Discovery of a Potent, Selective T‑type Calcium Channel Blocker as a Drug Candidate for the Treatment of Generalized Epilepsies
Bezençon, Olivier, Heidmann, Bibia, Siegrist, Romain, Stamm, Simon, Richard, Sylvia, Pozzi, Davide, Corminboeuf, Olivier, Roch, Catherine, Kessler, Melanie, Ertel, Eric A., Reymond, Isabelle, Pfeifer, Thomas, de Kanter, Ruben, Toeroek-Schafroth, Michael, Moccia, Luca G., Mawet, Jacques, Moon, Richard, Rey, Markus, Capeleto, Bruno, Fournier, Elvire
Published in Journal of medicinal chemistry (14.12.2017)
Published in Journal of medicinal chemistry (14.12.2017)
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Journal Article
Structure–Activity Relationship, Drug Metabolism and Pharmacokinetics Properties Optimization, and in Vivo Studies of New Brain Penetrant Triple T‑Type Calcium Channel Blockers
Siegrist, Romain, Pozzi, Davide, Jacob, Gaël, Torrisi, Caterina, Colas, Kilian, Braibant, Bertrand, Mawet, Jacques, Pfeifer, Thomas, de Kanter, Ruben, Roch, Catherine, Kessler, Melanie, Corminboeuf, Olivier, Bezençon, Olivier
Published in Journal of medicinal chemistry (08.12.2016)
Published in Journal of medicinal chemistry (08.12.2016)
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Journal Article
Discovery, synthesis and SAR of 2-acyl-1-biarylmethyl pyrazolidines, dual orexin receptor antagonists designed as fast and short-acting sleeping drugs
Surivet, Jean-Philippe, Kessler, Melanie, Vaillant, Catherine, Aissaoui, Hamed, Bezençon, Olivier, Busch, Louise, Kiry, Manon, Lüthi, Urs, Marck, Nicolas, Masse, Florence, Peters, Jens-Uwe, Sweatman, Catherine, Weigel, Aude, Kohl, Christopher
Published in Bioorganic & medicinal chemistry (01.10.2024)
Published in Bioorganic & medicinal chemistry (01.10.2024)
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Journal Article
Preparation, Antiepileptic Activity, and Cardiovascular Safety of Dihydropyrazoles as Brain-Penetrant T‑Type Calcium Channel Blockers
Remen, Lubos, Bezençon, Olivier, Simons, Lloyd, Gaston, Rick, Downing, Dennis, Gatfield, John, Roch, Catherine, Kessler, Melanie, Mosbacher, Johannes, Pfeifer, Thomas, Grisostomi, Corinna, Rey, Markus, Ertel, Eric A, Moon, Richard
Published in Journal of medicinal chemistry (22.09.2016)
Published in Journal of medicinal chemistry (22.09.2016)
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Journal Article
Design and Preparation of Potent, Nonpeptidic, Bioavailable Renin Inhibitors
Bezençon, Olivier, Bur, Daniel, Weller, Thomas, Richard-Bildstein, Sylvia, Remeň, Luboš, Sifferlen, Thierry, Corminboeuf, Olivier, Grisostomi, Corinna, Boss, Christoph, Prade, Lars, Delahaye, Stéphane, Treiber, Alexander, Strickner, Panja, Binkert, Christoph, Hess, Patrick, Steiner, Beat, Fischli, Walter
Published in Journal of medicinal chemistry (25.06.2009)
Published in Journal of medicinal chemistry (25.06.2009)
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Journal Article
Correction to Structure–Activity Relationship, Drug Metabolism and Pharmacokinetics Properties Optimization, and in Vivo Studies of New Brain Penetrant Triple T‑Type Calcium Channel Blockers
Siegrist, Romain, Pozzi, Davide, Jacob, Gaël, Torrisi, Caterina, Colas, Kilian, Braibant, Bertrand, Mawet, Jacques, Pfeifer, Thomas, de Kanter, Ruben, Roch, Catherine, Kessler, Melanie, Moon, Richard, Corminboeuf, Olivier, Bezençon, Olivier
Published in Journal of medicinal chemistry (09.03.2017)
Published in Journal of medicinal chemistry (09.03.2017)
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Journal Article
Milestones to the Discovery of T-type Calcium Channel Blockers for the Treatment of Generalized Epilepsies
Bezençon, Olivier, Siegrist, Romain, Heidmann, Bibia, Pozzi, Davide, Stamm, Simon, Remeň, Luboš, Richard, Sylvia, Simons, Lloyd, Gaston, Rick, Downing, Dennis, Grisostomi, Corinna, Roch, Catherine, Kessler, Melanie, Gatfield, John, Moon, Richard, Pfeifer, Thomas, Mosbacher, Johannes, Reymond, Isabelle, Ertel, Eric A, de Kanter, Ruben, Capeleto, Bruno, Fournier, Elvire, Rey, Markus, Moccia, Luca, Toeroek-Schafroth, Michael, Roscher, René, Schindelholz, Benno
Published in Chimia (25.10.2017)
Published in Chimia (25.10.2017)
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Journal Article
Piperidine-based renin inhibitors: Upper chain optimization
Corminboeuf, Olivier, Bezençon, Olivier, Remeň, Ľuboš, Grisostomi, Corinna, Richard-Bildstein, Sylvia, Bur, Daniel, Prade, Lars, Strickner, Panja, Hess, Patrick, Fischli, Walter, Steiner, Beat, Treiber, Alexander
Published in Bioorganic & medicinal chemistry letters (01.11.2010)
Published in Bioorganic & medicinal chemistry letters (01.11.2010)
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Journal Article
