Search Results - "OKONOGI KENJI" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

A Small-Molecule, Nonpeptide CCR5 Antagonist with Highly Potent and Selective Anti-HIV-1 Activity

A Small-Molecule, Nonpeptide CCR5 Antagonist with Highly Potent and Selective Anti-HIV-1 Activity

by Baba, Masanori, Nishimura, Osamu, Kanzaki, Naoyuki, Okamoto, Mika, Sawada, Hidekazu, Iizawa, Yuji, Shiraishi, Mitsuru, Aramaki, Yoshio, Okonogi, Kenji, Ogawa, Yasuaki, Meguro, Kanji, Fujino, Masahiko
Published in Proceedings of the National Academy of Sciences - PNAS (11.05.1999)

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In vitro antimicrobial activity of T-91825, a novel anti-MRSA cephalosporin, and in vivo anti-MRSA activity of its prodrug, TAK-599

In vitro antimicrobial activity of T-91825, a novel anti-MRSA cephalosporin, and in vivo anti-MRSA activity of its prodrug, TAK-599

by Iizawa, Yuji, Nagai, Junko, Ishikawa, Tomoyasu, Hashiguchi, Shohei, Nakao, Masafumi, Miyake, Akio, Okonogi, Kenji
Published in Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy (01.06.2004)

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Formation of Azole-Resistant Candida albicans by Mutation of Sterol 14-Demethylase P450

Formation of Azole-Resistant Candida albicans by Mutation of Sterol 14-Demethylase P450

by ASAI, K, TSUCHIMORI, N, OKONOGI, K, PERFECT, J. R, GOTOH, O, YOSHIDA, Y
Published in Antimicrobial Agents and Chemotherapy (01.05.1999)

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Studies on Anti-MRSA Parenteral Cephalosporins I. Synthesis and Antibacterial Activity of 7β-[2-(5-Amino-l52, 4-thiadiazol-3-yl)-2(Z)-hydroxyiminoacetamido]-3-(substituted imidazo[1, 2-6]-pyridazinium-1-yl)methyl-3-cephem-4-carboxylates and Related Compounds

Studies on Anti-MRSA Parenteral Cephalosporins I. Synthesis and Antibacterial Activity of 7β-[2-(5-Amino-l52, 4-thiadiazol-3-yl)-2(Z)-hydroxyiminoacetamido]-3-(substituted imidazo[1, 2-6]-pyridazinium-1-yl)methyl-3-cephem-4-carboxylates and Related Compounds

by ISHIKAWA, TOMOYASU, IIZAWA, YIJJI, OKONOGI, KENJI, MIYAKE, AKIO
Published in Journal of antibiotics (25.10.2000)

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Molecular cloning and nucleotide sequence determination of the regulator region of mecA gene in methicillin-resistant Staphylococcus aureus (MRSA)

Molecular cloning and nucleotide sequence determination of the regulator region of mecA gene in methicillin-resistant Staphylococcus aureus (MRSA)

by Hiramatsu, Keiichi, Asada, Kazumi, Suzuki, Eiko, Okonogi, Kenji, Yokota, Takeshi
Published in FEBS letters (24.02.1992)

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In Vitro and In Vivo Antifungal Activities of TAK-456, a Novel Oral Triazole with a Broad Antifungal Spectrum

In Vitro and In Vivo Antifungal Activities of TAK-456, a Novel Oral Triazole with a Broad Antifungal Spectrum

by TSUCHIMORI, Noboru, HAYASHI, Ryogo, KITAMOTO, Naomi, ASAI, Kentaro, KITAZAKI, Tomoyuki, IIZAWA, Yuji, ITOH, Katsumi, OKONOGI, Kenji
Published in Antimicrobial Agents and Chemotherapy (01.05.2002)

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Inhibitory Effects of Small-Molecule CCR5 Antagonists on Human Immunodeficiency Virus Type 1 Envelope-Mediated Membrane Fusion and Viral Replication

