A new brain‐penetrant glucosylceramide synthase inhibitor as potential Therapeutics for Gaucher disease
Fujii, Takahiro, Tanaka, Yuta, Oki, Hideyuki, Sato, Sho, Shibata, Sachio, Maru, Takamitsu, Tanaka, Yuta, Tanaka, Maiko, Onishi, Tomohiro
Published in Journal of neurochemistry (01.11.2021)
Published in Journal of neurochemistry (01.11.2021)
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Discovery of an Orally Bioavailable, Brain-Penetrating, in Vivo Active Phosphodiesterase 2A Inhibitor Lead Series for the Treatment of Cognitive Disorders
Mikami, Satoshi, Sasaki, Shigekazu, Asano, Yasutomi, Ujikawa, Osamu, Fukumoto, Shoji, Nakashima, Kosuke, Oki, Hideyuki, Kamiguchi, Naomi, Imada, Haruka, Iwashita, Hiroki, Taniguchi, Takahiko
Published in Journal of medicinal chemistry (28.09.2017)
Published in Journal of medicinal chemistry (28.09.2017)
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Discovery of Novel, Highly Potent, and Selective Quinazoline-2-carboxamide-Based Matrix Metalloproteinase (MMP)-13 Inhibitors without a Zinc Binding Group Using a Structure-Based Design Approach
Nara, Hiroshi, Sato, Kenjiro, Naito, Takako, Mototani, Hideyuki, Oki, Hideyuki, Yamamoto, Yoshio, Kuno, Haruhiko, Santou, Takashi, Kanzaki, Naoyuki, Terauchi, Jun, Uchikawa, Osamu, Kori, Masakuni
Published in Journal of medicinal chemistry (13.11.2014)
Published in Journal of medicinal chemistry (13.11.2014)
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Discovery of a Novel Series of Pyrazolo[1,5-a]pyrimidine-Based Phosphodiesterase 2A Inhibitors Structurally Different from N-((1S)-1-(3-Fluoro-4-(trifluoromethoxy)phenyl)-2-methoxyethyl)-7-methoxy-2-oxo-2,3-dihydropyrido[2,3-b]pyrazine-4(1H)-carboxamide (TAK-915), for the Treatment of Cognitive Disorders
Mikami, Satoshi, Kawasaki, Masanori, Ikeda, Shuhei, Negoro, Nobuyuki, Nakamura, Shinji, Nomura, Izumi, Ashizawa, Tomoko, Kokubo, Hironori, Hoffman, Isaac Dylan, Zou, Hua, Oki, Hideyuki, Uchiyama, Noriko, Hiura, Yuuto, Miyamoto, Maki, Itou, Yuuki, Nakashima, Masato, Iwashita, Hiroki, Taniguchi, Takahiko
Published in Chemical & pharmaceutical bulletin (2017)
Published in Chemical & pharmaceutical bulletin (2017)
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Design and synthesis of a novel 2-oxindole scaffold as a highly potent and brain-penetrant phosphodiesterase 10A inhibitor
Yoshikawa, Masato, Kamisaki, Haruhi, Kunitomo, Jun, Oki, Hideyuki, Kokubo, Hironori, Suzuki, Akihiro, Ikemoto, Tomomi, Nakashima, Kosuke, Kamiguchi, Naomi, Harada, Akina, Kimura, Haruhide, Taniguchi, Takahiko
Published in Bioorganic & medicinal chemistry (15.11.2015)
Published in Bioorganic & medicinal chemistry (15.11.2015)
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Novel approach of fragment-based lead discovery applied to renin inhibitors
Tawada, Michiko, Suzuki, Shinkichi, Imaeda, Yasuhiro, Oki, Hideyuki, Snell, Gyorgy, Behnke, Craig A., Kondo, Mitsuyo, Tarui, Naoki, Tanaka, Toshimasa, Kuroita, Takanobu, Tomimoto, Masaki
Published in Bioorganic & medicinal chemistry (15.11.2016)
Published in Bioorganic & medicinal chemistry (15.11.2016)
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Discovery of N -[5-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2- b ]pyridazin-6-yl}oxy)-2-methylphenyl]-1,3-dimethyl-1 H -pyrazole-5-carboxamide (TAK-593), a highly potent VEGFR2 kinase inhibitor
Miyamoto, Naoki, Sakai, Nozomu, Hirayama, Takaharu, Miwa, Kazuhiro, Oguro, Yuya, Oki, Hideyuki, Okada, Kengo, Takagi, Terufumi, Iwata, Hidehisa, Awazu, Yoshiko, Yamasaki, Seiji, Takeuchi, Toshiyuki, Miki, Hiroshi, Hori, Akira, Imamura, Shinichi
Published in Bioorganic & medicinal chemistry (01.04.2013)
Published in Bioorganic & medicinal chemistry (01.04.2013)
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Crystal structure of methionine aminopeptidase from hyperthermophile, Pyrococcus furiosus
Tahirov, T H, Oki, H, Tsukihara, T, Ogasahara, K, Yutani, K, Ogata, K, Izu, Y, Tsunasawa, S, Kato, I
Published in Journal of molecular biology (20.11.1998)
Published in Journal of molecular biology (20.11.1998)
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Refined structure of orthorhombic lysozyme crystallized at high temperature: correlation between morphology and intermolecular contacts
Oki, Hideyuki, Matsuura, Yoshiki, Komatsu, Hiroshi, Chernov, Alexander A.
