Preclinical Characterization of PC786, an Inhaled Small-Molecule Respiratory Syncytial Virus L Protein Polymerase Inhibitor
Coates, Matthew, Brookes, Daniel, Kim, Young-In, Allen, Heather, Fordyce, Euan A F, Meals, Elizabeth A, Colley, Thomas, Ciana, Claire-Lise, Parra, Guillaume F, Sherbukhin, Vladimir, Stockwell, Jennifer A, Thomas, Jennifer C, Hunt, S Fraser, Anderson-Dring, Lauren, Onions, Stuart T, Cass, Lindsey, Murray, Peter J, Ito, Kazuhiro, Strong, Pete, DeVincenzo, John P, Rapeport, Garth
Published in Antimicrobial agents and chemotherapy (01.09.2017)
Published in Antimicrobial agents and chemotherapy (01.09.2017)
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Discovery of Narrow Spectrum Kinase Inhibitors: New Therapeutic Agents for the Treatment of COPD and Steroid-Resistant Asthma
Onions, Stuart T, Ito, Kazuhiro, Charron, Catherine E, Brown, Richard J, Colucci, Marie, Frickel, Fritz, Hardy, George, Joly, Kevin, King-Underwood, John, Kizawa, Yasuo, Knowles, Ian, Murray, P. John, Novak, Andrew, Rani, Anjna, Rapeport, Garth, Smith, Alun, Strong, Peter, Taddei, David M, Williams, Jonathan G
Published in Journal of medicinal chemistry (10.03.2016)
Published in Journal of medicinal chemistry (10.03.2016)
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Discovery of novel benzothienoazepine derivatives as potent inhibitors of respiratory syncytial virus
Fordyce, Euan A.F., Brookes, Daniel W., Lise-Ciana, Claire, Coates, Matthew S., Hunt, S. Fraser, Ito, Kazuhiro, King-Underwood, John, Onions, Stuart T., Parra, Guillaume F., Rapeport, Garth, Sherbukhin, Vladimir, Stockwell, Jennifer A., Strong, Peter, Thomas, Jennifer C., Murray, John
Published in Bioorganic & medicinal chemistry letters (15.05.2017)
Published in Bioorganic & medicinal chemistry letters (15.05.2017)
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Conformationally restricted benzothienoazepine respiratory syncytial virus inhibitors: their synthesis, structural analysis and biological activities
Fordyce, Euan A. F., Hunt, S. Fraser, Crepin, Damien, Onions, Stuart T., Parra, Guillaume F., Sleigh, Chris J., King-Underwood, John, Finch, Harry, Murray, John
Published in MedChemComm (01.03.2018)
Published in MedChemComm (01.03.2018)
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Correction: Conformationally restricted benzothienoazepine respiratory syncytial virus inhibitors: their synthesis, structural analysis and biological activities
Fordyce, Euan A. F, Fraser Hunt, S, Crepin, Damien, Onions, Stuart T, Parra, Guillaume F, Sleigh, Chris J, King-Underwood, John, Finch, Harry, Murray, John
Published in MedChemComm (01.04.2018)
Published in MedChemComm (01.04.2018)
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A Self-Assembled Tetracopper Triple-Stranded Helicate: Towards the Controlled Synthesis of Finite One-Dimensional Magnetic Chains
Matthews, Craig J., Onions, Stuart T., Morata, Gérald, Davis, Lisa J., Heath, Sarah L., Price, Daniel J.
Published in Angewandte Chemie (International ed.) (14.07.2003)
Published in Angewandte Chemie (International ed.) (14.07.2003)
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Mixed Valence Mn(II)/Mn(III) [3 × 3] Grid Complexes: Structural, Electrochemical, Spectroscopic, and Magnetic Properties
Thompson, Laurence K, Kelly, Timothy L, Dawe, Louise N, Grove, Hilde, Lemaire, Martin T, Howard, Judith A. K, Spencer, Elinor C, Matthews, Craig J, Onions, Stuart T, Coles, Simon J, Horton, Peter N, Hursthouse, Michael B, Light, Mark E
Published in Inorganic chemistry (29.11.2004)
Published in Inorganic chemistry (29.11.2004)
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Self-Assembly of a Spin-Coupled Octanuclear Copper(II) Circular Array from a Single-Stranded Ligand
Onions, Stuart T., Heath, Sarah L., Price, Daniel J., Harrington, Ross W., Clegg, William, Matthews, Craig J.
