Structural basis for telmisartan-mediated partial activation of PPAR gamma
Amano, Yasushi, Yamaguchi, Tomohiko, Ohno, Kazuki, Niimi, Tatsuya, Orita, Masaya, Sakashita, Hitoshi, Takeuchi, Makoto
Published in Hypertension research (01.07.2012)
Published in Hypertension research (01.07.2012)
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In silico, in vitro, X-ray crystallography, and integrated strategies for discovering spermidine synthase inhibitors for Chagas disease
Yoshino, Ryunosuke, Yasuo, Nobuaki, Hagiwara, Yohsuke, Ishida, Takashi, Inaoka, Daniel Ken, Amano, Yasushi, Tateishi, Yukihiro, Ohno, Kazuki, Namatame, Ichiji, Niimi, Tatsuya, Orita, Masaya, Kita, Kiyoshi, Akiyama, Yutaka, Sekijima, Masakazu
Published in Scientific reports (27.07.2017)
Published in Scientific reports (27.07.2017)
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Pharmacophore modeling for anti-Chagas drug design using the fragment molecular orbital method
Yoshino, Ryunosuke, Yasuo, Nobuaki, Inaoka, Daniel Ken, Hagiwara, Yohsuke, Ohno, Kazuki, Orita, Masaya, Inoue, Masayuki, Shiba, Tomoo, Harada, Shigeharu, Honma, Teruki, Balogun, Emmanuel Oluwadare, da Rocha, Josmar Rodrigues, Montanari, Carlos Alberto, Kita, Kiyoshi, Sekijima, Masakazu
Published in PloS one (11.05.2015)
Published in PloS one (11.05.2015)
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Unique “delta lock” structure of telmisartan is involved in its strongest binding affinity to angiotensin II type 1 receptor
Ohno, Kazuki, Amano, Yasushi, Kakuta, Hirotoshi, Niimi, Tatsuya, Takakura, Shoji, Orita, Masaya, Miyata, Keiji, Sakashita, Hitoshi, Takeuchi, Makoto, Komuro, Issei, Higaki, Jitsuo, Horiuchi, Masatsugu, Kim-Mitsuyama, Shokei, Mori, Yutaka, Morishita, Ryuichi, Yamagishi, Sho-ichi
Published in Biochemical and biophysical research communications (07.01.2011)
Published in Biochemical and biophysical research communications (07.01.2011)
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Synthetic studies on novel Syk inhibitors. Part 1: Synthesis and structure–activity relationships of pyrimidine-5-carboxamide derivatives
Hisamichi, Hiroyuki, Naito, Ryo, Toyoshima, Akira, Kawano, Noriyuki, Ichikawa, Atsushi, Orita, Akiko, Orita, Masaya, Hamada, Noritaka, Takeuchi, Makoto, Ohta, Mitsuaki, Tsukamoto, Shin-ichi
Published in Bioorganic & medicinal chemistry (15.08.2005)
Published in Bioorganic & medicinal chemistry (15.08.2005)
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Journal Article
Macrophage Migration Inhibitory Factor and the Discovery of Tautomerase Inhibitors
Orita, Masaya, Yamamoto, Satoshi, Katayama, Naoko, Fujita, Shigeo
Published in Current pharmaceutical design (01.01.2002)
Published in Current pharmaceutical design (01.01.2002)
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Journal Article
Discovery of highly potent and selective biphenylacylsulfonamide-based β3-adrenergic receptor agonists and molecular modeling based on the solved X-ray structure of the β2-adrenergic receptor: Part 6
HATTORI, Kouji, ORITA, Masaya, MATSUI, Shigeo, IMAMURA, Emiko, UESHIMA, Koji, YAMAMOTO, Takao, YAMAMOTO, Nobuhiro, ISHIKAWA, Hirofumi, NAKANO, Keiko, UNAMI, Naoko, HAMADA, Kaori, MATSUMURA, Yasuhiro, TODA, Susumu, TAKAMURA, Fujiko, IMANISHI, Masashi, ITOU, Shinji, NAKAJIMA, Yutaka, TANABE, Daisuke, WASHIZUKA, Kenichi, ARAKI, Takanobu, SAKURAI, Minoru
Published in Bioorganic & medicinal chemistry letters (01.08.2009)
Published in Bioorganic & medicinal chemistry letters (01.08.2009)
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Journal Article
Accelerating quantum chemistry calculations with graphical processing units - toward in high-density (HD) silico drug discovery
Hagiwara, Yohsuke, Ohno, Kazuki, Orita, Masaya, Koga, Ryota, Endo, Toshio, Akiyama, Yutaka, Sekijima, Masakazu
Published in Current computer-aided drug design (01.09.2013)
Published in Current computer-aided drug design (01.09.2013)
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Journal Article
Design and Synthesis of Non-peptidic Inhibitors for the Syk C-Terminal SH2 Domain Based on Structure-Based In-Silico Screening
Niimi, Tatsuya, Orita, Masaya, Okazawa-Igarashi, Miwa, Sakashita, Hitoshi, Kikuchi, Kazumi, Ball, Evelyn, Ichikawa, Atsushi, Yamagiwa, Yoko, Sakamoto, Shuichi, Tanaka, Akihiro, Tsukamoto, Shinichi, Fujita, Shigeo, Tatsuta, Kuniaki, Maeda, Yasuhide, Chikauchi, Ken
Published in Journal of medicinal chemistry (20.12.2001)
Published in Journal of medicinal chemistry (20.12.2001)
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Journal Article
Binding Modes of Two Novel Non-Nucleoside Reverse Transcriptase Inhibitors, YM-215389 and YM-228855, to HIV Type-1 Reverse Transcriptase
Kodama, Eiichi, Orita, Masaya, Masuda, Naoyuki, Yamamoto, Osamu, Fujii, Masahiro, Ohgami, Tetsuro, Kageyama, Shunji, Ohta, Mitsuaki, Hatta, Toshifumi, Inoue, Hiroshi, Suzuki, Hiroshi, Sudo, Kenji, Shimizu, Yasuaki, Matsuoka, Masao
Published in Antiviral chemistry & chemotherapy (01.06.2008)
Published in Antiviral chemistry & chemotherapy (01.06.2008)
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Evidence for the Rate-Limiting Departure of the 5‘-Oxygen in Nonenzymatic and Hammerhead Ribozyme-Catalyzed Reactions
Zhou, De-Min, Usman, Nassim, Wincott, Francine E, Matulic-Adamic, Jasenka, Orita, Masaya, Zhang, Li-He, Komiyama, Makoto, Kumar, Penmetcha K. R, Taira, Kazunari
Published in Journal of the American Chemical Society (26.06.1996)
Published in Journal of the American Chemical Society (26.06.1996)
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Journal Article
Lead generation and examples opinion regarding how to follow up hits
Orita, Masaya, Ohno, Kazuki, Warizaya, Masaichi, Amano, Yasushi, Niimi, Tatsuya
Published in Methods in enzymology (2011)
Published in Methods in enzymology (2011)
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Journal Article
4‑Hydroxypyridazin-3(2H)‑one Derivatives as Novel d‑Amino Acid Oxidase Inhibitors
Hondo, Takeshi, Warizaya, Masaichi, Niimi, Tatsuya, Namatame, Ichiji, Yamaguchi, Tomohiko, Nakanishi, Keita, Hamajima, Toshihiro, Harada, Katsuya, Sakashita, Hitoshi, Matsumoto, Yuzo, Orita, Masaya, Takeuchi, Makoto
Published in Journal of medicinal chemistry (09.05.2013)
Published in Journal of medicinal chemistry (09.05.2013)
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