Unlocking P(V): Reagents for chiral phosphorothioate synthesis
Knouse, Kyle W, deGruyter, Justine N, Schmidt, Michael A, Zheng, Bin, Vantourout, Julien C, Kingston, Cian, Mercer, Stephen E, Mcdonald, Ivar M, Olson, Richard E, Zhu, Ye, Hang, Chao, Zhu, Jason, Yuan, Changxia, Wang, Qinggang, Park, Peter, Eastgate, Martin D, Baran, Phil S
Published in Science (American Association for the Advancement of Science) (21.09.2018)
Published in Science (American Association for the Advancement of Science) (21.09.2018)
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Effects of BMS-902483, an α7 nicotinic acetylcholine receptor partial agonist, on cognition and sensory gating in relation to receptor occupancy in rodents
Pieschl, Rick L., Miller, Regina, Jones, Kelli M., Post-Munson, Debra J., Chen, Ping, Newberry, Kimberly, Benitex, Yulia, Molski, Thaddeus, Morgan, Daniel, McDonald, Ivar M., Macor, John E., Olson, Richard E., Asaka, Yukiko, Digavalli, Siva, Easton, Amy, Herrington, James, Westphal, Ryan S., Lodge, Nicholas J., Zaczek, Robert, Bristow, Linda J., Li, Yu-Wen
Published in European journal of pharmacology (15.07.2017)
Published in European journal of pharmacology (15.07.2017)
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Identification and characterization of a MAPT-targeting locked nucleic acid antisense oligonucleotide therapeutic for tauopathies
Easton, Amy, Jensen, Marianne L., Wang, Congwei, Hagedorn, Peter H., Li, Yuwen, Weed, Michael, Meredith, Jere E., Guss, Valerie, Jones, Kelli, Gill, Martin, Krause, Carol, Brown, Jeffrey M., Hunihan, Lisa, Natale, Joanne, Fernandes, Alda, Lu, Yifeng, Polino, Joe, Bookbinder, Mark, Cadelina, Greg, Benitex, Yulia, Sane, Ramola, Morrison, John, Drexler, Dieter, Mercer, Stephen E., Bon, Charlotte, Pandya, Nikhil J., Jagasia, Ravi, Ou Yang, Tai-Hsien, Distler, Tania, Grüninger, Fiona, Meldgaard, Michael, Terrigno, Marco, Macor, John E., Albright, Charles F., Loy, James, Hoeg, Anja M., Olson, Richard E., Cacace, Angela M.
Published in Molecular therapy. Nucleic acids (13.09.2022)
Published in Molecular therapy. Nucleic acids (13.09.2022)
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Process Optimization for the Large-Scale Preparation of (2S,3aR,7aS)-tert-Butyl Hexahydro-2,5-methanopyrrolo[3,2‑c]pyridine-1(4H)‑carboxylate, an Intermediate for Nicotinic Acetylcholine Receptor Agonists
Jarugu, Lokesh Babu, Reddy, China Anki, Chikkananjunda, Nanjundaswamy Kanikahalli, Krishnamoorthy, Suresh, Sarvanakumar, Pon, Sankar, Ulaganathan, Arunachalam, Pirama Nayagam, McDonald, Ivar M, Olson, Richard E, Rampulla, Richard, Mathur, Arvind, Gupta, Anuradha
Published in Organic process research & development (21.09.2018)
Published in Organic process research & development (21.09.2018)
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Allele-Selective Knockdown of MYH7 Using Antisense Oligonucleotides
Anderson, Brian R., Jensen, Marianne L., Hagedorn, Peter H., Little, Sean C., Olson, Richard E., Ammar, Ron, Kienzle, Bernadette, Thompson, John, McDonald, Ivar, Mercer, Stephen, Vikesaa, Jonas, Nordbo, Bettina, Iben, Larry, Cao, Yang, Natale, Joanne, Dalton-Kay, Greg, Cacace, Angela, Hansen, Bo R., Hedtjärn, Maj, Koch, Troels, Bristow, Linda J.
