Regulatory enhancer profiling of mesenchymal-type gastric cancer reveals subtype-specific epigenomic landscapes and targetable vulnerabilities
Ho, Shamaine Wei Ting, Sheng, Taotao, Xing, Manjie, Ooi, Wen Fong, Xu, Chang, Sundar, Raghav, Huang, Kie Kyon, Li, Zhimei, Kumar, Vikrant, Ramnarayanan, Kalpana, Zhu, Feng, Srivastava, Supriya, Isa, Zul Fazreen Bin Adam, Anene-Nzelu, Chukwuemeka George, Razavi-Mohseni, Milad, Shigaki, Dustin, Ma, Haoran, Tan, Angie Lay Keng, Ong, Xuewen, Lee, Ming Hui, Tay, Su Ting, Guo, Yu Amanda, Huang, Weitai, Li, Shang, Beer, Michael A., Foo, Roger Sik Yin, Teh, Ming, Skanderup, Anders Jacobsen, Teh, Bin Tean, Tan, Patrick
Published in Gut (01.02.2023)
Published in Gut (01.02.2023)
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Integrated paired-end enhancer profiling and whole-genome sequencing reveals recurrent CCNE1 and IGF2 enhancer hijacking in primary gastric adenocarcinoma
Ooi, Wen Fong, Nargund, Amrita M, Lim, Kevin Junliang, Zhang, Shenli, Xing, Manjie, Mandoli, Amit, Lim, Jing Quan, Ho, Shamaine Wei Ting, Guo, Yu, Yao, Xiaosai, Lin, Suling Joyce, Nandi, Tannistha, Xu, Chang, Ong, Xuewen, Lee, Minghui, Tan, Angie Lay-Keng, Lam, Yue Ning, Teo, Jing Xian, Kaneda, Atsushi, White, Kevin P, Lim, Weng Khong, Rozen, Steven G, Teh, Bin Tean, Li, Shang, Skanderup, Anders J, Tan, Patrick
Published in Gut (01.06.2020)
Published in Gut (01.06.2020)
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Journal Article
Epigenomic profiling of primary gastric adenocarcinoma reveals super-enhancer heterogeneity
Ooi, Wen Fong, Xing, Manjie, Xu, Chang, Yao, Xiaosai, Ramlee, Muhammad Khairul, Lim, Mei Chee, Cao, Fan, Lim, Kevin, Babu, Deepak, Poon, Lai-Fong, Lin Suling, Joyce, Qamra, Aditi, Irwanto, Astrid, Qu Zhengzhong, James, Nandi, Tannistha, Lee-Lim, Ai Ping, Chan, Yang Sun, Tay, Su Ting, Lee, Ming Hui, Davies, James O. J., Wong, Wai Keong, Soo, Khee Chee, Chan, Weng Hoong, Ong, Hock Soo, Chow, Pierce, Wong, Chow Yin, Rha, Sun Young, Liu, Jianjun, Hillmer, Axel M., Hughes, Jim R., Rozen, Steve, Teh, Bin Tean, Fullwood, Melissa Jane, Li, Shang, Tan, Patrick
Published in Nature communications (28.09.2016)
Published in Nature communications (28.09.2016)
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Journal Article
VHL Deficiency Drives Enhancer Activation of Oncogenes in Clear Cell Renal Cell Carcinoma
Yao, Xiaosai, Tan, Jing, Lim, Kevin Junliang, Koh, Joanna, Ooi, Wen Fong, Li, Zhimei, Huang, Dachuan, Xing, Manjie, Chan, Yang Sun, Qu, James Zhengzhong, Tay, Su Ting, Wijaya, Giovani, Lam, Yue Ning, Hong, Jing Han, Lee-Lim, Ai Ping, Guan, Peiyong, Ng, Michelle Shu Wen, He, Cassandra Zhengxuan, Lin, Joyce Suling, Nandi, Tannistha, Qamra, Aditi, Xu, Chang, Myint, Swe Swe, Davies, James O J, Goh, Jian Yuan, Loh, Gary, Tan, Bryan C, Rozen, Steven G, Yu, Qiang, Tan, Iain Bee Huat, Cheng, Christopher Wai Sam, Li, Shang, Chang, Kenneth Tou En, Tan, Puay Hoon, Silver, David Lawrence, Lezhava, Alexander, Steger, Gertrud, Hughes, Jim R, Teh, Bin Tean, Tan, Patrick
Published in Cancer discovery (01.11.2017)
Published in Cancer discovery (01.11.2017)
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Journal Article
HNF4α pathway mapping identifies wild-type IDH1 as a targetable metabolic node in gastric cancer
Xu, Chang, Ooi, Wen Fong, Qamra, Aditi, Tan, Jing, Chua, Benjamin Yan-Jiang, Ho, Shamaine Wei Ting, Das, Kakoli, Adam Isa, Zul Fazreen, Li, Zhimei, Yao, Xiaosai, Yan, Tingdong, Xing, Manjie, Huang, Kie Kyon, Lin, Joyce Suling, Nandi, Tannistha, Tay, Su Ting, Lee, Ming Hui, Tan, Angie Lay Keng, Ong, Xuewen, Ashktorab, Hassan, Smoot, Duane, Li, Shang, Ng, Shyh-Chang, Teh, Bin Tean, Tan, Patrick
Published in Gut (01.02.2020)
Published in Gut (01.02.2020)
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Journal Article
