An Update on Overcoming MDR1-Mediated Multidrug Resistance in Cancer Chemotherapy
Takara, Kohji, Sakaeda, Toshiyuki, Okumura, Katsuhiko
Published in Current pharmaceutical design (01.01.2006)
Published in Current pharmaceutical design (01.01.2006)
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Journal Article
MDR1 Genotype-Related Pharmacokinetics and Pharmacodynamics
Sakaeda, Toshiyuki, Nakamura, Tsutomu, Okumura, Katsuhiko
Published in Biological & pharmaceutical bulletin (01.11.2002)
Published in Biological & pharmaceutical bulletin (01.11.2002)
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Journal Article
Pharmacogenetics of MDR1 and its impact on the pharmacokinetics and pharmacodynamics of drugs
Sakaeda, Toshiyuki, Nakamura, Tsutomu, Okumura, Katsuhiko
Published in Pharmacogenomics (01.07.2003)
Published in Pharmacogenomics (01.07.2003)
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Journal Article
Genetic polymorphisms associated with adverse events and elimination of methotrexate in childhood acute lymphoblastic leukemia and malignant lymphoma
Imanishi, Hiroyuki, Okamura, Noboru, Yagi, Mariko, Noro, Yukari, Moriya, Yuka, Nakamura, Tsutomu, Hayakawa, Akira, Takeshima, Yasuhiro, Sakaeda, Toshiyuki, Matsuo, Masafumi, Okumura, Katsuhiko
Published in Journal of human genetics (01.02.2007)
Published in Journal of human genetics (01.02.2007)
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Journal Article
Effects of acid and lactone forms of eight HMG-CoA reductase inhibitors on CYP-mediated metabolism and MDR1-mediated transport
SAKAEDA, Toshiyuki, FUJINO, Hideki, KOMOTO, Chiho, KAKUMOTO, Mikio, JIN, Jiang-Shu, IWAKI, Koichi, NISHIGUCHI, Kohshi, NAKAMURA, Tsutomu, OKAMURA, Noboru, OKUMURA, Katsuhiko
Published in Pharmaceutical research (01.03.2006)
Published in Pharmaceutical research (01.03.2006)
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Journal Article
Effect of the mutation (C3435T) at exon 26 of the MDR1 gene on expression level of MDR1 messenger ribonucleic acid in duodenal enterocytes of healthy Japanese subjects
Nakamura, Tsutomu, Sakaeda, Toshiyuki, Horinouchi, Masanori, Tamura, Takao, Aoyama, Nobuo, Shirakawa, Toshiro, Matsuo, Masafumi, Kasuga, Masato, Okumura, Katsuhiko
Published in Clinical pharmacology and therapeutics (01.04.2002)
Published in Clinical pharmacology and therapeutics (01.04.2002)
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Journal Article
Pharmacogenetics of drug transporters and its impact on the pharmacotherapy
Sakaeda, Toshiyuki, Nakamura, Tsutomu, Okumura, Katsuhiko
Published in Current topics in medicinal chemistry (01.01.2004)
Published in Current topics in medicinal chemistry (01.01.2004)
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Journal Article
MDR1 Genotype-related pharmacokinetics of digoxin after single oral administration in healthy japanese subjects
SAKAEDA, Toshiyuki, NAKAMURA, Tsutomu, KASUGA, Masato, OKUMURA, Katsuhiko, HORINOUCHI, Masanori, KAKUMOTO, Mikio, OHMOTO, Nobuko, SAKAI, Toshiyuki, MORITA, Yoshinori, TAMURA, Takao, AOYAMA, Nobuo, HIRAI, Midori
Published in Pharmaceutical research (01.10.2001)
Published in Pharmaceutical research (01.10.2001)
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Journal Article
Effects of α-adrenoceptor antagonists on ABCG2/BCRP-mediated resistance and transport
Takara, Kohji, Yamamoto, Kazuhiro, Matsubara, Mika, Minegaki, Tetsuya, Takahashi, Minoru, Yokoyama, Teruyoshi, Okumura, Katsuhiko
Published in PloS one (15.02.2012)
Published in PloS one (15.02.2012)
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Journal Article
Potential tumor markers of renal cell carcinoma: α-Enolase for postoperative follow up, and galectin-1 and galectin-3 for primary detection
Kaneko, Naoki, Gotoh, Akinobu, Okamura, Noboru, Matsuo, Ei-ichi, Terao, Shuji, Watanabe, Makoto, Yamada, Yuji, Hamami, Gaku, Nakamura, Tsutomu, Ikekita, Masahiko, Okumura, Katsuhiko, Nishimura, Osamu
Published in International journal of urology (01.05.2013)
Published in International journal of urology (01.05.2013)
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Journal Article
Effect of CPS14217C>A genotype on valproic-acid-induced hyperammonemia