Published in Acta crystallographica. Section D, Biological crystallography. (01.01.1999)
Published in Acta crystallographica. Section D, Biological crystallography. (01.01.1999)
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Cryo-EM Structure of K+-Bound hERG Channel Complexed with the Blocker Astemizole
Asai, Tatsuki, Adachi, Naruhiko, Moriya, Toshio, Oki, Hideyuki, Maru, Takamitsu, Kawasaki, Masato, Suzuki, Kano, Chen, Sisi, Ishii, Ryohei, Yonemori, Kazuko, Igaki, Shigeru, Yasuda, Satoshi, Ogasawara, Satoshi, Senda, Toshiya, Murata, Takeshi
Published in Structure (London) (04.03.2021)
Published in Structure (London) (04.03.2021)
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Synthesis and structure activity relationship studies of benzothieno[3,2-b]furan derivatives as a novel class of IKKbeta inhibitors
Sugiyama, Hideyuki, Yoshida, Masato, Mori, Kouji, Kawamoto, Tomohiro, Sogabe, Satoshi, Takagi, Terufumi, Oki, Hideyuki, Tanaka, Toshimasa, Kimura, Hiroyuki, Ikeura, Yoshinori
Published in Chemical & pharmaceutical bulletin (2007)
Published in Chemical & pharmaceutical bulletin (2007)
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Journal Article
Discovery of a B‑Cell Lymphoma 6 Protein–Protein Interaction Inhibitor by a Biophysics-Driven Fragment-Based Approach
Kamada, Yusuke, Sakai, Nozomu, Sogabe, Satoshi, Ida, Koh, Oki, Hideyuki, Sakamoto, Kotaro, Lane, Weston, Snell, Gyorgy, Iida, Motoo, Imaeda, Yasuhiro, Sakamoto, Junichi, Matsui, Junji
Published in Journal of medicinal chemistry (25.05.2017)
Published in Journal of medicinal chemistry (25.05.2017)
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Discovery of 142-Fluoro-4-(1H-pyrazol-1-yl)phenyl]-5-methoxy-3-(1phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one (TAK-063), a Highly Potent, Selective, and Orally Active Phosphodiesterase 10A (PDE10A) Inhibitor
Kunitomo, Jun, Yoshikawa, Masato, Fushimi, Makoto, Kawada, Akira, Quinn, John F., Oki, Hideyuki, Kokubo, Hironori, Kondo, Mitsuyo, Nakashima, Kosuke, Kamiguchi, Naomi, Suzuki, Kazunori, Kimura, Haruhide, Taniguchi, Takahiko
Published in Journal of medicinal chemistry (27.11.2014)
Published in Journal of medicinal chemistry (27.11.2014)
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T-448, a specific inhibitor of LSD1 enzyme activity, improves learning function without causing thrombocytopenia in mice
Matsuda, Satoru, Baba, Rina, Oki, Hideyuki, Morimoto, Shinji, Toyofuku, Masashi, Igaki, Shigeru, Kamada, Yusuke, Iwasaki, Shinji, Matsumiya, Kota, Hibino, Ryosuke, Kamada, Hiroko, Hirakawa, Takeshi, Iwatani, Misa, Tsuchida, Ken, Hara, Ryujiro, Ito, Mitsuhiro, Kimura, Haruhide
Published in Neuropsychopharmacology (New York, N.Y.) (01.07.2019)
Published in Neuropsychopharmacology (New York, N.Y.) (01.07.2019)
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Journal Article
Design, synthesis, and structure–activity relationship of TAK-418 and its derivatives as a novel series of LSD1 inhibitors with lowered risk of hematological side effects
Hattori, Yasushi, Matsumoto, Shigemitsu, Morimoto, Shinji, Daini, Masaki, Toyofuku, Masashi, Matsuda, Satoru, Baba, Rina, Murakami, Koji, Iwatani, Misa, Oki, Hideyuki, Iwasaki, Shinji, Matsumiya, Kouta, Tominari, Yusuke, Kimura, Haruhide, Ito, Mitsuhiro
Published in European journal of medicinal chemistry (05.09.2022)
