Interaction with WDR5 Promotes Target Gene Recognition and Tumorigenesis by MYC
Thomas, Lance R., Wang, Qingguo, Grieb, Brian C., Phan, Jason, Foshage, Audra M., Sun, Qi, Olejniczak, Edward T., Clark, Travis, Dey, Soumyadeep, Lorey, Shelly, Alicie, Bethany, Howard, Gregory C., Cawthon, Bryan, Ess, Kevin C., Eischen, Christine M., Zhao, Zhongming, Fesik, Stephen W., Tansey, William P.
Published in Molecular cell (07.05.2015)
Published in Molecular cell (07.05.2015)
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Discovery of Potent Myeloid Cell Leukemia 1 (Mcl-1) Inhibitors Using Fragment-Based Methods and Structure-Based Design
Friberg, Anders, Vigil, Dominico, Zhao, Bin, Daniels, R. Nathan, Burke, Jason P, Garcia-Barrantes, Pedro M, Camper, DeMarco, Chauder, Brian A, Lee, Taekyu, Olejniczak, Edward T, Fesik, Stephen W
Published in Journal of medicinal chemistry (10.01.2013)
Published in Journal of medicinal chemistry (10.01.2013)
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Approach for targeting Ras with small molecules that activate SOS-mediated nucleotide exchange
Burns, Michael C., Qi Sun, Daniels, R. Nathan, Camper, DeMarco, Kennedy, J. Phillip, Phan, Jason, Olejniczak, Edward T., Lee, Taekyu, Waterson, Alex G., Rossanese, Olivia W., Fesik, Stephen W.
Published in Proceedings of the National Academy of Sciences - PNAS (04.03.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (04.03.2014)
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Structural biology of the Bcl-2 family of proteins
Petros, Andrew M., Olejniczak, Edward T., Fesik, Stephen W.
Published in BBA - Molecular Cell Research (01.03.2004)
Published in BBA - Molecular Cell Research (01.03.2004)
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Book Review
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Discovery of Potent Antagonists of the Antiapoptotic Protein XIAP for the Treatment of Cancer
Oost, Thorsten K, Sun, Chaohong, Armstrong, Robert C, Al-Assaad, Ali-Samer, Betz, Stephen F, Deckwerth, Thomas L, Ding, Hong, Elmore, Steven W, Meadows, Robert P, Olejniczak, Edward T, Oleksijew, Andrew, Oltersdorf, Tilman, Rosenberg, Saul H, Shoemaker, Alexander R, Tomaselli, Kevin J, Zou, Hua, Fesik, Stephen W
Published in Journal of medicinal chemistry (26.08.2004)
Published in Journal of medicinal chemistry (26.08.2004)
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Solution structure and mutational analysis of pituitary adenylate cyclase-activating polypeptide binding to the extracellular domain of PAC1-RS
Sun, Chaohong, Song, Danying, Davis-Taber, Rachel A, Barrett, Leo W, Scott, Victoria E, Richardson, Paul L, Pereda-Lopez, Ana, Uchic, Marie E, Solomon, Larry R, Lake, Marc R, Walter, Karl A, Hajduk, Philip J, Olejniczak, Edward T
Published in Proceedings of the National Academy of Sciences - PNAS (08.05.2007)
Published in Proceedings of the National Academy of Sciences - PNAS (08.05.2007)
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ALARM NMR: A Rapid and Robust Experimental Method To Detect Reactive False Positives in Biochemical Screens
Huth, Jeffrey R, Mendoza, Renaldo, Olejniczak, Edward T, Johnson, Robert W, Cothron, Darlene A, Liu, Yaya, Lerner, Claude G, Chen, Jun, Hajduk, Philip J
Published in Journal of the American Chemical Society (12.01.2005)
Published in Journal of the American Chemical Society (12.01.2005)
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Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain
Fesik, Stephen W, Liu, Zhihong, Sun, Chaohong, Olejniczak, Edward T, Meadows, Robert P, Betz, Stephen F, Oost, Thorsten, Herrmann, Julia, Wu, Joe C
Published in Nature (London) (21.12.2000)
Published in Nature (London) (21.12.2000)
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Structure of the N-Terminal RNA-Binding Domain of the SARS CoV Nucleocapsid Protein
Huang, Qiulong, Yu, Liping, Petros, Andrew M, Gunasekera, Angelo, Liu, Zhihong, Xu, Nan, Hajduk, Philip, Mack, Jamey, Fesik, Stephen W, Olejniczak, Edward T
Published in Biochemistry (Easton) (25.05.2004)
Published in Biochemistry (Easton) (25.05.2004)
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Novel p-Arylthio Cinnamides as Antagonists of Leukocyte Function-Associated Antigen-1/Intracellular Adhesion Molecule-1 Interaction. 2. Mechanism of Inhibition and Structure-Based Improvement of Pharmaceutical Properties