Design and optimization of new piperidines as renin inhibitors
Corminboeuf, Olivier, Bezençon, Olivier, Grisostomi, Corinna, Remeň, Ľuboš, Richard-Bildstein, Sylvia, Bur, Daniel, Prade, Lars, Hess, Patrick, Strickner, Panja, Fischli, Walter, Steiner, Beat, Treiber, Alexander
Published in Bioorganic & medicinal chemistry letters (01.11.2010)
Published in Bioorganic & medicinal chemistry letters (01.11.2010)
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Journal Article
Discovery and evaluation of Ca(v)3.2-selective T-type calcium channel blockers
Bezencon, Olivier, Remen, Lubos, Richard, Sylvia, Roch, Catherine, Kessler, Melanie, Ertel, Eric A., Moon, Richard, Mawet, Jacques, Pfeifer, Thomas, Capeleto, Bruno
Published in Bioorganic & medicinal chemistry letters (01.12.2017)
Published in Bioorganic & medicinal chemistry letters (01.12.2017)
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Journal Article
Discovery and evaluation of Ca(v)3.1-selective T-type calcium channel blockers
Bezencon, Olivier, Remen, Lubos, Richard, Sylvia, Roch, Catherine, Kessler, Melanie, Moon, Richard, Mawet, Jacques, Ertel, Eric A., Pfeifer, Thomas, Capeleto, Bruno
Published in Bioorganic & medicinal chemistry letters (01.12.2017)
Published in Bioorganic & medicinal chemistry letters (01.12.2017)
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Journal Article
New classes of potent and bioavailable human renin inhibitors
Remeň, L’uboš, Bezençon, Olivier, Richard-Bildstein, Sylvia, Bur, Daniel, Prade, Lars, Corminboeuf, Olivier, Boss, Christoph, Grisostomi, Corinna, Sifferlen, Thierry, Strickner, Panja, Hess, Patrick, Delahaye, Stéphane, Treiber, Alexander, Weller, Thomas, Binkert, Christoph, Steiner, Beat, Fischli, Walter
Published in Bioorganic & medicinal chemistry letters (01.12.2009)
Published in Bioorganic & medicinal chemistry letters (01.12.2009)
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Journal Article
Design and optimization of a substituted amino propanamide series of renin inhibitors for the treatment of hypertension
Chen, Austin, Bayly, Christopher, Bezençon, Olivier, Richard-Bildstein, Sylvia, Dubé, Daniel, Dubé, Laurence, Gagné, Sébastien, Gallant, Michel, Gaudreault, Mireille, Grimm, Erich, Houle, Robert, Lacombe, Patrick, Laliberté, Sébastien, Lévesque, Jean-François, Liu, Suzanna, MacDonald, Dwight, Mackay, Bruce, Martin, David, McKay, Dan, Powell, David, Remeň, L’uboš, Soisson, Stephen, Toulmond, Sylvie
Published in Bioorganic & medicinal chemistry letters (01.04.2010)
Published in Bioorganic & medicinal chemistry letters (01.04.2010)
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Journal Article
TRIAZOLE COMPOUNDS AS T-TYPE CALCIUM CHANNEL BLOCKERS
BEZENCON, OLIVIER, SIEGRIST, ROMAIN, STAMM, SIMON, HEIDMANN, BIBIA, GATFIELD, JOHN
Year of Publication 14.02.2023
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Year of Publication 14.02.2023
Patent
PYRAZOLE COMPOUNDS AND THEIR USE AS T-TYPE CALCIUM CHANNEL BLOCKERS
BEZENCON, OLIVIER, SIEGRIST, ROMAIN, STAMM, SIMON, HEIDMANN, BIBIA, GATFIELD, JOHN
Year of Publication 03.01.2023
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Year of Publication 03.01.2023
Patent
Discovery and evaluation of Cav3.2-selective T-type calcium channel blockers
Bezençon, Olivier, Remeň, Luboš, Richard, Sylvia, Roch, Catherine, Kessler, Melanie, Ertel, Eric A., Moon, Richard, Mawet, Jacques, Pfeifer, Thomas, Capeleto, Bruno
Published in Bioorganic & medicinal chemistry letters (01.12.2017)
Published in Bioorganic & medicinal chemistry letters (01.12.2017)
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Journal Article
Discovery and evaluation of Cav3.1-selective T-type calcium channel blockers
Bezençon, Olivier, Remeň, Luboš, Richard, Sylvia, Roch, Catherine, Kessler, Melanie, Moon, Richard, Mawet, Jacques, Ertel, Eric A., Pfeifer, Thomas, Capeleto, Bruno
Published in Bioorganic & medicinal chemistry letters (01.12.2017)
Published in Bioorganic & medicinal chemistry letters (01.12.2017)
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Journal Article
CYCLOBUTYL-UREA DERIVATIVES
SURIVET, Jean-Philippe, DEYMIER, Caroline, PETERS, Jens-Uwe, SIEGRIST, Romain, BEZENCON, Olivier
Year of Publication 28.09.2023
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Year of Publication 28.09.2023
Patent
Discovery and evaluation of Ca v 3.1-selective T-type calcium channel blockers
Bezençon, Olivier, Remeň, Luboš, Richard, Sylvia, Roch, Catherine, Kessler, Melanie, Moon, Richard, Mawet, Jacques, Ertel, Eric A, Pfeifer, Thomas, Capeleto, Bruno
Published in Bioorganic & medicinal chemistry letters (01.12.2017)
Published in Bioorganic & medicinal chemistry letters (01.12.2017)
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Journal Article