Published in Angewandte Chemie (International ed.) (26.03.2004)
Published in Angewandte Chemie (International ed.) (26.03.2004)
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Synthesis, structure and magnetism of a unique dodecanuclearcopper(ii) ‘picture frame’ held in a 4 × 4 grid-like assemblyElectronic supplementary information (ESI) available: plot of magnetic susceptibility of 1 versus temperature. See http://www.rsc.org/suppdata/cc/b2/b210891g
Matthews, Craig J., Onions, Stuart T., Morata, Gérald, Salvia, Margarita Bosch, Elsegood, Mark R. J., Price, Daniel J.
Published in Chemical communications (Cambridge, England) (23.01.2003)
Published in Chemical communications (Cambridge, England) (23.01.2003)
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In Vitro and In Vivo Antifungal Profile of a Novel and Long-Acting Inhaled Azole, PC945, on Aspergillus fumigatus Infection
Colley, Thomas, Alanio, Alexandre, Kelly, Steven L, Sehra, Gurpreet, Kizawa, Yasuo, Warrilow, Andrew G S, Parker, Josie E, Kelly, Diane E, Kimura, Genki, Anderson-Dring, Lauren, Nakaoki, Takahiro, Sunose, Mihiro, Onions, Stuart, Crepin, Damien, Lagasse, Franz, Crittall, Matthew, Shannon, Jonathan, Cooke, Michael, Bretagne, Stéphane, King-Underwood, John, Murray, John, Ito, Kazuhiro, Strong, Pete, Rapeport, Garth
Published in Antimicrobial agents and chemotherapy (01.05.2017)
Published in Antimicrobial agents and chemotherapy (01.05.2017)
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Fragment-Based Discovery of a Potent, Orally Bioavailable Inhibitor That Modulates the Phosphorylation and Catalytic Activity of ERK1/2
Heightman, Tom D, Berdini, Valerio, Braithwaite, Hannah, Buck, Ildiko M, Cassidy, Megan, Castro, Juan, Courtin, Aurélie, Day, James E. H, East, Charlotte, Fazal, Lynsey, Graham, Brent, Griffiths-Jones, Charlotte M, Lyons, John F, Martins, Vanessa, Muench, Sandra, Munck, Joanne M, Norton, David, O’Reilly, Marc, Palmer, Nick, Pathuri, Puja, Reader, Michael, Rees, David C, Rich, Sharna J, Richardson, Caroline, Saini, Harpreet, Thompson, Neil T, Wallis, Nicola G, Walton, Hugh, Wilsher, Nicola E, Woolford, Alison J.-A, Cooke, Michael, Cousin, David, Onions, Stuart, Shannon, Jonathan, Watts, John, Murray, Christopher W
Published in Journal of medicinal chemistry (14.06.2018)
Published in Journal of medicinal chemistry (14.06.2018)
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Discovery of ASTX029, A Clinical Candidate Which Modulates the Phosphorylation and Catalytic Activity of ERK1/2
Heightman, Tom D., Berdini, Valerio, Bevan, Luke, Buck, Ildiko M., Carr, Maria G., Courtin, Aurelie, Coyle, Joseph E., Day, James E. H., East, Charlotte, Fazal, Lynsey, Griffiths-Jones, Charlotte M., Howard, Steven, Kucia-Tran, Justyna, Martins, Vanessa, Muench, Sandra, Munck, Joanne M., Norton, David, O'Reilly, Marc, Palmer, Nicholas, Pathuri, Puja, Peakman, Torren M., Reader, Michael, Rees, David C., Rich, Sharna J., Shah, Alpesh, Wallis, Nicola G., Walton, Hugh, Wilsher, Nicola E., Woolford, Alison J-A, Cooke, Michael, Cousin, David, Onions, Stuart, Shannon, Jonathan, Watts, John, Murray, Christopher W.
