subtype expressing cells
Johnson, Bryan G, Wright, Rebecca A, Arnold, M.Brian, Wheeler, William J, Ornstein, Paul L, Schoepp, Darryle D
Published in Neuropharmacology (01.10.1999)
Published in Neuropharmacology (01.10.1999)
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Journal Article
In vitro pharmacological and rat pharmacokinetic characterization of LY3020371, a potent and selective mGlu2/3 receptor antagonist
Witkin, Jeffrey M., Ornstein, Paul L., Mitch, Charles H., Li, Renhua, Smith, Stephon C., Heinz, Beverly A., Wang, Xu-Shan, Xiang, Chuanxi, Carter, Joan H., Anderson, Wesley H., Li, Xia, Broad, Lisa M., Pasqui, Francesca, Fitzjohn, Stephen M., Sanger, Helen E., Smith, Jodi L., Catlow, John, Swanson, Steven, Monn, James A.
Published in Neuropharmacology (15.03.2017)
Published in Neuropharmacology (15.03.2017)
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Journal Article
Privileged structure based ligands for melanocortin receptors—4,4-Disubstituted piperidine derivatives
Kuklish, Steven L., Backer, Ryan T., Briner, Karin, Doecke, Christopher W., Husain, Saba, Mullaney, Jeffrey T., Ornstein, Paul L., Zgombick, John M., O’Brien, Thomas P., Fisher, Matthew J.
Published in Bioorganic & medicinal chemistry letters (15.07.2006)
Published in Bioorganic & medicinal chemistry letters (15.07.2006)
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Journal Article
Synthesis and structure–activity relationships of novel dipeptides and reduced dipeptides as ligands for melanocortin subtype-4 receptor
Shi, Qing, Ornstein, Paul L., Briner, Karin, Richardson, Timothy I., Arnold, Macklin B., Backer, Ryan T., Buckmaster, Jennifer L., Canada, Emily J., Doecke, Christopher W., Hertel, Larry W., Honigschmidt, Nick, Hsiung, Hansen M., Husain, Saba, Kuklish, Steve L., Martinelli, Michael J., Mullaney, Jeffrey T., O’Brien, Thomas P., Reinhard, Matt R., Rothhaar, Roger, Shah, Jikesh, Wu, Zhipei, Xie, Chaoyu, Zgombick, John M., Fisher, Matthew J.
Published in Bioorganic & medicinal chemistry letters (01.05.2006)
Published in Bioorganic & medicinal chemistry letters (01.05.2006)
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Discovery of (1S,2R,3S,4S,5R,6R)‑2-Amino-3-[(3,4-difluorophenyl)sulfanylmethyl]-4-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid Hydrochloride (LY3020371·HCl): A Potent, Metabotropic Glutamate 2/3 Receptor Antagonist with Antidepressant-Like Activity
Chappell, Mark D, Li, Renhua, Smith, Stephon C, Dressman, Bruce A, Tromiczak, Eric G, Tripp, Allie E, Blanco, Maria-Jesus, Vetman, Tatiana, Quimby, Steven J, Matt, James, Britton, Thomas C, Fivush, Adam M, Schkeryantz, Jeffrey M, Mayhugh, Daniel, Erickson, Jon A, Bures, Mark G, Jaramillo, Carlos, Carpintero, Mercedes, Diego, José Eugenio de, Barberis, Mario, Garcia-Cerrada, Susana, Soriano, José F, Antonysamy, Stephen, Atwell, Shane, MacEwan, Iain, Condon, Bradley, Sougias, Christine, Wang, Jing, Zhang, Aiping, Conners, Kris, Groshong, Chris, Wasserman, Stephen R, Koss, John W, Witkin, Jeffrey M, Li, Xia, Overshiner, Carl, Wafford, Keith A, Seidel, Wesley, Wang, Xu-Shan, Heinz, Beverly A, Swanson, Steven, Catlow, John T, Bedwell, David W, Monn, James A, Mitch, Charles H, Ornstein, Paul L
Published in Journal of medicinal chemistry (22.12.2016)
Published in Journal of medicinal chemistry (22.12.2016)
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Journal Article
Privileged structure based ligands for melanocortin-4 receptors—Aliphatic piperazine derivatives
Briner, Karin, Collado, Iván, Fisher, Matthew J., García-Paredes, Cristina, Husain, Saba, Kuklish, Steven L., Mateo, Ana I., O’Brien, Thomas P., Ornstein, Paul L., Zgombick, John, de Frutos, Óscar
Published in Bioorganic & medicinal chemistry letters (01.07.2006)
Published in Bioorganic & medicinal chemistry letters (01.07.2006)
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Journal Article
Modulation of TARP γ 8-Containing AMPA Receptors as a Novel Therapeutic Approach for Chronic Pain
Knopp, Kelly L, Simmons, Rosa Maria A, Guo, Wenhong, Adams, Benjamin L, Gardinier, Kevin M, Gernert, Douglas L, Ornstein, Paul L, Porter, Warren, Reel, Jon, Ding, Chunjin, Wang, He, Qian, Yuewei, Burris, Kevin D, Need, Anne, Barth, Vanessa, Swanson, Steven, Catlow, John, Witkin, Jeffrey M, Zwart, Ruud, Sher, Emanuele, Choong, Kar-Chan, Wall, Theron M, Schober, Douglas, Felder, Christian C, Kato, Akihiko S, Bredt, David S, Nisenbaum, Eric S
Published in The Journal of pharmacology and experimental therapeutics (01.06.2019)
Published in The Journal of pharmacology and experimental therapeutics (01.06.2019)
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