Inhibitory Effects of Small-Molecule CCR5 Antagonists on Human Immunodeficiency Virus Type 1 Envelope-Mediated Membrane Fusion and Viral Replication

by TAKASHIMA, Katsunori, MIYAKE, Hiroshi, FURUTA, Rika A, FUJISAWA, Jun-Ichi, IIZAWA, Yuji, KANZAKI, Naoyuki, SHIRAISHI, Mitsuru, OKONOGI, Kenji, BABA, Masanori
Published in Antimicrobial Agents and Chemotherapy (01.12.2001)

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Efficacy of TAK-457, a Novel Intravenous Triazole, against Invasive Pulmonary Aspergillosis in Neutropenic Mice

Efficacy of TAK-457, a Novel Intravenous Triazole, against Invasive Pulmonary Aspergillosis in Neutropenic Mice

by HAYASHI, Ryogo, KITAMOTO, Naomi, IIZAWA, Yuji, ICHIKAWA, Takashi, ITOH, Katsumi, KITAZAKI, Tomoyuki, OKONOGI, Kenji
Published in Antimicrobial Agents and Chemotherapy (01.02.2002)

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Optically Active Antifungal Azoles. XII. Synthesis and Antifungal Activity of the Water-Soluble Prodrugs of 1-[(1R, 2R)-2-(2, 4-Difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1, 2, 4-triazol-1-yl)propyl]-3-[4-(1H-1-tetrazolyl)phenyl]-2-imidazolidinone

Optically Active Antifungal Azoles. XII. Synthesis and Antifungal Activity of the Water-Soluble Prodrugs of 1-[(1R, 2R)-2-(2, 4-Difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1, 2, 4-triazol-1-yl)propyl]-3-[4-(1H-1-tetrazolyl)phenyl]-2-imidazolidinone

by ICHIKAWA, Takashi, KITAZAKI, Tomoyuki, MATSUSHITA, Yoshihiro, YAMADA, Masami, HAYASHI, Ryogo, YAMAGUCHI, Masashi, KIYOTA, Yutaka, OKONOGI, Kenji, ITOH, Katsumi
Published in Chemical & pharmaceutical bulletin (2001)

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Studies on anti-MRSA parenteral cephalosporins - III. Synthesis and antibacterial activity of 7 beta-[2-(5-amino-1,2,4-thiadiazol-3-yl)-2(Z)-alkoxyiminoacetamido]-3-[(E)-2-(1-alkylimidazo[1,2-b]pyridazinium-6-yl)thiovinyl]-3-cephem-4-carboxylates and related compounds

Studies on anti-MRSA parenteral cephalosporins - III. Synthesis and antibacterial activity of 7 beta-[2-(5-amino-1,2,4-thiadiazol-3-yl)-2(Z)-alkoxyiminoacetamido]-3-[(E)-2-(1-alkylimidazo[1,2-b]pyridazinium-6-yl)thiovinyl]-3-cephem-4-carboxylates and related compounds

by Ishikawa, T, Kamiyama, K, Nakayama, Y, Iizawa, Y, Okonogi, K, Miyake, A
Published in Journal of antibiotics (25.03.2001)

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Optically Active Antifungal Azoles. X. Synthesis and Antifungal Activity of N-[4-(Azolyl)phenyl]- and N-[4-(Azolylmethyl)phenyl]-N'-[(1R, 2R)-2-(2, 4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1, 2, 4-triazol-1-yl)propyl]-azolones

Optically Active Antifungal Azoles. X. Synthesis and Antifungal Activity of N-[4-(Azolyl)phenyl]- and N-[4-(Azolylmethyl)phenyl]-N'-[(1R, 2R)-2-(2, 4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1, 2, 4-triazol-1-yl)propyl]-azolones

by KITAZAKI, Tomoyuki, ICHIKAWA, Takashi, TASAKA, Akihiro, HOSONO, Hiroshi, MATSUSHITA, Yoshihiro, HAYASHI, Ryogo, OKONOGI, Kenji, ITOH, Katsumi
Published in Chemical & pharmaceutical bulletin (2000)

