Effects of the V2-Receptor Antagonist OPC-41061 and the Loop Diuretic Furosemide Alone and in Combination in Rats
Takahiro Hirano, Yoshitaka Yamamura, Shigeki Nakamura, Toshiyuki Onogawa, Toyoki Mori
Published in The Journal of pharmacology and experimental therapeutics (01.01.2000)
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Published in The Journal of pharmacology and experimental therapeutics (01.01.2000)
Journal Article
OPC-41061, a Highly Potent Human Vasopressin V2-Receptor Antagonist: Pharmacological Profile and Aquaretic Effect by Single and Multiple Oral Dosing in Rats
Yamamura, Y, Nakamura, S, Itoh, S, Hirano, T, Onogawa, T, Yamashita, T, Yamada, Y, Tsujimae, K, Aoyama, M, Kotosai, K, Ogawa, H, Yamashita, H, Kondo, K, Tominaga, M, Tsujimoto, G, Mori, T
Published in The Journal of pharmacology and experimental therapeutics (01.12.1998)
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Published in The Journal of pharmacology and experimental therapeutics (01.12.1998)
Journal Article
Characterization of a novel aquaretic agent, OPC‐31260, as an orally effective, nonpeptide vasopressin V2 receptor antagonist
Yamamura, Yoshitaka, Ogawa, Hidenori, Yamashita, Hiroshi, Chihara, Tomihiko, Miyamoto, Hisashi, Nakamura, Shigeki, Onogawa, Toshiyuki, Yamashita, Tatsuya, Hosokawa, Tetsumi, Mori, Toyoki, Tominaga, Michiaki, Yabuuchi, Youichi
Published in British journal of pharmacology (01.04.1992)
Published in British journal of pharmacology (01.04.1992)
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Journal Article
OPC-21268, an Orally Effective, Nonpeptide Vasopressin V1 Receptor Antagonist
Yamamura, Yoshitaka, Ogawa, Hidenori, Chihara, Tomihiko, Kondo, Kazumi, Onogawa, Toshiyuki, Nakamura, Shigeki, Mori, Toyoki, Tominaga, Michiaki, Yabuuchi, Youichi
Published in Science (American Association for the Advancement of Science) (26.04.1991)
Published in Science (American Association for the Advancement of Science) (26.04.1991)
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Journal Article
Antidiuretic Effects of a Novel Nonpeptide Vasopressin V2-Receptor Agonist, OPC-51803, Administered Orally to Dogs
Nakamura, Shigeki, Hirano, Takahiro, Onogawa, Toshiyuki, Itoh, Shuji, Hashimoto, Ayako, Yamamura, Yoshitaka, Kondo, Kazumi, Mori, Toyoki, Kambe, Toshimi
Published in Journal of Pharmacological Sciences (2004)
Published in Journal of Pharmacological Sciences (2004)
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Journal Article
Effects of Tolvaptan on Systemic and Renal Hemodynamic Function in Dogs with Congestive Heart Failure
Onogawa, Toshiyuki, Sakamoto, Yuki, Nakamura, Shigeki, Nakayama, Sunao, Fujiki, Hiroyuki, Yamamura, Yoshitaka
Published in Cardiovascular drugs and therapy (01.12.2011)
Published in Cardiovascular drugs and therapy (01.12.2011)
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Journal Article
Therapeutic Effects of Tolvaptan, a Potent, Selective Nonpeptide Vasopressin V2 Receptor Antagonist, in Rats with Acute and Chronic Severe Hyponatremia
Miyazaki, Toshiki, Yamamura, Yoshitaka, Onogawa, Toshiyuki, Nakamura, Shigeki, Kinoshita, Shizuo, Nakayama, Sunao, Fujiki, Hiroyuki, Mori, Toyoki
Published in Endocrinology (Philadelphia) (01.07.2005)
Published in Endocrinology (Philadelphia) (01.07.2005)
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Effects of Tolvaptan on Systemic and Renal Hemodynamic Function in Dogs with Congestive Heart Failure: An arginine-vasopressin V2 receptor antagonist, Tolvaptan for treatment of heart failure with volume overload - Evidence from nonclinical studies to clinical trials
ONOGAWA, Toshiyuki, SAKAMOTO, Yuki, NAKAMURA, Shigeki, NAKAYAMA, Sunao, FUJIKI, Hiroyuki, YAMAMURA, Yoshitaka
Published in Cardiovascular drugs and therapy (2011)
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Published in Cardiovascular drugs and therapy (2011)
Journal Article
7-Chloro-5-hydroxy-1-[2-methyl-4-(2-methylbenzoylamino)benzoyl]-2,3,4,5-tetrahydro-1 H -1-benzazepine (OPC-41061): A potent, orally active nonpeptide arginine vasopressin V 2 receptor antagonist
Kondo, Kazumi, Ogawa, Hidenori, Yamashita, Hiroshi, Miyamoto, Hisashi, Tanaka, Michinori, Nakaya, Kenji, Kitano, Kazuyoshi, Yamamura, Yoshitaka, Nakamura, Shigeki, Onogawa, Toshiyuki, Mori, Toyoki, Tominaga, Michiaki
Published in Bioorganic & medicinal chemistry (01.08.1999)
Published in Bioorganic & medicinal chemistry (01.08.1999)
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Journal Article