Published in Journal of medicinal chemistry (26.08.2021)
Published in Journal of medicinal chemistry (26.08.2021)
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In Vitro and In Vivo Efficacy of a Novel and Long-Acting Fungicidal Azole, PC1244, on Aspergillus fumigatus Infection
Colley, Thomas, Sehra, Gurpreet, Chowdhary, Anuradha, Alanio, Alexandre, Kelly, Steven L, Kizawa, Yasuo, Armstrong-James, Darius, Fisher, Matthew C, Warrilow, Andrew G S, Parker, Josie E, Kelly, Diane E, Kimura, Genki, Nishimoto, Yuki, Sunose, Mihiro, Onions, Stuart, Crepin, Damien, Lagasse, Franz, Crittall, Matthew, Shannon, Jonathan, McConville, Matthew, King-Underwood, John, Naylor, Alan, Bretagne, Stéphane, Murray, John, Ito, Kazuhiro, Strong, Pete, Rapeport, Garth
Published in Antimicrobial agents and chemotherapy (01.05.2018)
Published in Antimicrobial agents and chemotherapy (01.05.2018)
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호흡기 세포융합 바이러스 감염의 치료에 유용한 벤조디아제핀 유도체
COCKERILL GEORGE STUART, WARNER ANDREW JOSEPH, GOOD JAMES, BARRETT MATTHEW, COCHRANE EDWARD JAMES, AVERY CRAIG ALEX, ONIONS STUART THOMAS
Year of Publication 14.03.2023
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Year of Publication 14.03.2023
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호흡기 세포융합 바이러스 감염의 치료에 유용한 벤조디아제핀 유도체
JONES STEFAN PAUL, COCKERILL GEORGE STUART, WARNER ANDREW JOSEPH, GOOD JAMES, BARRETT MATTHEW, COCHRANE EDWARD JAMES, AVERY CRAIG ALEX, ONIONS STUART THOMAS
Year of Publication 14.03.2023
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Year of Publication 14.03.2023
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Targeting p300/CBP in lethal prostate cancer
Welti, Jonathan, Sharp, Adam, Brooks, Nigel, Yuan, Wei, McNair, Christopher, Chand, Saswati N., Pal, Abhijit, Figueiredo, Ines, Riisnaes, Ruth, Gurel, Bora, Rekowski, Jan, Bogdan, Denisa, West, William, Young, Barbara, Raja, Meera, Prosser, Amy, Lane, Jordan, Thomson, Stuart, Worthington, Jenny, Onions, Stuart, Shannon, Jonathan, Paoletta, Silvia, Brown, Richard, Smyth, Don, Harbottle, Gareth W., Gil, Veronica S., Miranda, Susana, Crespo, Mateus, Ferreira, Ana, Pereira, Rita, Tunariu, Nina, Carreira, Suzanne, Neeb, Antje J., Ning, Jian, Swain, Amanda, Taddei, David, Schiewer, Matthew J., Knudsen, Karen E., Pegg, Neil, de Bono, Johann S.
Published in Cancer discovery (11.01.2021)
Published in Cancer discovery (11.01.2021)
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Conformationally restricted benzothienoazepine respiratory syncytial virus inhibitors: their synthesis, structural analysis and biological activitiesElectronic supplementary information (ESI) available. See DOI: 10.1039/c8md00033f
Fordyce, Euan A. F, Fraser Hunt, S, Crepin, Damien, Onions, Stuart T, Parra, Guillaume F, Sleigh, Chris J, King-Underwood, John, Finch, Harry, Murray, John
Year of Publication 20.03.2018
Year of Publication 20.03.2018
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Conformationally restricted benzothienoazepine respiratory syncytial virus inhibitors: their synthesis, structural analysis and biological activities† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c8md00033f
Fordyce, Euan A. F., Fraser Hunt, S., Crepin, Damien, Onions, Stuart T., Parra, Guillaume F., Sleigh, Chris J., King-Underwood, John, Finch, Harry, Murray, John
Published in MedChemComm (20.02.2018)
Published in MedChemComm (20.02.2018)
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P38 MAP 1--3-4-2--4--1- 1-PYRAZOLYL-3-4-2-ANILINOPYRIMIDIN-4-YLOXY NAPTHTHALEN-1-YL UREAS AS P38 MAP KINASE INHIBITORS
KING UNDERWOOD JOHN, FILLIERS WALTER, BROECKX RUDY, LONGSHAW ALISTAIR IAN, ITO KAZUHIRO, CHARRON CATHERINE ELISABETH, COPMANS ALEX, ONIONS STUART THOMAS
Year of Publication 03.07.2019
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Year of Publication 03.07.2019
Patent