Published in Molecular therapy. Nucleic acids (06.03.2020)
Published in Molecular therapy. Nucleic acids (06.03.2020)
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Acute Neurotoxicity of Antisense Oligonucleotides After Intracerebroventricular Injection Into Mouse Brain Can Be Predicted from Sequence Features
Hagedorn, Peter H, Brown, Jeffrey M, Easton, Amy, Pierdomenico, Maria, Jones, Kelli, Olson, Richard E, Mercer, Stephen E, Li, Dong, Loy, James, Høg, Anja M, Jensen, Marianne L, Gill, Martin, Cacace, Angela M
Published in Nucleic acid therapeutics (01.06.2022)
Published in Nucleic acid therapeutics (01.06.2022)
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Hyperdynamic microtubules, cognitive deficits, and pathology are improved in tau transgenic mice with low doses of the microtubule-stabilizing agent BMS-241027
Barten, Donna M, Fanara, Patrizia, Andorfer, Cathy, Hoque, Nina, Wong, P Y Anne, Husted, Kristofor H, Cadelina, Gregory W, Decarr, Lynn B, Yang, Ling, Liu, Victoria, Fessler, Chancy, Protassio, Joan, Riff, Timothy, Turner, Holly, Janus, Christopher G, Sankaranarayanan, Sethu, Polson, Craig, Meredith, Jere E, Gray, Gemma, Hanna, Amanda, Olson, Richard E, Kim, Soong-Hoon, Vite, Gregory D, Lee, Francis Y, Albright, Charles F
Published in The Journal of neuroscience (23.05.2012)
Published in The Journal of neuroscience (23.05.2012)
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Identification and Preclinical Pharmacology of the γ-Secretase Modulator BMS-869780
Toyn, Jeremy H., Thompson, Lorin A., Lentz, Kimberley A., Meredith, Jere E., Burton, Catherine R., Sankaranararyanan, Sethu, Guss, Valerie, Hall, Tracey, Iben, Lawrence G., Krause, Carol M., Krause, Rudy, Lin, Xu-Alan, Pierdomenico, Maria, Polson, Craig, Robertson, Alan S., Denton, R. Rex, Grace, James E., Morrison, John, Raybon, Joseph, Zhuo, Xiaoliang, Snow, Kimberly, Padmanabha, Ramesh, Agler, Michele, Esposito, Kim, Harden, David, Prack, Margaret, Varma, Sam, Wong, Victoria, Zhu, Yingjie, Zvyaga, Tatyana, Gerritz, Samuel, Marcin, Lawrence R., Higgins, Mendi A., Shi, Jianliang, Wei, Cong, Cantone, Joseph L., Drexler, Dieter M., Macor, John E., Olson, Richard E., Ahlijanian, Michael K., Albright, Charles F.
Published in International journal of alzheimer's disease (2014)
Published in International journal of alzheimer's disease (2014)
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An amide-based sulfenamide prodrug of gamma secretase inhibitor BMS–708163 delivers parent drug from an oral conventional solid dosage form in male beagle dog
Guarino, Victor R., Olson, Richard E., Everlof, J. Gerry, Wang, Nenghui, McDonald, Ivar, Haskell, Roy, Clarke, Wendy, Lentz, Kimberley A.
Published in Bioorganic & medicinal chemistry letters (01.02.2020)
Published in Bioorganic & medicinal chemistry letters (01.02.2020)
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The γ-Secretase Modulator, BMS-932481, Modulates Aβ Peptides in the Plasma and Cerebrospinal Fluid of Healthy Volunteers
Soares, Holly D, Gasior, Maciej, Toyn, Jeremy H, Wang, Jun-Sheng, Hong, Quan, Berisha, Flora, Furlong, Michael T, Raybon, Joseph, Lentz, Kimberley A, Sweeney, Francis, Zheng, Naiyu, Akinsanya, Billy, Berman, Robert M, Thompson, Lorin A, Olson, Richard E, Morrison, John, Drexler, Dieter M, Macor, John E, Albright, Charlie F, Ahlijanian, Michael K, AbuTarif, Malaz
Published in The Journal of pharmacology and experimental therapeutics (01.07.2016)
Published in The Journal of pharmacology and experimental therapeutics (01.07.2016)
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Journal Article
Synthesis of functionalized derivatives of the gamma-secretase modulator BMS-932481 and identification of its major metabolite
Zhang, Yunhui, Boy, Kenneth M., Wu, Yong-Jin, Ramirez, Antonio, Toyn, Jeremy H., Ahlijanian, Michael K., Albright, Charles F., Zhuo, Xiaoliang, Johnson, Benjamin M., Denton, R. Rex, Olson, Richard E., Thompson, Lorin A., Macor, John E.
