SARS-CoV-2 tropism, entry, replication, and propagation: Considerations for drug discovery and development
Murgolo, Nicholas, Therien, Alex G, Howell, Bonnie, Klein, Daniel, Koeplinger, Kenneth, Lieberman, Linda A, Adam, Gregory C, Flynn, Jessica, McKenna, Philip, Swaminathan, Gokul, Hazuda, Daria J, Olsen, David B
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Published in PLoS pathogens (01.02.2021)
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High-Throughput Enantiopurity Analysis Using Enantiomeric DNA‑Based Sensors
Feagin, Trevor A, Olsen, David P. V, Headman, Zachary C, Heemstra, Jennifer M
Published in Journal of the American Chemical Society (01.04.2015)
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Human monoclonal antibody HCV1 effectively prevents and treats HCV infection in chimpanzees
Morin, Trevor J, Broering, Teresa J, Leav, Brett A, Blair, Barbra M, Rowley, Kirk J, Boucher, Elisabeth N, Wang, Yang, Cheslock, Peter S, Knauber, Michael, Olsen, David B, Ludmerer, Steve W, Szabo, Gyongyi, Finberg, Robert W, Purcell, Robert H, Lanford, Robert E, Ambrosino, Donna M, Molrine, Deborah C, Babcock, Gregory J
Published in PLoS pathogens (01.08.2012)
Published in PLoS pathogens (01.08.2012)
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Dual Plasmepsin-Targeting Antimalarial Agents Disrupt Multiple Stages of the Malaria Parasite Life Cycle
Favuzza, Paola, de Lera Ruiz, Manuel, Thompson, Jennifer K., Triglia, Tony, Ngo, Anna, Steel, Ryan W.J., Vavrek, Marissa, Christensen, Janni, Healer, Julie, Boyce, Christopher, Guo, Zhuyan, Hu, Mengwei, Khan, Tanweer, Murgolo, Nicholas, Zhao, Lianyun, Penington, Jocelyn Sietsma, Reaksudsan, Kitsanapong, Jarman, Kate, Dietrich, Melanie H., Richardson, Lachlan, Guo, Kai-Yuan, Lopaticki, Sash, Tham, Wai-Hong, Rottmann, Matthias, Papenfuss, Tony, Robbins, Jonathan A., Boddey, Justin A., Sleebs, Brad E., Sabroux, Hélène Jousset, McCauley, John A., Olsen, David B., Cowman, Alan F.
Published in Cell host & microbe (08.04.2020)
Published in Cell host & microbe (08.04.2020)
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MK-5172, a Selective Inhibitor of Hepatitis C Virus NS3/4a Protease with Broad Activity across Genotypes and Resistant Variants
SUMMA, Vincenzo, LUDMERER, Steven W, GATES, Adam T, GRAHAM, Donald J, HARPER, Steven, HAZUDA, Daria J, MCHALE, Carolyn, MONTEAGUDO, Edith, PUCCI, Vincenzo, ROWLEY, Michael, RUDD, Michael T, SORIANO, Aileen, MCCAULEY, John A, STAHLHUT, Mark W, VACCA, Joseph P, OLSEN, David B, LIVERTON, Nigel J, CARROLL, Steven S, FANDOZZI, Christine, BURLEIN, Christine, CLAUDIO, Giuliano, COLEMAN, Paul J, DIMUZIO, Jillian M, FERRARA, Marco, DI FILIPPO, Marcello
Published in Antimicrobial Agents and Chemotherapy (01.08.2012)
Published in Antimicrobial Agents and Chemotherapy (01.08.2012)
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Intrathecal Morphine versus Intrathecal Hydromorphone for Analgesia after Cesarean Delivery: A Randomized Clinical Trial
Sharpe, Emily E, Molitor, Rochelle J, Arendt, Katherine W, Torbenson, Vanessa E, Olsen, David A, Johnson, Rebecca L, Schroeder, Darrell R, Jacob, Adam K, Niesen, Adam D, Sviggum, Hans P
Published in Anesthesiology (Philadelphia) (01.06.2020)
Published in Anesthesiology (Philadelphia) (01.06.2020)
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Pharmacological validation of dihydrofolate reductase as a drug target in Mycobacterium abscessus
Aragaw, Wassihun Wedajo, Negatu, Dereje A, Bungard, Christopher J, Dartois, Véronique A, Marrouni, Abdellatif El, Nickbarg, Elliott B, Olsen, David B, Warrass, Ralf, Dick, Thomas
Published in Antimicrobial agents and chemotherapy (10.01.2024)
Published in Antimicrobial agents and chemotherapy (10.01.2024)
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Discovery of MK-8742: An HCV NS5A Inhibitor with Broad Genotype Activity
Coburn, Craig A., Meinke, Peter T., Chang, Wei, Fandozzi, Christine M., Graham, Donald J., Hu, Bin, Huang, Qian, Kargman, Stacia, Kozlowski, Joseph, Liu, Rong, McCauley, John A., Nomeir, Amin A., Soll, Richard M., Vacca, Joseph P., Wang, Dahai, Wu, Hao, Zhong, Bin, Olsen, David B., Ludmerer, Steven W.