Yagi, Mariko, Nakamura, Tsutomu, Okizuka, Yo, Oyazato, Yoshinobu, Kawasaki, Yoko, Tsuneishi, Shuichi, Sakaeda, Toshiyuki, Matsuo, Masafumi, Okumura, Katsuhiko, Okamura, Noboru
Published in Pediatrics international (01.10.2010)
Published in Pediatrics international (01.10.2010)
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Journal Article
MDR1 Haplotype Frequencies in Japanese and Caucasian, and in Japanese Patients with Colorectal Cancer and Esophageal Cancer
Komoto, Chiho, Nakamura, Tsutomu, Sakaeda, Toshiyuki, Kroetz, Deanna L., Yamada, Toshio, Omatsu, Hideaki, Koyama, Tatsuya, Okamura, Noboru, Miki, Ikuya, Tamura, Takao, Aoyama, Nobuo, Kasuga, Masato, Okumura, Katsuhiko
Published in Drug metabolism and pharmacokinetics (01.01.2006)
Published in Drug metabolism and pharmacokinetics (01.01.2006)
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Journal Article
Significant genetic linkage of MDR1 polymorphisms at positions 3435 and 2677: Functional relevance to pharmacokinetics of digoxin
HORINOUCHI, Masanori, SAKAEDA, Toshiyuki, NAKAMURA, Tsutomu, MORITA, Yoshinori, TAMURA, Takao, AOYAMA, Nobuo, KASUGA, Masato, OKUMURA, Katsuhiko
Published in Pharmaceutical research (01.10.2002)
Published in Pharmaceutical research (01.10.2002)
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Journal Article
Induction of Human P-Glycoprotein in Caco-2 cells: Development of a Highly Sensitive Assay System for P-Glycoprotein-Mediated Drug Transport
Shirasaka, Yoshiyuki, Kawasaki, Masae, Sakane, Toshiyasu, Omatsu, Hideaki, Moriya, Yuka, Nakamura, Tsutomu, Sakaeda, Toshiyuki, Okumura, Katsuhiko, Langguth, Peter, Yamashita, Shinji
Published in DRUG METABOLISM AND PHARMACOKINETICS (01.01.2006)
Published in DRUG METABOLISM AND PHARMACOKINETICS (01.01.2006)
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Journal Article
Knock-down of Sorcin Induces Up-regulation of MDR1 in HeLa Cells
Kawakami, Megumi, Nakamura, Tsutomu, Okamura, Noboru, Komoto, Chiho, Markova, Svetlana, Kobayashi, Hironao, Hashimoto, Naofumi, Okumura, Katsuhiko, Sakaeda, Toshiyuki
Published in Biological & Pharmaceutical Bulletin (01.06.2007)
Published in Biological & Pharmaceutical Bulletin (01.06.2007)
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Journal Article
Cytotoxic Effects of 27 Anticancer Drugs in HeLa and MDR1-Overexpressing Derivative Cell Lines
Takara, Kohji, Sakaeda, Toshiyuki, Yagami, Tatsurou, Kobayashi, Hironao, Ohmoto, Nobuko, Horinouchi, Masanori, Nishiguchi, Kohshi, Okumura, Katsuhiko
Published in Biological & pharmaceutical bulletin (01.06.2002)
Published in Biological & pharmaceutical bulletin (01.06.2002)
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Journal Article
Antiproliferative Activity of Rhinacanthus nasutus (L.) KURZ Extracts and the Active Moiety, Rhinacanthin C
Gotoh, Akinobu, Sakaeda, Toshiyuki, Kimura, Takashi, Shirakawa, Toshiro, Wada, Yoshitaka, Wada, Atsushi, Kimachi, Tetsutaro, Takemoto, Yoshiji, Iida, Akira, Iwakawa, Seigo, Hirai, Midori, Tomita, Hisako, Okamura, Noboru, Nakamura, Tsutomu, Okumura, Katsuhiko
Published in Biological & Pharmaceutical Bulletin (01.07.2004)
Published in Biological & Pharmaceutical Bulletin (01.07.2004)
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Journal Article
Effects of Polymorphisms of MDR1, MRP1, and MRP2 Genes on Their mRNA Expression Levels in Duodenal Enterocytes of Healthy Japanese Subjects
Moriya, Yuka, Nakamura, Tsutomu, Horinouchi, Masanori, Sakaeda, Toshiyuki, Tamura, Takao, Aoyama, Nobuo, Shirakawa, Toshiro, Gotoh, Akinobu, Fujimoto, Sadaki, Matsuo, Masafumi, Kasuga, Masato, Okumura, Katsuhiko
Published in Biological & pharmaceutical bulletin (01.10.2002)
Published in Biological & pharmaceutical bulletin (01.10.2002)
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Journal Article
CYP2C19 genotype and pharmacokinetics of three proton pump inhibitors in healthy subjects
SAKAI, Toshiyuki, AOYAMA, Nobuo, KASUGA, Masato, OKUMURA, Katsuhiko, KITA, Tomoko, SAKAEDA, Toshiyuki, NISHIGUCHI, Kohshi, NISHITORA, Yukari, HOHDA, Takashi, SIRASAKA, Daisuke, TAMURA, Takao, TANIGAWARA, Yusuke
Published in Pharmaceutical research (01.06.2001)
Published in Pharmaceutical research (01.06.2001)
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