HoxC5 and miR-615-3p target newly evolved genomic regions to repress hTERT and inhibit tumorigenesis
Yan, TingDong, Ooi, Wen Fong, Qamra, Aditi, Cheung, Alice, Ma, DongLiang, Sundaram, Gopinath Meenakshi, Xu, Chang, Xing, Manjie, Poon, LaiFong, Wang, Jing, Loh, Yan Ping, Ho, Jess Hui Jie, Ng, Joscelyn Jun Quan, Ramlee, Muhammad Khairul, Aswad, Luay, Rozen, Steve G., Ghosh, Sujoy, Bard, Frederic A., Sampath, Prabha, Tergaonkar, Vinay, Davies, James O. J., Hughes, Jim R., Goh, Eyleen, Bi, Xuezhi, Fullwood, Melissa Jane, Tan, Patrick, Li, Shang
Published in Nature communications (08.01.2018)
Published in Nature communications (08.01.2018)
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Journal Article
Chromatin Rewiring by Mismatch Repair Protein MSH2 Alters Cell Adhesion Pathways and Sensitivity to BET Inhibition in Gastric Cancer
Nargund, Amrita M, Xu, Chang, Mandoli, Amit, Okabe, Atsushi, Chen, Gao Bin, Huang, Kie Kyon, Sheng, Taotao, Yao, Xiaosai, Teo, Jia Ming Nickolas, Sundar, Raghav, Kok, Yee Jiun, See, Yi Xiang, Xing, Manjie, Li, Zhimei, Yong, Chern Han, Anand, Aparna, A I, Zul Fazreen, Poon, Lai Fong, Ng, Michelle Shu Wen, Koh, Javier Yu Peng, Ooi, Wen Fong, Tay, Su Ting, Ong, Xuewen, Tan, Angie Lay Keng, Grabsch, Heike I, Fullwood, Melissa J, Teh, Tean Bin, Bi, Xuezhi, Kaneda, Atsushi, Li, Shang, Tan, Patrick
Published in Cancer research (Chicago, Ill.) (18.07.2022)
Published in Cancer research (Chicago, Ill.) (18.07.2022)
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Antimicrobial resistance to ceftazidime involving loss of penicillin-binding protein 3 in Burkholderia pseudomallei
Chantratita, Narisara, Rholl, Drew A, Sim, Bernice, Wuthiekanun, Vanaporn, Limmathurotsakul, Direk, Amornchai, Premjit, Thanwisai, Aunchalee, Chua, Hui Hoon, Ooi, Wen Fong, Holden, Matthew T. G, Day, Nicholas P, Tan, Patrick, Schweizer, Herbert P, Peacock, Sharon J
Published in Proceedings of the National Academy of Sciences - PNAS (11.10.2011)
Published in Proceedings of the National Academy of Sciences - PNAS (11.10.2011)
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Journal Article
Nanoscale chromatin profiling of gastric adenocarcinoma reveals cancer-associated cryptic promoters and somatically acquired regulatory elements
Muratani, Masafumi, Deng, Niantao, Ooi, Wen Fong, Lin, Suling Joyce, Xing, Manjie, Xu, Chang, Qamra, Aditi, Tay, Su Ting, Malik, Simeen, Wu, Jeanie, Lee, Ming Hui, Zhang, Shenli, Tan, Luke Lin Chuen, Chua, Huihoon, Wong, Wai Keong, Ong, Hock Soo, Ooi, London Lucien, Chow, Pierce Kah-How, Chan, Weng Hoong, Soo, Khee Chee, Goh, Liang Kee, Rozen, Steve, Teh, Bin Tean, Yu, Qiang, Ng, Huck Hui, Tan, Patrick
Published in Nature communications (10.07.2014)
Published in Nature communications (10.07.2014)
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Journal Article
The condition-dependent transcriptional landscape of Burkholderia pseudomallei
Ooi, Wen Fong, Ong, Catherine, Nandi, Tannistha, Kreisberg, Jason F, Chua, Hui Hoon, Sun, Guangwen, Chen, Yahua, Mueller, Claudia, Conejero, Laura, Eshaghi, Majid, Ang, Roy Moh Lik, Liu, Jianhua, Sobral, Bruno W, Korbsrisate, Sunee, Gan, Yunn Hwen, Titball, Richard W, Bancroft, Gregory J, Valade, Eric, Tan, Patrick
Published in PLoS genetics (01.09.2013)
Published in PLoS genetics (01.09.2013)
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Journal Article
Epigenomic Promoter Alterations Amplify Gene Isoform and Immunogenic Diversity in Gastric Adenocarcinoma
Qamra, Aditi, Xing, Manjie, Padmanabhan, Nisha, Kwok, Jeffrey Jun Ting, Zhang, Shenli, Xu, Chang, Leong, Yan Shan, Lee Lim, Ai Ping, Tang, Qianqao, Ooi, Wen Fong, Suling Lin, Joyce, Nandi, Tannistha, Yao, Xiaosai, Ong, Xuewen, Lee, Minghui, Tay, Su Ting, Keng, Angie Tan Lay, Gondo Santoso, Erna, Ng, Cedric Chuan Young, Ng, Alvin, Jusakul, Apinya, Smoot, Duane, Ashktorab, Hassan, Rha, Sun Young, Yeoh, Khay Guan, Peng Yong, Wei, Chow, Pierce K H, Chan, Weng Hoong, Ong, Hock Soo, Soo, Khee Chee, Kim, Kyoung-Mee, Wong, Wai Keong, Rozen, Steven G, Teh, Bin Tean, Kappei, Dennis, Lee, Jeeyun, Connolly, John, Tan, Patrick