Published in ChemMedChem (01.12.2013)
Published in ChemMedChem (01.12.2013)
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Activity of Tricyclic Pyrrolopyrimidine Gyrase B Inhibitor against Mycobacterium abscessus
Madani, Abdeldjalil, Negatu, Dereje A., El Marrouni, Abdellatif, Miller, Randy R., Boyce, Christopher W., Murgolo, Nicholas, Bungard, Christopher J., Zimmerman, Matthew D., Dartois, Véronique, Gengenbacher, Martin, Olsen, David B., Dick, Thomas
Published in Antimicrobial agents and chemotherapy (20.09.2022)
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The Tuberculosis Drug Accelerator at year 10: what have we learned?
Aldridge, Bree B, Barros-Aguirre, David, Barry, 3rd, Clifton E, Bates, Robert H, Berthel, Steven J, Boshoff, Helena I, Chibale, Kelly, Chu, Xin-Jie, Cooper, Christopher B, Dartois, Véronique, Duncan, Ken, Fotouhi, Nader, Gusovsky, Fabian, Hipskind, Philip A, Kempf, Dale J, Lelièvre, Joël, Lenaerts, Anne J, McNamara, Case W, Mizrahi, Valerie, Nathan, Carl, Olsen, David B, Parish, Tanya, Petrassi, H Michael, Pym, Alexander, Rhee, Kyu Y, Robertson, Gregory T, Rock, Jeremy Michael, Rubin, Eric J, Russell, Betsy, Russell, David G, Sacchettini, James C, Schnappinger, Dirk, Schrimpf, Michael, Upton, Anna M, Warner, Peter, Wyatt, Paul Graham, Yuan, Ying
Published in Nature medicine (01.08.2021)
Published in Nature medicine (01.08.2021)
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Discovery and Structure–Activity-Relationship Study of N‑Alkyl-5-hydroxypyrimidinone Carboxamides as Novel Antitubercular Agents Targeting Decaprenylphosphoryl-β‑d‑ribose 2′-Oxidase
Oh, Sangmi, Park, Yumi, Engelhart, Curtis A, Wallach, Joshua B, Schnappinger, Dirk, Arora, Kriti, Manikkam, Michelle, Gac, Brian, Wang, Hongwu, Murgolo, Nicholas, Olsen, David B, Goodwin, Michael, Sutphin, Michelle, Weiner, Danielle M, Via, Laura E, Boshoff, Helena I. M, Barry, Clifton E
Published in Journal of medicinal chemistry (21.11.2018)
Published in Journal of medicinal chemistry (21.11.2018)
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Structure activity relationship of N-1 substituted 1,5-naphthyrid-2-one analogs of oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad-spectrum antibacterial agents (Part-9)
Singh, Sheo B., Tan, Christopher M., Kaelin, David, Meinke, Peter T., Miesel, Lynn, Olsen, David B., Fukuda, Hideyuki, Kishii, Ryuta, Takei, Masaya, Ohata, Kohei, Takeuchi, Tomoko, Shibue, Taku, Takano, Hisashi, Nishimura, Akinori, Fukuda, Yasumichi
Published in Bioorganic & medicinal chemistry letters (01.11.2022)
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A single center descriptive study of local anesthetic dose in knee arthroplasty: Was there evidence of local anesthetic systemic toxicity?
Douglas, Rachel N., Niesen, Adam D., Johnson, Rebecca L., Olsen, David A., Taunton, Michael J., Portner, Erica R., Acker, Christopher T., Hanson, Andrew C., Kopp, Sandra L.