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Studies on Anti-MRSA Parenteral Cephalosporins. I. Synthesis and Antibacterial Activity of 7.BETA.-[2-(5-Amino-1,2,4-thiadiazol-3-yl)-2(Z)-hydroxyiminoacetamido]-3-(substituted imidazo [1,2-b]-pyridazinium-1-yl)methyl-3-cephem-4-carboxylates and Related Compounds

Studies on Anti-MRSA Parenteral Cephalosporins. I. Synthesis and Antibacterial Activity of 7.BETA.-[2-(5-Amino-1,2,4-thiadiazol-3-yl)-2(Z)-hydroxyiminoacetamido]-3-(substituted imidazo [1,2-b]-pyridazinium-1-yl)methyl-3-cephem-4-carboxylates and Related Compounds

by ISHIKAWA, TOMOYASU, IIZAWA, YIJJI, OKONOGI, KENJI, MIYAKE, AKIO
Published in Journal of antibiotics (2000)

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Studies on Anti-MRSA Parenteral Cephalosporins II. Synthesis and Antibacterial Activity of 7β-[2-(5-Amino-1, 2, 4-thiadiazol-3-yl)-2(Z)-alkoxyiminoacetamido]-3-(substituted imidazo[1, 2-b]pyridazinium-1-yl)methyl-3-cephem-4-carboxylates and Related Compounds

Studies on Anti-MRSA Parenteral Cephalosporins II. Synthesis and Antibacterial Activity of 7β-[2-(5-Amino-1, 2, 4-thiadiazol-3-yl)-2(Z)-alkoxyiminoacetamido]-3-(substituted imidazo[1, 2-b]pyridazinium-1-yl)methyl-3-cephem-4-carboxylates and Related Compounds

by ISHIKAWA, TOMOYASU, KAMIYAMA, KJEIJI, MATSUNAGA, NOBUYUKI, TAWADA, HIROYUKI, IIZAWA, YUJI, OKONOGI, KENJI, MIYAKE, AKIO
Published in Journal of antibiotics (25.10.2000)

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Studies on Anti-MRSA Parenteral Cephalosporins: IV. A Novel Water-soluble N-Phosphono Type Prodrug for Parenteral Administration

Studies on Anti-MRSA Parenteral Cephalosporins: IV. A Novel Water-soluble N-Phosphono Type Prodrug for Parenteral Administration

by ISHIKAWA, TOMOYASU, NAKAYAMA, YUTAKA, TOMIMOTO, MITSUMI, NIWA, SHIN-ICHI, KAMIYAMA, KEIJI, HASHIGUCHI, SHOHEI, IIZAWA, YUJI, OKONOGI, KENJI, MIYAKE, AKIO
Published in Journal of antibiotics (2001)

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Studies on Anti-MRSA Parenteral Cephalosporins. III. Synthesis and Antibacterial Activity of 7.BETA.-[2-(5-Amino-1,2,4-thiadiazol-3-yl)-2(Z)-alkoxyiminoacetamido]-3-[(E)-2-(1-alkylimidazo[1,2-b]pyridazinium-6-yl)thiovinyl]-3-cephem-4-carboxylates and Related Compounds

Studies on Anti-MRSA Parenteral Cephalosporins. III. Synthesis and Antibacterial Activity of 7.BETA.-[2-(5-Amino-1,2,4-thiadiazol-3-yl)-2(Z)-alkoxyiminoacetamido]-3-[(E)-2-(1-alkylimidazo[1,2-b]pyridazinium-6-yl)thiovinyl]-3-cephem-4-carboxylates and Related Compounds

by ISHIKAWA, TOMOYASU, KAMIYAMA, KEIJI, NAKAYAMA, YUTAKA, IIZAWA, YUJI, OKONOGI, KENJI, MIYAKE, AKIO
Published in Journal of antibiotics (2001)

