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Discovery of Novel 2-Aminobenzamide Inhibitors of Heat Shock Protein 90 as Potent, Selective and Orally Active Antitumor Agents

Discovery of Novel 2-Aminobenzamide Inhibitors of Heat Shock Protein 90 as Potent, Selective and Orally Active Antitumor Agents

by Huang, Kenneth H, Veal, James M, Fadden, R. Patrick, Rice, John W, Eaves, Jeron, Strachan, Jon-Paul, Barabasz, Amy F, Foley, Briana E, Barta, Thomas E, Ma, Wei, Silinski, Melanie A, Hu, Mei, Partridge, Jeffrey M, Scott, Anisa, DuBois, Laura G, Freed, Tiffany, Steed, Paul M, Ommen, Andy J, Smith, Emilie D, Hughes, Philip F, Woodward, Angela R, Hanson, Gunnar J, McCall, W. Stephen, Markworth, Christopher J, Hinkley, Lindsay, Jenks, Matthew, Geng, Lifeng, Lewis, Meredith, Otto, James, Pronk, Bert, Verleysen, Katleen, Hall, Steven E
Published in Journal of medicinal chemistry (23.07.2009)

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Journal Article

Discovery of novel aminoquinazolin-7-yl 6,7-dihydro-indol-4-ones as potent, selective inhibitors of heat shock protein 90

Discovery of novel aminoquinazolin-7-yl 6,7-dihydro-indol-4-ones as potent, selective inhibitors of heat shock protein 90

by Huang, Kenneth H., Barta, Thomas E., Rice, John W., Smith, Emilie D., Ommen, Andy J., Ma, Wei, Veal, James M., Fadden, R. Patrick, Barabasz, Amy F., Foley, Briana E., Hughes, Philip F., Hanson, Gunnar J., Markworth, Christopher J., Silinski, Melanie, Partridge, Jeffrey M., Steed, Paul M., Hall, Steven E.
Published in Bioorganic & medicinal chemistry letters (01.04.2012)

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Journal Article

2-ARYLIMIDAZO[1,2-B]PYRIDAZINE, 2-PHENYLIMIDAZO[1,2-A]PYRIDINE, AND 2-PHENYLIMIDAZO[1,2-A]PYRAZINE DERIVATIVES

2-ARYLIMIDAZO[1,2-B]PYRIDAZINE, 2-PHENYLIMIDAZO[1,2-A]PYRIDINE, AND 2-PHENYLIMIDAZO[1,2-A]PYRAZINE DERIVATIVES

by HUANG KENNETH H, ATKINSON ROBERT N, OMMEN ANDY J, VEAL JAMES M, SMITH EMILIE D
Year of Publication 14.02.2014

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Patent

2-ARYLIMIDAZO[1,2-B]PYRIDAZINE, 2-PHENYLIMIDAZO[1,2-A]PYRIDINE, AND 2-PHENYLIMIDAZO[1,2-A]PYRAZINE DERIVATIVES

2-ARYLIMIDAZO[1,2-B]PYRIDAZINE, 2-PHENYLIMIDAZO[1,2-A]PYRIDINE, AND 2-PHENYLIMIDAZO[1,2-A]PYRAZINE DERIVATIVES

by HUANG, KENNETH H, SMITH, EMILIE D, VEAL, JAMES M, OMMEN, ANDY J, ATKINSON, ROBERT N
Year of Publication 05.03.2019

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Patent

derivados de 2-arilimidazo [1,2-b] piridazina, 2-fenilimidazo [1,2-a] piridina, e 2-fenilimidazo [1,2-a] pirazina

derivados de 2-arilimidazo [1,2-b] piridazina, 2-fenilimidazo [1,2-a] piridina, e 2-fenilimidazo [1,2-a] pirazina

by ANDY J. OMMEN, JAMES M. VEAL, ROBERT N. ATKINSON, KENNETH H. HUANG, EMILIE D. SMITH
Year of Publication 10.07.2018

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Patent

2-arylimidazo[1,2-b]pyridazine, 2-phenylimidazo[1,2-a]pyridine, and 2-phenylimidazo[1,2-a]pyrazine derivatives

2-arylimidazo[1,2-b]pyridazine, 2-phenylimidazo[1,2-a]pyridine, and 2-phenylimidazo[1,2-a]pyrazine derivatives

by HUANG, KENNETH H, SMITH, EMILIE D, VEAL, JAMES M, OMMEN, ANDY J, ATKINSON, ROBERT N
Year of Publication 08.09.2016