Published in Journal of clinical anesthesia (01.10.2024)
Published in Journal of clinical anesthesia (01.10.2024)
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MK-7009, a Potent and Selective Inhibitor of Hepatitis C Virus NS3/4A Protease
LIVERTON, Nigel J, CARROLL, Steven S, OLSEN, David B, RUDD, Michael T, STAHLHUT, Mark, VACCA, Joseph P, DIMUZIO, Jillian, FANDOZZI, Christine, GRAHAM, Donald J, HAZUDA, Daria, KATHERINE HOLLOWAY, M, LUDMERER, Steven W, MCCAULEY, John A, MCINTYRE, Charles J
Published in Antimicrobial Agents and Chemotherapy (01.01.2010)
Published in Antimicrobial Agents and Chemotherapy (01.01.2010)
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Invention of MK-7845, a SARS-CoV‑2 3CL Protease Inhibitor Employing a Novel Difluorinated Glutamine Mimic
Shurtleff, Valerie W., Layton, Mark E., Parish, Craig A., Perkins, James J., Schreier, John D., Wang, Yunyi, Adam, Gregory C., Alvarez, Nadine, Bahmanjah, Soheila, Bahnck-Teets, Carolyn M., Boyce, Christopher W., Burlein, Christine, Cabalu, Tamara D., Campbell, Brian T., Carroll, Steven S., Chang, Wonsuk, de Lera Ruiz, Manuel, Dolgov, Enriko, Fay, John F., Fox, Nicholas G., Goh, Shih Lin, Hartingh, Timothy J., Hurzy, Danielle M., Kelly, Michael J., Klein, Daniel J., Klingler, Franca-Maria, Krishnamurthy, Harini, Kudalkar, Shalley, Mayhood, Todd W., McKenna, Philip M., Murray, Edward M., Nahas, Debbie, Nawrat, Christopher C., Park, Steven, Qian, Dongming, Roecker, Anthony J., Sharma, Vijeta, Shipe, William D., Su, Jing, Taggart, Robert V., Truong, Quang, Wu, Yin, Zhou, Xiaoyan, Zhuang, Ningning, Perlin, David S., Olsen, David B., Howe, John A., McCauley, John A.
Published in Journal of medicinal chemistry (14.03.2024)
Published in Journal of medicinal chemistry (14.03.2024)
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Discovery of Vaniprevir (MK-7009), a Macrocyclic Hepatitis C Virus NS3/4a Protease Inhibitor
McCauley, John A, McIntyre, Charles J, Rudd, Michael T, Nguyen, Kevin T, Romano, Joseph J, Butcher, John W, Gilbert, Kevin F, Bush, Kimberly J, Holloway, M. Katharine, Swestock, John, Wan, Bang-Lin, Carroll, Steven S, DiMuzio, Jillian M, Graham, Donald J, Ludmerer, Steven W, Mao, Shi-Shan, Stahlhut, Mark W, Fandozzi, Christine M, Trainor, Nicole, Olsen, David B, Vacca, Joseph P, Liverton, Nigel J
Published in Journal of medicinal chemistry (25.03.2010)
Published in Journal of medicinal chemistry (25.03.2010)
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Novel Pan-Coronavirus 3CL Protease Inhibitor MK-7845: Biological and Pharmacological Profiling
Alvarez, Nadine, Adam, Gregory C, Howe, John A, Sharma, Vijeta, Zimmerman, Matthew D, Dolgov, Enriko, Rasheed, Risha, Nizar, Fatima, Sahay, Khushboo, Nelson, Andrew M, Park, Steven, Zhou, Xiaoyan, Burlein, Christine, Fay, John F, Iwamoto, Daniel V, Bahnck-Teets, Carolyn M, Getty, Krista L, Lin Goh, Shih, Salhab, Imad, Smith, Keith, Boyce, Christopher W, Cabalu, Tamara D, Murgolo, Nicholas, Fox, Nicholas G, Mayhood, Todd W, Shurtleff, Valerie W, Layton, Mark E, Parish, Craig A, McCauley, John A, Olsen, David B, Perlin, David S
Published in Viruses (01.07.2024)
Published in Viruses (01.07.2024)
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Thiazomycin, nocathiacin and analogs show strong activity against clinical strains of drug-resistant Mycobacterium tuberculosis
Singh, Sheo B., Xu, Libo, Meinke, Peter T., Kurepina, Natalia, Kreiswirth, Barry N., Olsen, David B., Young, Katherine
Published in Journal of antibiotics (01.05.2017)
Published in Journal of antibiotics (01.05.2017)
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Invasive lionfish (Pterois volitans): a potential human health threat for ciguatera fish poisoning in tropical waters
Robertson, Alison, Garcia, Ana C, Quintana, Harold A Flores, Smith, Tyler B, Castillo, 2nd, Bernard F, Reale-Munroe, Kynoch, Gulli, Joseph A, Olsen, David A, Hooe-Rollman, Jennifer I, Jester, Edward L E, Klimek, Brian J, Plakas, Steven M
Published in Marine drugs (27.12.2013)
Published in Marine drugs (27.12.2013)
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