Monoamine oxidase B oxidizes a novel multikinase inhibitor KW-2449 to its iminium ion and aldehyde oxidase further converts it to the oxo-piperazine form in human
Hosogi, Jun, Ohashi, Rui, Maeda, Hiroshi, Tashiro, Satoshi, Fuse, Eiichi, Yamamoto, Yorihiro, Kuwabara, Takashi
Published in Drug metabolism and pharmacokinetics (01.10.2017)
Published in Drug metabolism and pharmacokinetics (01.10.2017)
Get full text
Journal Article
An iminium ion metabolite hampers the production of the pharmacologically active metabolite of a multikinase inhibitor KW‐2449 in primates: irreversible inhibition of aldehyde oxidase and covalent binding with endogenous proteins
Hosogi, Jun, Ohashi, Rui, Maeda, Hiroshi, Fujita, Kazuhiro, Ushiki, Junko, Kuwabara, Takashi, Yamamoto, Yorihiro, Imamura, Toru
Published in Biopharmaceutics & drug disposition (01.03.2018)
Published in Biopharmaceutics & drug disposition (01.03.2018)
Get full text
Journal Article
Analytical method validation for biomarkers as a drug development tool: points to consider
Ohtsu, Yoshiaki, Tanaka, Seiji, Igarashi, Harue, Kakehi, Masaaki, Mori, Tamiki, Nakamura, Takahiro, Ohashi, Rui, Shimizu, Hiroyuki, Yasuda, Yutaka, Okayama, Takashige, Kakuo, Hiroyuki, Yokoi, Hiroyuki, Horiuchi, Mizuki, Katashima, Masataka, Nakamura, Ryosuke, Saito, Kosuke, Saito, Yoshiro
Published in Bioanalysis (01.09.2021)
Published in Bioanalysis (01.09.2021)
Get full text
Journal Article
CONTROL APPARATUS
SUZUKI SHOTARO, MIURA YUICHI, KANESHIMA YOSHIHARU, OHASHI RUI, MURAKAMI HIROKI
Year of Publication 01.11.2018
Get full text
Year of Publication 01.11.2018
Patent
HYDRAULIC BRAKE RELEASE DEVICE
SUZUKI SHOTARO, MIURA YUICHI, KANESHIMA YOSHIHARU, OHASHI RUI, MURAKAMI HIROKI
Year of Publication 01.11.2018
Get full text
Year of Publication 01.11.2018
Patent
BELT-SHAPED BODY CONVEYING DEVICE
HIRATA KENSUKE, ISHIBASHI KIEN, OHASHI RUI, HASEGAWA TAKAAKI, KUSUMI TOMOO
Year of Publication 07.09.2017
Get full text
Year of Publication 07.09.2017
Patent
BELT-SHAPED BODY CONVEYING DEVICE
HIRATA KENSUKE, ISHIBASHI KIEN, OHASHI RUI, HASEGAWA TAKAAKI, KUSUMI TOMOO
Year of Publication 07.09.2017
Get full text
Year of Publication 07.09.2017
Patent