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Patent

2-ARYLIMIDAZO[1,2-B]PYRIDAZINE, 2-PHENYLIMIDAZO[1,2-A]PYRIDINE, AND 2-PHENYLIMIDAZO[1,2-A]PYRAZINE DERIVATIVES

2-ARYLIMIDAZO[1,2-B]PYRIDAZINE, 2-PHENYLIMIDAZO[1,2-A]PYRIDINE, AND 2-PHENYLIMIDAZO[1,2-A]PYRAZINE DERIVATIVES

by HUANG, KENNETH H, VEAL, JAMES M, SMITH, EMILIE, D, OMMEN, ANDY J, ATKINSON, ROBERT N
Year of Publication 16.12.2015

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Patent

2-arylimidazo[1,2-B]pyridazine, 2-phenylimidazo[1,2-A]pyridine, and 2-phenylimidazo[1,2-A]pyrazine derivatives

2-arylimidazo[1,2-B]pyridazine, 2-phenylimidazo[1,2-A]pyridine, and 2-phenylimidazo[1,2-A]pyrazine derivatives

by HUANG KENNETH H, ATKINSON ROBERT N, OMMEN ANDY J, VEAL JAMES M, SMITH EMILIE D
Year of Publication 28.10.2014

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Patent

2-ARYLIMIDAZO[1,2-B]PYRIDAZINE, 2-PHENYLIMIDAZO[1,2-A]PYRIDINE, AND 2-PHENYLIMIDAZO[1,2-A]PYRAZINE DERIVATIVES

2-ARYLIMIDAZO[1,2-B]PYRIDAZINE, 2-PHENYLIMIDAZO[1,2-A]PYRIDINE, AND 2-PHENYLIMIDAZO[1,2-A]PYRAZINE DERIVATIVES

by HUANG, KENNETH H, VEAL, JAMES M, SMITH, EMILIE, D, OMMEN, ANDY J, ATKINSON, ROBERT N
Year of Publication 11.09.2013

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Patent

2-arylimidazo[1,2-b]pyridazine, 2-phenylimidazo[1,2-a]pyridine, and 2-phenylimidazo[1,2-a]pyrazine derivatives

2-arylimidazo[1,2-b]pyridazine, 2-phenylimidazo[1,2-a]pyridine, and 2-phenylimidazo[1,2-a]pyrazine derivatives

by HUANG, KENNETH H, SMITH, EMILIE D, VEAL, JAMES M, OMMEN, ANDY J, ATKINSON, ROBERT N
Year of Publication 20.06.2013

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Patent

2-ARYLIMIDAZO[1,2-B]PYRIDAZINE, 2-PHENYLIMIDAZO[1,2-A]PYRIDINE, AND 2-PHENYLIMIDAZO[1,2-A]PYRAZINE DERIVATIVES

2-ARYLIMIDAZO[1,2-B]PYRIDAZINE, 2-PHENYLIMIDAZO[1,2-A]PYRIDINE, AND 2-PHENYLIMIDAZO[1,2-A]PYRAZINE DERIVATIVES

by HUANG KENNETH H, ATKINSON ROBERT N, OMMEN ANDY J, VEAL JAMES M, SMITH EMILIE D
Year of Publication 12.07.2012

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Patent

2-ARYLIMIDAZO[1,2-B]PYRIDAZINE, 2-PHENYLIMIDAZO[1,2-A]PYRIDINE, AND 2-PHENYLIMIDAZO[1,2-A]PYRAZINE DERIVATIVES

2-ARYLIMIDAZO[1,2-B]PYRIDAZINE, 2-PHENYLIMIDAZO[1,2-A]PYRIDINE, AND 2-PHENYLIMIDAZO[1,2-A]PYRAZINE DERIVATIVES

by HUANG, KENNETH H, VEAL, JAMES M, SMITH, EMILIE, D, OMMEN, ANDY J, ATKINSON, ROBERT N
Year of Publication 28.06.2012

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Patent

2-ARYLIMIDAZO[1,2-B]PYRIDAZINE, 2-PHENYLIMIDAZO[1,2-A]PYRIDINE, AND 2-PHENYLIMIDAZO[1,2-A]PYRAZINE DERIVATIVES

2-ARYLIMIDAZO[1,2-B]PYRIDAZINE, 2-PHENYLIMIDAZO[1,2-A]PYRIDINE, AND 2-PHENYLIMIDAZO[1,2-A]PYRAZINE DERIVATIVES

by HUANG, KENNETH H, SMITH, EMILIE D, VEAL, JAMES M, OMMEN, ANDY J, ATKINSON, ROBERT N
Year of Publication 28.06.2012