7-chloro-5-hydroxy-1-[2-methyl-4-(2-methylbenzoyl-amino)benzoyl]-2,3,4,5-tetrahydro-1H-1-benzazepine (OPC-41061) : A potent, orally active nonpeptide arginine vasopressin V2 receptor antagonist
KONDO, K, OGAWA, H, MORI, T, TOMINAGA, M, YAMASHITA, H, MIYAMOTO, H, TANAKA, M, NAKAYA, K, KITANO, K, YAMAMURA, Y, NAKAMURA, S, ONOGAWA, T
Published in Bioorganic & medicinal chemistry (01.08.1999)
Published in Bioorganic & medicinal chemistry (01.08.1999)
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Journal Article
NITROGEN-CONTAINING COMPOUND AND PHARMACEUTICAL COMPOSITION
KOGA YASUO, MENJO YASUHIRO, UEDA MASATAKA, ONOGAWA TOSHIYUKI, OSHIMA KUNIO, TAKEMURA KENSHO, TAIRA SHINICHI, ISONO NAOHIRO, NAKAYAMA SUNAO, YAMABE HOKUTO, OSHIYAMA TAKASHI, MATSUMURA SHUJI, ITOTANI MOTOHIRO, TSUJIMAE KENJI, NAGASE TAKESHI, TAI KUNINORI
Year of Publication 12.11.2015
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Year of Publication 12.11.2015
Patent
A novel compound OPC-6535 inhibits leukocyte activation and reduces infarct size after 5 hr reperfusion in a porcine myocardial infarction model
Onogawa, Toshiyuki, Nagamoto, Hisashi, Maeda, Takashi, Aoyama, Masashi, Miyakoda, Goro, Sumida, Takumi, Mori, Toyoki
Published in Japanese Journal of Pharmacology (1998)
Published in Japanese Journal of Pharmacology (1998)
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Journal Article
NITROGEN-CONTAINING COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF ATRIAL FIBRILLATION
KOGA YASUO, MENJO YASUHIRO, UEDA MASATAKA, ONOGAWA TOSHIYUKI, OSHIMA KUNIO, MATSUMURA SHUUJI, TAIRA SHINICHI, ISONO NAOHIRO, TAKEMURA NORIAKI, NAKAYAMA SUNAO, YAMABE HOKUTO, OSHIYAMA TAKASHI, ITOTANI MOTOHIRO, TSUJIMAE KENJI, TAI KUNINORI, NAGASE TSUYOSHI
Year of Publication 20.07.2012
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Year of Publication 20.07.2012
Patent
BENZODIAZEPINE COMPOUND AND PHARMACEUTICAL COMPOSITION
KOGA YASUO, OSHIYAMA TAKASHI, MENJO YASUHIRO, UEDA MASATAKA, ONOGAWA TOSHIYUKI, TSUJIMAE KENJI, OSHIMA KUNIO, TAI KUNINORI, TAIRA SHINICHI, MATSUMURA SHUUJI, NAKAYAMA SUNAO, YAMABE HOKUTO
Year of Publication 29.11.2010
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Year of Publication 29.11.2010
Patent
OPC-21268 Antagonizes Arginine Vasopressin-Induced Vasoconstrictor Response in the Spinally-Anesthetized Dog
Tomihiko Chihara, Shigeki Nakamura, Toshiyuki Onogawa, Tatsuya Yamashita, Yoshitaka Yamamura, Toyoki Mori, Michiaki Tominaga, Youichi Yabuuchi
Published in Japanese Journal of Pharmacology (1995)
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Published in Japanese Journal of Pharmacology (1995)
Journal Article
Antidiuretic effects of a novel nonpeptide vasopressin V(2)-receptor agonist, OPC-51803, administered orally to dogs
Nakamura, Shigeki, Hirano, Takahiro, Onogawa, Toshiyuki, Itoh, Shuji, Hashimoto, Ayako, Yamamura, Yoshitaka, Kondo, Kazumi, Mori, Toyoki, Kambe, Toshimi
Published in Journal of pharmacological sciences (01.04.2004)
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Published in Journal of pharmacological sciences (01.04.2004)
Journal Article
Antidiuretic Effects of a Novel Nonpeptide Vasopressin V sub(2)-Receptor Agonist, OPC-51803, Administered Orally to Dogs
Nakamura, Shigeki, Hirano, Takahiro, Onogawa, Toshiyuki, Itoh, Shuji, Hashimoto, Ayako, Yamamura, Yoshitaka, Kondo, Kazumi, Mori, Toyoki, Kambe, Toshimi
Published in Journal of pharmacological sciences (01.01.2004)
Published in Journal of pharmacological sciences (01.01.2004)
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Journal Article
Effect of OPC-31260, vasopressin V2 antagonist, on renal function in anesthetized dogs
Yamashita, Tatsuya, Yamamura, Yoshitaka, Chihara, Tomihiko, Nakamura, Shigeki, Onogawa, Toshiyuki, Yamada, Yoshihisa, Mori, Toyoki, Tominaga, Michiaki, Yabuuchi, Youichi
Published in Japanese Journal of Pharmacology (1993)
Published in Japanese Journal of Pharmacology (1993)
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Journal Article
OPC-21268 Antagonizes Arginine Vasopressin-Induced Vasoconstrictor Response in the Spinally-Anesthetized Dog
Chihara, Tomihiko, Nakamura, Shigeki, Onogawa, Toshiyuki, Yamashita, Tatsuya, Yamamura, Yoshitaka, Mori, Toyoki, Tominaga, Michiaki, Yabuuchi, Youichi
Published in Japanese journal of pharmacology (1995)
Published in Japanese journal of pharmacology (1995)
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Journal Article