Published in European journal of medicinal chemistry (05.09.2022)
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Design, Synthesis, and Biological Evaluation of a Novel Series of 4‑Guanidinobenzoate Derivatives as Enteropeptidase Inhibitors with Low Systemic Exposure for the Treatment of Obesity
Ikeda, Zenichi, Kakegawa, Keiko, Kikuchi, Fumiaki, Itono, Sachiko, Oki, Hideyuki, Yashiro, Hiroaki, Hiyoshi, Hideyuki, Tsuchimori, Kazue, Hamagami, Kenichi, Watanabe, Masanori, Sasaki, Masako, Ishihara, Youko, Tohyama, Kimio, Kitazaki, Tomoyuki, Maekawa, Tsuyoshi, Sasaki, Minoru
Published in Journal of medicinal chemistry (23.06.2022)
Published in Journal of medicinal chemistry (23.06.2022)
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Journal Article
Design, synthesis, and biological activity of novel, potent, and highly selective fused pyrimidine-2-carboxamide-4-one-based matrix metalloproteinase (MMP)-13 zinc-binding inhibitors
Nara, Hiroshi, Sato, Kenjiro, Kaieda, Akira, Oki, Hideyuki, Kuno, Haruhiko, Santou, Takashi, Kanzaki, Naoyuki, Terauchi, Jun, Uchikawa, Osamu, Kori, Masakuni
Published in Bioorganic & medicinal chemistry (01.12.2016)
Published in Bioorganic & medicinal chemistry (01.12.2016)
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Discovery of Novel, Highly Potent, and Selective Matrix Metalloproteinase (MMP)-13 Inhibitors with a 1,2,4-Triazol-3-yl Moiety as a Zinc Binding Group Using a Structure-Based Design Approach
Nara, Hiroshi, Kaieda, Akira, Sato, Kenjiro, Naito, Takako, Mototani, Hideyuki, Oki, Hideyuki, Yamamoto, Yoshio, Kuno, Haruhiko, Santou, Takashi, Kanzaki, Naoyuki, Terauchi, Jun, Uchikawa, Osamu, Kori, Masakuni
Published in Journal of medicinal chemistry (26.01.2017)
Published in Journal of medicinal chemistry (26.01.2017)
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Discovery of Clinical Candidate N‑((1S)‑1-(3-Fluoro-4-(trifluoromethoxy)phenyl)-2-methoxyethyl)-7-methoxy-2-oxo-2,3-dihydropyrido[2,3‑b]pyrazine-4(1H)‑carboxamide (TAK-915): A Highly Potent, Selective, and Brain-Penetrating Phosphodiesterase 2A Inhibitor for the Treatment of Cognitive Disorders
Mikami, Satoshi, Nakamura, Shinji, Ashizawa, Tomoko, Nomura, Izumi, Kawasaki, Masanori, Sasaki, Shigekazu, Oki, Hideyuki, Kokubo, Hironori, Hoffman, Isaac D, Zou, Hua, Uchiyama, Noriko, Nakashima, Kosuke, Kamiguchi, Naomi, Imada, Haruka, Suzuki, Noriko, Iwashita, Hiroki, Taniguchi, Takahiko
Published in Journal of medicinal chemistry (28.09.2017)
Published in Journal of medicinal chemistry (28.09.2017)
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Journal Article
Discovery of Brain-Penetrant Glucosylceramide Synthase Inhibitors with a Novel Pharmacophore
Tanaka, Yuta, Seto, Masaki, Kakegawa, Keiko, Takami, Kazuaki, Kikuchi, Fumiaki, Yamamoto, Takeshi, Nakamura, Minoru, Daini, Masaki, Murakami, Masataka, Ohashi, Tomohiro, Kasahara, Takahito, Wang, Junsi, Ikeda, Zenichi, Wada, Yasufumi, Puenner, Florian, Fujii, Takahiro, Inazuka, Masakazu, Sato, Sho, Suzaki, Tomohiko, Oak, Jeong-Ho, Takai, Yuichi, Kohara, Hiroshi, Kimoto, Kouya, Oki, Hideyuki, Mikami, Satoshi, Sasaki, Minoru, Tanaka, Yuta
Published in Journal of medicinal chemistry (10.03.2022)
Published in Journal of medicinal chemistry (10.03.2022)
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