Lead Identification of 8‑(Methylamino)-2-oxo-1,2-dihydroquinoline Derivatives as DNA Gyrase Inhibitors: Hit-to-Lead Generation Involving Thermodynamic Evaluation
Ushiyama, Fumihito, Amada, Hideaki, Takeuchi, Tomoki, Tanaka-Yamamoto, Nozomi, Kanazawa, Harumi, Nakano, Koichiro, Mima, Masashi, Masuko, Aiko, Takata, Iichiro, Hitaka, Kosuke, Iwamoto, Kunihiko, Sugiyama, Hiroyuki, Ohtake, Norikazu
Published in ACS omega (05.05.2020)
Published in ACS omega (05.05.2020)
Get full text
Journal Article
Identification of highly selective and potent orexin receptor 1 antagonists derived from a dual orexin receptor 1/2 antagonist based on the structural framework of pyrazoylethylbenzamide
Futamura, Aya, Nozawa, Dai, Araki, Yuko, Tamura, Yunoshin, Tokura, Seiken, Kawamoto, Hiroshi, Tokumaru, Yuichi, Kakihara, Sora, Aoki, Takeshi, Ohtake, Norikazu
Published in Bioorganic & medicinal chemistry (15.10.2017)
Published in Bioorganic & medicinal chemistry (15.10.2017)
Get full text
Journal Article
Design, Synthesis, and Discovery of a Novel CCR1 Antagonist
Naya, Akira, Sagara, Yufu, Ohwaki, Kenji, Saeki, Toshihiko, Ichikawa, Daisuke, Iwasawa, Yoshikazu, Noguchi, Kazuhito, Ohtake, Norikazu
Published in Journal of medicinal chemistry (26.04.2001)
Published in Journal of medicinal chemistry (26.04.2001)
Get full text
Journal Article
Structure–Activity Relationships of 2-(Benzothiazolylthio)acetamide Class of CCR3 Selective Antagonist
Naya, Akira, Kobayashi, Kensuke, Ishikawa, Makoto, Ohwaki, Kenji, Saeki, Toshihiko, Noguchi, Kazuhito, Ohtake, Norikazu
Published in Chemical & Pharmaceutical Bulletin (2003)
Published in Chemical & Pharmaceutical Bulletin (2003)
Get full text
Journal Article
Discovery of a novel CCR3 selective antagonist
Naya, Akira, Kobayashi, Kensuke, Ishikawa, Makoto, Ohwaki, Kenji, Saeki, Toshihiko, Noguchi, Kazuhito, Ohtake, Norikazu
Published in Bioorganic & medicinal chemistry letters (07.05.2001)
Published in Bioorganic & medicinal chemistry letters (07.05.2001)
Get full text
Journal Article
Discovery of 2-Aminothiazole-4-carboxamides, a Novel Class of Muscarinic M3 Selective Antagonists, through Solution-Phase Parallel Synthesis
Sagara, Yufu, Mitsuya, Morihiro, Uchiyama, Minaho, Ogino, Yoshio, Kimura, Toshifumi, Ohtake, Norikazu, Mase, Toshiaki
Published in Chemical & pharmaceutical bulletin (2005)
Published in Chemical & pharmaceutical bulletin (2005)
Get full text
Journal Article
Pharmacological Properties of (2R)-N-[1-(6-Aminopyridin-2-ylmethyl)piperidin-4-yl]-2-[(1R)-3,3-difluorocyclopentyl]-2- hydroxy-2-phenylacetamide: A Novel Muscarinic Antagonist with M2-Sparing Antagonistic Activity
Hiroyasu Hirose, Ikuo Aoki, Toshifumi Kimura, Toru Fujikawa, Tomoshige Numazawa, Kaori Sasaki, Akio Sato, Takuro Hasegawa, Masaru Nishikibe, Morihiro Mitsuya, Norikazu Ohtake, Toshiaki Mase, Kazuhito Noguchi
Published in The Journal of pharmacology and experimental therapeutics (01.05.2001)
Get full text
Published in The Journal of pharmacology and experimental therapeutics (01.05.2001)
Journal Article
Fragment-Based Discovery of Novel Non-Hydroxamate LpxC Inhibitors with Antibacterial Activity
Yamada, Yousuke, Takashima, Hajime, Walmsley, David Lee, Ushiyama, Fumihito, Matsuda, Yohei, Kanazawa, Harumi, Yamaguchi-Sasaki, Toru, Tanaka-Yamamoto, Nozomi, Yamagishi, Junya, Kurimoto-Tsuruta, Risa, Ogata, Yuya, Ohtake, Norikazu, Angove, Hayley, Baker, Lisa, Harris, Richard, Macias, Alba, Robertson, Alan, Surgenor, Allan, Watanabe, Hayato, Nakano, Koichiro, Mima, Masashi, Iwamoto, Kunihiko, Okada, Atsushi, Takata, Iichiro, Hitaka, Kosuke, Tanaka, Akihiro, Fujita, Kiyoko, Sugiyama, Hiroyuki, Hubbard, Roderick E
Published in Journal of medicinal chemistry (10.12.2020)
Published in Journal of medicinal chemistry (10.12.2020)
Get full text
Journal Article