Liu, Gang, Huth, Jeffrey R, Olejniczak, Edward T, Mendoza, Renaldo, DeVries, Peter, Leitza, Sandra, Reilly, Edward B, Okasinski, Gregory F, Fesik, Stephen W, von Geldern, Thomas W
Published in Journal of medicinal chemistry (12.04.2001)
Published in Journal of medicinal chemistry (12.04.2001)
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Defining the p53 DNA‐binding domain/Bcl‐xL‐binding interface using NMR
Petros, Andrew M, Gunasekera, Angelo, Xu, Nan, Olejniczak, Edward T, Fesik, Stephen W
Published in FEBS letters (13.02.2004)
Published in FEBS letters (13.02.2004)
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Integrative Genomic Analysis of Small-Cell Lung Carcinoma Reveals Correlates of Sensitivity to Bcl-2 Antagonists and Uncovers Novel Chromosomal Gains
Olejniczak, Edward T, Van Sant, Charles, Anderson, Mark G, Wang, Gang, Tahir, Stephen K, Sauter, Guido, Lesniewski, Rick, Semizarov, Dimitri
Published in Molecular cancer research (01.04.2007)
Published in Molecular cancer research (01.04.2007)
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A Novel MCL1 Inhibitor Combined with Venetoclax Rescues Venetoclax-Resistant Acute Myelogenous Leukemia
Ramsey, Haley E, Fischer, Melissa A, Lee, Taekyu, Gorska, Agnieszka E, Arrate, Maria Pia, Fuller, Londa, Boyd, Kelli L, Strickland, Stephen A, Sensintaffar, John, Hogdal, Leah J, Ayers, Gregory D, Olejniczak, Edward T, Fesik, Stephen W, Savona, Michael R
Published in Cancer discovery (01.12.2018)
Published in Cancer discovery (01.12.2018)
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Discovery of a novel small molecule binding site of human survivin
Wendt, Michael D., Sun, Chaohong, Kunzer, Aaron, Sauer, Daryl, Sarris, Kathy, Hoff, Ethan, Yu, Liping, Nettesheim, David G., Chen, Jun, Jin, Sha, Comess, Kenneth M., Fan, Yihong, Anderson, Steven N., Isaac, Binumol, Olejniczak, Edward T., Hajduk, Philip J., Rosenberg, Saul H., Elmore, Steven W.
Published in Bioorganic & medicinal chemistry letters (01.06.2007)
Published in Bioorganic & medicinal chemistry letters (01.06.2007)
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Journal Article
Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-Mediated Activation
Sun, Qi, Burke, Jason P., Phan, Jason, Burns, Michael C., Olejniczak, Edward T., Waterson, Alex G., Lee, Taekyu, Rossanese, Olivia W., Fesik, Stephen W.
Published in Angewandte Chemie International Edition (18.06.2012)
Published in Angewandte Chemie International Edition (18.06.2012)
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SOS-NMR: A Saturation Transfer NMR-Based Method for Determining the Structures of Protein−Ligand Complexes
Hajduk, Philip J, Mack, Jamey C, Olejniczak, Edward T, Park, Chang, Dandliker, Peter J, Beutel, Bruce A
Published in Journal of the American Chemical Society (03.03.2004)
Published in Journal of the American Chemical Society (03.03.2004)
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Discovery of 2‑Indole-acylsulfonamide Myeloid Cell Leukemia 1 (Mcl-1) Inhibitors Using Fragment-Based Methods
Pelz, Nicholas F, Bian, Zhiguo, Zhao, Bin, Shaw, Subrata, Tarr, James C, Belmar, Johannes, Gregg, Claire, Camper, DeMarco V, Goodwin, Craig M, Arnold, Allison L, Sensintaffar, John L, Friberg, Anders, Rossanese, Olivia W, Lee, Taekyu, Olejniczak, Edward T, Fesik, Stephen W
Published in Journal of medicinal chemistry (10.03.2016)
Published in Journal of medicinal chemistry (10.03.2016)
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A surface groove essential for viral Bcl-2 function during chronic infection in vivo
Loh, Joy, Huang, Qiulong, Petros, Andrew M, Nettesheim, David, van Dyk, Linda F, Labrada, Lucia, Speck, Samuel H, Levine, Beth, Olejniczak, Edward T, Virgin, 4th, Herbert W
Published in PLoS pathogens (01.09.2005)
Published in PLoS pathogens (01.09.2005)
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Discovery of WD Repeat-Containing Protein 5 (WDR5)–MYC Inhibitors Using Fragment-Based Methods and Structure-Based Design
Chacón Simon, Selena, Wang, Feng, Thomas, Lance R, Phan, Jason, Zhao, Bin, Olejniczak, Edward T, Macdonald, Jonathan D, Shaw, J. Grace, Schlund, Caden, Payne, William, Creighton, Joy, Stauffer, Shaun R, Waterson, Alex G, Tansey, William P, Fesik, Stephen W
Published in Journal of medicinal chemistry (23.04.2020)
Published in Journal of medicinal chemistry (23.04.2020)
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