Published in Bioorganic & medicinal chemistry letters (15.11.2020)
Published in Bioorganic & medicinal chemistry letters (15.11.2020)
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Identification and Characterization of Presenilin-independent Notch Signaling
Berechid, Bridget E., Kitzmann, Magali, Foltz, Daniel R., Roach, Arthur H., Seiffert, Dietmar, Thompson, Lorin A., Olson, Richard E., Bernstein, Alan, Donoviel, Dorit B., Nye, Jeffrey S.
Published in The Journal of biological chemistry (08.03.2002)
Published in The Journal of biological chemistry (08.03.2002)
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Pharmacodynamics of selective inhibition of γ-secretase by avagacestat
Albright, Charles F, Dockens, Randy C, Meredith, Jr, Jere E, Olson, Richard E, Slemmon, Randy, Lentz, Kimberley A, Wang, Jun-Sheng, Denton, R Rex, Pilcher, Gary, Rhyne, Paul W, Raybon, Joseph J, Barten, Donna M, Burton, Catherine, Toyn, Jeremy H, Sankaranarayanan, Sethu, Polson, Craig, Guss, Valerie, White, Randy, Simutis, Frank, Sanderson, Thomas, Gillman, Kevin W, Starrett, Jr, John E, Bronson, Joanne, Sverdlov, Oleksandr, Huang, Shu-Pang, Castaneda, Lorna, Feldman, Howard, Coric, Vlad, Zaczek, Robert, Macor, John E, Houston, John, Berman, Robert M, Tong, Gary
Published in The Journal of pharmacology and experimental therapeutics (01.03.2013)
Published in The Journal of pharmacology and experimental therapeutics (01.03.2013)
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Design and Synthesis of a New Series of 4‑Heteroarylamino-1′-azaspiro[oxazole-5,3′-bicyclo[2.2.2]octanes as α7 Nicotinic Receptor Agonists. 1. Development of Pharmacophore and Early Structure–Activity Relationship
Cook, James, Zusi, F. Christopher, McDonald, Ivar M, King, Dalton, Hill, Matthew D, Iwuagwu, Christiana, Mate, Robert A, Fang, Haiquan, Zhao, Rulin, Wang, Bei, Cutrone, Jingfang, Ma, Baoqing, Gao, Qi, Knox, Ronald J, Matchett, Michele, Gallagher, Lizbeth, Ferrante, Meredith, Post-Munson, Debra, Molski, Thaddeus, Easton, Amy, Miller, Regina, Jones, Kelli, Digavalli, Siva, Healy, Francine, Lentz, Kimberley, Benitex, Yulia, Clarke, Wendy, Natale, Joanne, Siuciak, Judith A, Lodge, Nicholas, Zaczek, Robert, Denton, Rex, Morgan, Daniel, Bristow, Linda J, Macor, John E, Olson, Richard E
Published in Journal of medicinal chemistry (22.12.2016)
Published in Journal of medicinal chemistry (22.12.2016)
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Preclinical Characterization of ( R )-3-((3 S ,4 S )-3-fluoro-4-(4-hydroxyphenyl)piperidin-1-yl)-1-(4-methylbenzyl)pyrrolidin-2-one (BMS-986169), a Novel, Intravenous, Glutamate N -Methyl-d-Aspartate 2B Receptor Negative Allosteric Modulator with Potential in Major Depressive Disorder
Bristow, Linda J, Gulia, Jyoti, Weed, Michael R, Srikumar, Bettadapura N, Li, Yu-Wen, Graef, John D, Naidu, Pattipati S, Sanmathi, Charulatha, Aher, Jayant, Bastia, Tanmaya, Paschapur, Mahesh, Kalidindi, Narasimharaju, Kumar, Kuchibhotla Vijaya, Molski, Thaddeus, Pieschl, Rick, Fernandes, Alda, Brown, Jeffrey M, Sivarao, Digavalli V, Newberry, Kimberly, Bookbinder, Mark, Polino, Joseph, Keavy, Deborah, Newton, Amy, Shields, Eric, Simmermacher, Jean, Kempson, James, Li, Jianqing, Zhang, Huiping, Mathur, Arvind, Kallem, Raja Reddy, Sinha, Meenakshee, Ramarao, Manjunath, Vikramadithyan, Reeba K, Thangathirupathy, Srinivasan, Warrier, Jayakumar, Islam, Imadul, Bronson, Joanne J, Olson, Richard E, Macor, John E, Albright, Charlie F, King, Dalton, Thompson, Lorin A, Marcin, Lawrence R, Sinz, Michael
