Lethal DNA Lesions Caused by Direct and Indirect Actions of X rays are Repaired via Different DSB Repair Pathways under Aerobic and Anoxic Conditions
Hirayama, Ryoichi, Ito, Atsushi, Uzawa, Akiko, Matsumoto, Yoshitaka, Noguchi, Miho, Li, Huizi, Suzuki, Motofumi, Ando, Koichi, Okayasu, Ryuichi, Hasegawa, Sumitaka, Furusawa, Yoshiya
Published in Radiation research (01.05.2021)
Published in Radiation research (01.05.2021)
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Journal Article
Radiosensitization effect of poly(ADP‐ribose) polymerase inhibition in cells exposed to low and high liner energy transfer radiation
Hirai, Takahisa, Shirai, Hidenori, Fujimori, Hiroaki, Okayasu, Ryuichi, Sasai, Keisuke, Masutani, Mitsuko
Published in Cancer science (01.06.2012)
Published in Cancer science (01.06.2012)
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Radiosensitization by PARP inhibition to proton beam irradiation in cancer cells
Hirai, Takahisa, Saito, Soichiro, Fujimori, Hiroaki, Matsushita, Keiichiro, Nishio, Teiji, Okayasu, Ryuichi, Masutani, Mitsuko
Published in Biochemical and biophysical research communications (09.09.2016)
Published in Biochemical and biophysical research communications (09.09.2016)
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Resistance of Bacillus subtilis Spore DNA to Lethal Ionizing Radiation Damage Relies Primarily on Spore Core Components and DNA Repair, with Minor Effects of Oxygen Radical Detoxification
Moeller, Ralf, Raguse, Marina, Reitz, Günther, Okayasu, Ryuichi, Li, Zuofeng, Klein, Stuart, Setlow, Peter, Nicholson, Wayne L
Published in Applied and Environmental Microbiology (01.01.2014)
Published in Applied and Environmental Microbiology (01.01.2014)
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Visualisation of γH2AX foci caused by heavy ion particle traversal; distinction between core track versus non-track damage
Nakajima, Nakako Izumi, Brunton, Holly, Watanabe, Ritsuko, Shrikhande, Amruta, Hirayama, Ryoichi, Matsufuji, Naruhiro, Fujimori, Akira, Murakami, Takeshi, Okayasu, Ryuichi, Jeggo, Penny, Shibata, Atsushi
Published in PloS one (14.08.2013)
Published in PloS one (14.08.2013)
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Recent Advances in the Biology of Heavy-Ion Cancer Therapy
Hamada, Nobuyuki, Imaoka, Tatsuhiko, Masunaga, Shin-ichiro, Ogata, Toshiyuki, Okayasu, Ryuichi, Takahashi, Akihisa, Kato, Takamitsu A, Kobayashi, Yasuhiko, Ohnishi, Takeo, Ono, Koji, Shimada, Yoshiya, Teshima, Teruki
Published in JOURNAL OF RADIATION RESEARCH (2010)
Published in JOURNAL OF RADIATION RESEARCH (2010)
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Nontoxic concentration of DNA‐PK inhibitor NU7441 radio‐sensitizes lung tumor cells with little effect on double strand break repair
Sunada, Shigeaki, Kanai, Hideki, Lee, Younghyun, Yasuda, Takeshi, Hirakawa, Hirokazu, Liu, Cuihua, Fujimori, Akira, Uesaka, Mitsuru, Okayasu, Ryuichi
Published in Cancer science (01.09.2016)
Published in Cancer science (01.09.2016)
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TAS-116, a Novel Hsp90 Inhibitor, Selectively Enhances Radiosensitivity of Human Cancer Cells to X-rays and Carbon Ion Radiation
Lee, Younghyun, Sunada, Shigeaki, Hirakawa, Hirokazu, Fujimori, Akira, Nickoloff, Jac A, Okayasu, Ryuichi
Published in Molecular cancer therapeutics (01.01.2017)
Published in Molecular cancer therapeutics (01.01.2017)
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Novel function of HATs and HDACs in homologous recombination through acetylation of human RAD52 at double-strand break sites
Yasuda, Takeshi, Kagawa, Wataru, Ogi, Tomoo, Kato, Takamitsu A, Suzuki, Takehiro, Dohmae, Naoshi, Takizawa, Kazuya, Nakazawa, Yuka, Genet, Matthew D, Saotome, Mika, Hama, Michio, Konishi, Teruaki, Nakajima, Nakako Izumi, Hazawa, Masaharu, Tomita, Masanori, Koike, Manabu, Noshiro, Katsuko, Tomiyama, Kenichi, Obara, Chizuka, Gotoh, Takaya, Ui, Ayako, Fujimori, Akira, Nakayama, Fumiaki, Hanaoka, Fumio, Sugasawa, Kaoru, Okayasu, Ryuichi, Jeggo, Penny A, Tajima, Katsushi