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Patent

2-arylimidazo[1,2-b]pyridazine, 2-phenylimidazo[1,2-a]pyridine, and 2-phenylimidazo[1,2-a]pyrazine derivatives

2-arylimidazo[1,2-b]pyridazine, 2-phenylimidazo[1,2-a]pyridine, and 2-phenylimidazo[1,2-a]pyrazine derivatives

by HUANG, KENNETH H, SMITH, EMILIE D, VEAL, JAMES M, OMMEN, ANDY J, ATKINSON, ROBERT N
Year of Publication 11.03.2018

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Patent

2-ARYLIMIDAZO[1,2-B]PYRIDAZINE,2-PHENYLIMIDAZO[1,2-A]PYRIDINE, AND 2- PHENYLIMIDAZO[1,2-A]PYRAZINE DERIVATIVES 2-[12-B]2-[12-A] 2-[12-A]

2-ARYLIMIDAZO[1,2-B]PYRIDAZINE,2-PHENYLIMIDAZO[1,2-A]PYRIDINE, AND 2- PHENYLIMIDAZO[1,2-A]PYRAZINE DERIVATIVES 2-[12-B]2-[12-A] 2-[12-A]

by HUANG, Kenneth H. H, OMMEN, Andy J. J, VEAL, James M. M, ATKINSON, Robert N. N, SMITH, Emilie, D. D
Year of Publication 18.08.2017

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Patent

2-ARYLIMIDAZO[1,2-B]PYRIDAZINE, 2-PHENYLIMIDAZO[1,2-A]PYRIDINE, AND 2-PHENYLIMIDAZO[1,2-A]PYRAZINE DERIVATIVES

2-ARYLIMIDAZO[1,2-B]PYRIDAZINE, 2-PHENYLIMIDAZO[1,2-A]PYRIDINE, AND 2-PHENYLIMIDAZO[1,2-A]PYRAZINE DERIVATIVES

by ANDY J. OMMEN, ROBERT N. ATKINSON, JAMES M. VEAL, KENNETH H. HUANG, EMILIE D. SMITH
Year of Publication 01.11.2013

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Patent

2-arylimidazo[1,2-]pyridazine, 2-phenylimidazo[1,2-a]pyridine, and 2-phenylimidazo[1,2-a]pyrazine derivatives

2-arylimidazo[1,2-]pyridazine, 2-phenylimidazo[1,2-a]pyridine, and 2-phenylimidazo[1,2-a]pyrazine derivatives

by HUANG KENNETH H, ATKINSON ROBERT N, OMMEN ANDY J, VEAL JAMES M, SMITH EMILIE D
Year of Publication 21.08.2013

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Patent

2-arylimidazo[1,2-b]pyridazine, 2-phenylimidazo[1,2-a]pyridine, and 2-phenylimidazo[1,2-a]pyrazine derivatives

2-arylimidazo[1,2-b]pyridazine, 2-phenylimidazo[1,2-a]pyridine, and 2-phenylimidazo[1,2-a]pyrazine derivatives

by HUANG, KENNETH H, SMITH, EMILIE D, VEAL, JAMES M, OMMEN, ANDY J, ATKINSON, ROBERT N
Year of Publication 16.02.2013

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Patent

TETRAHYDROINDOLE AND TETRAHYDROINDAZOLE DERIVATIVES

TETRAHYDROINDOLE AND TETRAHYDROINDAZOLE DERIVATIVES

by VEAL, JAMES, M, MCCALL, W., STEPHEN, OMMEN, ANDY, J, WOODWARD, ANGELA, R, HUGHES, PHILIP, F, SMITH, EMILIE, D, HUANG, KENNETH, HE, BARTA, THOMAS, E, MA, WEI
Year of Publication 27.01.2010

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Patent

TETRAHYDROINDOLE AND TETRAHYDROINDAZOLE DERIVATIVES

TETRAHYDROINDOLE AND TETRAHYDROINDAZOLE DERIVATIVES

by VEAL, JAMES, M, MCCALL, W., STEPHEN, OMMEN, ANDY, J, WOODWARD, ANGELA, R, HUGHES, PHILIP, F, SMITH, EMILIE, D, HUANG, KENNETH, HE, BARTA, THOMAS, E, MA, WEI
Year of Publication 18.12.2008

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Patent