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Studies on Anti-MRSA Parenteral Cephalosporins. II. Synthesis and Antibacterial Activity of 7.BETA.-[2-(5-Amino-1,2,4-thiadiazol-3-yl)-2(Z)-alkoxyiminoacetamido]-3-(substituted imidazo [1,2-b]pyridazinium-1-yl)methyl-3-cephem-4-carboxylates and Related Compounds

Studies on Anti-MRSA Parenteral Cephalosporins. II. Synthesis and Antibacterial Activity of 7.BETA.-[2-(5-Amino-1,2,4-thiadiazol-3-yl)-2(Z)-alkoxyiminoacetamido]-3-(substituted imidazo [1,2-b]pyridazinium-1-yl)methyl-3-cephem-4-carboxylates and Related Compounds

by ISHIKAWA, TOMOYASU, KAMIYAMA, KJEIJI, MATSUNAGA, NOBUYUKI, TAWADA, HIROYUKI, IIZAWA, YUJI, OKONOGI, KENJI, MIYAKE, AKIO
Published in Journal of antibiotics (2000)

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In Vitro and In Vivo Efficacy of the Triazole TAK-187 against Cryptococcus neoformans

In Vitro and In Vivo Efficacy of the Triazole TAK-187 against Cryptococcus neoformans

by SCHELL, W. A, MADEIRA DUBOC DE ALMEIDA, G, DODGE, R. K, OKONOGI, K, PERFECT, J. R
Published in Antimicrobial Agents and Chemotherapy (01.10.1998)

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Optically Active Antifungal Azoles. VIII. Synthesis and Antifungal Activity of 1-((1R,2R)-2-(2,4-Difluoro- and 2-Fluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl)-3-(4-substituted phenyl)-2(1H,3H)-imidazolones and 2-Imidazolidinones

Optically Active Antifungal Azoles. VIII. Synthesis and Antifungal Activity of 1-((1R,2R)-2-(2,4-Difluoro- and 2-Fluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl)-3-(4-substituted phenyl)-2(1H,3H)-imidazolones and 2-Imidazolidinones

by KITAZAKI, Tomoyuki, TASAKA, Akihiro, TAMURA, Norikazu, MATSUSHITA, Yoshihiro, HOSONO, Hiroshi, HAYASHI, Ryogo, OKONOGI, Kenji, ITOH, Katsumi
Published in Chemical & pharmaceutical bulletin (1999)

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Optically Active Antifungal Azoles. VII. Synthesis and Antifungal Activity of Stereoisomers of 2-((1R,2R)-2-(2,4-Difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl)-4-(4-(2,2,3,3-tetrafluoropropoxy)phenyl)-3(2H,4H)-1,2,4-triazolone (TAK-187)

Optically Active Antifungal Azoles. VII. Synthesis and Antifungal Activity of Stereoisomers of 2-((1R,2R)-2-(2,4-Difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl)-4-(4-(2,2,3,3-tetrafluoropropoxy)phenyl)-3(2H,4H)-1,2,4-triazolone (TAK-187)

by TASAKA, Akihiro, KITAZAKI, Tomoyuki, TSUCHIMORI, Noboru, MATSUSHITA, Yoshihiro, HAYASHI, Rryogo, OKONOGI, Kenji, ITOH, Katsumi
Published in Chemical & pharmaceutical bulletin (1997)

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Emergence of methicillin-resistant clones from cephamycin-resistant Staphylococcus aureus

Emergence of methicillin-resistant clones from cephamycin-resistant Staphylococcus aureus

by Okonogi, K, Noji, Y, Kondo, M, Imada, A, Yokota, T
Published in Journal of antimicrobial chemotherapy (01.11.1989)

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