Published in PLoS genetics (28.03.2018)
Published in PLoS genetics (28.03.2018)
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Oxygen Enhancement Ratio in Radiation-Induced Initial DSBs by an Optimized Flow Cytometry-based Gamma-H2AX Analysis in A549 Human Cancer Cells
Sunada, Shigeaki, Hirakawa, Hirokazu, Fujimori, Akira, Uesaka, Mitsuru, Okayasu, Ryuichi
Published in Radiation research (01.11.2017)
Published in Radiation research (01.11.2017)
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Contributions of direct and indirect actions in cell killing by high-LET radiations
Hirayama, Ryoichi, Ito, Atsushi, Tomita, Masanori, Tsukada, Teruyo, Yatagai, Fumio, Noguchi, Miho, Matsumoto, Yoshitaka, Kase, Yuki, Ando, Koichi, Okayasu, Ryuichi, Furusawa, Yoshiya
Published in Radiation research (01.02.2009)
Published in Radiation research (01.02.2009)
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Pre-exposure to ionizing radiation stimulates DNA double strand break end resection, promoting the use of homologous recombination repair
Nakajima, Nakako Izumi, Hagiwara, Yoshihiko, Oike, Takahiro, Okayasu, Ryuichi, Murakami, Takeshi, Nakano, Takashi, Shibata, Atsushi
Published in PloS one (31.03.2015)
Published in PloS one (31.03.2015)
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The complexity of DNA double strand break is a crucial factor for activating ATR signaling pathway for G2/M checkpoint regulation regardless of ATM function
Xue, Lian, Furusawa, Yoshiya, Okayasu, Ryuichi, Miura, Masahiko, Cui, Xing, Liu, Cuihua, Hirayama, Ryoichi, Matsumoto, Yoshitaka, Yajima, Hirohiko, Yu, Dong
Published in DNA repair (01.01.2015)
Published in DNA repair (01.01.2015)
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OH Radicals from the Indirect Actions of X-Rays Induce Cell Lethality and Mediate the Majority of the Oxygen Enhancement Effect
Hirayama, Ryoichi, Ito, Atsushi, Noguchi, Miho, Matsumoto, Yoshitaka, Uzawa, Akiko, Kobashi, Gen, Okayasu, Ryuichi, Furusawa, Yoshiya
Published in Radiation research (01.11.2013)
Published in Radiation research (01.11.2013)
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A comprehensive analysis of radiosensitization targets; functional inhibition of DNA methyltransferase 3B radiosensitizes by disrupting DNA damage regulation
Fujimori, Hiroaki, Sato, Akira, Kikuhara, Sota, Wang, Junhui, Hirai, Takahisa, Sasaki, Yuka, Murakami, Yasufumi, Okayasu, Ryuichi, Masutani, Mitsuko
Published in Scientific reports (15.12.2015)
Published in Scientific reports (15.12.2015)
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Metabolism and the Paradoxical Effects of Arsenic: Carcinogenesis and Anticancer
XING CUI, KOBAYASHI, Yayoi, AKASHI, Makoto, OKAYASU, Ryuichi
Published in Current medicinal chemistry (01.09.2008)
Published in Current medicinal chemistry (01.09.2008)
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Radiosensitization of human lung cancer cells by the novel purine-scaffold Hsp90 inhibitor, PU-H71
SEGAWA, TATSUYA, FUJII, YOSHIHIRO, TANAKA, AYA, BANDO, SHIN-ICHI, OKAYASU, RYUICHI, OHNISHI, KEN, KUBOTA, NOBUO
Published in International journal of molecular medicine (01.03.2014)
Published in International journal of molecular medicine (01.03.2014)
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Repair of DNA damage induced by accelerated heavy ions in mammalian cells proficient and deficient in the non-homologous end-joining pathway
Okayasu, Ryuichi, Okada, Maki, Okabe, Atsushi, Noguchi, Miho, Takakura, Kaoru, Takahashi, Sentaro
Published in Radiation research (01.01.2006)
Published in Radiation research (01.01.2006)
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