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Discovery of Novel 2-Aminobenzamide Inhibitors of Heat Shock Protein 90 as Potent, Selective and Orally Active Antitumor Agents

Discovery of Novel 2-Aminobenzamide Inhibitors of Heat Shock Protein 90 as Potent, Selective and Orally Active Antitumor Agents

by Huang, Kenneth H, Veal, James M, Fadden, R. Patrick, Rice, John W, Eaves, Jeron, Strachan, Jon-Paul, Barabasz, Amy F, Foley, Briana E, Barta, Thomas E, Ma, Wei, Silinski, Melanie A, Hu, Mei, Partridge, Jeffrey M, Scott, Anisa, DuBois, Laura G, Freed, Tiffany, Steed, Paul M, Ommen, Andy J, Smith, Emilie D, Hughes, Philip F, Woodward, Angela R, Hanson, Gunnar J, McCall, W. Stephen, Markworth, Christopher J, Hinkley, Lindsay, Jenks, Matthew, Geng, Lifeng, Lewis, Meredith, Otto, James, Pronk, Bert, Verleysen, Katleen, Hall, Steven E
Published in Journal of medicinal chemistry (23.07.2009)

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Journal Article

Discovery of novel aminoquinazolin-7-yl 6,7-dihydro-indol-4-ones as potent, selective inhibitors of heat shock protein 90

Discovery of novel aminoquinazolin-7-yl 6,7-dihydro-indol-4-ones as potent, selective inhibitors of heat shock protein 90

by Huang, Kenneth H., Barta, Thomas E., Rice, John W., Smith, Emilie D., Ommen, Andy J., Ma, Wei, Veal, James M., Fadden, R. Patrick, Barabasz, Amy F., Foley, Briana E., Hughes, Philip F., Hanson, Gunnar J., Markworth, Christopher J., Silinski, Melanie, Partridge, Jeffrey M., Steed, Paul M., Hall, Steven E.
Published in Bioorganic & medicinal chemistry letters (01.04.2012)

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Journal Article

Application of Chemoproteomics to Drug Discovery: Identification of a Clinical Candidate Targeting Hsp90

Application of Chemoproteomics to Drug Discovery: Identification of a Clinical Candidate Targeting Hsp90

by Fadden, Patrick, Huang, Kenneth H., Veal, James M., Steed, Paul M., Barabasz, Amy F., Foley, Briana, Hu, Mei, Partridge, Jeffrey M., Rice, John, Scott, Anisa, Dubois, Laura G., Freed, Tiffany A., Silinski, Melanie A. Rehder, Barta, Thomas E., Hughes, Philip F., Ommen, Andy, Ma, Wei, Smith, Emilie D., Spangenberg, Angela Woodward, Eaves, Jeron, Hanson, Gunnar J., Hinkley, Lindsay, Jenks, Matthew, Lewis, Meredith, Otto, James, Pronk, Gijsbertus J., Verleysen, Katleen, Haystead, Timothy A., Hall, Steven E.
Published in Chemistry & biology (30.07.2010)

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Journal Article

2-ARYLIMIDAZO[1,2-B]PYRIDAZINE, 2-PHENYLIMIDAZO[1,2-A]PYRIDINE, AND 2-PHENYLIMIDAZO[1,2-A]PYRAZINE DERIVATIVES

2-ARYLIMIDAZO[1,2-B]PYRIDAZINE, 2-PHENYLIMIDAZO[1,2-A]PYRIDINE, AND 2-PHENYLIMIDAZO[1,2-A]PYRAZINE DERIVATIVES

by HUANG KENNETH H, ATKINSON ROBERT N, OMMEN ANDY J, VEAL JAMES M, SMITH EMILIE D
Year of Publication 14.02.2014

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Patent

2-ARYLIMIDAZO[1,2-B]PYRIDAZINE, 2-PHENYLIMIDAZO[1,2-A]PYRIDINE, AND 2-PHENYLIMIDAZO[1,2-A]PYRAZINE DERIVATIVES

2-ARYLIMIDAZO[1,2-B]PYRIDAZINE, 2-PHENYLIMIDAZO[1,2-A]PYRIDINE, AND 2-PHENYLIMIDAZO[1,2-A]PYRAZINE DERIVATIVES

by HUANG, KENNETH H, SMITH, EMILIE D, VEAL, JAMES M, OMMEN, ANDY J, ATKINSON, ROBERT N
Year of Publication 05.03.2019