Published in The Journal of pharmacology and experimental therapeutics (01.12.2017)
Published in The Journal of pharmacology and experimental therapeutics (01.12.2017)
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Journal Article
Design and synthesis of a novel series of (1′S,2R,4′S)-3H-4′-azaspiro[benzo[4,5]imidazo[2,1-b]oxazole-2,2′-bicyclo[2.2.2]octanes] with high affinity for the α7 neuronal nicotinic receptor
Cook, James, Zusi, F. Christopher, Hill, Matthew D., Fang, Haiquan, Pearce, Bradley, Park, Hyunsoo, Gallagher, Lizbeth, McDonald, Ivar M., Bristow, Linda, Macor, John E., Olson, Richard E.
Published in Bioorganic & medicinal chemistry letters (15.11.2017)
Published in Bioorganic & medicinal chemistry letters (15.11.2017)
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Journal Article
Robust Translation of γ-Secretase Modulator Pharmacology across Preclinical Species and Human Subjects
Toyn, Jeremy H, Boy, Kenneth M, Raybon, Joseph, Meredith, Jr, Jere E, Robertson, Alan S, Guss, Valerie, Hoque, Nina, Sweeney, Francis, Zhuo, Xiaoliang, Clarke, Wendy, Snow, Kimberly, Denton, R Rex, Zuev, Dmitry, Thompson, Lorin A, Morrison, John, Grace, James, Berisha, Flora, Furlong, Michael, Wang, Jun-Sheng, Lentz, Kimberly A, Padmanabha, Ramesh, Cook, Lynda, Wei, Cong, Drexler, Dieter M, Macor, John E, Albright, Charlie F, Gasior, Maciej, Olson, Richard E, Hong, Quan, Soares, Holly D, AbuTarif, Malaz, Ahlijanian, Michael K
Published in The Journal of pharmacology and experimental therapeutics (01.07.2016)
Published in The Journal of pharmacology and experimental therapeutics (01.07.2016)
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Journal Article
Synergistic inhibition of Aβ production by combinations of γ-secretase modulators
Robertson, Alan S., Iben, Lawrence G., Wei, Cong, Meredith, Jere E., Drexler, Dieter M., Banks, Martyn, Vite, Gregory D., Olson, Richard E., Thompson, Lorin A., Albright, Charles F., Ahlijanian, Michael K., Toyn, Jeremy H.
Published in European journal of pharmacology (05.10.2017)
Published in European journal of pharmacology (05.10.2017)
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Hohlraum designs for high velocity implosions on NIF
Meezan, Nathan B., Hicks, Damien G., Callahan, Debra A., Olson, Richard E., Schneider, Marilyn S., Thomas, Cliff A., Robey, Harry F., Celliers, Peter M., Kline, John L., Dixit, Shamasundar N., Michel, Pierre A., Jones, Ogden S., Clark, Daniel S., Ralph, Joseph E., Döppner, Tilo, MacKinnon, Andrew J., Haan, Steven W., Landen, Otto L., Glenzer, Siegfried H., Suter, Laurence J., Edwards, Michael J., MacGowan, Brian J., Lindl, John D., Atherton, Lawrence J.
Published in EPJ Web of conferences (01.01.2013)
Published in EPJ Web of conferences (01.01.2013)
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