Published in Cancer discovery (01.06.2017)
Published in Cancer discovery (01.06.2017)
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Journal Article
A Burkholderia pseudomallei Toxin Inhibits Helicase Activity of Translation Factor eIF4A
CRUZ-MIGONI, Abimael, HAUTBERGUE, Guillaume M, MARSHALL, Laura E, MOBBS, George W, MOHAMED, Rahmah, NATHAN, Sheila, NGUGI, Sarah A, ONG, Catherine, WEN FONG OOI, PARTRIDGE, Lynda J, PHILLIPS, Helen L, FIRDAUS RAIH, M, ARTYMIUK, Peter J, RUZHEINIKOV, Sergei, SARKAR-TYSON, Mitali, SEDELNIKOVA, Svetlana E, SMITHER, Sophie J, TAN, Patrick, TITBALL, Richard W, WILSON, Stuart A, RICE, David W, BAKER, Patrick J, BOKORI-BROWN, Monika, CHANG, Chung-Te, DICKMAN, Mark J, ESSEX-LOPRESTI, Angela, HARDING, Sarah V, NOR MUHAMMAD MAHADI
Published in Science (American Association for the Advancement of Science) (11.11.2011)
Published in Science (American Association for the Advancement of Science) (11.11.2011)
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Journal Article
Integrative epigenomic and high-throughput functional enhancer profiling reveals determinants of enhancer heterogeneity in gastric cancer
Sheng, Taotao, Ho, Shamaine Wei Ting, Ooi, Wen Fong, Xu, Chang, Xing, Manjie, Padmanabhan, Nisha, Huang, Kie Kyon, Ma, Lijia, Ray, Mohana, Guo, Yu Amanda, Sim, Ngak Leng, Anene-Nzelu, Chukwuemeka George, Chang, Mei Mei, Razavi-Mohseni, Milad, Beer, Michael A, Foo, Roger Sik Yin, Sundar, Raghav, Chan, Yiong Huak, Tan, Angie Lay Keng, Ong, Xuewen, Skanderup, Anders Jacobsen, White, Kevin P, Jha, Sudhakar, Tan, Patrick
Published in Genome medicine (11.10.2021)
Published in Genome medicine (11.10.2021)
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DNA methylation signature predictive of benefit from neoadjuvant chemotherapy in esophageal adenocarcinoma: Results from the MRC OEO2 phase III trial
Sundar, Raghav, Ng, Alvin, Zouridis, Hermioni, Sheng, Taotao, Zhang, Shenli, Lee, Ming Hui, Padmanabhan, Nisha, Ooi, Wen Fong, Qamra, Aditi, Nankivell, Matthew Guy, Langley, Ruth E., Allum, William H., Cunningham, David, Grabsch, Heike I, Tan, Patrick
Published in Journal of clinical oncology (01.02.2019)
Published in Journal of clinical oncology (01.02.2019)
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Journal Article
Evolutionary Analysis of Burkholderia pseudomallei Identifies Putative Novel Virulence Genes, Including a Microbial Regulator of Host Cell Autophagy
Singh, Arvind Pratap, Lai, Shu-chin, Nandi, Tannistha, Chua, Hui Hoon, Ooi, Wen Fong, Ong, Catherine, Boyce, John D, Adler, Ben, Devenish, Rodney J, Tan, Patrick
Published in Journal of Bacteriology (01.12.2013)
Published in Journal of Bacteriology (01.12.2013)
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Journal Article
Segmental chromosome aberrations converge on overexpression of mitotic spindle regulatory genes in high-risk neuroblastoma
Ooi, Wen Fong, Re, Angela, Sidarovich, Viktoryia, Canella, Valentina, Arseni, Natalia, Adami, Valentina, Guarguaglini, Giulia, Giubettini, Maria, Scaruffi, Paola, Stigliani, Sara, Lavia, Patrizia, Tonini, Gian Paolo, Quattrone, Alessandro
Published in Genes chromosomes & cancer (01.06.2012)
Published in Genes chromosomes & cancer (01.06.2012)
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Journal Article
Abstract 3559: Functional characterization of HNF4α in gastric cancer
Xu, Chang, Ooi, Wen Fong, Qamra, Aditi, Tan, Patrick
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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