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Patent

2-arylimidazo[1,2-b]pyridazine, 2-phenylimidazo[1,2-a]pyridine, and 2-phenylimidazo[1,2-a]pyrazine derivatives

2-arylimidazo[1,2-b]pyridazine, 2-phenylimidazo[1,2-a]pyridine, and 2-phenylimidazo[1,2-a]pyrazine derivatives

by HUANG, KENNETH H, SMITH, EMILIE D, VEAL, JAMES M, OMMEN, ANDY J, ATKINSON, ROBERT N
Year of Publication 08.09.2016

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Patent

2-ARYLIMIDAZO[1,2-B]PYRIDAZINE, 2-PHENYLIMIDAZO[1,2-A]PYRIDINE, AND 2-PHENYLIMIDAZO[1,2-A]PYRAZINE DERIVATIVES

2-ARYLIMIDAZO[1,2-B]PYRIDAZINE, 2-PHENYLIMIDAZO[1,2-A]PYRIDINE, AND 2-PHENYLIMIDAZO[1,2-A]PYRAZINE DERIVATIVES

by HUANG, KENNETH H, VEAL, JAMES M, SMITH, EMILIE, D, OMMEN, ANDY J, ATKINSON, ROBERT N
Year of Publication 16.12.2015

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Patent

2-arylimidazo[1,2-B]pyridazine, 2-phenylimidazo[1,2-A]pyridine, and 2-phenylimidazo[1,2-A]pyrazine derivatives

2-arylimidazo[1,2-B]pyridazine, 2-phenylimidazo[1,2-A]pyridine, and 2-phenylimidazo[1,2-A]pyrazine derivatives

by HUANG KENNETH H, ATKINSON ROBERT N, OMMEN ANDY J, VEAL JAMES M, SMITH EMILIE D
Year of Publication 28.10.2014

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Patent

2-ARYLIMIDAZO[1,2-B]PYRIDAZINE, 2-PHENYLIMIDAZO[1,2-A]PYRIDINE, AND 2-PHENYLIMIDAZO[1,2-A]PYRAZINE DERIVATIVES

2-ARYLIMIDAZO[1,2-B]PYRIDAZINE, 2-PHENYLIMIDAZO[1,2-A]PYRIDINE, AND 2-PHENYLIMIDAZO[1,2-A]PYRAZINE DERIVATIVES

by HUANG, KENNETH H, VEAL, JAMES M, SMITH, EMILIE, D, OMMEN, ANDY J, ATKINSON, ROBERT N
Year of Publication 11.09.2013

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Patent

2-arylimidazo[1,2-b]pyridazine, 2-phenylimidazo[1,2-a]pyridine, and 2-phenylimidazo[1,2-a]pyrazine derivatives

2-arylimidazo[1,2-b]pyridazine, 2-phenylimidazo[1,2-a]pyridine, and 2-phenylimidazo[1,2-a]pyrazine derivatives

by HUANG, KENNETH H, SMITH, EMILIE D, VEAL, JAMES M, OMMEN, ANDY J, ATKINSON, ROBERT N
Year of Publication 20.06.2013

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Patent

2-ARYLIMIDAZO[1,2-B]PYRIDAZINE, 2-PHENYLIMIDAZO[1,2-A]PYRIDINE, AND 2-PHENYLIMIDAZO[1,2-A]PYRAZINE DERIVATIVES

2-ARYLIMIDAZO[1,2-B]PYRIDAZINE, 2-PHENYLIMIDAZO[1,2-A]PYRIDINE, AND 2-PHENYLIMIDAZO[1,2-A]PYRAZINE DERIVATIVES

by HUANG KENNETH H, ATKINSON ROBERT N, OMMEN ANDY J, VEAL JAMES M, SMITH EMILIE D
Year of Publication 12.07.2012

