Crystal structure of NOD2 and its implications in human disease
Maekawa, Sakiko, Ohto, Umeharu, Shibata, Takuma, Miyake, Kensuke, Shimizu, Toshiyuki
Published in Nature communications (10.06.2016)
Published in Nature communications (10.06.2016)
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Journal Article
Cryo-EM structures of Toll-like receptors in complex with UNC93B1
Ishida, Hanako, Asami, Jinta, Zhang, Zhikuan, Nishizawa, Tomohiro, Shigematsu, Hideki, Ohto, Umeharu, Shimizu, Toshiyuki
Published in Nature structural & molecular biology (01.02.2021)
Published in Nature structural & molecular biology (01.02.2021)
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Journal Article
Structural basis of CpG and inhibitory DNA recognition by Toll-like receptor 9
Ohto, Umeharu, Shibata, Takuma, Tanji, Hiromi, Ishida, Hanako, Krayukhina, Elena, Uchiyama, Susumu, Miyake, Kensuke, Shimizu, Toshiyuki
Published in Nature (London) (30.04.2015)
Published in Nature (London) (30.04.2015)
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Journal Article
Improving particle quality in cryo-EM analysis using a PEGylation method
Zhang, Zhikuan, Shigematsu, Hideki, Shimizu, Toshiyuki, Ohto, Umeharu
Published in Structure (London) (07.10.2021)
Published in Structure (London) (07.10.2021)
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Journal Article
Structural basis for the oligomerization-mediated regulation of NLRP3 inflammasome activation
Ohto, Umeharu, Kamitsukasa, Yukie, Ishida, Hanako, Zhang, Zhikuan, Murakami, Karin, Hirama, Chie, Maekawa, Sakiko, Shimizu, Toshiyuki
Published in Proceedings of the National Academy of Sciences - PNAS (15.03.2022)
Published in Proceedings of the National Academy of Sciences - PNAS (15.03.2022)
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Journal Article
Structure of IZUMO1–JUNO reveals sperm–oocyte recognition during mammalian fertilization
Ohto, Umeharu, Ishida, Hanako, Krayukhina, Elena, Uchiyama, Susumu, Inoue, Naokazu, Shimizu, Toshiyuki
Published in Nature (London) (23.06.2016)
Published in Nature (London) (23.06.2016)
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Journal Article
Mechanisms controlling nucleic acid-sensing Toll-like receptors
Miyake, Kensuke, Shibata, Takuma, Ohto, Umeharu, Shimizu, Toshiyuki, Saitoh, Shin-Ichiroh, Fukui, Ryutaro, Murakami, Yusuke
Published in International immunology (08.03.2018)
Published in International immunology (08.03.2018)
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Journal Article
Structure of SARS-CoV-2 membrane protein essential for virus assembly
Zhang, Zhikuan, Nomura, Norimichi, Muramoto, Yukiko, Ekimoto, Toru, Uemura, Tomoko, Liu, Kehong, Yui, Moeko, Kono, Nozomu, Aoki, Junken, Ikeguchi, Mitsunori, Noda, Takeshi, Iwata, So, Ohto, Umeharu, Shimizu, Toshiyuki
Published in Nature communications (05.08.2022)
Published in Nature communications (05.08.2022)
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Journal Article
Structure of the bile acid transporter and HBV receptor NTCP
Asami, Jinta, Kimura, Kanako Terakado, Fujita-Fujiharu, Yoko, Ishida, Hanako, Zhang, Zhikuan, Nomura, Yayoi, Liu, Kehong, Uemura, Tomoko, Sato, Yumi, Ono, Masatsugu, Yamamoto, Masaki, Noda, Takeshi, Shigematsu, Hideki, Drew, David, Iwata, So, Shimizu, Toshiyuki, Nomura, Norimichi, Ohto, Umeharu
Published in Nature (London) (30.06.2022)
Published in Nature (London) (30.06.2022)
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Journal Article
Guanosine and its modified derivatives are endogenous ligands for TLR7
Shibata, Takuma, Ohto, Umeharu, Nomura, Shosaku, Kibata, Kayoko, Motoi, Yuji, Zhang, Yan, Murakami, Yusuke, Fukui, Ryutaro, Ishimoto, Tatsushi, Sano, Shigetoshi, Ito, Tomoki, Shimizu, Toshiyuki, Miyake, Kensuke
Published in International immunology (01.05.2016)
Published in International immunology (01.05.2016)
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Journal Article
Structural Analyses of Toll-like Receptor 7 Reveal Detailed RNA Sequence Specificity and Recognition Mechanism of Agonistic Ligands
Zhang, Zhikuan, Ohto, Umeharu, Shibata, Takuma, Taoka, Masato, Yamauchi, Yoshio, Sato, Ryota, Shukla, Nikunj M., David, Sunil A., Isobe, Toshiaki, Miyake, Kensuke, Shimizu, Toshiyuki
Published in Cell reports (Cambridge) (18.12.2018)
Published in Cell reports (Cambridge) (18.12.2018)
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Journal Article
Small-molecule inhibition of TLR8 through stabilization of its resting state
Zhang, Shuting, Hu, Zhenyi, Tanji, Hiromi, Jiang, Shuangshuang, Das, Nabanita, Li, Jing, Sakaniwa, Kentaro, Jin, Jin, Bian, Yanyan, Ohto, Umeharu, Shimizu, Toshiyuki, Yin, Hang
Published in Nature chemical biology (01.01.2018)
Published in Nature chemical biology (01.01.2018)
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