Discovery of MGS0274, an ester prodrug of a metabotropic glutamate receptor 2/3 agonist with improved oral bioavailability
Urabe, Hiroki, Miyakoshi, Naoki, Ohtake, Norikazu, Nozoe, Akiko, Ochi, Motoki, Fukasawa, Misako, Kinoshita, Kohnosuke, Yamaguchi, Jun-ichi, Marumo, Toshiyuki, Hikichi, Hirohiko, Chaki, Shigeyuki, Hashihayata, Takashi
Published in European journal of medicinal chemistry (01.10.2020)
Published in European journal of medicinal chemistry (01.10.2020)
Get full text
Journal Article
Lead optimization of 8-(methylamino)-2-oxo-1,2-dihydroquinolines as bacterial type II topoisomerase inhibitors
Ushiyama, Fumihito, Amada, Hideaki, Mihara, Yasuhiro, Takeuchi, Tomoki, Tanaka-Yamamoto, Nozomi, Mima, Masashi, Kamitani, Masafumi, Wada, Reiko, Tamura, Yunoshin, Endo, Mayumi, Masuko, Aiko, Takata, Iichiro, Hitaka, Kosuke, Sugiyama, Hiroyuki, Ohtake, Norikazu
Published in Bioorganic & medicinal chemistry (15.11.2020)
Published in Bioorganic & medicinal chemistry (15.11.2020)
Get full text
Journal Article
Design, synthesis and biological evaluation of novel 7-azaspiro[3.5]nonane derivatives as GPR119 agonists
Matsuda, Daisuke, Kawamura, Madoka, Kobashi, Yohei, Shiozawa, Fumiyasu, Suga, Youichirou, Fusegi, Keiko, Nishimoto, Shinichi, Kimura, Kayo, Miyoshi, Masako, Takayama, Noriko, Kakinuma, Hiroyuki, Ohtake, Norikazu
Published in Bioorganic & medicinal chemistry (01.05.2018)
Published in Bioorganic & medicinal chemistry (01.05.2018)
Get full text
Journal Article
Novel 3H-[1,2,3]triazolo[4,5-c]pyridine derivatives as GPR119 agonists: Synthesis and structure-activity/solubility relationships
Matsuda, Daisuke, Kobashi, Yohei, Mikami, Ayako, Kawamura, Madoka, Shiozawa, Fumiyasu, Kawabe, Kenichi, Hamada, Makoto, Nishimoto, Shinichi, Kimura, Kayo, Miyoshi, Masako, Takayama, Noriko, Kakinuma, Hiroyuki, Ohtake, Norikazu
Published in Bioorganic & medicinal chemistry (15.08.2017)
Published in Bioorganic & medicinal chemistry (15.08.2017)
Get full text
Journal Article
High-Contrast PET Imaging of Vasopressin V 1B Receptors with a Novel Radioligand, 11 C-TASP699
Koga, Kazumi, Nagai, Yuji, Hanyu, Masayuki, Yoshinaga, Mitsukane, Chaki, Shigeyuki, Ohtake, Norikazu, Ozaki, Satoshi, Zhang, Ming-Rong, Suhara, Tetsuya, Higuchi, Makoto
Published in Journal of Nuclear Medicine (01.10.2017)
Published in Journal of Nuclear Medicine (01.10.2017)
Get full text
Journal Article
High-Contrast PET Imaging of Vasopressin V^sub 1B^ Receptors with a Novel Radioligand, ^sup 11^C-TASP699
Koga, Kazumi, Nagai, Yuji, Hanyu, Masayuki, Yoshinaga, Mitsukane, Chaki, Shigeyuki, Ohtake, Norikazu, Ozaki, Satoshi, Zhang, Ming-Rong, Suhara, Tetsuya, Higuchi, Makoto
Published in The Journal of nuclear medicine (1978) (01.10.2017)
Get full text
Published in The Journal of nuclear medicine (1978) (01.10.2017)
Journal Article
Novel 3 H -[1,2,3]triazolo[4,5- c ]pyridine derivatives as GPR119 agonists: Synthesis and structure-activity/solubility relationships
Matsuda, Daisuke, Kobashi, Yohei, Mikami, Ayako, Kawamura, Madoka, Shiozawa, Fumiyasu, Kawabe, Kenichi, Hamada, Makoto, Nishimoto, Shinichi, Kimura, Kayo, Miyoshi, Masako, Takayama, Noriko, Kakinuma, Hiroyuki, Ohtake, Norikazu
Published in Bioorganic & medicinal chemistry (01.08.2017)
Published in Bioorganic & medicinal chemistry (01.08.2017)
Get full text
Journal Article
Discovery and in vitro and in vivo profiles of N-ethyl-N-[2-[3-(5-fluoro-2-pyridinyl)-1H-pyrazol-1-yl]ethyl]-2-(2H-1,2,3-triazol-2-yl)-benzamide as a novel class of dual orexin receptor antagonist
Suzuki, Ryo, Nozawa, Dai, Futamura, Aya, Nishikawa-Shimono, Rie, Abe, Masahito, Hattori, Nobutaka, Ohta, Hiroshi, Araki, Yuko, Kambe, Daiji, Ohmichi, Mari, Tokura, Seiken, Aoki, Takeshi, Ohtake, Norikazu, Kawamoto, Hiroshi
Published in Bioorganic & medicinal chemistry (15.03.2015)
Published in Bioorganic & medicinal chemistry (15.03.2015)
Get full text
Journal Article