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Patent

2-ARYLIMIDAZO[1,2-B]PYRIDAZINE, 2-PHENYLIMIDAZO[1,2-A]PYRIDINE, AND 2-PHENYLIMIDAZO[1,2-A]PYRAZINE DERIVATIVES

2-ARYLIMIDAZO[1,2-B]PYRIDAZINE, 2-PHENYLIMIDAZO[1,2-A]PYRIDINE, AND 2-PHENYLIMIDAZO[1,2-A]PYRAZINE DERIVATIVES

by HUANG, KENNETH H, VEAL, JAMES M, SMITH, EMILIE, D, OMMEN, ANDY J, ATKINSON, ROBERT N
Year of Publication 28.06.2012

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Patent

2-ARYLIMIDAZO[1,2-B]PYRIDAZINE, 2-PHENYLIMIDAZO[1,2-A]PYRIDINE, AND 2-PHENYLIMIDAZO[1,2-A]PYRAZINE DERIVATIVES

2-ARYLIMIDAZO[1,2-B]PYRIDAZINE, 2-PHENYLIMIDAZO[1,2-A]PYRIDINE, AND 2-PHENYLIMIDAZO[1,2-A]PYRAZINE DERIVATIVES

by HUANG, KENNETH H, SMITH, EMILIE D, VEAL, JAMES M, OMMEN, ANDY J, ATKINSON, ROBERT N
Year of Publication 28.06.2012

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Patent

2-arylimidazo[1,2-b]pyridazine, 2-phenylimidazo[1,2-a]pyridine, and 2-phenylimidazo[1,2-a]pyrazine derivatives

2-arylimidazo[1,2-b]pyridazine, 2-phenylimidazo[1,2-a]pyridine, and 2-phenylimidazo[1,2-a]pyrazine derivatives

by HUANG, KENNETH H, SMITH, EMILIE D, VEAL, JAMES M, OMMEN, ANDY J, ATKINSON, ROBERT N
Year of Publication 11.03.2018

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Patent

2-ARYLIMIDAZO[1,2-B]PYRIDAZINE,2-PHENYLIMIDAZO[1,2-A]PYRIDINE, AND 2- PHENYLIMIDAZO[1,2-A]PYRAZINE DERIVATIVES 2-[12-B]2-[12-A] 2-[12-A]

2-ARYLIMIDAZO[1,2-B]PYRIDAZINE,2-PHENYLIMIDAZO[1,2-A]PYRIDINE, AND 2- PHENYLIMIDAZO[1,2-A]PYRAZINE DERIVATIVES 2-[12-B]2-[12-A] 2-[12-A]

by HUANG, Kenneth H. H, OMMEN, Andy J. J, VEAL, James M. M, ATKINSON, Robert N. N, SMITH, Emilie, D. D
Year of Publication 18.08.2017

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Patent

Quinazoline derivatives for the treatment of cancer

Quinazoline derivatives for the treatment of cancer

by Huang, Kenneth He, Veal, James, Barta, Thomas, Smith, Emilie D, Ma, Wei, Ommen, Andy
Year of Publication 16.03.2010

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Patent

ISOQUINOLINE, QUINAZOLINE AND PHTHALAZINE DERIVATIVES

ISOQUINOLINE, QUINAZOLINE AND PHTHALAZINE DERIVATIVES

by BARTA, THOMAS, OMMEN, ANDY, VEAL, JAMES, SMITH, EMILIE, D, HUANG, KENNETH, MA, WEI
Year of Publication 17.06.2009

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Patent

Quinazoline derivatives for the treatment of cancer

Quinazoline derivatives for the treatment of cancer

by HUANG KENNETH HE, OMMEN ANDY, BARTA THOMAS, MA WEI, VEAL JAMES, SMITH EMILIE D
Year of Publication 16.03.2010

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Patent

Isoquinoline, Quinazoline and Phthalazine Derivatives

Isoquinoline, Quinazoline and Phthalazine Derivatives

by OMMEN ANDY, HUANG KENNETH H, BARTA THOMAS, MA WEI, VEAL JAMES, SMITH EMILIE D
Year of Publication 20.03.2008

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Patent

ISOQUINOLINE, QUINAZOLINE AND PHTHALAZINE DERIVATIVES

ISOQUINOLINE, QUINAZOLINE AND PHTHALAZINE DERIVATIVES

by BARTA, THOMAS, OMMEN, ANDY, VEAL, JAMES, SMITH, EMILIE, D, HUANG, KENNETH, HE, MA, WEI
Year of Publication 06.11.2008

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Patent